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Lipopolysaccharide activates ERK. 699 / 717
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"LPS induced activation of both p38 mitogen activated protein kinase (MAPK) and extracellular signal regulated kinase (ERK) in C6 cells."
11684090
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"Results showed that either palmitate or LPS quickly activated ERK, JNK and NFkappaB signaling."
30273577
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"Additionally, others have also reported that butyrate may inhibit NF-κB and ERK signaling pathways to play anti-inflammatory effects in IFN-γ-stimulated RAW 264.7 cells or LPS-induced RAW 264.7 cells by inhibiting NF-κB and ERK signaling pathways [67,68]."
34384038
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"Finally, western blot analysis showed that saurolactam dose-dependently inhibited LPS induced extracellular signal regulated kinase (ERK)/mitogen-activated protein (MAP) kinase activation and nuclear factor (NF)-kappaB translocation into the nucleus."
19962455
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"The lack of an effect on the activation of ERK, however, is not entirely unexpected as LPS induced activation of ERK1/2 is through a RAF independent mechanism via the MAP3K TPL-2."
20637838
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"If LPS activation of ERK1/2 mediated the effects on P o, they would be expected to precede changes in transcription and alphaENaC abundance."
19823867
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"The phosphorylation of JNK, p38 MAPK, and ERK1/2 increased in cells treated with LPS alone."
25810745
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"We therefore focussed our research on identifying activators of the MEK and ERK cassette that were stimulated by LPS, inhibited by the anti CD14 blocking antibody 28C5 and essential for cytokine produ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17126402
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"Mechanistically, TFSB blocked LPS and CSE induced activation of ERK, Akt, and PKCalpha."
31209984
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"NO had no effect on LPS stimulated ERK1/2 and p38 MAPK activation, suggesting that the inhibitory action of NO occurs downstream of MAPK cascades."
16683234
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"These findings indicate that Cot and Tpl2 is essential for LPS induced ERK activation and RANKL induction in osteoblasts."
12821717
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"LPS induced DC maturation involves activation of p38, extracellular signal regulated kinase (ERK)/mitogen-activated protein kinases, and NF-kappaB."
14568957
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"Use of the inactive analog (U0124) of U0126 did not prevent LNFPIII-NGC or LPS induced ERK activation (XREF_FIG)."
26340260
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"Moreover, over-expression of DOK3 (FLAG tagged DOK3) in RAW264.7 macrophage cells attenuated LPS induced ERK activation (XREF_FIG)."
22761938
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"P38, JNK, ERK and NF-kappaB subunit p65 inhibitors could significantly inhibit the secretion of IL-1beta, TNF-alpha and HMGB1 induced by LPS."
32862374
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"We found that MCL did not affect the activation of LPS induced ERK, JNK and p38 MAPKs (XREF_FIG)."
26984741
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"LPS induced ERK, p38, JNK, Akt, and IkappaBalpha phosphorylation in neutrophils was not affected by pretreatment of cells with IFN-gamma, suggesting that IFN-gamma affects the pathway downstream or in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24140406
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"However, further studies are necessary to clearly demonstrate the exact mechanism by which avicularin inhibits LPS induced activation of ERK signaling pathway."
24009846
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"Furthermore , we observed that LPS stimulation can markedly increase p38 , ERK1 / 2 , and JNK phosphorylation ; however , Farrerol markedly decreased the ERK1 / 2 and JNK1 / 2 phosphorylation but had no effect on the p38 phosphorylation in LPS-stimulated RAW264.7 cells ( Figure 7A-D ) ."
30011811
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"Pretreatment with the nontoxic immunomodulator monophosphoryl lipid A (MPLA) prevents inhibition by LPS through activation of a TLR4-TRIF-PI3K pathway that prevents LPS induced ERK activation."
31241993
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"The present study suggests that in BEAS-2B cells and U937 cells, LPS probably activates ERK1/2 pathway and JNK pathway, which in turn initiate AP-1 activity, and leading to MMP-9 expression."
30468094
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"The underlying mechanism is that Lico.A inhibites LPS induced microglial activation via downregulation the activation of ERK1/2 and NF-kappaB p65 pathways."
28937602
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"Pre-treatment of HAM with PD98059 (50 muM) clearly inhibits LPS induced ERK activation and was without significant effect on p38 and JNK phosphorylation."
17916230
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"Mixtures of recombinant growth factors inhibit the production of pro inflammatory mediators and cytokines in LPS stimulated RAW 264.7 cells by inactivating the ERK and NF-kappaB pathways."
24888317
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"Notably matching the profile of pathways modulated in Vav deficient macrophages, Themis2 appeared to enhance the LPS induced activation of both p38 and ERK compared to parental RAW cells whereas activation of JNK in the same cells was unaffected (XREF_FIG)."
20644716
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"However, LPS induced extracellular signal regulated kinase (ERK) activation was prolonged in pMphi comparing with sMphi."
16636012
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"We stimulated cells for 10, 20, 40 and 60 minutes to observe the pERK induction pattern and found that LNFPIII-NGC drives late activation of ERK with peak phosphorylation at 60 mins, whereas LPS induced ERK activation as early as 20 mins (XREF_FIG)."
26340260
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"As shown in XREF_FIG, inotilone suppressed the LPS induced activation of ERK, JNK, and p38 MAPKs in a time dependent manner."
22590514
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"Moreover, diosgenin pretreatment significantly suppressed LPS-induced extracellular signal-regulated kinase (ERK) activation."
34638697
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"First, phosphorylation of MAPK, a signaling protein representative of ERK, JNK, and p38, activated by LPS, was confirmed by western blotting."
33572173
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"LPS stimulated HSCs activate ERK1/2 and NFkB in hepatocytes."
26031389
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"LPS stimulation of macrophages strongly activates not only the Erk1/2 MAP kinases, but also the other two known types of mammalian MAP kinases, p38 and JNK1 and JNK2."
9314552
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"However, in the present study, we did not find a role of Ksr1 in LPS induced ERK activation in lung macrophages."
23221422
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"LPS activation of ERK requires TPL-2 release from associated NF-kappaB1 p105, which blocks TPL-2 access to its substrate, the ERK kinase MEK."
17709378
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"Expression of a dominant negative form of TLR4 in human SMC attenuated LPS induced ERK1/2 and MCP-1 release."
15863460
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"PEP-1-Prx2 significantly decreased the phosphorylation of LPS induced ERK1/2, p38 and JNK."
25241246
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"LPS induced activation of ERK and JNK MAPK is enhanced by the stimulation of BAFF."
28374824
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"Aqueous extract of Dipsacus asperoides suppresses lipopolysaccharide-stimulated inflammatory responses by inhibiting the ERK1/2 signaling pathway in RAW 264.7 macrophages."
30415062
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"Generation of TNF-alpha, IL-1beta, ROS, and NO and ERK activation in cultured astrocytes treated with lipopolysaccharide (1mug/ml) were also prevented by 4-O-methylhonokiol in a dose dependent manner."
20974250
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"We also found that p38 and ERK1/2 pathways are activated by LPS as well as by photobiomodulation."
31390315
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"TLR4- and TLR2-BBPs also strongly inhibited LPS induced activation of ERK."
17312106
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"HLJD Modulated AMPK and ERK1/2 Signaling Pathway Caused by LPS."
29576800
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"In the present study, AUDA attenuated phosphorylation of P38 but not JNK or ERK induced by LPS or IFN-gamma, indicating that the P38-MAPK pathway could represent a molecular target for sEH inhibition and thus mediate its anti-inflammatory properties in activated microglia."
29262558
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"Here, we observed that LPS or PMA increased ERK1/2 and mTORC1 activity (assessed by S6K phosphorylation) and this effect was abolished by calphostin C (a PKC inhibitor) and U0126 (a MEK and ERK inhibitor)."
30073169
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"In addition, blank Lipo did not modify the activation of p38, JNK, or ERK induced by LPS, as shown in XREF_FIG."
29317816
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"LPS plays little or no role in the induction of iNOS in human cells including astrocytes and hepatocytes (Liu et al., 1996; Geller et al., 1995), therefore, we can not address the role of LPS induced [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12020969
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"One possible explanation for this is that LPS stimulation alone modestly activates ERK1/2."
26157342
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"The bacterial lipopolysaccharide (LPS) was able to activate extracellular signal regulated kinase (ERK) and p38 kinase subgroups of MAP kinases in microglia and astrocytes."
9464988
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"LPS induced activation of ERK1/2 results in transcription of early growth response protein 1 (Egr-1), involved in binding to the TNF-alpha promoter and increasing TNF-alpha expression [XREF_BIBR]."
32821333
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"In addition, LPS activated TAK1 negatively regulates mitogen activated protein kinase and extracellular signal regulated kinase kinase kinase 3 (MEKK3)."
27671672
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"Consistently, our study showed that pre-treatment of RAW 264.7 cells with PNAP-6 and PNAP-8 decreased the LPS induced activation of ERK, p38 MAPK, and JNK."
28060845
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"In control cells treated with DMSO, LPS stimulation induced ERK activation in parallel to DOK3 degradation, with a peak at 20 minutes consistent with degradation of 50% of DOK3."
22761938
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"Interestingly, despite inhibition of Raf-1 kinase activation, paclitaxel treatment exhibited no effect on LPS induced ERK activation."
10988356
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"Following LPS stimulation, TLR9 gene expression was upregulated within 1 h and reached peak level at about 3 h. LPS stimulation activated NF-kappaB, ERK and p38 MAPK signal pathways."
11947920
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"Specifically, our results show that even though LPS induced JNK and IkappaBalpha phosphorylation are sensitive to knockdown levels of TRAF6, LPS induced ERK pathway is not significantly affected by ev[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17507094
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"LPS pretreatment completely ablated LPS induced ERK signaling, as previously reported (XREF_FIG)."
20978539
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"The new data presented here show that short exposure of RPE cells to lipopolysaccharide (LPS) induces an early and transient activation of the extracellular signal regulated kinase (ERK1/2)."
27006973
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"Together, these observations suggest that LPS and overnutrition activates the ERK pathway thereby promoting the development of inflammation and fibrosis."
34557866
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"Using human keratinocytes, we investigated the effect of 3,4,5-triCQA on the LPS stimulated production of inflammatory mediators in relation to the nuclear factor (NF)-kB, Akt and ERK pathways."
22947851
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"Accordingly, depletion of Arl11 impaired both LPS stimulated pro inflammatory cytokine production by macrophages, and their ability to control intracellular replication of Salmonella LPS stimulated activation of extracellular signal regulated kinase (ERK) and p38 mitogen activated protein kinase (MAPK) was substantially compromised in Arl11 silenced macrophages."
29618517
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"Consistent with in vivo study, NBP had significant inhibitory effect on LPS stimulated ERK activation while the phosphorylation of JNK and p38 MAPK were not affected (XREF_FIG)."
30873019
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"Although we showed LPS activated ERK signaling with a simultaneous increase of RANKL and M-CSF in calvarial tissues, we were not able to identify the specific cell types that play a major role in inflammatory osteolysis."
19895919
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"LPS and MTP-PE induce a rapid activation of the extracellular regulated kinase (ERK) isoenzymes-1 and -2."
10815618
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"Our data also showed that C5a and LPS at 100ng/mL activated NF-kappaB, p38 MAPK, Erk1/2 and Akt signaling pathway in a time course study (XREF_SUPPLEMENTARY)."
27624143
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"LPS stimulation triggered ERK1/2 activation that was sustained in GM/DCs but not in IL-4 and DCs."
22070873
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"TGFbeta1 suppresses LPS induced ERK regulated p47 phox phosphorylation."
18566433
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"LPS induced ERK activation was enhanced by ME synergistically, but JNK activation was only slightly attenuated by high concentration of ME, and no change was observed in p38 MAPK activation."
25133186
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"However, IMD in the PVN decreased the LPS induced ERK activation, which was also effectively prevented by AM22-52."
30276527
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"LA also alleviates LPS induced acute lung and kidney injury through NF-kappaB and p38 and ERK mitogen activated protein kinase (MAPK) signaling and attenuates pertussis toxin induced autoimmune encephalomyelitis by reducing the production of tumor necrosis factor-alpha and interferon-gamma in vivo [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
28704925
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"C suppressed the production of LPS induced inflammatory mediators by inhibiting the p38 and ERK MAPK pathways."
24983461
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"Many studies have shown that LPS activates ERK1/2, JNK, and p38 in macrophages XREF_BIBR and that many of the downstream targets of MAPK pathways are transcription factors, which regulate various genes encoding inflammatory mediators XREF_BIBR; XREF_BIBR; XREF_BIBR."
24265867
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"The bacterial lipopolysaccharide (LPS) was able to activate extracellular signal regulated kinase (ERK) and p38 kinase subgroups of MAP kinases in microglia and astrocytes."
9464988
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"Interestingly, LPS stimulation did not elicit activation of ERK1/2 but indeed induced marked activation of JNK1/2, p38, and p65 and NF-kappaB in a time dependent manner."
24618100
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"Confirming prior work, LPS rapidly induces activation of p38, JNK and ERK (XREF_FIG)."
31969384
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"The Aqueous Extract from Horseradish Interferes with LPS Activated ERK Signalling."
28182113
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"An intriguing finding is that zerumbone did not have an effect on lipopolysaccharide (LPS)-triggered activation of mitogen activated protein kinases (MAPKs; extracellular signal regulated kinase 1/2, c-Jun N-terminal kinase1/2, p38MAPK) or key transcription factors (activator protein-1 and nuclear factor kappaB; NF-kappaB), while it targeted a post-transcriptional mechanism."
29610550
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"In macrophages, Tpl2 and Cot is essential for the activation of ERK by LPS via TLR4 and the export of TNF-alpha mRNA from the nucleus [XREF_BIBR]."
15575964
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"It also inhibited LPS induced activation of ERK 1/2, p38, JNK, and IkappaBalpha."
28443180
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"Taken together, our findings reveal that ARL11 is required for LPS induced ERK1/2 and p38 activation, which in turn promotes macrophage effector functions."
29618517
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"Because IL-6 activates ERK1/2, which has been reported to be a kinase for STAT3 phosphorylation on Ser 727, and we have previously reported that GW501516 prevents LPS induced ERK1/2 activation in adipocytes, we evaluated the effect of the PPAR-delta agonist on the activation of this kinase."
21617181
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"A great deal of work on primary human macrophage cultures as well as on immortalized cell lines shows that LPS systematically activates the Erk1/2 MAP Kinase pathway [XREF_BIBR - XREF_BIBR]."
20148136
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"Recently we demonstrated that lipopolysaccharide (LPS) promotes activation of the Ras and ERK cascade in medfly hemocytes and that phagocytosis of Escherichia coli by insect hemocytes is mediated by an integrin dependent process via the activation of FAK and Src complex (J Biol Chem 273 (1998) 14813; FEBS Letters 496 (2001) 55)."
14563359
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"Since PKC phosphorylates Raf, which acts directly upstream of MEK [20] and since LPS induced ERK-1/2 activation may be mediated by PKC [21], we reasoned that PKC may be involved in LPS mediated phosph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14505805
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"PKC- and ERK dependent activation of I kappa B kinase by lipopolysaccharide in macrophages : enhancement by P2Y receptor mediated CaMK activation."
11682454
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"Our data show that LPS activates not only the p38 but also the ERK1/2 MAPK in Kupffer cells, resulting in enhanced TNF-alpha production."
12061785
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"Since only 50 muM dimer B2 has shown the significant inhibitory effects on COX-2 transcription and expression, this concentration was selected to use in the following experiments.Because LPS induced C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16681998
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"In addition, LPS induced activation of extracellular signal regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK) was suppressed by quercetin and galangin."
29207037
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"Thus, these results indicate that both LPS and alpha-synuclein induce activation of p38 and ERK1/2 in microglial cells and p38 activation is required for induction of pro inflammatory cytokines and NO production."
28256519
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"Pretreatment of cells with IFN-gamma did not affect LPS induced ERK, p38, JNK, Akt, and IkappaBalpha phosphorylation, suggesting that IFN-gamma-mediated enhancement of LPS induced TNF-alpha production[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24140406
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"The results demonstrated that LOS has no effects on the phosphorylation levels of ERK1/2 while exogenous LPS significantly activated the ERK signaling in GBS monocytes."
