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Prostaglandins inhibits UCHL1. 5 / 5
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"In addition, some cyclopentenone prostaglandins, such as delta12-PGJ2 and 15d-PGJ2, inhibit the activities of UCH-L1 and induce ubiquitinated protein aggregation in neuronal cells, which may provide a molecular mechanism linking inflammation with neurodegeneration [XREF_BIBR, XREF_BIBR]."
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"Sequestosome 1/p62 and ubiquitin C-terminal hydrolase L1 (UCH-L1), which is inhibited by some of the prostaglandins of the J2 series, were co-localized in the protein aggregates containing ubiquitinat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, the oxidative stress products cyclopentenone prostaglandins (CyPGs) and 4-hydroxynonenal (4-HNE) both decrease UCH-L1 solubility and facilitate aberrant protein interactions [XREF_BIBR]."
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"Additionally, the release of prostaglandins, such as biologically active cyclopentenone prostaglandins, that are massively produced in the rat brain after temporary focal ischemia, selectively blocks Uch-L1 activity."
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"Moreover, J2 prostaglandins inhibit the de-ubiquitinating enzyme UCH-L1, which is down-regulated in AD brains; UCH-L1 down-regulation is inversely proportional to the number of neurofibrillary tangles."
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