IndraLab

Statements

USP18 activates ITGAX. 3 / 3
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"However, it should be noted that in this study, USP18 expression in tumor cells not only affected tumor cell activity, but also regulated immune cells in tumor microenvironment in that tumor cell USP18 expression also activated CD11c + dendritic cells residing in the tumor."
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"In GM-CSF-supplemented culture, over-expression of Usp18 restored the development of CD11b + CD11c + cells in Usp18 deficient BM cells, but did not affect DC development in wild-type BM cells (XREF_FIG), which confirmed the notion that the development defect of BM-DCs is intrinsic to Usp18 deficient cells."
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"Only virus infection, supported by the Usp18 driven enforced virus replication process in CD11c + APCs is efficient in breaking immunologic tolerance to pancreatic islet cells in our model."
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