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Lipopolysaccharide activates ERK. 1000 / 1167
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"The present study suggests that LPS stimulation activates ERK in Muller cells, whereas the total amount of ERK is unchanged."
11923227
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"LPS pretreatment completely ablated LPS induced ERK signaling, as previously reported (XREF_FIG)."
20978539
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"To determine the effect of amentoflavone on LPS activated ERK activity, immunoprecipitated ERK (prepared from RAW264.7 cells (5 x 10 6 cells/mL) that had been treated with LPS in the presence or absence of amentoflavone) was incubated with MBP according to the manufacturer 's instructions."
23970815
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"LPS mediated ERK, JNK, and p38 activation in LAB m/m and WT DCs was similar."
22308309
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"We conclude that LPS + H/R initiates tyrosine kinase- and ERK1/2 sensitive signaling that synergistically reduces inter-endothelial electrical coupling by dephosphorylating PKA specific serine residues of Cx40."
18521823
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"However, fermented HR-A and B significantly suppressed LPS induced ERK and JNK MAPKs phosphorylation [Figure XREF_FIG and XREF_FIG]."
25298686
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"Although not directly related to polymicrobial sepsis, lipopolysaccharide (LPS)-induced activation of p38-MAPK and ERK stimulates NOS II in cardiac myocytes ( LaPoint and Isenovic, 1999 )."
17612571
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"We stimulated cells for 10, 20, 40 and 60 minutes to observe the pERK induction pattern and found that LNFPIII-NGC drives late activation of ERK with peak phosphorylation at 60 mins, whereas LPS induced ERK activation as early as 20 mins (XREF_FIG)."
26340260
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"Increased LPS induced cytokine expression in the absence of ANXA1 was accompanied by significantly increased LPS induced activation of ERK and JNK MAPK and was abrogated by inhibition of either of these pathways."
19553536
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"It was confirmed that activation of p90RSK served as a critical checkpoint for AhR upregulation by PUN and LPS, which induced AhR upregulation by activating the MEK/ERK and PDK1 pathways that ultimately targeted c-fos."
39363344
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"We also showed that LANSO inhibited activation of NF-kappaB and ERK induced by LPS and HpWE, which could account for why LANSO exerts anti-inflammatory effects."
19590712
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"XREF_FIG E demonstrates that TR6 and TR11 prevented LPS induced ERK activation for a duration of at least 1 h post-stimulation."
22648407
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"After Serinc2 overexpression, the LPS-activated STAT3, p38, and ERK were significantly inhibited (Fig. 3D and E)."
35799194
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"Although LPS significantly activated ERK pathway, it was not suppressed by RJ."
29849495
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"It is known that, in DCs of the D1 cell line, LPS activates the ERK pathway, playing a role in DC maturation and in preventing apoptosis after maturation XREF_BIBR."
25255446
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"We hypothesized that LPS mainly activates the Cdc42 , p38 and ERK1 / 2 MAPK , and PI3K signaling pathways ."
24451252
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"In this regard, ERK1/2 activation is induced by C5a in neutrophils, and by TNFalpha or LPS in primary monocytes XREF_BIBR, XREF_BIBR."
33139717
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"In addition, the increased phosphorylation of members of the mitogen-activated protein kinase (MAPK) family, including p38, ERK1/2, and JNK induced by LPS, was inhibited in cells treated with 1."
36838505
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"In mammalian monocytes/macrophages, LPS activates ERK, p38 and JNK in a Ras/Rho-dependent manner [23] ."
15878392
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"The ERK and JNK are rapidly activated by LPS in macrophages and have been implicated in both inflammation and immune response ( Guha and Mackman, 2001 )."
18556161
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"Use of the inactive analog (U0124) of U0126 did not prevent LNFPIII-NGC or LPS induced ERK activation (XREF_FIG)."
26340260
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"Since only 50 muM dimer B2 has shown the significant inhibitory effects on COX-2 transcription and expression, this concentration was selected to use in the following experiments.Because LPS induced C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16681998
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"As shown in Fig. 4 A , LPS could activate ERK1/2, p38MAPK, JNK and NF-κB pathways in BMDCs."
18006062
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"Furthermore, studies with several cell culture systems indicate that lipopolysaccharide (LPS) can activate P38 MAPK, ERK, and JNK signaling [XREF_BIBR]."
27514378
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"Cucurbitacin D itself did not trigger the phospho-ERK but enhanced LPS-induced activation of ERK in both THP-1 cells and BMDMs, which was completely abolished by the treatment of ERK1/2 kinase inhibit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24140411
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"LPS-stimulation alone resulted in a rapid activation of both p38 and ERK, peaked at 30 min and then declined."
22497732
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"AEGS suppressed LPS-induced activation of ERK1/2 and JNK in a dose-dependent manner ( Fig. 5 )."
18556161
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"We showed that the pre-incubation with the ERK inhibitor completely blocked LPS-induced ERK activation."