23411097
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"The present study demonstrated that lutein and zeaxanthin inhibited the secretion of IL-8 induced by LPS through the activation of JNK1/2 and NF-kappaB signal pathway, but not p38 and ERK pathway; this is consistent with the animal study, which showed that lutein inhibited the activation of NF-kappaB in the iris-ciliary body in LPS induced uveitis and in cultured macrophages [XREF_BIBR, XREF_BIBR]."
26609426
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"However, this compound did not inhibit LPS induced activation of extracellular signal regulated kinase and stress activated protein kinase and c-Jun NH (2)-terminal kinase, but significantly impaired activation of p38 mitogen activated protein kinase."
16183703
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"Overall, these results suggested that the knockdown of circDHTKD1 alleviated the LPS-induced production of inflammatory cytokines and activation of the ERK pathway in BEAS-2B cells through the miR-338-3p/ETS1 axis."
37273760
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"It is known that, in DCs of the D1 cell line, LPS activates the ERK pathway, playing a role in DC maturation and in preventing apoptosis after maturation XREF_BIBR."
25255446
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"In contrast, OEA treatment markedly reduced the activation of ERK1/2 induced by LPS, while the total protein levels of ERK1/2 remained unchanged, which indicates that OEA blocked the activation but not the biosynthesis of ERK1/2."
27721381
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"KP suppressed LPS-induced activation of ERK1/2 and JNK in a dose-dependent manner (Fig. 3), while the amount of kinases was unaffected by either LPS or KP treatment."
21286382
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"In addition, it also inhibited the LPS induced activation of ERK1/2."
32802090
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"In this study, we examined the inhibitory effect of diosmetin on MAP kinase pathway and NO production activated by LPS in raw 264.7 cells, and as a result, diosmetin inhibits the LPS induced activation of ERK, p38 and JNK pathway and it also inhibits iNOS expression and NO production."
| PMC
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"PD98059 and SB203580 could inhibit LPS induced activation of ERK and p38kinase, respectively, at the dose of 30 muM."
11947920
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"Further, miR-335 inhibited LPS mediated ERK1/2 activation."
34211970
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"Furthermore, the pathways used by Salmonella and LPS to stimulate ERK are identical, suggesting that kinase activation might be solely mediated by LPS."
10024537
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"Therefore, we investigated the influence of malvidin on LPS induced activation of ERK, JNK and p38-MAPK."
23755222
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"In line with these observations, NPe attenuated the activation of ERK pathway induced by LPS, whereas total ERK levels did not change (Figure 4B)."
29140265
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"Higher LPS concentrations (10mug/mL) also failed to induce ERK activation (data not shown)."
21941410
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"Because ligation of TLR4 triggers the activation of MAP kinase and NF-kappaB, leading to production of proinflammatory cytokines through the MyD88 dependent pathway, we investigated the activation of MAP kinase such as JNK, p38, and ERK1/2 in macrophages treated with LPS or 2,000 kDa gamma-PGA."
19294383
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"Likewise, LPS increased the activation of p42/44 and p38 in wounded HCEC."
25183764
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"Our study indicates that the C-terminal ankyrin repeat domain of p105, which is known to interact with and stabilize TPL-2, inhibits IFN-beta expression by facilitating LPS induced ERK activation."
21217011
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"These protective effects were mediated through MPLA stimulation of a TRIF dependent PI3K-Akt pathway that prevents sepsis- and LPS induced ERK activation."
29741098
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"Treatment with (+)-pentazocine suppressed inflammatory responses of retinal microglia and inhibited LPS induced activation of ERK and JNK MAPK."
24812552
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"As presented in XREF_FIG, heat stress alone or LPS combined with heat stress induced activation of p38, ERK and JNK."
28656249
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"LPS treatment in astrocytes activates ERK, a kinase activated in response to cellular stress 64 that can also activate NF-kappaB 65."
28687727
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"ESAT-6 treatment was found to have no effect on the ERK kinase activity in the nucleus over the basal level (Fig XREF_FIG); furthermore, ESAT-6 antagonized the LPS induced ERK activation."
17915024
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"So, to evaluate whether LPS induces the ERK pathway, we determined ERK phosphorylation at residues Thr 202 and Tyr 204."
30073169
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"Moreover, Smith et al. (2015) showed that in endotoxemic conditions, LPS systemic exposure promoted the activation of TLR-4 and MAPK/ERK pathway, inducing a significant decrease in PGC-1α synthesis."
33995028
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"These results suggest that miR-101 may regulate the LPS induced activation of ERK1/2, p38 or JNK through targeting DUSP1."
26158762
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"LPS induces activation of all three major classes of MAPKs : p38, JNK, and ERK."
18803301
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"In conclusion, our findings demonstrated for the first time, that signaling initiated by WISP1-integrin ligation modulated LPS induced ERK activation and primed macrophages to an enhanced response to LPS exposure."
27349568
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"As shown in Figures XREF_FIG and XREF_FIG, torilin significantly suppressed LPS induced ERK1/2, p38, and JNK1/2 activation in a dose dependent manner while it had no effect on PI3k and Akt phosphorylation."
28316375
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"Avicularin significantly attenuated LPS induced activation of ERK signaling pathway in a concentration dependent manner."
24009846
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"Additional evidence suggesting that P2 receptors are involved in LPS mediated macrophage activation comes from the work of Hu et al. [XREF_BIBR] wherein it was shown that pretreatment of RAW 264.7 macrophages with P2 receptor antagonists, oATP or pyridoxal-phosphate-6-azophenyl-2-4-disulfonic acid (PPADS), inhibited LPS stimulated NO production and/or iNOS expression and attenuated LPS activation of NF-kappaB and ERK-1/2."
18404417
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"Consistent with the enhancement of cytokine responses observed, LPS stimulated ERK activation was strongly enhanced in both PDMCs and BMMCs from ST2 deficient mice."
29540770
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"Further study of the signaling mechanisms revealed that although LPS can activate both Erk MAP kinase and PI3 kinase pathways, only blocking of PI3K abolished both Bcl-x upregulation and the enhanced survival phenotype, suggesting that the PI3K signaling mediated the upregulation of Bcl-x for the LPS induced pro survival in GM-DCs."
29624724
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"Pretreatment with MPLA prevented LPS induced ERK activation; this effect was dependent on PI3K."
28356284
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"In addition, ERK activation by LPS was not altered in the presence of Salp15, demonstrating that Salp15 does not sequester MEK away from ERK and thereby inhibiting LPS induced cytokine production."
18282094
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"Because the protein amount of the kinase did not change during the course of stimulation, the findings suggest that LPS induces activation of ERK."
12384141
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"Pon1 deficiency in rat primary microglia activated Trem2 pathway but decreased LPS-induced ERK activation."
35589918
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"Moreover, ambroxol significantly alleviated LPS induced the influx of inflammatory cells and the extracellular signal regulated kinase 1/2 (Erk 1/2) expression in lung tissues, and inhibited increases in the mRNA expression of the pro inflammatory cytokines tumor necrosis factor (TNF)-alpha, CCL-2 (monocyte chemotactic protein-1), KC (keratinocyte cell protein) and interleukin (IL)-1beta in lung tissues."
26872986
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"LPS have been reported to activate ERKs in some cell types, but no such effects were observed in our experiments with the rat liver epithelial WB-F344 cells, even when we used LPS isolated from Salmonella typhimurium, a serotype producing LPS known to induce significant biological responses."
19619572
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"AP-1 promoter activity and p38 MAPK activation but not PKC, ERK and JNK activation induced by LPS were attenuated by oregonin."
16025135
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"Pretreatment of cells with either GSE or NAC increased the early LPS stimulated activation of p42/44 but had little effect on the sustained phase."
12942544
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"In addition, chronic alcohol intake activates LPS induced ERK1/2 activation, which contributes to TNF-alpha expression in murine hepatic macrophages."
25009584
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"The fact that, in mice with a nonfunctional TLR4, ERK could not be activated by LPS, indicates an upstream connection between CD14 and TLR and the MAPK pathway [33]."
10758406
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"First, LPS stimulates ERK phosphorylation in both Ksr1-deficent and Ksr1-proficient lung macrophages in a similar pattern; this finding excludes a role for Ksr1 as a regulator in LPS induced ERK activation of alveolar macrophages."
23221422
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"Incubated with either different concentrations of GSP for 6 h or 40 muM GSP 0 to 6 h, A2780/T cells were treated with 1 mug/ml LPS for 30 min, the LPS treated A2780/T cells were significantly induced the MAPK and ERK pathway (XREF_FIG)."
23967153
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"Forced expression of either adaptor, but not a mutant having a Tyr and Phe substitution, in macrophages inhibited LPS induced Erk activation and TNF-alpha production."
15699069
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"LPS stimulation of extracellular signal regulated kinase 1/2 (ERK1/2) and p38 MAPK was inhibited by torilin."
19298258
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"ERK1/2 and pERK1/2 induced by LPS were significantly inhibited by glabridin."
28039487
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"In addition, ERK (1/2) was activated by the coincubation of LPS with LrS."
25329163
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"Youssef et al. showed that LPS can quickly activate p38, ERK, and JNK signaling in microglia [XREF_BIBR]."
33727946
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"Moreover, we found that p38MAPK, JNK, and ERK were activated by APAP or LPS alone or in association."
19589095
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"In contrast, mercury alone had no effect on activation of extracellular signal regulated kinase (ERK) but inhibited LPS induced ERK activation."
15803865
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"The involvement of D3R in the regulation of the ERK1/2 signaling pathway caused by LPS induced depressive like behavior was evaluated by performing western blotting analysis."
29390063
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"Consistent with this model, we determined that LPS induced mRNA stabilization was p38 and ERK dependent (XREF_FIG)."
28237795
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"HTS and LPS induced prompt activation of both p38 and ERKs that peaked at 30 minutes."
10922992
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"Considering that LPS can induce the activation of p38MAPK and ERK-1/2 activation in normal macrophages, this phenomenon may be specific to TAMs."
33224886
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"As previously reported [23,24], we observed that LPS could activate the stress activated MAPKs, JNK and p38 as well as Raf-1 and ERK pathway in both 70Z/3 and spleen cells."
10988356
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"Given previous reports of an essential role for proteasomal degradation of IkappaB kinase phosphorylated p105 in LPS activation of ERK mitogen activated protein kinase, we tested for a role of rafts in compartmentalization of these events."
18815123
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"Moreover, LPS was also found to stimulate ERK, p38 MAPK, JNK, and Akt activities in U87 cells."
18616930
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"Nevertheless, the effects of fully sulfated heparin on LPS stimulated ERK1/2 signaling were marked and significant (P < 0.001, n = 7) while desulfated heparin had no significant effects (XREF_FIG)."
26495958
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"The role of MEK1 in LPS mediated ERK activation and its effect on cytokine production in BMDMs is poorly understood."
26208884
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"Notably, Ntcp and Bsep RNA levels were maintained at 78Ϯ50% and 60Ϯ46% of control levels, respectively.following authors have indicated they have no relationships to disclose: Claus Hellerbrand, Marcus Mü hlbauer, Martin Fleck, Thomas Weiss, Matthias Froh, Sabine Hoves, Jü rgen Schö lmerich956 ENHANCED LPS-STIMULATED ERK1/2 ACTIVATION AND TNFÁ SECRETION BY RAT KUPFFER CELLS AFTER CHRONIC ETHANOL FEEDING IS MEDIATED VIA INCREASED PRODUCTION OF REACTIVE OXYGEN SPECIES (ROS) BY NADPH OXIDASE Varsha Thakur, Megan R. McMullen, Qifang Wang, Laura E. Nagy, Case Western Reserve University, Cleveland, OHBackground: Production of ROS by Kupffer cells (KC) contributes to the development of chronic ethanol (EtOH)-induced liver injury."
| PMC
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"In microglia, argon did not substantially interfere with LPS induced ERK1/2 activation and inflammatory cytokine induction."
22094065
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"For instance, LPS can activate MEK and ERK through PKC zeta [XREF_BIBR]."
28804793
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"LPS strongly induced ERK activation in iDCs after 10 min of stimulation, as previously reported."
17462920
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"In addition, Cortex Phellodendri inhibited inducible nitric oxide synthase (iNOS), activated nuclear factor-kappaB (NF-kappaB) by degradation and phosphorylation of IkappaBalpha, and attenuated phosphorylation of mitogen activated protein kinases such as ERK1/2, p38, and JNK in mice treated with lipopolysaccharide [XREF_BIBR]."
25834623
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"The results show that LPS can markedly activate ERK1/2 pathway in mKC."
11835717
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"Furthermore, if we blocked LPS induced ERK signaling by U0126, the expression of connexin 43 and UDP release was also inhibited dramatically."
26783339
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"LPS has been shown to activate the extracellular signal regulated kinase, c-Jun NH 2 -terminal kinase (JNK), and p38 MAP kinases in murine macrophages but, to date, the signal transduction pathways activated during DC maturation have not been characterized."
9841930
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"XREF_BIBR, XREF_BIBR To study the molecular mechanism underlying the downregulation of these signaling pathways, we investigated the inhibitory effects of these AMAC compounds (3f, 3m, 4b, and 4d) on ERK1/2 and NF-kappaB stimulated by LPS."
25834403
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"In addition, LPS treatment also induces a more sustained activation of ERK and p38 than PMA."
25768345
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"BRE was seen to inhibite the LPS induced ERK and JNK activation in RAW 264.7 cells."
33505935
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"Stimulation with the S1P 3 agonist (Compound 20), increased ERK-1/2 phosphorylation by two-fold in cells not treated with LPS and was further elevated in cells pre-challenged with LPS."
21887342
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"In agreement with these reports, we found that LPS and TNFalpha activated Erk1/2, NFkB, IkBalpha pathways, whereas IL6 induced only activation of Erk1/2 signalling in our HSMM model."
24521217
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"These results indicate that both high and low doses of LPS activate ERK signaling in Sam68 KO cells and the role of Sam68 in LPS induced ERK activation is not highly dependent on the dose of LPS (XREF_SUPPLEMENTARY)."
27374795
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"Furthermore, avicularin significantly attenuated LPS induced activation of ERK signaling pathway."
24009846
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"The first aim was to determine whether LPS induces ERK1/2 activation and changes in epithelial permeability in epithelial cells alone or only in the presence of immune cells."
15025824
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"LPS dependent stimulation of PI3K activity, ERK1/2 activation, and p38 kinase activity was greater in PerMphi from db/db mice as compared with db/+ mice."
17202326
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"However, although ERK phosphorylation in cells treated 15d-PGJ 2 alone was not detected, a remarkable increase in ERK phosphorylation in VSMCs that were treated with 15d-PGJ 2 / LPS relative to VSMCs that were treated with LPS alone was also detected (XREF_FIG)."
20107546
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"However, LPS did not stimulate ERK1/2 activation in BV-2 cells, indicating that ERK1/2 activation is not involved in LPS action in this cell type, which is consistent with previous finding [XREF_BIBR]."
18036262
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"For instance, LPS can activate MEK and ERK through PKC zeta."
30710049
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"Moreover, LPS could induce the activation of p38 mitogen activated protein kinase (MAPK) and c-jun N-terminal kinase but not extracellular signal regulated kinase."
12473078
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"The phosphorylation of intracellular signaling molecules of NF-kB pathway, including phosphoinositide 3-kinase (PI3K)/p85, AKT, inhibitor of NF-kappaB (IkappaBalpha) kinase alpha/beta (IKKalpha and beta) and IkappaBalpha, and TRAF family member associated NF-kappaB activator (TNAK)-binding kinase 1 (TBK1), a key intracellular signaling molecule of IRF-3 pathway, as well as MARK pathways were activated by extracellular LPS, as expected, in WT Raw264.7 macrophages, while their activations, with the exception of ERK, were reduced in p204 deficient Raw264.7 macrophages treated with LPS."
29472103
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"Moreover, the up-regulation of P-gp expression, the activation of AKT and NF-kappaB and MAPK and ERK pathway induced by LPS was attenuated by GSP administration."
23967153
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"Exposure to Cpn60.1, Cpn60.2 or LPS enhanced ERK1/2 activation with increases in phosphorylation evident between 10 and 30 min and maximal after 60-90 min stimulation."
17178391
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"In macrophages, ERK1/2 was activated about 6-fold by LPS, while no activation was observed in the presence of TEGDMA after 15 and 30 min."
