IndraLab

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PSMD14 decreases the amount of VHLL. 2 / 2
| 2

reach
"Based on the results obtained from RNAi screening targeting candidates that are present on the list derived from SARS-CoV-2 M IP/MS, we also attempted to identify the proteins that negatively regulate VLP release, especially the deubiquitinating enzyme POH1; knockdown of POH1 increased VLP release (Fig. S1A and Fig. 5A)."

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"Our data showed that overexpression of wild-type POH1, but not of the catalytic dead C120S mutant, decreases the M-E interaction (Fig. 5F), the ubiquitin level of M (Fig. 5G), and VLP release (Fig. 5H)."