34303666
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"Eicosanoid signaling is upregulated by lipopolysaccharide (LPS), pro inflammatory cytokines interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha, nuclear factor kappa-B (NF-kappaB), and mitogen activated protein kinases (MAPK) p38, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinases (JNK), all of which are all important mediators of neuroinflammation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23709104
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"Furthermore, studies with several cell culture systems indicate that lipopolysaccharide (LPS) can activate P38 MAPK, ERK, and JNK signaling [XREF_BIBR]."
27514378
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"Further evidence for differences in the Toll like receptor mediated signalling pathways between macrophages and microglia come from the recent observation that LPS potently stimulates ERK activation i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12225885
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"Then we detected the effect of TLR4 ligand LPS on the activation of TLR4 downstream signal pathways, including MAPK and NF-κB. Western blot results showed that the treatment of THP-1 cells with 1 μg/m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27720227
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"We also evaluated the effect of vitisin A on LPS-induced activation of ERK1/2 and p38 and regulation of NF-κB, which leads to iNOS expression in RAW 264.7 macrophage cells.The following antibodies wer[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19135555
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"AEGS greatly inhibited the LPS-induced ERK1/2 and JNK after LPS application."
18556161
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"As shown in Fig. 5 A, the addition of LPS to the culture medium strongly induced p38MAPK and ERK1/2 signaling."
26794904
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"Eicosanoid signaling is upregulated by lipopolysaccharide (LPS), pro inflammatory cytokines interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha, nuclear factor kappa-B (NF-kappaB), and mitogen activated protein kinases (MAPK) p38, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinases (JNK), all of which are all important mediators of neuroinflammation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23709104
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"Here, we investigated whether ERK1/2-dependent BDNF synthesis induced by LPS is mediated by LPS-triggered activation of microglia."
35995236
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"The phosphorylation of JNK, p38 MAPK, and ERK1/2 increased in cells treated with LPS alone."
25810745
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"Considering that LPS can induce the activation of p38MAPK and ERK-1/2 activation in normal macrophages, this phenomenon may be specific to TAMs."
33224886
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"In addition, recent studies demonstrated an anti-inflammatory effect of LPA during experimental endotoxemia by reducing organ injury [13] and LPS induced plasma TNF alpha production, thorough the acti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21703599
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"Consistent with the aforementioned findings, we found that LPS can activate p38MAPK and ERK1/2 signaling in C2C12 cells.Both the Smad and MAPK pathways are essential components of BMP signaling during[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26794904
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"Mechanically, western blotting and immunofluorescence assay showed that EgCF abolished the activation of nuclear factor (NF)-kappaB p65, p38 mitogen activated protein kinase (MAPK) and ERK1/2 signalling pathways by LPS stimulation in mouse macrophages."
33775265
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"For example, Wang et al. confirmed that circRNA CDR1as facilitated the proliferative ability of periodontal ligament stem cells (PDLSCs) isolated from PDL tissues under LPS treatment via activating ERK signal pathway through miR-7."
35678490
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"Furthermore, siKRAS significantly reduced downstream ERK-1/2 activation induced by LPS."
30402038
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"Results demonstrated that AQ-5 inhibited LPS-induced activation of Erk1/2, especially at concentrations of 4 and 8 μg/ml ( Fig. 10 )."
28161427
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"However, only Q and K effectively attenuated LPS induced extracellular signal regulated kinase and p38 elevations."
33642342
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"When phosphorylation of p38 and Erk1/2 was compared, no significant changes in P-p38 were obvious (not shown); S100A9 and S100A8/A9 pretreatments increased p-Erk1/2 above amounts found in lungs from mice treated with LPS alone (XREF_FIG)."
28074060
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"Although the data from the minocycline pretreatment experiment do not seem to support this hypothesis, further studies should be performed to directly confirm the role of microglia in the antidepressa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35995236
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"LPS caused down-regulation of I-kappaBalpha and activation of JNK, p38, and Erk MAPKs with distinct kinetics (XREF_FIG, right), similarly to previous reports."
18195069
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"7,8-DHF also inhibits the LPS-induced degradation of IκB and activation of MAPK pathways (ERK, p38, and JNK), dampening the proinflammatory cytokines production ( Park et al., 2014 )."
36165856
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"However, the addition of ATL-III repressed the LPS induced ERK1/2, JNK1/2 and p38 activity in macrophages compared to the controls treated with LPS alone."
26667579
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"The essential oil inhibited LPS-stimulated inflammation by blocking the JNK, NF-κB, and ERK pathways in macrophages and demonstrated that C. medica possesses anti-inflammatory properties."
37376044
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"A recent study reported that LPS activated Erk and Akt signaling pathway during inflammation [33]."
37509832
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"In addition, they did not affect the LPS induced activation of ERK1/2 and JNK (Part A and B in Figures 3-4)."
24960169
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"First, we observed that LPS induced activation of phosphorylated-p44/42 ERK."
24950815
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"LPS mediates the inflammatory response by activating ERKs, p38 MAPK, and JNKs."
24195792
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"Interestingly, curcumin at 10 muM had contrasting effects on the kinetic of LPS induced activation of ERK MAPKinases : an initial dose dependent increased activation 10 min after stimulation, was followed by a very marked inhibitory effect 30 and 60 min after LPS stimulation."