20096453
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"The finding that inhibition of ERK attenuated the effect of LPS was surprising, as LPS failed to stimulate ERK activity in human neutrophils in several previous studies [32-34]."
11369515
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"Immunoblotting using cell extracts showed higher ERK phosphorylation in cells treated with PA and LPS than in those treated with LPS alone (XREF_FIG)."
32975056
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"Finally, we showed that the inhibition of LPS stimulated ERK activation by simvastatin was reversed by GGPP."
18625914
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"The specificity of each antiserum for activated MAPKs in pigtailed macaques was confirmed by Western blot analysis of primary macaque macrophages that had been treated with lipopolysaccharide for 15 m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14742241
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"We also found that LPS activates both the ERK MAP kinase and the NF-kappaB transcription factor."
9841930
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"Moreover both forms of LPS activated NF-kappaB, p38 MAPK and ERK pathways, but not the SAPK and JNK pathway."
23554896
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"Activation of ERK by LPS was eliminated by a selective IRAK-1 inhibitor, establishing IRAK-1 as the upstream mediator of ERK activation."
31241993
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"Both P. gingivalis LPS and E. coli LPS activated ERK1/2 in a similar manner (XREF_FIG.2)."
23554896
reach
"Recent studies done by Skinner et al. demonstrated that LPS induced ERK activation is responsible for regulation of TNF-alpha nuclear export through modulating exon junction complex proteins, TAP and NxT1, in macrophages [XREF_BIBR]."
19447225
reach
"To study the effect of EGFR activation on the generation of TNF-alpha and the occurrence of cardiac dysfuncetion during sepsis, PD168393 and erlotinib (both are EGFR inhibitors) were applied to decreased the production of TNF-alpha and phosphrylation of ERK1/2 and p38 induced by LPS in cardiomyocytes."
26486084
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"Retraction: Tetrandrine Suppresses Lipopolysaccharide-Induced Microglial Activation by Inhibiting NF-kappaB and ERK Signaling Pathways in BV2 Cells."
31671159
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"Forced expression of Dok-1 or Dok-2 inhibits LPS induced Erk activation and TNF-alpha production."
15699069
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"RDSW regressed the LPS induced ERK 1/2 and JNK 1/2 phosphorylations in RAW 264.7 macrophage cells."
29088069
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"ERK1/2 (Immunoblot) in RAW cells treated with LPS (1ug/ml) in the presence and absence of LDN.The docked conformation of naltrexone at the binding interface of RBD and ACE2 complex obtained from AutoDock (A) and interface amino acid residues involved in non bonded contacts are labelled (B)."
32930058
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"Further analysis showed that LPS induced a more dramatic activation of ERK and cell proliferation in Cx43 +/+ spleen cells, which was associated with a higher pro oxidative state, as indicated by the increased NADPH oxidase 2 (NOX2), TXNIP, p38 activation and protein carbonylation."
31752090
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"Previously reported results showed that ketamine and propofol can suppress LPS induced upregulation of IL-1beta and extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation in glia cells and brains [XREF_BIBR, XREF_BIBR]."
33381594
reach
"ERK was strongly phosphorylated in the hUCB-MSCs treated with Pam 3 CSK 4, whereas LPS induced only mild activation of ERK, which correlated with intensity of Alizarin Red S staining."
21042538
reach
"In contrast, LPS in the presence of RA or rIL-10 led to ERK activation independent of MEK1."
26208884
reach
"In addition, dasatinib affects LPS-induced downstream AKT and/or ERK signaling to alter neuroinflammation in BV2 microglial cells, primary microglial cells, and primary astrocytes (Fig. 17)."
31655606
reach
"LPS stimulation of monocytes induces ERK activation, which then phosphorylates various cytoplasmic and nuclear substrates that regulate cell growth, survival, and death."
35240935
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"We have demonstrated that expression of a C-terminal fragment of p105 that does not contain the Rel homology domain (p105DeltaN) rescues LPS induced ERK activation and inhibits LPS induced Ifnb expression XREF_BIBR."
22427889
reach
"Consistently, knockdown of endogenous H-Ras in BMDMs specifically inhibited curdlan- or yeast induced phosphorylation of ERK (XREF_FIG) but had no effect on alpha-mannans- or LPS induced ERK activation (XREF_FIG)."
25267792
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"Furthermore, BRE pre-treatment of the cells for 1 h significantly decreased ERK and JNK activation that was induced by LPS (XREF_FIG)."
33505935
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"Our study demonstrated that Sa.LTA decreased LPS induced ERK activation in splenocytes and B cells."
29367683
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"Moreover, CD pretreatment abrogated adherence induced activation of Pyk2, a major focal adhesion kinase, and ERK 1/2, a component of the mitogen activated protein kinase (MAPK) signaling pathway, and it completely inhibited LPS induced ERK 1/2 activation."
11837785
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"Statistical analysis of the fold change of the relative density suggested that EGFR inhibition does not affect LPS activation of p38, ERK1/2, and JNK in RAW 264.7 macrophages (XREF_SUPPLEMENTARY)."
24391216
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"In macrophages, LPS activates ERK1/2, p38 MAPK, and Jun N-terminal kinase (JNK) XREF_BIBR."
25192391
reach
"Other studies have revealed that lipopolysaccharide (LPS) induces ERK 1/2 activation through TRIF and MyD88- and TRIF dependent signaling in vivo and in vitro [XREF_BIBR - XREF_BIBR]."
29977930
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"Pretreatment of the cells with a MEK inhibitor, U0126, also abolished LPS induced ERK phosophorylation (data not shown)."
23221422
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"As LPS activates the ERK pathway through TLR4 in macrophages 27, we then examined ERK activation during M1 polarization."
23752925
reach
"Furthermore, LPC was able to block LPS induced ERK activation (XREF_FIG)."
24312681
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"We have demonstrated that LPS activates ERK1/2 and PLA 2 in platelets."
29136006
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"One possible mechanism is that LPS stimulates the TLR4 and ERK1/2 signaling which in turn activates hormone sensitive lipase and adipocyte triglyceride lipase."
21314942
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"The phosphorylation of cPLA 2 alpha at 1 hour and phosphorylation of ERK1/2 at 10 minutes were significantly prevented in mice treated with SC-215 prior to LPS challenge, but the induction of phospho-p38 at 10 minutes were not affected upon SC-215 pretreated and remained similar to LPS challenge values (XREF_FIG)."
24130900
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"XREF_FIG shows LPS induced activation of ERK, p38, and JNK (indicated by an increase in phosphorylation of the activated tyrosine and threonine sites) that was inhibited by ash exposure."
23478268
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"Pre-incubation of cap with various concentrations (1-25microM) for 30min did not alter LPS activated ERK and JNK as shown in Fig."
28273917
reach
"Experimental evidence demonstrates that LPS stimulation of murine peritoneal macrophages activated ERK1/2 signaling, causing the subsequent induction of TNF-alpha secretion."
32655419
reach
"Moreover, VD3 and HX630 inhibited LPS induced activation of extracellular signal regulated kinase (ERK) and nuclear translocation of nuclear factor kappaB (NF-kappaB)."
27401255
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"Our results revealed that LPS induced ERK activation is not sensitive to the low levels of TRAF6 because ERK1/2 phosphorylation was not significantly affected in TRAF6 knockdown cells compared to cont[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17507094
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"LPS signalling is known to be mediated via all three MAPK : JNK, p38, and ERK, and results in IL-1b expression [XREF_BIBR]."
24083466
reach
"Further evidence for differences in the Toll like receptor mediated signalling pathways between macrophages and microglia come from the recent observation that LPS potently stimulates ERK activation i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12225885
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"Addition of low doses of LPS had no effects on iHsp70 expression, but strongly activated ERK."
23043959
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"Accumulating evidence suggests that LPS can activate nuclear factor-kappa B (NF-kappaB) and three mitogen activated protein kinase (MAPK) pathways, inculding the c-Jun NH2-terminal kinase (JNK), extracellular signal regulated kinase (ERK), and p38 pathways, which result in the overexpression of inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), NO and prostaglandin (PG) E 2."
26722219
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"Our laboratory previously demonstrated that Porphyromonas gingivalis LPS mediated activation of ERK in human monocytes was severely reduced upon inhibition of PI3K."
19109187
reach
"The C-terminal region of p105 is necessary for LPS induced ERK activation and it has been suggested that ERK activity inhibits both IFN-beta and IL-12 p40 following LPS stimulation."
22427889
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"Gefitinib suppressed LPS induced activation of ERK1/2 and STAT3 by blocking EGFR activation in HK-2 cells."
29207668
reach
"TLR4 stimulation by LPS increases ERK1/2 activity in macrophages by engaging the tumor progression locus‐2 (TPL‐2)/MEK1/2/ERK1/2 cascade."
34061465
reach
"Neither LPS nor anisomycin induced an increase in ERK, perhaps because of high basal levels of ERK activity resulting from culture in GM-CSF (Valledor et al., 2000)."
12617997
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"LPS can also stimulate phospho-ERK1/2 (p-ERK1/2) and phospho-cytosolic phospholipase A 2 (p-cPLA 2) pathways in primary and BV-2 microglial cells [XREF_BIBR]."
30795510
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"Given the importance of the canonical form of transcription factor NF-kappaB in both the production of the components of the oxidative stress response (p47 and p67 are regulated by NF-kappaB), and in the regulatory effects of ROS in activating microglia (NF-kappaB controls ERK activity induced by LPS signaling, XREF_FIG), inhibitors of the canonical pathway of NF-kappaB should provide strong evidence of the role of oxidative stress responses in PD."
22544998
reach
"Furthermore, studies with several cell culture systems indicate that lipopolysaccharide (LPS) can activate P38 MAPK, ERK, and JNK signaling [XREF_BIBR]."
27514378
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"Our data argue that the LPS induced activation of ERK and p38 is integrated by Mnk1 and that the signal is transmitted to TNFalpha translation through the phosphorylation of eIF4E.The activity of MK2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431125
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"The MAP kinases activated by LPS (ERK, JNK and p38) are critical regulators of pro inflammatory cytokine production, including TNF-alpha and IL-6."
22301548
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"* Results shown here demonstrate that the early and the late LPS induced ERK1/2 activation are differentially modulated by PIP2-PLC and PLD pathways."
27006973
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"In line with those observations, we revealed that the intra-tracheal administration of LPS induces the activation of ERK1/2 and P38 in mouse lung tissues."
34072430
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"LPC blocks LPS induced ERK activation in peritoneal macrophages but not in TLR transfected cells."
24312681
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"Western blot analysis showed that LPS treatment elicited the activation of ERK 1/2 and p38 MAP kinases."
12203390
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"AMs stimulated with lipopolysaccharide activated ERK and MAPK, in addition to JNK and p38, and showed translocation of NF-kappaB."
10657941
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"However this division is somewhat of an oversimplification since some mitogens can stimulate JNK and SAPK and p38, and the proinflammatory cytokines and LPS can activate the erks."
9918123
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"Effects of rice hull extract on lipopolysaccharide induced extracellular signal regulated kinase and c-Jun N-terminal kinase activation."
27867272
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"As expected, LPS stimulated activation of a known ERK activating kinase, MEK1 (Derijard et al., 1995) in WT cells."
12667451
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"We have previously shown that inducible inflammatory mediator production is inhibited by a post-transcriptional mechanism, since mycolactone does not modulate the LPS dependent activation of ERK, JNK, p38 MAPK or NFkappaB and induced levels of mRNA are maintained or even enhanced XREF_BIBR."
24699819
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"LPS treatment in human retinal pigment epithelial cells activated ERK signaling, which is required for cytokine gene transcription [XREF_BIBR]."
29301251
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"Interestingly, we found that IRF-8-/- macrophages were impaired in the activation of LPS induced ERK and JNK and the production of proinflammatory cytokines induced by LPS or IFN-gamma plus LPS."
16484229
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"One study recently found that treatment of bone-marrow-derived macrophages with Li induces degradation of p105 that subsequently leads to inhibition of LPS induced ERK pathway and therefore LPS induced TNFalpha transcription [XREF_BIBR]."
23904208
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"An in vitro study of murine Kupffer cells showed that LPS stimulation increased the activation of p38, ERK, and JNK, with the activation of p38 and ERK being the most prominent."
20599223
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"One of the Lactobacillus gasseri strains, SF1109, strongly inhibited : (1) Pseudomonas aeruginosa growth; (2) Escherichia coli biofilm production; (3) LPS induction of P-ERK1/2 in HCT116 cells, and was selected for further characterisation of the secreted active molecule."
27824276
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"The p38, ERK1/2 and JNK pathways were activated by LPS; however, the p38 and ERK1/2 pathways were blocked in AQP-1-overexpressing cells."
29731819
reach
"The results showed that the phosphorylation of ERK1/2 was significantly upregulated in the LPS group compared with the control (P < 0.05), whereas alpha-mangostin reversed the LPS induced ERK1/2 activation (XREF_FIG)."
23833675
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"Interestingly, our results indicated that pre- or post-treatment with CA140 significantly suppressed LPS stimulated ERK signaling in BV2 microglial cells."
30309372
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"The LPS increased the p/t volume of ERK up to 2.26 +/- 0.091."
28665991
reach
"Furthermore, ALOE reduced the protein expression of P65 in NF-κB signaling pathway and suppressed LPS-induced activation of ERK and JNK, instead of p38 MAPK pathway."
36742263
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"On osteoclasts, icariin suppresses LPS mediated activation of the p38 and JNK; while on the osteoblasts, icariin reduced the LPS induced activation of ERK1/2 and I-kappa-B-alpha (IkappaBalpha), but increased the activation of p38."
20554188
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"The present study suggests that LPS stimulation activates ERK in Muller cells, whereas the total amount of ERK is unchanged."
11923227
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"Specifically, LPS activation of the p38, JNK1/2 and ERK1/2 MAPK signaling pathways that regulate proinflammatory gene expression in macrophages were significantly reduced in PTEN -/- macrophages, which have enhanced Akt activation."
19447494
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"In vitro experiments have shown that TPL-2 expression in neutrophils is required for LPS activation of ERK1/2 and induction of tumour necrosis factor (TNF) secretion, similar to that in macrophages (Acuff et al, 2017)."
33881780
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"However, only Q and K effectively attenuated LPS induced extracellular signal regulated kinase and p38 elevations."
33642342
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"These results as well as ours placed LPS and IFNgamma activation of ERK1/2 and cPLA 2 upstream of the NF-kappaB transcriptional pathway."
26520095
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"In the late phase of LPS exposure, 2-AG could reverse the decrease of GS expression and activation of ERK1/2 induced by LPS."
30075820
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"All results imply that GLP-2 inhibits LPS induced microglia activation by collectively regulating ERK1/2, JNK1/2 and p65."
26861286
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"Both PPARgamma ligands only have the effect of inhibiting LPS mediated ERK activity, but not p38 or JNK (XREF_FIG C)."
33339154
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"We also detected an increase in ERK phosphorylation in SHR VSMCs treated with 15d-PGJ 2 / LPS."
20107546
reach
"Our results also suggest that LPS stimulation alone can not activate ERK1/2 through MEK2 in the absence of MEK1 unless additional receptors are engaged (e.g. IL-10 receptor or the RA receptor)."
28804793
reach
"The cells treated with mmLDL and LPS showed higher ERK phosphorylation than those treated with LPS alone (XREF_FIG)."
32975056
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"Conversely, in macrophages, through its regulation of p105, GRK5 negatively regulates LPS stimulated ERK activation."
28950947
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"Our biochemical analysis here showed that LPS mediated activation of ERK, JNK, and p38 MAPKs was enhanced in LAB -/- DCs, indicating that LAB negatively regulates MAPK activation in TLR4 mediated signaling."
22308309
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"In a subsequent study, we demonstrated that p38 kinase, rather than ERK1/2, was activated in Dami cells by LPS in dose- and time dependent manner, suggesting that the phosphorylation of ERK and p38 is regulated by different mechanisms and that p38 kinase plays the key role in the response of Dami cells to LPS stimulation (XREF_FIG)."
26330186
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"Moreover, LPS pretreatment enhanced the activation of NF-kappaB, ERK and JNK by MDP in hepatocytes."
22218461
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"In macrophages, LPS stimulates the simultaneous activation of all three classes of MAP kinases, ERK, c-jun N-terminal kinase, and p38, albeit with differential activation kinetics."
