A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

BRAF binds PBK and KRAS. 3 / 3
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"Molecular analysis of sporadic CRCs in Group 2 showed that diffuse TOPK expression was associated with KRAS and BRAF mutations (p<0.001) and with poor outcome in patients with either mutation in univariate and multivariate analysis ( P =0.017)."
"In sporadic CRC, diffuse TOPK expression was associated with the presence of KRAS or BRAF mutation, underlining the involvement of TOPK in ERK/MAPK signalling."
"As a MAPKK-like protein, it is a downstream molecule of KRAS and BRAF , both of which are associated with diffuse expression of TOPK ( xref )."