24011306
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"In monocytic cells, ESAT-6 inhibits LPS induced activation of ERKs, and binds to TLR2 and inhibits Akt and NF-kappaB activation."
19265145
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"It is well-known that LPS activates ERK, p38 and JNK MAPkinases."
17916230
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"LPS induced phosphorylation of p38 kinase was maximal at 2 h and markedly diminished at 8 h : LPS activation of ERK1/2 and JNK 1/2 peaked at 30 min and persisted over the 4-h time period."
14644621
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"For example, parthenolide can affect MAP kinase signaling stimulated by LPS, and ERK and AP-1 activity stimulated by TNF-alpha and IL-1beta."
23418625
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"One possible explanation for this is that LPS stimulation alone modestly activates ERK1/2."
26157342
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"The bacterial lipopolysaccharide (LPS) was able to activate extracellular signal regulated kinase (ERK) and p38 kinase subgroups of MAP kinases in microglia and astrocytes."
9464988
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"Effects of capillarisin (CPS) on lipopolysaccharide (LPS)-induced activation of (A) ERK, (B) JNK, and (C) p38."
23131135
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"In the present study, we found that Erk1/2 signaling was activated by both LPS and TNFα, which is consistent with previous reports on bovine and buffalo GC [ 50 , 63 ]."
32619562
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"Additionally, an in vitro study found decreased expression of MCP-1 and LPS-induced IL-6 secretion as well as inhibition of NF-κB, JNK, ERK pathways after GIP treatment [47] ."
34126341
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"The recognized LPS with TLR will activate the p38/MAPK, 21 extracellular signal-regulated kinase (ERK), 21 and c-jun N-terminal kinases (JNK) 22 and, in the final, activate the nuclear factor kappa B (NF-κB), 23 and produces proinflammatory cytokines such as TNF-α."
38049119
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"Pre-treatment of HAM with PD98059 (50 muM) clearly inhibits LPS induced ERK activation and was without significant effect on p38 and JNK phosphorylation."
17916230
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"Exosomes containing miR-873a-5p reduced LPS-induced microglial M1 transition and inflammation by lowering ERK and NF-κB p65 activation, as confirmed in vitro and in vivo studies [145]."
39695750
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"To study the effect of EGFR activation on the generation of TNF-alpha and the occurrence of cardiac dysfuncetion during sepsis, PD168393 and erlotinib (both are EGFR inhibitors) were applied to decreased the production of TNF-alpha and phosphrylation of ERK1/2 and p38 induced by LPS in cardiomyocytes."
26486084
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"The bacterial lipopolysaccharide (LPS) was able to activate extracellular signal regulated kinase (ERK) and p38 kinase subgroups of MAP kinases in microglia and astrocytes."
9464988
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"LPS has been shown to activate the extracellular signal regulated kinase, c-Jun NH 2 -terminal kinase (JNK), and p38 MAP kinases in murine macrophages but, to date, the signal transduction pathways activated during DC maturation have not been characterized."
9841930
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"It was also found that TAOK1 enhances the LPS-induced activation of ERK1/2 by interacting with TRAF6 (TNF receptor-associated factor 6) and TPL2 (MAP3K8)."
38136890
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"LPS induced NF-κB, p38 and ERK MAPK activation by phosphorylation in both MST1/2 and MST1/2 cKO BMDMs, and almost same levels of protein activation was observed between MST1/2 and MST1/2 cKO (Figure 3B and S3B-D)."
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"Our results suggest that oleuropein can prove to be a useful compound to investigate the effects of prevention of inflammatory response in neurodegenerative processes caused by the activation of micro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28385187
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"Since LPS has been shown to activate the ERK, JNK, and p38 MAP kinases in murine macrophages, we investigated whether LPS activated MAP kinases in the D1 cells."
9841930
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"Furthermore, LPS stimulation also activates the ERK, JNK, and P38 MAPK signaling pathways to trigger and amplify inflammatory response via up-regulating the expression of pro-inflammatory genes [37] ."
35988521
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"Further, consistent with the essential role for Tpl2 in ERK signaling, the LPS stimulated ERK1/2 activation was also restored in the p105 transduced cells."
12667451
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"Exposure of macrophages to lipopolysaccharide (LPS), a classical TLR4 agonist, has been shown to activate the MEK and ERK cascade in vitro."
27031380
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"Further analysis showed that LPS induced a more dramatic activation of ERK and cell proliferation in Cx43 +/+ spleen cells, which was associated with a higher pro oxidative state, as indicated by the increased NADPH oxidase 2 (NOX2), TXNIP, p38 activation and protein carbonylation."
31752090
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"Our results constitute the first evidence of PLD2 dependent LPS induced ERK1/2 activation in RPE cells."
25172550
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"For instance, LPS can activate MEK and ERK through PKC zeta [XREF_BIBR]."