10586030
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"In macrophages, lipopolysaccharide activates ERK, JNK and SAPK, and p38, and all are required for the translation of tumor necrosis factor (J Swantek, M Cobb, T Geppert, unpublished data)."
9069255
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"LPS treatment of chicken heterophils (which are functionally equivalent to mammalian neutrophils) activates both Erk and p38 MAPK signaling pathways downstream of TLRs to induce the secretion of pro inflammatory cytokines."
21527280
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"This inhibition resulted in downregulation of LPS induced ERK1/2 activation in the nucleus and subsequent expression of c-Myc, a key factor in macrophage activation."
17915024
eidos
"We hypothesized that LPS mainly activates the Cdc42 , p38 and ERK1 / 2 MAPK , and PI3K signaling pathways ."
24451252
eidos
"In BV2 cells ( a murine microglial cell line ) , LPS increases the Ca2 + concentration and upregulates CaMKII phosphorylation , thus inducing ERK1 / 2 and NF-kappaB phosphorylation , which stimulate microglial activation and the expression of pro-inflammatory cytokines and enzymes ( Wu et al ., 2018 ) ."
33329005
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"LPS similarly increased ERK activity in HLMVEC within 4h and the activity remained greater than baseline for up to 16h post-LPS stimulation (Online Figure VIB and VIC)."
33926208
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"Treatment with ginsenoside Rg1 suppresses downstream inflammatory markers by inhibiting the phosphorylation levels of IkappaB, nuclear translocation of p65 subunit of NF-kappaB, and phosphorylation level of ERK1/2 kinase induced by LPS [XREF_BIBR]."
24073012
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"The LPS mediated activation of ERK and JNK in macrophages was then examined and it was shown that these signalling pathways were defective in KO mice."
12160628
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"In a nuclear factor-DNA binding assay, the cooperative effect of mmLDL and LPS costimulation on c-Jun and c-Fos DNA binding, but not on p65 or p50, was dependent on mmLDL induced activation of extracellular signal regulated kinase (ERK) 1/2."
20489162
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"To clarify the phosphorylation sites on C/EBPbeta by LPS activated ERK, these two amino acids were separately mutated to alanine by point mutation to create the C/EBPbeta-S 64A and C/EBPbeta-T 188A mutants."
26114754
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"LPS, IL-1beta, and TNF-alpha, which mediate ocular inflammation, stimulate activation of p38, ERK, and Akt kinases in the corneal cell line."
16760261
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"A possibility, however, is that PI3 kinase activation of PKC overcomes the PKB block of Raf activity as PI3 kinase activation of PKC has been reported necessary for LPS induced ERK1/2 activation (Proc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17126402
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"High dose LPS stimulation activated ERK, SAPK, and p38 kinases in both C3H and HeN and C3H and HeJ Mphi."
9921718
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"To study this, we examined whether Tt-ME modulates LPS stimulated ERK upstream kinases MEK1/2, MKK3/6, TAK1, and IRAK1."
31929819
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"We show here that DOK3 is a negative regulator of TLR signaling by limiting LPS induced ERK activation and cytokine responses in macrophages."
22761938
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"LPS activates ERK1/2, which is a MAPK."
32034213
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"Also, sargaquinoic acid influenced the phosphorylation of JNK1/2 MAPK, except ERK1/2 and p38 MAPKs, stimulated by LPS."
22758221
reach
"In the current study, LPS induced the phosphorylation of ERK1/2 in RAW264.7 cells in the absence of pheophytin a. Pheophytin a modulated LPS induced ERK1/2 production, with the response being reversed by the ERK1/2 inhibitor U0126."
25501336
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"LPS activates all three types of MAPKs in mouse macrophages and activated ERK, JNK, and p38 contribute to the expression of inflammatory mediators [XREF_BIBR]."
24348728
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"Recently we demonstrated that lipopolysaccharide (LPS) promotes activation of the Ras and ERK cascade in medfly hemocytes and that phagocytosis of Escherichia coli by insect hemocytes is mediated by an integrin dependent process via the activation of FAK and Src complex (J Biol Chem 273 (1998) 14813; FEBS Letters 496 (2001) 55)."
14563359
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"MEK2 is dispensable in LPS mediated ERK activation in BMDMs."
30710049
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"IL-1β or LPS treatment induced the robust activation of ERK in endothelial cells isolated from WT mice but not Gab2−/− mice (Figure 3D)."
33827252
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"In addition, inhibition of the ERK1/2 pathway suppressed the formation of calcium deposits in cells treated with LPS for 4 weeks (XREF_FIG)."
23640488
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"LPS stimulation induced a strong phoshorylation of JNK, ERK and p38 after 30 min, which was prevented in the presence of GIP, suggesting that GIP directly inhibits inflammatory activation of macrophag[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29884547
reach
"To examine the negative functional role of TAM receptors on microglia in response to TLR activation, we activated TLR4 on primary cultured microglia with LPS and found that LPS stimulation caused rapid activation of both ERK1/2 and p38 in TKO cells compared to WT microglia (XREF_FIG)."
24244024
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"Regarding the signalling pathways coupled to DRD5 in DCs, in a previous report we showed that DRD5 stimulation in DCs was coupled to the inhibition of ERK1/2 activation triggered by LPS."
29619030
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"LPS regulates tumor cells mainly through binding with toll like receptor 4 (TLR4), and then activates the PKC, MAPKs, JNK and ERK1/2 signaling pathways, thereby affecting the activity of the transcription factors AP-1 and NF-kappaB XREF_BIBR."
33456361
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"LPS induced a TLR4 dependent stimulation of NF-kappaB and the MAPKs p38, ERK1/2, and JNK."
21937604
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"Astragaloside IV decreased LPS stimulated activation of ERK in renal tissue during endotoxinemia."
28328867
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"XREF_FIG show that Agm promoted PI3K and ERK signaling compared with a control group under treated with LPS."
24465142
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"It has been repeatedly observed that ' activation ' of macrophages and other cells can lead to an accumulation of Anx-A1 at the plasma membrane where it can (for example) block EGF XREF_BIBR and LPS induced ERK activation XREF_BIBR and undoubtedly fulfil other intracellular roles."
19428336
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"MCE critically suppressed LPS induced activation of ERK and p38 and had a milder inhibitory effect on that of JNK."
24489593
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"DNase accessibility analysis was therefore employed to determine whether LPS activation of ERK resulted in modulation of chromatin remodeling at the promoter region of the G-CSF gene."
26114754
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"ATL inhibits LPS induced ERK and p38 MAPK activation."
21831303
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"ARL11 positively regulates LPS induced ERK1/2 activation in macrophages."
29618517
eidos
"LPS similarly increased ERK activity in HLMVEC within 4h and the activity remained greater than baseline for up to 16h post-LPS stimulation ( Online Figure VIB and VIC ) ."
33926208
reach
"As shown in Fig. 2, LPS stimulation resulted in activation of ERK, p38 kinase and NF-kappaB signal pathways."
11947920
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"LPS induced extracellular signal regulated kinase (ERK) 1/2 and p38 phosphorylation in the myocardium was prolonged in MKP1 (-/-) mice."
22198506
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"To clarify the relation between augmented MIF by LOS and ERK1/2 signaling in GBS, monocytes from GBS patients treated with LPS were used as the control for the LOS treated monocytes."
23411097
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"Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal regulated kinase in macrophages."
17709378
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"We found that silencing of RasGRP3 in peritoneal macrophages enhanced the activation of ERK1/2 stimulated by low doses of LPS, Poly (I : C) or CpG ODN (XREF_FIG)."
25118589
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"LPS mediated ERK, JNK, and p38 activation in LAB m/m and WT DCs was similar."
22308309
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"Also, LPC blocked LPS induced ERK activation in peritoneal macrophages but not in TLR transfected cells."
26925065
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"MAPK- (p38, ERK 1/2 and JNK) and NF-kappaB-mediated signaling pathways are differentially activated by LPS in human chorioamniotic cells (Jung et al., 2005; Shoji et al., 2007)."
19969371
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"MAPK signaling was targeted because LPS stimulation activates p38, ERK, and JNK."
32707636
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"TAOK1 promotes LPS induced activation of ERK1/2 by constitutively interacting with TRAF6 and TPL2."
32344244
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"LPS treatment of HGFs resulted in the activation of ERK1/2, p38 and JNK."
23278498
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"Taken together, these results suggest that p105 phosphorylation by GRK5 and binding of arrestin-2 negatively regulates LPS stimulated ERK activation."
16980301
eidos
"Our previous report also showed that LPS plus IFNgamma induces ERK activation in microglial cells [ 26,27 ] ."
30585203
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"To determine the effect of amentoflavone on LPS activated ERK activity, immunoprecipitated ERK (prepared from RAW264.7 cells (5 x 10 6 cells/mL) that had been treated with LPS in the presence or absence of amentoflavone) was incubated with MBP according to the manufacturer 's instructions."
23970815
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"In the present study we could elucidate the role of extracellular signal related MAPK in the murine model of LPS induced acute lung injury by using U0126, a specific inhibitor of MEK1/2, upstream kinases of ERK."
19428337
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"mRNA expression profile of SFKs and involvement of SFKs in the regulation of LPS induced Erk1/2 signaling in PBMCs of active BD patients."
30659554
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"In freshly isolated alveolar macrophages from wild type and Ksr1 deficient mice, LPS increased ERK activation, nuclear translocation of NFkB and expression of inflammatory cytokines and chemokines in a similar pattern."
23221422
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"The effects of basolateral LPS to activate ERK and inhibit HCO (3) (-) absorption were eliminated in MTALs from TLR4 (-/-) and myeloid differentiation factor 88 (MyD88) (-/-) mice but were preserved in MTALs from TIR (Toll and interleukin -1 receptor) domain containing adapter inducing interferon-beta (Trif) (-/-) mice."
21881005
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"When phosphorylation of p38 and Erk1/2 was compared, no significant changes in P-p38 were obvious (not shown); S100A9 and S100A8/A9 pretreatments increased p-Erk1/2 above amounts found in lungs from mice treated with LPS alone (XREF_FIG)."
28074060
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"To prove this hypothesis, LPS elicited ERK activation and mitogenesis were determined in Caco-2 cells pretreated with or without PP2, the inhibitor for Src family members."
25705585
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"As shown in XREF_SUPPLEMENTARY, LPS activated ERK1/2 and JNK in a time dependent manner, as evidenced by the increases in phosphorylated ERK1/2 and JNK, but not p-38."
26288180
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"This protective effect is mediated directly through MPLA stimulation of a TLR4-TRIF-PI3K-Akt pathway that prevents LPS induced ERK activation."
28356284
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"PKCzeta, an atypical protein kinase C isozyme, has been shown to play a central role in LPS induced activation of the ERK1/2 signalling pathways in macrophages."
18503635
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"Western blot analysis revealed that LPS stimulation induced the activation of ERK-1/2, p38 MAPK, and NF-kappaB, as well as Akt activation."
33777049
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"While LPS stimulation induced the activation of ERK1/2, SAPK and JNK, and p38 MAPK in RAW 264.7 cells, Shinbaro3 treatment suppressed the LPS induced phosphorylation of these MAPKs in a concentration dependent manner (XREF_FIG)."
29849490
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"In RAW264.7 cells, PDL treatment prevented LPS-induced activation of the ERK/Akt signaling pathway and significantly decreased the levels of inflammatory cytokines, such as IL-1β, IL-6, and TNF-α."
36797333
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"Equivalent levels of ERK1/2 activation by LPS in CD14 deficient RPMphi may be due to soluble CD14 provided by fetal calf serum in the medium and the high dose of LPS used XREF_BIBR."
19521507
eidos
"LPS also activates extracellular signal-regulated kinases 1/2 , mitogen-activated kinase p38 , mitochondrial reactive oxygen species , and MMP-9 expression [ 6,18 ] ."
33552397
trips
"G-CSF did not affect LPS-induced activation of ERK, p38, JNK, and NF-kappa B, indicating that G-CSF affects the pathway downstream or independently of these signaling molecules."
14736711
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"It has previously been demonstrated that phosphorylation of S930 in p105 is essential for LPS induced ERK activation XREF_BIBR, XREF_BIBR."
22427889
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"Ehrlichia chaffeensis downregulates surface Toll like receptors 2/4, CD14 and transcription factors PU.1 and inhibits lipopolysaccharide activation of NF-kappa B, ERK 1/2 and p38 MAPK in host monocytes."
14706103
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"It is well-known that LPS activates ERK, p38 and JNK MAPkinases."
17916230
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"DMF has also been reported to inhibit MSK1 phosphorylation in LPS stimulated dendritic cells, however in contrast to the data in keratinocytes, in dendritic cells DMF was able to reduce LPS induced ERK1/2, although not p38 or JNK, phosphorylation XREF_BIBR."
27498693
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"In mKC, LPS treatment resulted in transient and rapid increase of kinase activity of ERK1/2 that phosphorylated their specific substrate ELK-1, with maximal value at 30 minutes and a return near to baseline within 2 hours, and LPS induced ERK1/2 activity from LPS concentration of 10 pg/ml to the top activity at 100 ng/ml."
11835717
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"However, fermented HR-A and B significantly suppressed LPS induced ERK and JNK MAPKs phosphorylation [Figure XREF_FIG and XREF_FIG]."
25298686
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"Lastly, we tested whether dasatinib alters LPS-stimulated AKT and ERK signaling in mouse primary microglial cells."
31655606
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"While Western blotting showed that 100 microM PD 98059 completely inhibited LPS mediated ERK activation, oxidative response to fMLP by a chemiluminescence assay revealed that the same concentration inhibited the LPS primed oxidative burst by only 40%."
11292734
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"In conclusion, our results demonstrate that Ksr1 does not play a role in LPS induced ERK activation in lung alveolar macrophages and does not contribute to the development of ALI induced by LPS."
23221422
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"Although LPS potently stimulates ERK activation in RAW 264.7 macrophages, it does not activate ERK-1/-2 in BV-2 microglia."
11786532
eidos
"LPS activates ERK1 / 2 , JNK , and p38 MAPK , which ultimately control the activity of transcription factors regulating the expression of inflammation modulators , such as induced NO synthase ( iNOS ) , cyclooxygenase-2 ( COX-2 ) , TNF-alpha , IL-1alpha , IL-1beta , and IL-6 [ 44 ] ."
| PMC
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"The LPS tolerance in DOK3 deficient cells was accompanied by significant upregulation of SHIP1, IRAK-M, and SOCS1 suggesting that the enhanced ERK and NF-kappaB activation, induced by the initial LPS stimulation, primes the cells for rapid induction of tolerance upon re-challenge."
22761938
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"CA140 alters LPS induced ERK signaling in BV2 microglial cells."
30309372
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"However, rIL-10 and RA rescued LPS mediated ERK activation in MEK1 deficient macrophages."
26208884
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"To ensure that the increases in LPS induced ERK activation were not due to off-target effects of the lentivirus, BMM were derived from DOK3 deficient mice XREF_BIBR and stimulated with LPS."
22761938
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"Regarding the TLR4 mediated NF-kappaB and ERK signaling, overexpression of ROCK1 increased the activity (phosphorylation form) of ERK1/2, JNK, and p38 which was firstly induced by LPS (XREF_FIG, XREF_SUPPLEMENTARY)."
29804125
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"Further, consistent with the essential role for Tpl2 in ERK signaling, the LPS stimulated ERK1/2 activation was also restored in the p105 transduced cells."
12667451
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"Our results showed that LPS induced the activation of ERK and p38 MAP kinase in a Rac dependent manner, suggesting a mediatory role of Rac1 in LPS signaling to MAPKs stimulation."
12132588
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"PD184352 has been previously shown to block LPS induced ERK1/2 activation XREF_BIBR and is also able to block ERK1/2 phosphorylation in response to heat killed C. albicans (XREF_FIG)."
21060679
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"H 2 O 2 treatment exhibited little effect on LPS induced ERK activation."
10936514
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"In this regard, TLR4 stimulated TNFalpha expression has been shown to be mediated primarily via ERK in macrophages, because knockout of TPL2 and COT (a MAP3K) abolishes LPS induced ERK activation and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17507094
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"The classic Ras mediated pathway of ERK1/2 activation by LPS was confirmed when the specific Raf-1 inhibitor, GW 5074, and the MEK1/2 inhibitor, U0126, both reduced ERK activation by 51-60%."
