IndraLab

Statements


3 | 4

sparser
"Mechanistically, we demonstrated that HAPSTR1 is bound to LRPPRC and PSMD14 via immunoprecipitation."

sparser
"Mechanistically, PSMD14 directly interacts with LRPPRC and inhibits its ubiquitination, thereby inhibiting autophagy through LRPPRC/Beclin1-Bcl-2/SQSTM1 signaling pathway."

sparser
"This suggests that HAPSTR1 promotes the association of LRPPRC with PSMD14."

sparser
"This demonstrates that HAPSTR1 inhibits LRPPRC degradation through ubiquitination by enhancing the LRPPRCPSMD14 interaction."