28804793
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"Taking into account that LPS induced ERK1/2 activation was abolished by PLD2 inhibition but was not affected by preincubation the PLD1 inhibitor, our results suggest that PLD2 mediates COX-2 induction[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25172550
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"These results demonstrate that both classical PLD isoforms are activated in ARPE-19 cells exposed to HG.Previous work from our laboratory demonstrated that PLD2 mediates LPS-induced ERK1/2 activation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31059692
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"Our results also suggest that LPS stimulation alone can not activate ERK1/2 through MEK2 in the absence of MEK1 unless additional receptors are engaged (e.g. IL-10 receptor or the RA receptor)."
28804793
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"An in vitro study of murine Kupffer cells showed that LPS stimulation increased the activation of p38, ERK, and JNK, with the activation of p38 and ERK being the most prominent."
20599223
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"Therefore, our data suggest that dipyridamole is able to induce HO-1 expression in rat mesangial cells to reduce lipopolysaccharide-induced reactive oxygen species generation, and subsequently suppres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20940016
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"Fig. S1 LPS activates differentially NF-кB, ERK1/2 and PI3K-Akt signaling pathways in cardiac fibroblast."
27174187
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"MAPK signaling was targeted because LPS stimulation activates p38, ERK, and JNK."
32707636
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"To validate the regulatory role of JYGBF on ERK/ROS axis, LPS was used to activate ERK MAPK pathway."
40134435
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"Indeed, LPS induces p38, JNK and ERK activation in BV2 cells, as is well documented ( Lee and Kim, 2014; Liu et al., 2014 )."
27889490
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"In the current study, LPS induced the phosphorylation of ERK1/2 in RAW264.7 cells in the absence of pheophytin a. Pheophytin a modulated LPS induced ERK1/2 production, with the response being reversed by the ERK1/2 inhibitor U0126."
25501336
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"Furthermore, Western blot analysis showed that SibaCec significantly suppressed the LPS induced activation of ERK, p38, and the translocation of NF-kappaB p65 subunit."
26497304
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"These findings identify Tpl2 as a critical signaling component in the LPS stimulated MEK and ERK pathway, although how the function of Tpl2 is regulated remains unknown.The downstream targets of the L[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12667451
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"LPS similarly increased ERK activity in HLMVEC within 4h and the activity remained greater than baseline for up to 16h post-LPS stimulation ( Online Figure VIB and VIC ) ."
33926208
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"We also found that LPS activates both the ERK MAP kinase and the NF-kappaB transcription factor."
9841930
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"The activation of p38 but not ERK1/2 by LPS results in NF-kappaB activation and subsequent iNOS and NO release in macrophages."
22439901
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"LPS Activates ERK Kinases."
9841930
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"LPS caused activation of p38, JNK and ERK MAPKs in WT DCs."
21723158
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"The present results showed that sildenafil was a potent inhibitor of the phosphorylation of MAPKs including ERK1/2, p38 and JNK induced by LPS stimulation in N9 microglial cells."
21220057
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"LPS activates the RAS-RAF-mitogen-activated protein kinase/ERK kinase (MEK)-extracellular-signal-regulated kinase (ERK) signaling cascade in macrophages."
37833247
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"Methanol Fraction (ME) Upregulates LPS Activated Extracellular Signal Regulated Kinase (ERK) Signaling Pathway."
25133186
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"We and others have reported that ERK is activated by LPS [14–16]."
37833247
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"This signaling defect was not due to alteration in the kinetics of ERK activation, since extended LPS stimulation did not result in significant ERK activation in the nfkappab1 -/- cells."
12667451
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"Fig. 2 A shows that GSTP1 inhibited LPS-induced activation of ERK1/2, JNK and p38 in a dose dependent manner.In order to confirm the physiological effect of GSTP1 on regulating LPS stimulated MAPKs pa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16023107
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"As expected, LPS stimulated activation of a known ERK activating kinase, MEK1 (Derijard et al., 1995) in WT cells."
12667451
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"We found that LPS triggered transient activation of three MAP kinase subfamilies, ERK, JNK, and p38, in both immortalized and primary murine alveolar macrophages."
15590669
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"Mixtures of recombinant growth factors inhibit the production of pro inflammatory mediators and cytokines in LPS stimulated RAW 264.7 cells by inactivating the ERK and NF-kappaB pathways."
24888317
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"LPS induced ERK activation was enhanced by ME synergistically, but JNK activation was only slightly attenuated by high concentration of ME, and no change was observed in p38 MAPK activation."
25133186
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"We found that BBG attenuated LPS-stimulated activation of ERK1/2 after co-treatment for 2, 3 and 24 h, but not after 0.5 or 1 h ( Fig. 4 A)."
22750202
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"In CF, LPS activated NF-κB, ERK1/2, and PI3K-Akt with activation kinetics comparable to those described in the literature ( Laird et al., 2009; Stawowy et al., 2003 )."
27174187
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"Finally, LPS increased ERK1/2 and NF-κB activation, an effect that was inhibited by TAK-242."
27174187
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"Consistent with this model, we determined that LPS induced mRNA stabilization was p38 and ERK dependent (XREF_FIG)."
28237795
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"Together with the results obtained with endogenous Tpl2 complexes, these data suggest that p105 functions as a physiological inhibitor of Tpl2.The results presented in this paper demonstrate an unexpe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12667451
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"XREF_FIG show that Agm promoted PI3K and ERK signaling compared with a control group under treated with LPS."