17045653
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"Indeed, LPS induces p38, JNK, and ERK activation in BV2 cells [165,166]."
| PMC
reach
"As shown in XREF_FIG, LPS treatment significantly increased the level of the phosphorylated form of ERK, JNK, and p38."
28989571
reach
"Taken together, these findings indicate that Ksr1 plays a dispensable role in LPS induced ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model."
23221422
reach
"Other studies have revealed that lipopolysaccharide (LPS) induces ERK 1/2 activation through TRIF and MyD88- and TRIF dependent signaling in vivo and in vitro [XREF_BIBR - XREF_BIBR]."
29977930
reach
"Therefore, ECVs (LmV, LcV, and LpV) prevent inflammatory responses in the LPS-stimulated microglial cells by blocking the extracellular signal-regulated kinase (Erk) and p38 signaling pathways."
35159463
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"However, this compound did not inhibit LPS induced activation of extracellular signal regulated kinase and stress activated protein kinase and c-Jun NH (2)-terminal kinase, but significantly impaired activation of p38 mitogen activated protein kinase."
21184860
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"LPS and other inflammatory mediators such as tumor necrosis factor alpha (TNFalpha) activate ERK dependent lipolysis XREF_BIBR, XREF_BIBR."
24828250
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"We found that LPS triggered transient activation of three MAP kinase subfamilies, ERK, JNK, and p38, in both immortalized and primary murine alveolar macrophages."
15590669
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"H 2 S attenuates LPS induced activation of ERK1/2 and NF-kappaB signaling pathway in myometrium."
27035826
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"These results suggested that CuEO exerted anti-inflammatory effects in LPS stimulated RAW 264.7 cells via inhibition of NF-kappaB and mitogen activated protein kinases ERK and JNK signaling; the chemical could be used as a source of anti-inflammatory agents as well as dietary complement for health promotion."
26425131
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"Three types of MAP kinases (ERK1/2, p38, and JNK) can be activated by LPS in cardiomyocytes XREF_BIBR, XREF_BIBR."
22761733
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"Furthermore, it has been reported that a 100 nM incubation with the PI3 kinase inhibitor wortmannin inhibits LPS induced activation of ERK1/2 in LPS stimulated BAC1.2 F5 cells (Procyk et al., 1999)."
17126402
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"It was found that LPS induced ERK, JNK, and p38 MAPK activation in THP-1 cells as detected by Western blot analysis with corresponding phospho specific antibodies, while PMA induced ERK activation and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19027716
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"CWE blocked the LPS-induced degradation of IκBα as well as the activation of JNK, p38 and ERK1/2."
23190501
reach
"LPS activated Akt1-/- macrophages exhibited increased ERK1/2 activation (XREF_SUPPLEMENTARY) but no change in IkBalpha degradation (XREF_SUPPLEMENTARY), suggesting that Akt1 plays an inhibitory role in early TLR4 signals but its ablation is not sufficient to suppress pro inflammatory cytokine production at the early stages of endotoxemia."
19699171
reach
"LPS induced phosphorylation of p38 kinase was maximal at 2 h and markedly diminished at 8 h : LPS activation of ERK1/2 and JNK 1/2 peaked at 30 min and persisted over the 4-h time period."
14644621
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"LPS, fMLP, and LTB (4) stimulated similar levels of ERK and Akt activation."
11369515
reach
"Signaling cascade analysis showed that LPS induced activation of Erk, JNK, p38 mitogen-activated protein kinase (MAPK), and NF-κB, and RA treatments attenuated the activation of the three MAPKs and NF-κB. Moreover, cotreatment with RA and Erk, JNK, p38 MAPK, or NF-κB inhibitors further downregulated the mRNA expression of TNFα, IL-8, and iNOS, and decreased the production of TNFα, IL-8, and NO by A7r5 cells."
35455434
reach
"As shown in XREF_FIG, LPS alone failed to induce ERK1/2 activation but LPS stimulation in the presence of RA led to ERK1/2 phosphorylation."
26208884
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"In agreement with these reports, in our studies we found that LPS treatment of human macrophages induced the early activation of NF-kappaB, p38, JNK and ERK."
23911403
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"Consistent with a role for phosphorylation of serine 930 in LPS induced ERK activation and stabilization of c-Fos, expression of p105DeltaN but not p105DeltaNS930A rescued the defect in ERK activation and c-Fos induction observed in Nfkb1 -/- BMDM (XREF_FIG)."
22427889
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"Although the consequences of TPL-2 deficiency on cytokine production after TLR stimulation were very similar in BMDMs and BMDCs (XREF_FIG), it has been suggested previously that LPS does not stimulate ERK activation in BMDCs."
19667062
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"LPS has been shown to stimulate both ERK1/2 and ERK 5 in macrophages [XREF_BIBR]."
19823867
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"Therefore, we suggest that BBDE inhibited the LPS induced ERK signaling pathway and inflammatory response by reducing ROS generation in macrophage cells.Inflammation is based on pathological and physi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29864895
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"PD98059, which prevented TNF- and LPS induced ERK activation (not shown), proved to be a potent inhibitor of ODC induction, but did not influence NOS induction."
11852055
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"For example, one report suggested that LPS or GM-CSF induces ERK in macrophages, albeit with different kinetics [the latter induces ERK activation much more quickly -- 5 min vs. 15 min, respectively; ref.]"
27824592
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"To confirm that LPS-induced ERK activation was linked to NF-kB signaling, we monitored activation of NF-kB and ERK over time in RAW264.7 cells preincubated with or without 1 µM SC-1, an inhibitor of ERK activation, for 3 h and then treated with 1 μM LPS for 15–45 min using western blotting."
32034213
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"Additional in vitro experiment shows that DHA treatment plays a protective role in LPS induced vascular smooth muscle cell (VSMC) proliferation and inflammatory response by regulating ERK, p38 and NF-kappaB and p65 signaling pathways [XREF_BIBR]."
27482523
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"Our results show that the LPS induced activation of ERK, p38, and JNK increased DCN expression.In summary, this study showed that LPS enhanced DCN gene expression in mouse odontoblasts via the TLR4, M[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22414830
reach
"As shown in Figures XREF_FIG, XREF_FIG, and XREF_FIG, LPS treatment caused a marked increase in the phosphorylation of ERK1/2, JNK1/2, and p38 MAPK proteins at 5, 15, and 5min, respectively, whereas LPS induced ERK1/2, JNK1/2, and p38 MAPK phosphorylation was significantly inhibited by TS and GA treatment."
24723997
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"In freshly isolated alveolar macrophages from wild type and Ksr1 deficient mice, LPS increased ERK activation, nuclear translocation of NFkappaB and expression of inflammatory cytokines and chemokines in a similar pattern."
23221422
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"PI3K p110beta siRNA inhibited JNK activation, but not p38 MAPK or ERK activation, stimulated by LPS, while PI3K p110alpha siRNA did not affect LPS induced JNK, p38 MAPK, or ERK activation in both cell types."
19380768
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"ERK1/2 (Immunoblot) in RAW cells treated with LPS (1ug/ml) in the presence and absence of LDN.Figure 2. : The docked conformation of naltrexone at the binding interface of RBD and ACE2 complex obtained from AutoDock (A) and interface amino acid residues involved in non bonded contacts are labelled (B)."
32930058
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"In neuronal cultures, LPS failed to induce activation of p38 or ERK1/2, but induced significant activation of JNK, 30 min after LPS treatment (level of activation detected was similar to that detected in glial cultures)."
23034047
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"Our study showed that LPS increased the activation of p38, JNK, and Erk in BV2 cells."
25088370
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"Similarly, LPS activation of ERK1/2 and induction of TNFalpha expression were reduced in SH2 domain containing inositol 5 -phosphatase (SHIP) -1 -/- macrophages, which have enhanced Akt activity."
19447494
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"Vav null macrophages XREF_BIBR exhibit defects in LPS induced ERK and p38 MAPK signalling while JNK responses are normal XREF_BIBR."
20644716
reach
"Additionally, LPS stimulation activates MAPKs, such Erk and p38."
23667114
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"SME inhibited LPS-induced phosphorylation of ERK after 15–30 min, and the amount of p-ERK had returned to the basal level after 60 min in LPS-stimulated RAW264.7 cells pretreated with SME SME suppresses expression of signaling components involved in LPS-induced activation of ERK in RAW264.7 cells."
32034213
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"Interestingly, LPC blocked LPS induced ERK activation in peritoneal macrophages but not in TLR transfected cells."
24312681
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"In agreement with this observation, the inhibitors of ERK or JNK MAPK efficiently blocked IL-8 production in cells treated with the antibody and LPS."
25887375
reach
"These results suggest that SFEIO exerts its anti-inflammatory effects in LPS activated RAW 264.7 cells by down-regulating the activation of ERK, JNK, and NF-kappaB."
27822172
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"As a control, we verified that U0126 treatment inhibited LPS induced ERK1/2 activation (XREF_FIG)."
18443198
reach
"Previously, both C5a and LPS were shown to activate NF-kappaB, p38 MAPK, Erk1/2, JNK and PI3K signaling pathways in human monocytes XREF_BIBR XREF_BIBR."
27624143
reach
"However, no obvious difference was detected in the LPS-stimulated ERK1/2 pathway (Figure S3B)."
36072548
eidos
"LPS stimulation also activated ERK1 / 2 and increased its interaction with CDK5 ."
34164484
reach
"ERK and p38 kinase are activated by inflammatory mediators, including chemoattractants and GM-CSF [26-31], while LPS is reported to activate p38 kinase, but not ERK [32,33]."
11369515
reach
"These results can be compared with those published in 2015 by Kim et al. [88] who showed that BoNT/A inhibited LPS-upregulated NO production in RAW264.7 macrophages by blocking the activation of ERK and p38.Recently, many papers have shown that the inhibition of the MAPK family members (namely p38 and ERK1/2) leads to lower rates of neuropathy in animal models, down-regulated pro-nociceptive factors and enhanced opioid efficiency [84,89,90,91,92,93,94,95,96]."
29614835
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"Here, the depletion of PKC by PMA precluded the activation of ERK-1/2 and suppressed the induction of iNOS mediated by LPS, indicating that conventional and novel PKC isoforms are involved in LPS medi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14505805
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"Furthermore, both hypoxia and LPS activate ERK and MAPK signaling in trophoblast cells."
24035613
reach
"The current results showed that miR-124-3p promoted migration and viability of LPS-induced BV2 microglia, and inhibited apoptosis and phosphorylation of pro-inflammatory signaling pathways (p38 MAPK, Erk1/2, and PI3K/Akt) activated by LPS."
34277703
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"Cells that were co-stimulated with palmitate and mmLDL had significantly higher levels of phosphorylated ERK and p38 compared to the macrophages treated with LPS alone."
29518116
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"Another study showed that LPS stimulated ERK1/2 signaling compromised the integrity of the airway epithelial barrier and initiated the migration of leukocytes across the epithelium, and that epithelial permeability was diminished by ERK1/2 blockade."
29311915
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"Fig. 5 Effect of CpG ODN preexposure on LPS mediated activation of ERK, JNK, and p38 MAP kinases in RAW 264.7 cells."
12219019
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"In these cells the failure to activate MEK and ERK by LPS again correlated with TNF mRNA retention while other cytokines are normally expressed (Dumitru et al., 2000) ."
| PMC
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"The activation of p38 but not ERK1/2 by LPS results in NF-kappaB activation and subsequent iNOS and NO release in macrophages."
22439901
reach
"In addition, we also examined whether LPS could activate ERK1/2 signal in DSCs."
25757669
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"Interestingly, PP2 not only abrogated LPS increased ERK activation, but it also suppressed LPS mediated cellular growth."
25705585
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"Erk1/2 and Akt signaling pathways, which are responsible for the VSMC inflammatory response, were activated by LPS or PDGF stimulation, and SsnB significantly inhibited their activation."
25869499
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"The LPS induced increase in ERK1/2 and cPLA 2 alpha phosphorylation at 4 hours was ablated in astrocytes by U0126 in a dose dependent fashion (XREF_FIG), but pretreated with SB203580 did not affect PGE 2 production induced by LPS (data not shown)."
24130900
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"These effects of selenite were mediated by the MAPK protein ERK as selenite blunted LPS induced activation of ERK."
32373896
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"On the other hand, lipopolysaccharide stimulation of ERK1/2 was shown to increase TNFalpha production."
26069204
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"Exposure of macrophages to lipopolysaccharide (LPS), a classical TLR4 agonist, has been shown to activate the MEK and ERK cascade in vitro."
27031380
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"LPS stimulated extracellular signal regulated kinase (ERK) 1/2 and p38 phosphorylation, two signaling pathways regulated by ROS, were increased twofold in Kupffer cells from ethanol fed rats compared with pair fed controls."
16554353
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"LPS activates ERK in MPhi; however, it apparently does not do so in DCs."
27824592
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"Stimulation with a combination of sCD26 and DPPIV (+) and LPS upregulates ERK in the cytosol and c-Fos, NF-kappaB p65, NF-kappaB p50, and CUX1 in the nucleus (XREF_FIG, XREF_FIG)."
23805228
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"We have reported that chronic ethanol exposure, both in vivo and during culture, increases both LPS stimulated ERK1/2 and p38 activation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
14960183
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"Using a number of approaches : mouse embryonic fibroblasts (MEF) from wild-type (WT), beta-arrestins knockouts (KO), beta-arrestins 1 and 2 double KO, and MEFs with reconstituted WT beta-arrestins in the double KO cells, RNA interference (siRNA) specific knockdown of beta-arrestins, and overexpression of WT beta-arrestins, it was demonstrated that beta-arrestin 2 positively regulates LPS induced ERK 1/2 activation and both beta-arrestins 1 and 2 negatively regulate LPS induced NFkappaB activation."
17418896
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"We did not find that LPS can activate ERK in 30 min through upregulation of Wnt-1, which is a secreted lipid modified signaling glycoprotein [25]."
29032172
reach
"LPS treatment has been reported to induce ERK, JNK, and p38 activation in macrophages [XREF_BIBR]."
19294383
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"Further study showed that RPS5 knockdown substantially promoted LPS-induced IκB phosphorylation and degradation and enhanced LPS-induced ERK, JNK, and p38 phosphorylation (Xu et al., 2016)."
32117819
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"The results also indicated that LPS significantly activated ERK1/2 and STAT3 signaling pathways, and expression trend of them was consistent with direction of EGFR in HK2 cells."
29207668
reach
"LPS/TLR4 and TNFa/TNFR1 promote activity of PI3K/AKT, Ras/ERK, p38, and JNK kinases, whereas p38 and JNK can also become activated by Rac1 or RhoA."
35634305
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"These findings were consistent with LPS activation of ERK in vivo (XREF_FIG)."
19895919
reach
"PI3K and Akt activation leads to inhibition of the LPS dependent stimulation of IKK and NF-kappaB and p38 and ERK MAPKs."
25065531
reach
"The results showed that pretreatment with 2-AG inhibited the nuclear translocation of ERK1/2 and cytoplasmic GS downregulation induced by late LPS exposure."
30075820
reach
"In contrast to zymosan and bacteria, LPS stimulation induced a very weak activation of ERK, which was not affected by wortmannin."
10832097
reach
"As shown in XREF_FIG, NE could enhance LPS induced ERK and JNK phosphorylation as well as inhibit LPS induced P38 phosphorylation."
27237101
reach
"Since we found that IL-4 down-regulated LPS induction of ERK 1/2 (XREF_FIG), we next assessed the effects of blocking ERK 1/2 in CB CD34 + cell Eo/B CFU formation in the presence of LPS."
24971469
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"Pg LPS also induced ERK, p38, and JNK activation, and Pg LPS induced PAI-1 expression was inhibited by ERK/p38/JNK inhibitor pretreatment."
24500480
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"These results suggest that DOK3 protein levels inhibit LPS induced ERK activation."
22761938
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"Application of PP2 abrogates both LPS induced ERK activation and cellular proliferation."
25705585
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"DOK3 Inhibits LPS induced ERK Activation."
22761938
reach
"Pertinently, megalin is down-regulated via the LPS induced ERK1/2 signaling pathway [XREF_BIBR], through which, as noted earlier, both Cbl and * NO achieve their coincidentally regulatory, beneficial effects."
23781123
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"In particular, they found that LPS rapidly induces p38, ERK, and NF-kappaB within 15-30min in monocytes, followed by slower S6 induction at 2h."
