IndraLab

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Cyclin phosphorylates NPM1. 10 / 12
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"It is not known whether nucleophosmin can also be phosphorylated by the Cdk2 and cyclin A complex."
19277494
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"At late G 1 phase, NPM is phosphorylated by cyclin E-Cdk2, phosphorylation which induces NPM release from the centrosomes and the initiation of centrosomal duplication."
24475373
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"Cyclin E-Cdk2 mediated phosphorylation of NPM1 has been suggested to dissociate its binding from centrosomes at the G1-phase of the cell cycle and permit centrosome duplication prior to cell division [XREF_BIBR]."
24044516
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"In a model proposed by Fukasawa , centrosome disengagement in late G1 is licensed by the phosphorylation of nucleophosmin (NPM) by cyclin E/Cdk2 complexes ."
30381801
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"As phosphorylation of human NPM by cyclin E-cdk2 was reported to be essential for the initiation of centrosome duplication in late G 1, we considered that ARF might inhibit NPM phosphorylation in addition to retaining it in the nucleolus to arrest cell growth before S-phase entry."
19561638
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"Cdk2 activity is also synchronised with these events, as cyclin E1-Cdk2 phosphorylates nucleophosmin, CP110 and Mps1, promoting centrosome duplication [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
20180967
sparser
"Hence, it is thought that K cyclin-induced NPM1 phosphorylation triggers centrosome amplification."
19326462
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"Source dataExtended Data Fig. 8: a, In vitro phosphorylation of NPM1 IDR by CDK1/cyclin B. Purified NPM1-IDR (wild-type (WT) and phosphomimetic mutant (Pm)) was incubated with CDK1/cyclin B at room temperature for 60 min."
35513709
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"The exact role of this viral protein in regulating KSHV life cycle is not fully understood but studies indicate that v, Cyclin, and CDK6 complex mediated phosphorylation of nucleophosmin (NPM) facilitates NPM-LANA interaction and recruitment of HDAC1 to promote KSHV latency [XREF_BIBR]."
25594667
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"Phosphorylation of Npm is catalyzed by CK2 and the cyclin dependent kinase cdc2 and cdk1."
25772360