24465142
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"When the cells were treated with ES, LPS-induced ERK, JNK, and p38 phosphorylation were attenuated."
26386544
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"In addition, HTS and LPS induce activation of ERK which is required for PGI2 production."
10329108
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"These data raise the possibility that BBG first directly affects LPS–JNK signaling, and then blocks the signaling pathways involving ERK1/2 that are stimulated by LPS in an autocrine manner.In the pre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22750202
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"These results suggest that BAO supplementation can attenuate LPS-induced activation of the ERK, P38, and NF-κB signaling pathways in the jejunum of piglets."
38238856
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"In freshly isolated alveolar macrophages from wild type and Ksr1 deficient mice, LPS increased ERK activation, nuclear translocation of NFkappaB and expression of inflammatory cytokines and chemokines in a similar pattern."
23221422
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"In this study, we examined the inhibitory effect of diosmetin on MAP kinase pathway and NO production activated by LPS in raw 264.7 cells, and as a result, diosmetin inhibits the LPS induced activatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33045572
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"Taken together, these findings indicate that Ksr1 plays a dispensable role in LPS induced ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model."
23221422
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"Moreover, LPS decreases the body weight, water and feed intake and activates NF-kappaB, Jnk, Erk, and Nrf2."
37048522
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"The three MAPKs, ERK, p38 MAPK and JNK, are known to be activated by LPS, and several studies have demonstrated the significance of MAPKs in the transcriptional regulation of LPS-induced iNOS expressi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18378223
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"We and others have previously demonstrated that Cot/Tpl2 is indispensable for the LPS-induced activation of ERKs in macrophages, dendritic cells, and osteoblasts [16–19] ."
22673523
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"To further investigate the role of β-arrestins in LPS-induced ERK 1/2 activation, HEK-TLR4 cells were transfected with RNA interference specifically targeted to β-arrestin 1 or 2 (both β-arrestin 1 an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17418896
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"In this study, we show that prior chronic alcohol exposure for 7 days selectively increases subsequent LPS induced ERK MAPK activation that contributes to the increased LPS induced TNF-alpha production after chronic alcohol treatment."
19561104
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"LPS induced activation of ERK and JNK MAPK is enhanced by the stimulation of BAFF."
28374824
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"Alpinetin alleviates LPS-induced lung epithelial cell injury by inhibiting p38 and ERK1/2 signaling via aquaporin-1."
38217934
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"β-Arrestin 1 siRNA transfection had no effect on LPS-induced ERK 1/2 activation ( Fig. 3 A and B)."
17418896
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"Overexpression of wild type β-arrestin 1 and 2 had no effect on LPS-induced ERK 1/2 activation (data not shown)."
17418896
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"In this regard, it has been demonstrated that β-Arrestin 2 positively regulates LPS-induced ERK 1/2 activation and IL-8 production ( Fan et al., 2007 )."
27397760
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"Our data show that LPS activates not only the p38 but also the ERK1/2 MAPK in Kupffer cells, resulting in enhanced TNF-alpha production."
12061785
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"Consistent with the essential role of Tpl2 in ERK signaling (Dumitru et al., 2000), the LPS stimulated ERK activation is either completely abrogated (ERK1) or drastically diminished (ERK2) in nfkappab[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12667451
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"LPS stimulation of macrophages strongly activates not only the Erk1/2 MAP kinases, but also the other two known types of mammalian MAP kinases, p38 and JNK1 and JNK2."
9314552
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"Moreover, we found that LPS activated ERK phosphorylation only in macrophages, suggesting different pathways in LPS induced ERK activation in macrophages versus monocytes."
29317816
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"In macrophages, LPS activates ERK1/2, p38 MAPK, and Jun N-terminal kinase (JNK) XREF_BIBR."
25192391
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"The underlying mechanism is that Lico.A inhibites LPS induced microglial activation via downregulation the activation of ERK1/2 and NF-kappaB p65 pathways."
28937602
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"Pretreatment of the cells with a MEK inhibitor, U0126, also abolished LPS induced ERK phosophorylation (data not shown)."
23221422
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"Enrichment of ERK signaling by both LPS and (GT) -SWCNTs may indicate similar inflammatory signal transduction induced by the two molecules."
32955853
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"It is thus indicated that Cot/Tpl2 is not essential for the MyD88-indepent mRNA induction of chemokines.As it has previously been reported that Cot/Tpl2 is specifically essential for the LPS-induced E[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22673523
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"Our studies demonstrate that β-arrestins differentially regulate LPS-induced ERK 1/2 and NFκB signaling and positively mediate IL-6 and IL-8 production."
17418896
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"LPS activates all three types of MAPKs – p38, JNK, and ERK – in mouse macrophages ( Chen and Wang, 1999 )."
16899239
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"Of course, it is different that LPS activated MYD88 signaling by binding to the TLR4 receptor in previous research [24] while estradiol activated ERK signaling by binding to the nuclear and membrane receptors of estrogen in the present study."