26003204
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"Here, we found that LPS promoted EMT and ERK1/2 activation in HK2 cells, which were inhibited by silencing of IGFBP7."
31287495
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"LPS added directly to endothelial cultures induced significant activation of JNK and ERK1/2."
23034047
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"Consistently, LPS-induced ERK and p38 activation in Orai1 KO cells were similar to those in WT astrocytes (Fig. 3D–F)."
35780680
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"In the HBE-1 normal bronchial cell, only fully sulfated heparin 's effects on ERK signaling were of significance and again, desulfated heparin had little effect upon LPS induced ERK signaling."
26495958
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"We conclude that LPS + H/R initiates tyrosine kinase- and ERK1/2 sensitive signaling that synergistically reduces inter-endothelial electrical coupling by dephosphorylating PKA specific serine residues of Cx40."
18521823
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"We also showed that LANSO inhibited activation of NF-kappaB and ERK induced by LPS and HpWE, which could account for why LANSO exerts anti-inflammatory effects."
19590712
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"In contrast, E 2 did not affect the LPS induced activation of ERK1/2 and JNK (data not shown)."
24376635
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"Subfractions of the chloroform extract markedly suppressed LPS mediated activation of the extracellular signal regulated kinase and nuclear factor kappa-B."
23631491
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"GW843682X also inhibited LPS induced activation of ERK, p38 and NF-kappaB, which contributed to LPS induced up-regulation of TNF-alpha."
24205328
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"To determine if LPS induced ERK or JNK and p38 kinases are affected by paclitaxel treatment, we quantitated the activities of these kinases in spleen cells."
10988356
reach
"bPN also inhibited the LPS stimulated activation of JNK and ERK signaling, and inhibited the LPS stimulated degradation of I (K) B in the RAW264.7 cells."
21703595
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"Interestingly, curcumin at 10 muM had contrasting effects on the kinetic of LPS induced activation of ERK MAPKinases : an initial dose dependent increased activation 10 min after stimulation, was followed by a very marked inhibitory effect 30 and 60 min after LPS stimulation."
24011306
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"These findings identify Tpl2 as a critical signaling component in the LPS stimulated MEK and ERK pathway, although how the function of Tpl2 is regulated remains unknown.The downstream targets of the L[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12667451
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"LPS activated C-Jun N-terminal kinase, p38MAPK, and extracellular signal regulated kinase in wt cells, but the levels were much higher in p60-/-, p80-/-, and p60-/- p80-/- cells."
12695514
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"In this study, we demonstrated that administration of LPS and D-GalN initiated the activation of ERK, JNK, and p38 MAPK."
28430612
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"Depletion of S1PR1 in EC prevented ERK and STAT3 phosphorylation further indicating that LPS stimulated ERK and STAT3 via S1PR1 (Online Figure VIH through VIJ)."
33926208
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"We have previously shown that LPS induces rapid activation of NF-kappaB p65 and ERK1/2 in macrophages, while STAT1 and STAT3 are activated with delayed kinetics, due to IFN-beta production and signaling."
22925925
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"Co-incubation with U0126, SP600125 and SB202190 significantly suppressed LPS stimulated activation of ERK 1/2, JNK, and p38 MAPK, respectively."
17433832
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"Notably, the data presented here show for the first time that alpha2 NKA isoform silencing decreases LPS induced ERK activation and TNF-alpha release and modulates RelA nuclear translocation and, therefore, NF-kappaB activity."
28687727
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"MAPK signaling, including JNK, ERK1/2 and p38 MAPK, which can be activated by LPS and TNF-alpha, is reported to play an important role in LPS induced inflammation [XREF_BIBR]."
27191745
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"To examine whether ERK regulates P65-miR23a/27a/24 in GC, we treated GC cells with the ERK inhibitor PD98059 [XREF_BIBR] or ERK activator LPS [XREF_BIBR] and determined the levels of p-ERK, p-P65, miR-23a, miR-27a, and miR-24."
29866191
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"LPS upregulated the phosphorylated forms (i.e., activated forms) of p38, ERK1/2, and c-Fos (XREF_FIG), but these effects were attenuated by the CS or CSE pretreatments."
28617322
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"Effect of PRE on LPS-induced activation of ERK1/2, JNK, and p38 MAPK in RAW 264.7 macrophages."
26797110
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"LPS mediates the inflammatory response by activating ERKs, p38 MAPK, and JNKs."
24195792
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"These results suggest that increased BDNF synthesis through activation of ERK1/2 caused by a single LPS injection and subsequent TrkB signaling are required for the antidepressant effect of hippocampal microglial stimulation."
35995236
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"SME attenuated LPS-stimulated NLRP3 inflammasome activation in an ERK-dependent manner in BMDMs."
32034213
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"The present study indicated that p38 and ERK1/2 were activated and translocated into nucleus in astrocytes by LPS exposure with different patterns, i.e., p38 was firstly activated at 30min and reached peak at 2h while ERK1/2 activated at 1h and reached peak at 3h, while inhibition of p38 and ERK1/2 attenuated the changes of GS expression induced by LPS."
30075820
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"The Ras/Raf-1/MAP pathway is thought to play an active role in the modulation of cell survival, proliferation, and differentiation.In this study, our results clearly show that TLR4 mediates the LPS-induced activation of ERK1/2 proteins via Ras/Raf-1/MAP kinase."
30200495
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"In contrast, LPS-induced activation of ERK was attenuated by ajudecumin A treatment in a concentration-dependent manner (10, 20 and 40 μM, inhibition rate were 17.07, 30.50 and 53.26%, respectively, p < 0.05–0.001, Figure 5(A)."
31070535
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"Consequently, LPS induces enhanced ERK activation in the absence of DOK3."
22761938
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"Simvastatin also inhibited LPS stimulated ERK but not p38 MAPK and JNK."
18625914
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"In addition, LPS stimulation activated the ERK, p38, and JNK MAPK pathways."
22414830
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"Over expression of wild type beta-arrestins 1 and 2 had no effect on LPS induced ERK1/2 activation and LPS induced IL-8 production suggesting that endogenous beta-arrestins 1 and 2 are sufficient to mediate maximum ERK 1/2 activity and IL-8 production."
17418896
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"These results indicate that cFLIP is dispensable in LPS induced activation of Erk1/2 MAPKs, and plays a role in the downregulation of p38 and Jnk."
19109151
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"Furthermore, to confirm the role of MAPK pathway in MDR1 suppression by GSP, the MAPK and ERK pathway were activated by LPS in A2780/T cells."
23967153
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"Second, the blockade of Src like tyrosine kinases or Raf-1 inhibits LPS induced ERK activation; this inhibition suggests that the Raf-1/MEK/ERK signaling pathway is present and activated by Src like tyrosine kinases and Raf-1-dependent mechanisms, which do not require Ksr1 as a scaffold."
23221422
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"ERK activation has been previously shown to be critical for ICAM-1 expression, and in accordance with that report, we found that LPS induced ERK activation is critical for ICAM-1 expression in MDA-MB-231 cells and for their adhesion to monocytes (XREF_FIG), Several reports have suggested that NF-kappaB lies downstream of ERK, thus regulating ICAM-1 expression."
26299331
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"LPS induced endotoxin-tolerance with a significant inhibition of LPS stimulated TNF secretion and less p44 and p42 ERK kinase activation."
12688542
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"For example, CpG DNA upregulates the expression of the cellular inhibitor of apoptosis (c-IAP) 1 and 2, while it downregulates the levels of active caspase-3 in a PI3K dependent manner; HIV infected DCs become resistant to NK induced TRAIL mediated apoptosis due to the upregulation of the cellular-Flice-like inhibitory protein and c-IAP2; LPS activates ERK, which regulates DC survival."
24670806
trips
"Finally, we showed that the inhibition of LPS-stimulated ERK activation by simvastatin was reversed by GGPP."
18625914
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"Importantly, pretreatment with TS or GA inhibited the LPS induced activation of ERK1/2, JNK1/2, and p38MAPK."
24723997
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"LPS treatment induced activation of Erk1/2 within 30 min, which was dose-dependently inhibited by PD98059, a specific inhibitor of the Erk kinase (MEK)."
12465042
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"We show that treatment of differentiated THP-1 cells with purified Stx1 resulted in prolonged activation of c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase (MAPK) cascades, and lipopolysaccharides (LPS) rapidly triggered transient activation of JNK and p38 and prolonged activation of extracellular signal regulated kinase cascades."
16301326
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"Signaling analyses showed that LPS induced activation of ERK but not AMPK, which was constitutively activated in rENSpc neurons."
25497784
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"Numerous studies have shown that LPS activates ERK1/2 in monocytes and macrophages, and the MEK1/2 inhibitor, PD98059, blocked LPS induced TNFalpha activation in human monocytes."
26065826
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"We showed that LPS activated ERK, P38, and JNK in mouse bone marrow stromal cells after 15min incubation."
26000311
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"Anti-inflammatory effects of scoparone in a rat model of colitis have also been reported (151), while in BV2 microglial cells, scoparone attenuated LPS-induced neuroinflammatory responses by blocking interferon regulatory factor 3 (IRF3) and extracellular signal-regulated kinase (ERK) activation (126)."
35211087
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"In the lipopolysaccharide induced inflammatory response of rat embryonic ventricular myocardial cells (H 9 C 2 cells), our group also found [XREF_BIBR] that SPRC prevented nuclear factor-kappaB (NF-kappaB) activation and suppressed LPS induced extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation and intracellular reactive oxygen species (ROS) production."
26078822
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"Mosser et al. [36] reported Sp1 binding and induction of chromatin remodeling in the Il10 promoter of mouse macrophages in response to LPS stimulation in an ERK dependent manner."
21925952
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"LPS activates the NFκB pathway and all three MAPK pathways (ERK, JNK/SAPK, and p38α), leading to a wide range of cellular responses, including cell differentiation, survival or apoptosis, and inflammatory responses ."
34083739
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"Increased LPS induced cytokine expression in the absence of ANXA1 was accompanied by significantly increased LPS induced activation of ERK and JNK MAPK and was abrogated by inhibition of either of these pathways."
19553536
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"Pretreatment of RAW 264.7 with luteolin inhibited the LPS induced ERK1/2 and p38, but not JNK1/2, phosphorylation, and blocked the LPS induced TNF-alpha release."
12145106
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"Furthermore, siKRAS significantly reduced downstream ERK-1/2 activation induced by LPS."
30402038
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"However, herein we found that TI-I-175 did not significantly affect LPS induced activation of ERK1/2, p38MAPK and JNK (data not shown), indicating that MAPK signaling pathways are not implicated in the modulation of AP-1 by TI-I-175 in RAW 264.7 macrophages."
25767679
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"To determine the inhibitory effects of AG or U0126 on LPS activated ERK or IKKepsilon enzyme activities, immunoprecipitated phospho-ERK or IKKepsilon prepared from RAW264.7 cells (5 x 10 6 cells/mL) treated with LPS (1mug/mL) for 30 (ERK) or 10 (IKKepsilon) min were incubated with AG or U0126 in the presence or absence of substrate protein [myelin basic protein (MBP)] or immunoprecipitated IRF-3 from unstimulated RAW264.7 cells, according to the manufacturer 's instructions."
23840248
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"G-CSF did not affect LPS induced activation of ERK, p38, JNK, and NF-kappa B, indicating that G-CSF affects the pathway downstream or independently of these signaling molecules."
14736711
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"To test the possibility that the LPS induced nuclear translocation of NF-kappaB was ERK and/or p38 MAPK cascade dependent [25,26], we treated the cells with ERK and p38 MAPK pathways inhibitors."
23773963
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"In our study, we observed that both Pam3 and LPS activate ERK1/2, p38, and JNK to a similar extent, despite the differential effect of the applied ligands on pro- and anti-inflammatory cytokine levels."
29096690
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"In the septic AKI, LPS could significantly increase ERK1/2 activation, thus leading to tissue damage during AKI."
29311915
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"In contrast, in neuronal cultures, LPS activated JNK but not ERK1/2 or p38, and the specific JNK inhibitor SP600125 significantly blocked LPS induced KC expression and release."
23034047
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"Our results shown in the XREF_FIG indicate that benfotiamine significantly prevented the LPS induced activation ERK1/2 and the transcription factors NF-kB and Egr-1 which transcribe gene for COX-2 and mPGES-1 [XREF_BIBR]."
22067901
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"Recombinant HBsAg, an apoptotic like lipoprotein, interferes with the LPS induced activation of ERK-1/2 and JNK-1/2 in monocytes."
12270119
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"Moreover, LPS promoted the activation of the nuclear factor kappa-B and extracellular signal-regulated kinase/c-Jun NH-terminal kinase signaling pathways, which were inhibited by AuNPs."
34523392
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"Interestingly, LiCl pretreatment enhanced LPS induced MEK1/2 phosphorylation unlike ERK (data not shown) suggesting that Li 's effect on LPS induced ERK likely occurs below MEK1/2 and potentially via a protein that could directly affect ERK."
24277481
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"On the contrary, neither the phospholipase D 1 (PLD1) nor the PLD2 inhibition is able to modulate the early ERK1/2 activation induced by LPS in RPE cells."
27006973
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"It has been shown that chronic alcohol induces LPS induced ERK1/2 activation and subsequent transcription of Egr-1, an immediate early gene transcription factor, which contributes to TNFalpha expression in murine hepatic macrophages."
19398236
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"Taken together, dasatinib affects TLR4 signaling to modulate LPS-induced proinflammatory cytokine levels.AKT and ERK signaling are associated with LPS-induced immune responses via TLR4 signaling [37]."
31655606
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"These findings suggest that in the absence of DOK3, BMM are more sensitive to LPS induced ERK activation with subsequent upregulation of a gene expression profile that promotes endotoxin tolerance."
22761938
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"Cholesterol extraction from the intact macrophage with methyl-beta-cyclodextrin was sufficient to activate ERK, recapitulating the LPS-IkappaB kinase-p105-MEK-ERK cascade, whereas both it and the alternate raft disrupting agent nystatin blocked subsequent LPS activation of the ERK cascade."
18815123
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"LPS stimulation of microglia activates all three MAPK pathways : p38, ERK1/2 and JNK [XREF_BIBR, XREF_BIBR]."
21194439
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"Furthermore, siKRAS significantly reduced downstream ERK-1/2 activation induced by LPS."
30402038
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"Moreover, MOTS-c treatment significantly promoted p-AMPKalpha and SIRT1 expression and suppressed LPS induced ERK, JNK, p38, p65, and STAT3 activation in the mouse lung tissues."
31931370
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"KP greatly inhibited the LPS-induced ERK1/2 and JNK after LPS application."
21286382
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"Pretreatment (1h) with U0126 (10muM) strongly inhibited the activation of ERK and NF-kappaB induced by LPS (p < 0.01), which was similar to the effect of BTW."
33597862
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"Additionally, the LPS induced activation of extracellular signal regulated kinase 1/2 (ERK1/2), P38 and c-Jun N-terminal kinase (JNK) was suppressed by DPL extract."
30747232
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"Raf1 is reported to be involved in the LPS induced activation of ERK [21-23]."
12901876
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"Functional differences between TGF-M-DCs and TGF-GM-DCs included enhanced responses to LPS induced ERK, JNK, and P38 activation in TGF-M-DCs and their immune suppressive skewed cytokine release profiles."
17585053
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"LPS induced ERK signaling events critical to priming."
24623131
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"The maximal activity of LPS induced ERK, JNK, and p38 was 12- (30 min), 5- (30 min), and 16-fold (15 min), respectively."
11940570
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"LPS induced ERK1/2 activation through phosphorylation, which was inhibited by all the compounds tested, the most active being epigallocatechin (EG), followed by epigallocatechin gallate (EGCG) and C1."
21405989
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"LPS activation of ERK-1/2 additionally requires transphosphorylation of TPL-2 on serine 400 in its C terminus, which controls TPL-2 signaling to ERK-1/2 independently of p105."
22988300
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"LPS upregulated p38 and transiently ERK1/2, while GA led to more sustained activation of ERK1/2, only."
20511709
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"In our present study, similar results were obtained, with OOA significantly inhibiting the LPS activation of ERK and JNK pathway, which suggests that OOA is at least partly responsible for the anti-inflammatory effects previously observed."
