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Cyclin phosphorylates NPM1. 14 / 16
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"As phosphorylation of human NPM by cyclin E-cdk2 was reported to be essential for the initiation of centrosome duplication in late G 1, we considered that ARF might inhibit NPM phosphorylation in addition to retaining it in the nucleolus to arrest cell growth before S-phase entry."
19561638
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"For instance, CDK1/cyclin B phosphorylates NPM on several residues, which results in a decrease in the RNA-binding affinity of NPM [17] ."
16376875
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"In Kaposi's sarcoma herpesvirus (KSHV)-infected cells, NPM1 was phosphorylated by cyclin-dependent kinase (CDK) 6 after its activation by KSHV D-type cyclin, resulting in the accumulation of cells wit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It is not known whether nucleophosmin can also be phosphorylated by the Cdk2 and cyclin A complex."
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"Cdk2 activity is also synchronised with these events, as cyclin E1-Cdk2 phosphorylates nucleophosmin, CP110 and Mps1, promoting centrosome duplication [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
20180967
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"The exact role of this viral protein in regulating KSHV life cycle is not fully understood but studies indicate that v, Cyclin, and CDK6 complex mediated phosphorylation of nucleophosmin (NPM) facilitates NPM-LANA interaction and recruitment of HDAC1 to promote KSHV latency [XREF_BIBR]."
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"Cyclin E-Cdk2 mediated phosphorylation of NPM1 has been suggested to dissociate its binding from centrosomes at the G1-phase of the cell cycle and permit centrosome duplication prior to cell division [XREF_BIBR]."
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"This is coupled with phosphorylation of NPM by CDK1/cyclin B during mitosis (Peter et al., 1990) ."
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"Indeed, it has been shown that CDK1/cyclin B phosphorylates NPM on the residues other than Thr 199 [13] ."
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"At late G 1 phase, NPM is phosphorylated by cyclin E-Cdk2, phosphorylation which induces NPM release from the centrosomes and the initiation of centrosomal duplication."
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"Hence, it is thought that K cyclin-induced NPM1 phosphorylation triggers centrosome amplification."
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"Phosphorylation of Npm is catalyzed by CK2 and the cyclin dependent kinase cdc2 and cdk1."
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"In a model proposed by Fukasawa , centrosome disengagement in late G1 is licensed by the phosphorylation of nucleophosmin (NPM) by cyclin E/Cdk2 complexes ."
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"In particular, NPM1 phosphorylation by CDK1/cyclin B complex is the key event that initiates mitotic entry, and results in re-association of NPM1 with centrosomes during mitosis [ 37 , 38 ]."
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