36428305
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"Statistical analysis of the fold change of the relative density suggested that EGFR inhibition does not affect LPS activation of p38, ERK1/2, and JNK in RAW 264.7 macrophages (XREF_SUPPLEMENTARY)."
24391216
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"In LPS responsive HEK 293 cells, siRNA depletion of β-arrestin 2 significantly decreases LPS-induced ERK 1/2 activation, while depletion of β-arrestin 1 had no effect."
17418896
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"Over expression of β-arrestins 1 and 2 had no effect on LPS-induced ERK 1/2 activation, suggesting endogenous β-arrestins 1 and 2 are sufficient to mediate maximum ERK 1/2 activity.Our finding that β-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17418896
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"Our data suggest that β-arrestin 2 but not β-arrestin 1 mediates LPS-induced ERK 1/2 activation."
17418896
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"Vitamin C inhibited the LPS stimulated activation of p38 and ERK."
24983461
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"LPS activation of ERK requires TPL-2 release from associated NF-kappaB1 p105, which blocks TPL-2 access to its substrate, the ERK kinase MEK."
17709378
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"C suppressed the production of LPS induced inflammatory mediators by inhibiting the p38 and ERK MAPK pathways."
24983461
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"Taken together, our findings support the view that Ksr1 is not required for LPS induced ERK activation in freshly isolated alveolar macrophages."
23221422
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"However, in the present study, we did not find a role of Ksr1 in LPS induced ERK activation in lung macrophages."
23221422
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"ERK, JNK, and p38 MAP kinases are activated by LPS in microglia and inhibition of a respective kinase with pharmacological inhibitors : CEP11004 or CEP-1347 reduced cytokine production in LPS stimulated human and murine microglia cultures [XREF_BIBR, XREF_BIBR] or exposed to neurotoxic peptide Abeta1-40 [XREF_BIBR]."
22806180
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"First, LPS stimulates ERK phosphorylation in both Ksr1-deficent and Ksr1-proficient lung macrophages in a similar pattern; this finding excludes a role for Ksr1 as a regulator in LPS induced ERK activation of alveolar macrophages."
23221422
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"Second, the blockade of Src like tyrosine kinases or Raf-1 inhibits LPS induced ERK activation; this inhibition suggests that the Raf-1/MEK/ERK signaling pathway is present and activated by Src like tyrosine kinases and Raf-1-dependent mechanisms, which do not require Ksr1 as a scaffold."
23221422
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"In addition, the activation of ERK1/2 by LPS was suppressed by miR-335."
39131043
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"In conclusion, our results demonstrate that Ksr1 does not play a role in LPS induced ERK activation in lung alveolar macrophages and does not contribute to the development of ALI induced by LPS."
23221422
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"TPL-2 (S400A) expression also failed to reconstitute LPS activation of ERK and induction of TNF in Map3k8 (-/-) macrophages, which lack endogenous TPL-2."
17709378
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"Our results show that the LPS induced activation of ERK, p38, and JNK increased DCN expression.In summary, this study showed that LPS enhanced DCN gene expression in mouse odontoblasts via the TLR4, M[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22414830
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"The phosphorylation of cPLA 2 alpha at 1 hour and phosphorylation of ERK1/2 at 10 minutes were significantly prevented in mice treated with SC-215 prior to LPS challenge, but the induction of phospho-p38 at 10 minutes were not affected upon SC-215 pretreated and remained similar to LPS challenge values (XREF_FIG)."
24130900
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"Activation of ERK1/2, JNK, and p38 induced by LPS or E. coli was abrogated by the addition of progesterone in primary bovine endometrial epithelial cells [17]."
35476705
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"Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells : role of increased reactive oxygen in LPS stimulated ERK1/2 activation and TNF-alpha production."
16554353
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"HTS and LPS induced prompt activation of both p38 and ERKs that peaked at 30 minutes."
10922992
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"The LPS induced increase in ERK1/2 and cPLA 2 alpha phosphorylation at 4 hours was ablated in astrocytes by U0126 in a dose dependent fashion (XREF_FIG), but pretreated with SB203580 did not affect PGE 2 production induced by LPS (data not shown)."
24130900
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"These findings are consistent with our data that β-arrestin 2 depletion reduces LPS-induced ERK 1/2 activation and that PD98059 attenuated LPS-induced IL-8 production in HEK 293 cells."
17418896
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"In addition, LPS activated TAK1 negatively regulates mitogen activated protein kinase and extracellular signal regulated kinase kinase kinase 3 (MEKK3)."
27671672
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"LPS induced extracellular signal regulated kinase (ERK) 1/2 and p38 phosphorylation in the myocardium was prolonged in MKP1 (-/-) mice."
22198506
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"Here, we found that LPS promoted EMT and ERK1/2 activation in HK2 cells, which were inhibited by silencing of IGFBP7."
31287495
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"Noteworthy, it has been reported that TLR ligands such as LPS activate ERK and JNK pathways through their phosphorylation in 3T3-L1 adipocytes ( Kopp et al., 2010 )."
28216438
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"Li et al. have reported that emodin can inhibit LPS-induced activation of NF-κB, p38, ERK and JNK MAPKs signaling pathways in mice [32]."
