IndraLab

Statements

IKK_complex activates CYLD. 3 / 3
| 3
reach
"IKK mediated CYLD activation is expected to remove K63 linked polyubiquitins from PSD proteins and thus regulate their trafficking."
24928390
reach
"Thus, CYLD and SPATA2 form a highly stable heterotetramer.43 Phosphorylation-mediated allosteric changes of a protein can reason to dimerization, which facilitates the binding of many response regulators to their partners.76 Therefore, homo-dimerized IKKϵ-mediated Ser418 phosphorylation could promote dimerization of CYLD and thus facilitate the interaction of CYLD with SPATA2."
35958947
reach
"Unexpectedly, our recent study revealed that NEMO is modified by SUMO-3, and this modification prevents the access of CYLD to the IKK complex, thus impairing the negative action of CYLD, a de-ubiquiti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23953672