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UCHL5 leads to the deubiquitination of PGK1. 2 / 2
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"Furthermore, we demonstrated that pro-SFTPB negatively regulates PGK1 protein levels by binding to ADRM1 and suppressing complex formation by ADRM1, hRpn2 and UCH37; this weakened ADRM1/hRpn2/UCH37 complex-mediated PGK1 deubiquitination, thereby facilitating degradation of the PGK1 protein in NSCLC."
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"Importantly, we found colocalization of ADRM1 and PGK1 (Fig. 5d), and silencing of ADRM1 or UCH37 decreased PGK1 protein levels (Fig. 5e) and increased PGK1 ubiquitination in NSCLC cells (Fig. 5f), suggesting that the ADRM1/UCH37 axis is involved in the regulation of PGK1 deubiquitination."
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