29057806
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"As LPS activates the ERK pathway through TLR4 in macrophages 27, we then examined ERK activation during M1 polarization."
23752925
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"Next, we determined to what extent DEX or CpdA was able to inhibit LPS-induced activated p-MAPK/ERK and p-MAPK/p38, as parts of upstream inflammatory signaling pathways (control of LPS-induced phosphorylation depicted in Figure S7C)."
30215534
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"As shown in XREF_FIG, top panel, ERK is promptly activated by LPS and IFNgamma treatment and BHA did not block this activation."
23752925
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"It has been shown that LPS stimulation up-regulates the activities of MAPK family members, JNKs, p38 MAPKs and ERKs, in fibroblast and macrophage cell lines [10] ."
24201081
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"Our studies are in agreement, demonstrating that overexpression of β-arrestins 1 and 2 decreases LPS-induced NFκB activation and that siRNA depletion of β-arrestins increases LPS-induced NFκB activati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17418896
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"Our previous studies [2] have indicated that carnosol inhibited NO synthase (iNOS) and NF-κB promoter activity induced by LPS through suppressing p38 and ERK signaling pathway."
15627474
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"As Cot/Tpl2 is essential for the LPS-induced ERK activation [18,28] , it is suggested that Cot/Tpl2-mediated ERK activation is not necessary but rather inhibitory for the MyD88-independent induction o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22673523
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"Expression of a dominant negative form of TLR4 in human SMC attenuated LPS induced ERK1/2 and MCP-1 release."
15863460
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"Both DEX and CpdA were able to dephosphorylate LPS-activated MAPK/ERK but not MAPK/p38 (Figure 5C)."
30215534
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"Mosser et al. [36] reported Sp1 binding and induction of chromatin remodeling in the Il10 promoter of mouse macrophages in response to LPS stimulation in an ERK dependent manner."
21925952
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"This because, from our results, not all TLR4 downstream pathways are affected, for instance the LPS-dependent activation of ERK and p38 is not decreased by oxPLPS."
31054951
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"So, to evaluate whether LPS induces the ERK pathway, we determined ERK phosphorylation at residues Thr 202 and Tyr 204."
30073169
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"Similar findings from a prior study showed that LPS-induced ERK, p38, and JNK phosphorylation were substantially blocked when P. ligularis was used as a medication."
38283153
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"Moreover, LPS induced ERK activation was abolished by 10 -6 M U0126, a MEK inhibitor, which also reduced S6K phosphorylation induced by LPS."
30073169
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"The present results suggest that LCN2 knockdown protected LPS-induced ARDS model via inhibition of ferroptosis-related inflammation and oxidative stress by inhibiting the MAPK/ERK pathway, thereby presenting a novel target for the treatment of ARDS."
34969358
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"H 2 O 2 treatment exhibited little effect on LPS induced ERK activation."
10936514
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"In fps KR/KR macrophages, we reported subtle reductions in both cytokine-induced STAT activation and lipopolysaccharide-induced ERK activation [11] ."
14662333
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"We have reported that chronic ethanol exposure, both in vivo and during culture, increases both LPS stimulated ERK1/2 and p38 activation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
14960183
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"While lipopolysaccharide-induced Erk and JNK activation reversed the reduction by GLP-1RAs in VSMC migration (Supplementary Fig. 5)."
38173373
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"TGFbeta1 suppresses LPS induced ERK regulated p47 phox phosphorylation."
18566433
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"We show here that it is possible to produce virtually complete inhibition of lipopolysaccharide stimulated TNF-alpha mRNA accumulation by using a combination of ERK and p38 MAP kinase inhibitors."
11076936
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"Given the importance of the canonical form of transcription factor NF-kappaB in both the production of the components of the oxidative stress response (p47 and p67 are regulated by NF-kappaB), and in the regulatory effects of ROS in activating microglia (NF-kappaB controls ERK activity induced by LPS signaling, XREF_FIG), inhibitors of the canonical pathway of NF-kappaB should provide strong evidence of the role of oxidative stress responses in PD."
22544998
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"The MAP kinases activated by LPS (ERK, JNK and p38) are critical regulators of pro inflammatory cytokine production, including TNF-alpha and IL-6."
22301548
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"LPS treatment of HGFs resulted in the activation of ERK1/2, p38 and JNK."
23278498
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"Furthermore, molecular analysis indicated that Omegaven (TM) blocked LPS mediated increase in ERK1/2 activity (35% increase), an important LPS signal transduction pathway."
27072665
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"In mKC, LPS treatment resulted in transient and rapid increase of kinase activity of ERK1/2 that phosphorylated their specific substrate ELK-1, with maximal value at 30 minutes and a return near to baseline within 2 hours, and LPS induced ERK1/2 activity from LPS concentration of 10 pg/ml to the top activity at 100 ng/ml."
11835717
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"As shown in XREF_FIG, inotilone suppressed the LPS induced activation of ERK, JNK, and p38 MAPKs in a time dependent manner."
22590514
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"Consistent with previous findings, we also found that apigenin significantly inhibited LPS induced ERK1/2 and NF-kappaB activation in human THP-1 macrophages."
