IndraLab

Statements

USP14 binds HSPA8. 6 / 6
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sparser
"Another axis that mediates cross-talk between the proteasome and autophagy is the Usp14-Hsc70 axis."
32560122
sparser
"Using proteomic and in vitro cellular approaches for HD, Srinivasan and colleagues demonstrated that Usp14 and the chaperon Hsc70 dynamically interact."
32560122
sparser
"These findings demonstrated that modulating the USP14-HSC70 axis might offer an effective target in the management of Huntington’s disease by disturbing multiple proteastatic pathways."
35069211
sparser
"Proteasome inhibition enhanced binding of USP14 to HSC70, and to XBP1u and IRE1α proteins, demonstrating a role in the unfolded protein response."
31901637
reach
"Proteasome inhibition enhanced binding of USP14 to HSC70, and to XBP1u and IRE1alpha proteins, demonstrating a role in the unfolded protein response."
31901637
sparser
"Regulation of the USP14-HSC70 axis is therefore a potential therapeutic approach for Huntington disease, as it would beneficially affect a variety of protein homeostasis pathways ( xref )."
36187470