30190667
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"Although little is known about the regulation of Erk downstream of LPS, it was reported that a MAP kinase kinase kinase, Tpl2 and Cot, is required for the LPS mediated activation of Erk in macrophages."
15699069
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"Moreover, PGN and LPS induce differential activation of MAP kinases, with LPS strongly inducing all three families of kinases (ERK, JNK, and p38), whereas PGN only induces ERK and JNK without affecting p38."
23264652
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"Using SB203580, Chen and Wang (1999) has reported that activation of p38 MAPK but not ERK by LPS resulted in the stimulation of NF-kappaB-specific DNA protein binding, whereas Baldassare et al (1999) [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12603851
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"In addition, dioscoreanone in the range of 1.2-5microM significantly enhanced LPS induced ERK1/2 activation and dioscoreanone alone induced the activation of ERK1/2 proteins in a concentration- and time dependent response."
22678775
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"Here, TLR4 internalization was necessary for LPS induced ERK1/2 activation and TNFalpha production."
33643293
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"Interestingly, confocal analysis clearly indicated that LPS treatment induced a condensed localization of ERK in the cytoplasm; under amentoflavone treatment, this pattern was only weakly visible (data not shown)."
23970815
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"In addition, MT alleviated LPS induced activation of ERK, JNK and p38 signaling cascades."
19914257
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"It also inhibited TNFalpha- and IL6 induced activation of Erk1/2 in myotubes from overweight subjects, but did not change LPS induced activation of Erk1/2."
24521217
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"miR-101 regulates the LPS induced activation of ERK1/2, p38 and JNK and induces production of TGF-beta."
26158762
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"LPS stimulation and activation of ERKS, a MAPK protein, result in the generation of nitric oxide (NO) and reactive oxygen species (ROS) , which activate NF-κB to regulate NLRP3 inflammasome activation ."
32034213
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"Additional studies with murine macrophages expressing wild type and mutated TLR4 showed that TLR4 was implicated in LPS induced ERK and NFkappaB activation, and CD40 expression."
18187173
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"Early LPS induced ERK activation in retinal pigment epithelium cells is dependent on PIP 2 -PLC *."
27006973
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"LPS and HSC stimulated ERK1/2 activation, which was still persistent at 12 h (XREF_SUPPLEMENTARY), unlike the decline in JNK activation (XREF_SUPPLEMENTARY)."
26031389
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"The results of our findings point to H. pylori LPS induced ERK dependent cPLA (2) activation as a critical factor influencing the level of PAF generation, and hence the extent of pathological consequences of H. pylori infection on the synthesis of gastric mucin."
17440231
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"The results showed that LPS (1 mug/mL) induced marked activation of ERK1/2, p38 and JNK1/2 in a time dependent manner (XREF_FIG A)."
26861286
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"LPS caused activation of p38, JNK and ERK MAPKs in WT DCs."
21723158
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"Proliferating agents induce rapid ERK activation deactivation (i.e. between 5 and 10 minutes), whereas ERK activation by LPS starts 15 minutes after stimulation and lasts until 30 minutes after stimul[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11846217
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"LPS activation of Erk1/2, SAPK/JNK, and p38 , evident as an increase in the phosphorylated form of these kinases, occurred within 30 minutes and was not affected by fibrinogen or TG2-cross-linked fibrinogen (Figure 4A–D)."
35158413
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"Moreover, we found that LPS activated ERK phosphorylation only in macrophages, suggesting different pathways in LPS induced ERK activation in macrophages versus monocytes."
29317816
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"Pretreating murine macrophages (RAW 264.7) with luteolin inhibited LPS stimulated TNFalpha and IL-6 release, which was associated with blockage of LPS induced activation of nuclear factor kappa B (NF-kappaB) and mitogen activated protein kinase (MAPK) family members ERK, p38, and JNK [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
18991571
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"However, this difference was not observed in the alpha2 silenced groups, as LPS did not activate ERK in these groups."
28687727
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"Immunobloting data revealed the abilities of TAKI to inhibit TAK1, IKK, ERK, p38 and JNK activation induced by LPS."
26381601
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"We have previously shown that TPL-2 promotes the production of soluble TNF in LPS stimulated macrophages independently of ERK1/2 activation [XREF_BIBR]."
27402796
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"The increased LPS-induced activation of ERK1/2 in Bcl3 cells was sensitive to treatment with MEK1 inhibitor, demonstrating that it results from enhanced MEK1 activity (Fig. 2E)."
31772019
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"LPS stimulation increased ERK1/2 activation compared to unstimulated cells."
30515163
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"XREF_BIBR Existing reports suggest that RGD peptide ameliorated the LPS induced ERK signaling and also mitigated the inflammatory WISP1-integrin beta6 signaling pathway in lung inflammatory conditions."
33418136
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"* The data provide additional information regarding the LPS induced ERK1/2 signaling in RPE cells."
27006973
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"A time course of the activation and phosphorylation of ERK, JNK and p38 in microglia treated with LPS in the presence and absence of the Tpl2KI is shown in XREF_FIG."
24188160
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"To further confirm the finding that LPS activated ERK1/2 and STAT3 signaling pathways through activation of EGFR, we used gefitinib, a specific EGFR inhibitor, to block EGFR activation."
29207668
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"First, LPS activates not only ERK, but also JNK and p38 in Kupffer cells 30."
29317674
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"In cytoplasm both LPS and ESAT-6 increased ERK enzyme activity over basal level."
17915024
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"TPL-2 (S400A) expression also failed to reconstitute LPS activation of ERK and induction of TNF in Map3k8 (-/-) macrophages, which lack endogenous TPL-2."
17709378
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"Eicosanoid signaling is upregulated by lipopolysaccharide (LPS), pro inflammatory cytokines interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha, nuclear factor kappa-B (NF-kappaB), and mitogen activated protein kinases (MAPK) p38, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinases (JNK), all of which are all important mediators of neuroinflammation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23709104
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"Recently it was reported that LPS induced cytokine expression was increased in ANXA1 -/- macrophages, and that it was accompanied by significantly increased LPS induced activation of ERK and JNK MAPK [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22056994
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"Fucoidan, a sulfated polysaccharide attenuated inflammatory response in LPS-stimulated BV2 microglia by suppressing NF-κB and extracellular signal-regulated kinases (ERK)/MAPK/Akt pathways [92]."
32630301
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"Besides, enhanced ERK phosphorylation was also observed in splenocytes treated with LPS and Sa.LTA after the pretreatment with the JAK inhibitor."
29367683
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"Consistent with the essential role of Tpl2 in ERK signaling (Dumitru et al., 2000), the LPS stimulated ERK activation is either completely abrogated (ERK1) or drastically diminished (ERK2) in nfkappab[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12667451
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"Our studies indicated that ERK1/2, p38, JNK, NF-kappaB, AP-1 can be activated by LPS treatment."
27713159
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"LPS stimulation induced a strong phoshorylation of JNK, ERK and p38after 30min, which was prevented in the presence of GIP (XREF_FIG F-H), suggesting that GIP directly inhibits inflammatory activation of macrophages invitro."
29884547
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"To delineate the underlying mechanism, we showed that Tat inhibited the LPS activation of ERK1/2 but not the p38 mitogen activated protein kinases."
19622906
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"Another sigma-1 receptor agonist, (+)-pentazocine, reduced the release of tumor necrosis factor α (TNF-α), interleukin 10 (IL-10), monocyte chemoattractant protein-1 (MCP-1), and nitric oxide (NO) and inhibited LPS-induced activation of ERK and c-Jun N-terminal kinase (JNK) pathways (Zhao et al., 2014)."
| PMC
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"Activation of the A (3) AR or inhibition of intracellular Ca (2+) release also reduced LPS stimulated nuclear factor-kappaB (NF-kappaB) activation and extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation."
16188954
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"H 2 S also decreased LPS activated extracellular signal regulated kinase (ERK) 1/2 / nuclear factor (NF)-kappaB signaling pathways in myometrium."
27035826
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"Lipopolysaccharide (LPS) activates ERK1/2, p38 and JNK and SAPKs and all are required for the biosynthesis of tumor necrosis factor-alpha (TNF-alpha) (Geppert et al., 1994; Han et al., 1994; Lee et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10354710
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"Following 90 min of LPS stimulation the stability of the TNF-alpha message drops and TNF-alpha message levels begin to decrease, representing the recovery phase.Our data establish that LPS activation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17606294
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"LPS treatment significantly increased phosphorylation levels ERK 1/2, p38 and JNK 1/2 in RAW264.7 macrophages (P < 0.05; XREF_FIG)."
28677786
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"Finally, oral administration of AAE attenuated LPS induced memory and social impairment in mice and repressed LPS induced ERK and JNK activation in the cortices of mice."
34271112
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"As an aggregate, these studies support the hypothesis that one way by which LPS activates the ERK kinases is via activation of PC-PLC and that activation of a PC-PLC is an important component of macrophage activation by LPS."
10072552
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"Methanol Fraction (ME) Upregulates LPS Activated Extracellular Signal Regulated Kinase (ERK) Signaling Pathway."
25133186
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"As shown in XREF_FIG, top panel, ERK is promptly activated by LPS and IFNgamma treatment and BHA did not block this activation."
23752925
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"LPS also activated JNK1/2, p38 and ERK1/2 MAP kinases."
17149706
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"We show here that it is possible to produce virtually complete inhibition of lipopolysaccharide stimulated TNF-alpha mRNA accumulation by using a combination of ERK and p38 MAP kinase inhibitors."
11076936
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"XREF_FIG E demonstrates that TR6 and TR11 prevented LPS induced ERK activation for a duration of at least 1 h post-stimulation."
22648407
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"In macrophages, LPS activation of ERK, but not JNK or p38 MAPK, is mediated by the MAP 3-kinase TPL-2, which phosphorylates and activates the ERK specific MAPKKs MEK-1/2."
19667062
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"Moreover, LPS induced ERK activation was abolished by 10 -6 M U0126, a MEK inhibitor, which also reduced S6K phosphorylation induced by LPS."
30073169
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"LPS Activates ERK Kinases."
9841930
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"GRK2 can negatively regulate LPS-induced ERK pathway in macrophages and decrease cytokine production."
35430346
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"PAF pretreatment selectively increased LPS induced ERK 1/2, JNK and SAPK, NF-kappaB and AP-1 activation, and TNF-alpha production."
15665723
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"LPS at 100 ng/ml induced peak activation of MAPKs (p38 and ERK1/2) within 30 min of stimulation (XREF_FIG)."
18053081
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"6-S also inhibited LPS mediated ERK1/2 activation as well as NOS2 and MyD88 induced expression as determined by Western blot."
24039109
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"In this study, we show that prior chronic alcohol exposure for 7 days selectively increases subsequent LPS induced ERK MAPK activation that contributes to the increased LPS induced TNF-alpha production after chronic alcohol treatment."
19561104
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"CWE blocked the LPS induced degradation of IkappaBalpha as well as the activation of JNK, p38 and ERK1/2."
23190501
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"However, the treatment of macrophages with presence LPC and LPS a classical TLR ligand leads to a counteraction of LPS induced ERK activation but not of JNK and p38."
24312681
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"In addition, HTS and LPS induce activation of ERK which is required for PGI2 production."
10329108
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"Solanine A shows strong anti-inflammatory activity in LPS or IFN-γ activated macrophages and animal inflammatory models by inhibiting NF-κB, ERK1/2, AKT and STAT1 signaling pathways [84]."
34284780
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"Namely, it dramatically attenuated the activation of the LPS induced extracellular signal regulated kinase (ERK) 1/2 and p38 mitogen activated protein (MAP) kinase in a tissue specific manner."
14999056
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"In addition, LPS prolonged osteoclast survival by activating the Akt, NF-kappaB, and ERK pathways."
19258321
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"Taking into account that LPS induced ERK1/2 activation was abolished by PLD2 inhibition but was not affected by preincubation the PLD1 inhibitor, our results suggest that PLD2 mediates COX-2 induction[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25172550
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"EGCG has also been reported to inhibit the phenotypic and functional maturation of murine DCs by suppressing the LPS induced activation of ERK, JNK and p38 MAPK [XREF_BIBR]."
26185959
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"The cyclopentenone ring 2-cyclopenten-1-one also inhibited LPS induced ERK 1/2 activation; however, neither 15-PGJ2 nor the cyclopentenone inhibited PMA induced ERK 1/2 activation."
11310850
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"In macrophages and other types of cells, LPS activates three subclasses of MAPKs: extracellular signal-regulated kinase (ERK), c-Jun-terminal kinase (JNK) and p38."
21160452
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"In glial cultures, LPS induced activation of ERK1/2, p38 and JNK."
23034047
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"RAW 264.7 cells were treated with LPS for 12 h and then incubated with or without curcumin for another 1 h. Data showed that curcumin reduced LPS induced ERK1/2 activation."
21094287
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"(4) rHBsAg interferes with the LPS induced activation of ERK-1/2 and JNK1-1/2 MAP kinases, which might explain the reduction of TNFalpha mRNA [2]."
12270119
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"Furthermore, we found that 5-hydroxytryptophan played a role in LPS induced inducible nitric oxide synthase (iNOS), cyclo oxygenase-2 (COX-2) and extracellular-signal regulated protein kinase (ERK) activation."
19336883
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"Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells : role of increased reactive oxygen in LPS stimulated ERK1/2 activation and TNF-alpha production."
16554353
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"Furthermore, studies with several cell culture systems indicate that lipopolysaccharide (LPS) can activate P38 MAPK, ERK, and JNK signaling [XREF_BIBR]."
27514378
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"This is the first study to show that PN extract inhibits neurodegeneration in LPS-activated BV-2 microglia by targeting ERK signaling activity."
35671865
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"Many MPs are capable of inducing inflammatory pathways in DCs mediated by signaling via the extracellular signal regulated kinase 1/2 (ERK1/2) which can be activated by growth factors, cytokines, stress factors, viral infections, carcinogens, and bacterial components such as, lipopolysaccharide."
28894739
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"Collectively, these results demonstrated that rigosertib prevented the LPS‐induced activation of the MEK/ERK pathway."
34061465
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"After LPS treatment for 30 min, the MAPK signaling pathway in LPS-induced RAW 264.7 cells was activated, as evidenced by significantly increased protein phosphorylation levels of p38, ERK1/2 and JNK."
| PMC
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"Nox4 knockdown inhibited LPS induced ERK1/2, AP1, and NF-kB activation."
29085012
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"Pretreatment of THSG significantly enhanced LPS reduced AMPK activation and increased ERK1/2 activation even in the presence of LPS."
27504055
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"Our results constitute the first evidence of PLD2 dependent LPS induced ERK1/2 activation in RPE cells."
25172550
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"The previous paper has reported that LPS plus zVAD induced more ERK activation in BMDMs ."
30442927
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"In addition to its role in receptor internalization, beta-arrestin 2 is required for LPS induced extracellular signal regulated kinase (ERK) 1/2 activation in macrophages."
29507126
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"Knockdown of MLK4 enhanced LPS induced activation of JNK and ERK (XREF_FIG), while overexpression only reduced LPS induced ERK activation (XREF_FIG), suggesting that the effect of MLK4 on JNK and ERK activation is not all the same."
21602844
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"Thus, EP acts via the LDL receptor family to induce a potentiation of LPS induced ERK activation and an attenuation of LPS induced JNK activation."
18803301
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"To examine the direct effect of LPS on the activation of ERK1/2, p38 and JNK, H9c2 cells were treated with various concentrations of LPS (0.1-10mug/ml) for 15min to assess activation."
28878808
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"We found that SPRC prevented nuclear factor-kappaB (NF-kappaB) activation assessed by NF-kappaB p65 phosphorylation and IkappaBalpha degradation, suppressed LPS induced extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation and intracellular reactive oxygen species (ROS) production."
21308383
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"Expression of the C-terminal ankyrin repeat domain of p105 in Nfkb1 -/- macrophages, which reconstitutes LPS induced ERK activation, also suppresses IFN-beta secretion, consistent with the role of the C-terminal domain in stabilizing the steady-state expression of TPL-2."
21217011
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"Furthermore, Western blot analysis showed that SibaCec significantly suppressed the LPS induced activation of ERK, p38, and the translocation of NF-kappaB p65 subunit."
26497304
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"In this regard, ERK1/2 activation is induced by C5a in neutrophils, and by TNFalpha or LPS in primary monocytes XREF_BIBR, XREF_BIBR."
