IndraLab

Statements

Phenethyl caffeate inhibits PYCARD. 6 / 6
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"Moreover, CAPE significantly inhibited the formation of ASC dimers and reduced the abundance of NLRP3 inflammasome complexes in a dose dependent manner (XREF_FIG)."
32435622
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"Addition of CAPE attenuated precipitation of ASC with BT-CA, showing that CAPE prevented the binding of BT-CA to ASC (XREF_FIG)."
27934918
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"Co-immunoprecipitation study showed that CAPE prevented MSU induced association of NLRP3 and ASC in BMDMs (XREF_FIG)."
27934918
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"CAPE did not affect the mRNA levels of ASC, suggesting that CAPE did not inhibit the synthesis of ASC (XREF_SUPPLEMENTARY)."
27934918
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"These results suggest that CAPE suppresses the activation of the NLRP3 inflammasome by directly binding ASC, blocking the association of NLRP3 and ASC."
27934918
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"Consistently with the results with XREF_FIG, addition of CAPE abolished the precipitation of ASC with BT-CA in 293T cell lysates (XREF_FIG)."
27934918