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USP15 inhibits Interferon. 11 / 12
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"However, when expressed alone, USP15 inhibited the IFN signaling pathway."
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"We will discuss them one by one.In a study using HEK293 T cells and Sendai virus (SeV), knockdown of the gene transcribing USP15 resulted in upregulation of type I IFN, while overexpression of USP15 decreased type I interferon as USP15 showed dose-dependent inhibition of IFN-β [16] ."
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"Although we can not rule out the possibility that USP15 exerts its effects in a third uncharacterized manner, the data in this study demonstrate that USP15 sequesters the interaction between RIG-I and IPS-1, shedding light on the mechanisms underlying the catalytic-activity-independent antagonism of IFN by USP15."
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"Knockdown of USP15 results in upregulation of type I IFN ."
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"We will discuss the DUBs that influence the pathways of interferons (IFN), tumor necrosis factors (TNF), TNF-related apoptosis-inducing ligand (TRAIL), interleukins (IL) and chemokines.In a study using HEK293 T cells and Sendai virus (SeV), knockdown of the gene transcribing USP15 resulted in upregulation of type I IFN, while overexpression of USP15 decreased type I interferon as USP15 showed dose-dependent inhibition of IFN-β [16]."
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"To verify the specific mechanism of USP15 mediated IFN inhibition, we identified the DUB activity site His862 of USP15 in vivo and in vitro, and we presented evidence that USP15 functions as a RIG-I deubiquitinase and specifically removes Lys63 linked polyubiquitin chains."
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"In a study using HEK293T cells and Sendai virus (SeV), knockdown of the gene transcribing USP15 resulted in upregulation of type I IFN, while overexpression of USP15 decreased type I interferon as USP15 showed dose dependent inhibition of IFN-beta [XREF_BIBR]."
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"Reminding us USP15 may antagonize type I IFN induction independently of catalytic activity."
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"These findings taken together support the hypothesis that USP15 function as a negative regulator of IFN signaling.We also assessed whether USP15 deubiquitinase activity is required for its inhibitory role in SEV-induced IFN induction."
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"These results together suggested that both USP15 constructed in two different expression plasmids inhibited the production of IFN."
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"Furthermore , USP15 can be recruited by ubiquitin-conjugating enzyme UBE2S ( E2 ) to deubiquitylates TBK1 , inhibiting type I IFN production ( Huang et al ., 2020 ) ."
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