33139717
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"After a long 24 h exposure period, ERK1/2 and p38 were strongly activated by LPS, a combination of LPS and TEGDMA, and TEGDMA alone (15-20-fold)."
20096453
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"Starvation of mice decreased the concentration of arginine in the plasma and impaired the activation of ERK1/2 by LPS."
20716763
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"In glial cultures, LPS induced strong activation of ERK1/2, JNK and p38 in a time dependent manner, with maximum activation of p38 and JNK detected at 60 min, and ERK1/2 detected at 30 min (XREF_FIG a)."
23034047
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"Taken together, our findings support the view that Ksr1 is not required for LPS induced ERK activation in freshly isolated alveolar macrophages."
23221422
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"In macrophages and other types of cells, LPS activates three subclasses of MAPKs: extracellular signal-regulated kinase (ERK), c-Jun-terminal kinase (JNK) and p38."
21160452
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"A previous study showed that alogliptin, another DPP-4 inhibitor, also suppressed lipopolysaccharide induced ERK activation and MMP expression in U937 histocytes XREF_BIBR), which may be consistent with our results."
29321388
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"P. gingivalis LPS activated mainly through NF-κB, while P. gingivalis LPS primarily induced the p38/MAPK and ERK1/2 signaling pathways."
32085888
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"A competitive antagonist of vasoconstrictor effects of 20-HETE, 20-hydroxyeicosa-6 (Z),15 (Z)-dienoic acid, 20-HEDE (30 mg/kg, s.c.; 1 h after LPS) prevented the effects of 5,14-HEDGE on blood pressure, heart rate, expression and/or activity of sEH, CYP2C23, and ERK1/2 as well as TNF-alpha and IL-8 levels in rats treated with LPS."
23454652
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"LPS stimulated ERK, JNK, and p38 MAP kinases in J774 macrophages but with different activation kinetics."
20396387
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"Addition of low doses of LPS (10, 100 ng/ml) up to 1 mug/ml of LPS had no effect on iHsp70 expression, but strongly activated ERK."
23043959
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"This was shown to inhibit Toll like receptor-4-induced IkappaB kinase beta mediated phosphorylation of p105, thus negatively regulating lipopolysaccharide induced ERK activation in macrophages."
28950947
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"Furthermore, molecular analysis indicated that Omegaven (TM) blocked LPS mediated increase in ERK1/2 activity (35% increase), an important LPS signal transduction pathway."
27072665
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"Li et al. have reported that emodin can inhibit LPS-induced activation of NF-κB, p38, ERK and JNK MAPKs signaling pathways in mice [32]."
29057806
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"LPS treatment induced changes in MAPK/ERK, including increases in MAPK 1, MAPK 3, and dual-specificity mitogen-activated protein kinase kinase 2 (MAPK2K), of 2.1, 2.4, and 2.8-fold change increases, respectively (Table 2)."
33863932
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"Pretreatment with GLP-2 in BV-2 cells markedly blocked LPS induced activation of ERK1/2 (XREF_FIG A, B) and JNK1/2 (XREF_FIG A, D)."
26861286
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"Wu and colleagues verified that a pretreatment with LPS induced ERK-1/2 and P38 activation in A549 cells, a phenomenon related to an increase in TLR2 gene expression [XREF_BIBR]."
28894350
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"We have previously shown that Cbl leads to ubiquitination of DOK3 and associated protein, SOS1, to limit LPS induced ERK signaling in macrophages."
28650106
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"Although LPS activated three MAP kinases in murine macrophages, only JNK was targeted by CLEN : while LPS activated p38, ERK, and JNK, CLEN only attenuated the LPS induced rise of JNK activation."
28929026
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"This domain appears to be highly functional given that peptides derived from this sequence are able to bind LPS in vitro and inhibit LPS induced ERK activation in RAW 264.7 cells [XREF_BIBR, XREF_BIBR]."
21941410
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"These data demonstrate that the LPS induced early ERK1/2 depends exclusively on PIP 2 -PLC (XREF_FIG), while PLD2 activation is necessary to maintain ERK1/2 phosphorylation after 24h treatment XREF_BIBR."
27006973
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"Eicosanoid signaling is upregulated by lipopolysaccharide (LPS), pro inflammatory cytokines interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha, nuclear factor kappa-B (NF-kappaB), and mitogen activated protein kinases (MAPK) p38, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinases (JNK), all of which are all important mediators of neuroinflammation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23709104
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"In this research, E. coli LPS stimulated the vitalizations of the three MAPKs of ERK, JNK, and p38 in the RAW264.7 cells."
27488844
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"Collectively, these data support the novel concept that TLR4 activation in ASM elicits changes in ASM function that are regulated by opposing effects of MAPK signaling, wherein LPS induced ERK1/2 activation mediates NF-kappaB-dependent proasthmatic like changes in ASM function, whereas coactivation of p38 MAPK serves to homeostatically downregulate the proasthmatic effects of ERK1/2 activation."
16581829
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"Chronic alcohol enhances LPS induced ERK1/2 activation and transcription of Egr-1, contributing to murine hepatic macrophage activation [XREF_BIBR, XREF_BIBR]."
26201323
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"On the mitogen activated protein kinase, daphnoretin down-regulated the lipopolysaccharide augmented expression of phosphorylated c-Jun N-terminal kinase (pJNK), but not p38 and extracellular signal regulated kinase 1/2 (ERK1/2)."
28772243
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"The data suggest that AT-RvD1 can suppress LPS-induced kidney inflammation by modulating STAT3/ERK signaling."
24709673
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"Together with the results obtained with endogenous Tpl2 complexes, these data suggest that p105 functions as a physiological inhibitor of Tpl2.The results presented in this paper demonstrate an unexpe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12667451
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"In addition, BDB also inhibited the LPS induced activation of ERK1/2."
20691245
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"Since LPS has been shown to activate the ERK, JNK, and p38 MAP kinases in murine macrophages, we investigated whether LPS activated MAP kinases in the D1 cells."
9841930
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"Moreover, IL-21 inhibited LPS-mediated secretion of inflammatory cytokines, probably by downregulating the ERK1/2, in RA-SF MΦs. Conclusion ：For the first time, we indicated that IL-21 inhibits LPS-mediated cytokine production in RA-SF MΦs, and impairs pro-inflammatory activity of M1-like macrophages, hereby exerting anti-inflammatory effects on RA."
34842006
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"It should be noted that although ERK1/2 and p38 were activated by early LPS exposure and late LPS exposure, respectively, the activation was relatively weaker when compared to late and early LPS exposure, respectively."
30075820
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"We have shown that desialylation increases LPS induced ERK activation and cytokine expression in human PBMC."
24068662
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"Vitamin C inhibited the LPS stimulated activation of p38 and ERK."
24983461
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"Although LPS significantly activated ERK pathway, it was not suppressed by RJ."
29849495
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"In view of these findings, we examined whether RvD1 could inhibit LPS induced ERK1/2 activation and change endothelial permeability by protecting TJ integrity in endothelial cells and whether the changes in TJ protein expression could be reduced by inhibiting ERK1/2 activation."
24381712
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"Previous studies have established that LPS treatment of cells such as macrophages and synovial fibroblasts induce TLR4 mediated MyD88- and TRIF dependent ERK activation leading cytosolic PLA 2 activation and AA-COX-2-PGE 2 synthesis."
22448089
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"This signaling defect was not due to alteration in the kinetics of ERK activation, since extended LPS stimulation did not result in significant ERK activation in the nfkappab1 -/- cells."
12667451
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"As a control and to test LPS activity on the TLR-4 receptor, we observed a LPS activation of ERK pathway in the macrophage cell-line Raw 264.7 (Supp."
21941410
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"As a result, CPS inhibited proinflammatory cytokines, iNOS, and COX-2, which is attributed to the suppression of LPS induced ERK, JNK, and nuclear factor-kappaB (NF-kappaB) activation."
23131135
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"Cholinergic drugs reduce metabolic inflammation and diabetic myocardial injury by regulating the gut bacterial component lipopolysaccharide-induced ERK/Egr-1 pathway."
37039813
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"Meanwhile, we firstly illustrated BBD can inhibit LPS induced HSCs activation and proliferation in vitro through TLR4 and NF-kappaB and TLR4 and ERK signaling pathway, respectively."
27776340
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"In addition to facilitating LPS induced ERK activation, the C-terminal region of p105 contains ankyrin repeats similar to those found in the classical IkappaBs XREF_BIBR, XREF_BIBR."
22427889
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"Based on our results, we suggest that LPS induced Erk1/2 signaling may be involved in this suppressive effect of LPS on homeostatic and anti-inflammatory DAM genes."
31301160
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"Beyond the PI3K and Akt pathway, LPS stimulation also triggers the activation of small GTPases and the ERK, JNK and p38 MAPK pathways [XREF_BIBR]."
29136006
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"The effect of GRK2 on this pathway has been studied in a variety of contexts beginning with its role in macrophages where GRK2 was shown to negatively regulate LPS induced ERK signaling."
28950947
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"In monocytic cells, ESAT-6 inhibits LPS induced activation of ERKs, and binds to TLR2 and inhibits Akt and NF-kappaB activation."
19265145
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"Both LPS and EGF were stimulated ERK activation."
22675459
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"However, maximal phosphorylation of ERK was observed in cells treated with 50 mug/ml LPS."
12901876
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"Emodin suppressed Erk1/2 and p38 signaling induced by LPS in macrophages."
24740873
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"For example, parthenolide can affect MAP kinase signaling stimulated by LPS, and ERK and AP-1 activity stimulated by TNF-alpha and IL-1beta."
23418625
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"DOK3 deficient BMM demonstrated increased LPS induced ERK activation compared to wild type macrophages (XREF_FIG)."
22761938
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"2.3 High-Dose LPS Induces Microglial ERK and MAPK Signaling Molecules."
24513404
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"Although both LPS and VLP treatment activated ERK1/2, they did so with different kinetics."
17434557
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"Consistent with previous findings, we also found that apigenin significantly inhibited LPS induced ERK1/2 and NF-kappaB activation in human THP-1 macrophages."
25192391
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"We found that both LPS and alpha-synuclein induce activation of p38 and ERK1/2 in microglial cells and p38 activation is required for induction of pro inflammatory cytokines and NO production."
28256519
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"NaHS (10mg/kg/injection) significantly reversed LPS activation of p65 and ERK1/2 at all the time points observed (XREF_FIG, blue lines)."
27035826
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"Since LPS treatment leads to the enhancement of c-Src expression as well as its total activity, we thereby addressed the point of whether LPS might increase ERK activation by determining the ERK activities in control and LPS treated Caco-2 cells at various time points."
25705585
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"LPS caused down-regulation of I-kappaBalpha and activation of JNK, p38, and Erk MAPKs with distinct kinetics (XREF_FIG, right), similarly to previous reports."
18195069
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"These findings suggest that P. gulae LPS activates p38 and ERK1/2 via TLR2 and TLR4, leading to inflammatory responses in human gingival epithelial cells."
32827217
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"Moreover, antagonism of the MEK and ERK pathway potentiates LPS stimulated nitric oxide production, suggesting that LPS stimulated ERK activation can exert inhibitory effects in macrophage like cells."
11786532
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"The present results suggest that LCN2 knockdown protected LPS-induced ARDS model via inhibition of ferroptosis-related inflammation and oxidative stress by inhibiting the MAPK/ERK pathway, thereby presenting a novel target for the treatment of ARDS."
34969358
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"LPS activates ERK, p38 and JNK pathways in BMDMs."
29354064
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"The evolutionary divergence between mammalian and fish species is considerable, and we do not know if LPS can induce the IKK-NF-kappaB pathway and MAPK pathways (the ERK, JNK, and p38 pathways) in fish as in mammals."
16740160
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"Isabel Fernandez-Pisonero et al. revealed that S1P combined with lipopolysaccharide (LPS) activates human umbilical endothelial cells (HUVECs), famous endothelial cells, via NF-kappaB, ERK1/2, and p38 and activated HUVECs secrete IL-6 [XREF_BIBR]."
24686514
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"PP2 abolished LPS mediated ERK activation and LPS induced proliferation in Caco-2 cells."
25705585
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"In DOK3 knock-down cells, LPS stimulation induced earlier ERK activation compared to control cells (XREF_FIG)."
22761938
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"Both GRK2 and 5 can negatively regulate LPS induced ERK pathway in macrophages XREF_BIBR, XREF_BIBR."
26226012
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"Map3k8 D270A mutation inhibits LPS activation of the ERK1/2 MAPK pathway and its downstream target p90 RSK."
27402796
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"We show the anti CD14 blocking antibody 28C5 suppresses LPS induced ERK1/2 activation and TNF-alpha production in PBMC."
17126402
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"At concentrations of 0.5, 0.75, and 1mg/mL, treatment with BPTS inhibited levels of expression of LPS induced NF-kappaB and MAPKs (ERK, JNK, and p38) as well as production of proinflammatory mediators, such as nitric oxide (NO), prostaglandin E 2 (PGE 2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) by LPS."
22899961
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"Cot and Tpl2 is an essential upstream kinase in LPS mediated activation of ERKs."
22673523
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"The reason for the failure to demonstrate LPS stimulation of ERK activity in the previous studies is not clear, but may be related to differences in methodology or time of exposure to LPS."
11369515
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"PYR and ACh ameliorated diabetic myocardial injury by inhibiting the LPS-induced ERK/Egr-1 pathway and metabolic inflammation."
37039813
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"These results demonstrate that the AMPK and ERK pathways participate independently in LPS induction of TNF-alpha production by the ENS. Electrical field stimulation inhibits AMPK and lipopolysaccharide induced ERK activation."
25497784
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"Mechanically, western blotting and immunofluorescence assay showed that EgCF abolished the activation of nuclear factor (NF)-kappaB p65, p38 mitogen activated protein kinase (MAPK) and ERK1/2 signalling pathways by LPS stimulation in mouse macrophages."
33775265
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"We report that, in human PBMC, CD14 dependent LPS stimulation of p42/44 is regulated by PI3 kinase activity."
17126402
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"LPS activated Erk1/2 and induced iNOS and subsequent NO production."
10945876
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"In that pharmacological inhibitors of PI3K inhibited LPS induced activation of p21Ras, but not activation of ERK, we concluded that LPS induced activation of ERK occurs through a pathway that is not dependent on the activation of p21Ras."
16339563
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"As expected, we found that AL extract moderately inhibited LPS-induced ERK, JNK, and p38 MAPKs, since its inhibitory effects were seen only after cells were treated with the extract (in the presence of LPS) for 24 h (Figure 6A–D)."
32079307
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"The LPS stimulation of macrophages activates several intracellular signaling pathways that include the IκB kinase (IKK)–nuclear factor kappa B (NF-κB) pathway and three classical mitogen-activated protein kinase (MAPK) pathways: extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 [18,19,20]."
31671623
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"d-GalN/LPS treatment resulted in a marked inflammatory cytokine release and stimulated the activation of signal transducer and activator of transcription (STAT) 3, c-Jun N-terminal kinases (JNK) and extracellular signal-regulated kinase (ERK) signaling comparably in the hepatic compartment of Bcl-3 Hep and WT mice."
35641486
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"Taken together, these data indicate that Ko143 induced conversion of LPS stimulated DCs into tolerogenic DCs requires ERK signaling pathways."
25111504
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"NF-kappaB, ERK and p38 kinase signal pathways activated by LPS are involved in the upregulation of TLR9 gene expression by LPS."
11947920
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"In addition, pretreatment with NJ-6 significantly inhibited the LPS induced activation of ERK 1/2, JNK, and p38 (XREF_FIG)."
24795771
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"While MT itself did not elicit any effect on the phosphorylation status of these signaling molecules, it ablated LPS induced activation of ERK, JNK and p38."
19914257
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"ERK, JNK, and p38 MAP kinases are activated by LPS in microglia and inhibition of a respective kinase with pharmacological inhibitors : CEP11004 or CEP-1347 reduced cytokine production in LPS stimulated human and murine microglia cultures [XREF_BIBR, XREF_BIBR] or exposed to neurotoxic peptide Abeta1-40 [XREF_BIBR]."
22806180
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"As shown in XREF_FIG i, transfection of the human ortholog in ARL11 depleted RAW264.7 cells rescued LPS induced ERK1/2 and p38 activation."
29618517