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Statements

RHEB binds BRAF and RAF1. 4 / 4
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sparser
"In this paper we report a strong interaction between RHEB and BRAF that results in decreased BRAF-CRAF dimerization and decreased BRAF/MEK/ERK signaling."
29320991
sparser
"Here, we demonstrate for the first time that activation of Rheb is associated with decreased B-Raf and C-Raf phosphorylation at residues Ser-446 and Ser-338, respectively, concomitant with a decrease in the activities of both kinases and decreased heterodimerization of B-Raf and C-Raf."
16803888
sparser
"In this paper we report a strong interaction between RHEB and BRAF that results in decreased BRAF-CRAF dimerization and decreased RAF/MEK/ERK signaling."
29320991
sparser
"It has been reported that RHEB interacts with RAF kinases, however, reports are conflicting on whether RHEB binds both BRAF and CRAF, or just BRAF [ xref , xref , xref , xref ]."
29320991