25192391
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"Previous studies have shown that LPS can activate TAK1 and ERK1/2 in endothelial cells, promoting endothelial cell inflammation and increasing vascular permeability [26, 27]."
39699295
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"In addition, EGCG inhibits MIP-2 production and ERK1/2 activation induced by the LPS [36]."
37107345
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"Thus, these results indicate that both LPS and alpha-synuclein induce activation of p38 and ERK1/2 in microglial cells and p38 activation is required for induction of pro inflammatory cytokines and NO production."
28256519
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"LPS is able to activate the p38 and Erk MAPK pathways individually or simultaneously."
25936225
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"The results show that LPS can markedly activate ERK1/2 pathway in mKC."
11835717
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"Other studies have revealed that lipopolysaccharide (LPS) induces ERK 1/2 activation through TRIF and MyD88- and TRIF dependent signaling in vivo and in vitro [XREF_BIBR - XREF_BIBR]."
29977930
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"Carvacrol inhibits the ERK1/2 signalling pathway activated by LPS."
37550359
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"As shown in Figure 4 , LPS stimulation caused the activation of NF-κB, Akt, and p38, ERK1/2 and JNK."
36685596
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"Ryu et al. found that the LPS-stimulated AKT or ERK signaling in the brain leads to the production of proinflammatory cytokines."
39006974
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"Thus, EP acts via the LDL receptor family to induce a potentiation of LPS induced ERK activation and an attenuation of LPS induced JNK activation."
18803301
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"While LPS stimulation activated ERK1/2, SAPK/JNK, and p38 as expected, CE was found to inhibit LPS-induced activation of MAPKs ( Fig. 4 A)."
28782620
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"CWE blocked the LPS induced degradation of IkappaBalpha as well as the activation of JNK, p38 and ERK1/2."
23190501
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"Other studies have revealed that lipopolysaccharide (LPS) induces ERK 1/2 activation through TRIF and MyD88- and TRIF dependent signaling in vivo and in vitro [XREF_BIBR - XREF_BIBR]."
29977930
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"Further study showed that RPS5 knockdown substantially promoted LPS-induced IκB phosphorylation and degradation and enhanced LPS-induced ERK, JNK, and p38 phosphorylation (Xu et al., 2016)."
32117819
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"LPS stimulation increased the activities of ERK, JNK, and p38 MAPK ( Fig. 5 ), but in the presence of α-cubebenoate, the activity of JNK was reduced in a concentration-dependent manner, but not those [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24561384
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"TAOK1 promotes LPS induced activation of ERK1/2 by constitutively interacting with TRAF6 and TPL2."
32344244
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"Since we found that IL-4 down-regulated LPS induction of ERK 1/2 (XREF_FIG), we next assessed the effects of blocking ERK 1/2 in CB CD34 + cell Eo/B CFU formation in the presence of LPS."
24971469
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"However, downregulation of HK2 effectively alleviates ERK1/2 activation induced by LPS and mitigates endothelial inflammation [ 117 ]."
38011767
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"In addition, both ARC and ARC@DPBNP significantly suppressed the activation of ERK induced by LPS, as well as the inhibition of pyroptosis and M1 macrophage polarization."
38457983
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"ERK was strongly phosphorylated in the hUCB-MSCs treated with Pam 3 CSK 4, whereas LPS induced only mild activation of ERK, which correlated with intensity of Alizarin Red S staining."
21042538
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"Since EPS, a polysaccharide, has different chemical structures from NAC and possesses multi-function, we therefore reasoned that EPS reduced the LPS-induced ROS production and subsequently interfered [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24201081
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"However, PTS2 did not affect LPS-stimulated JNK, ERK and p38 activation ( Fig. 8 )."
18435922
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"To investigate whether exposure to heme influenced LPS-induced activation of ERK1/2, we analysed the phosphorylation status of this MAPK in LPS stimulated THP-1 cells pre-treated with heme."
38947312
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"LPS stimulation of dectin-1A/J774.1 and control/J774.1cells induced MAPK p38, ERK1/2, and NFκBα activation with the highest activation observed at the 2 h time point in both cells ( Fig. 2 A)."
33278951
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"However, IMD in the PVN decreased the LPS induced ERK activation, which was also effectively prevented by AM22-52."
30276527
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"ERK1/2 (Immunoblot) in RAW cells treated with LPS (1ug/ml) in the presence and absence of LDN.Figure 2. : The docked conformation of naltrexone at the binding interface of RBD and ACE2 complex obtained from AutoDock (A) and interface amino acid residues involved in non bonded contacts are labelled (B)."
32930058
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"As shown in Fig. 4 a , LPS caused a rapid stimulation of both p38 and ERK, within 0.5 h, as expected, whilst in B. melitensis stimulated cells, no phosphorylation was detected until 2 h ( Fig. 4 b)."
23628412
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"The role of MEK1 in LPS mediated ERK activation and its effect on cytokine production in BMDMs is poorly understood."
26208884
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"Map3k8 D270A mutation inhibits LPS activation of the ERK1/2 MAPK pathway and its downstream target p90 RSK."
27402796
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"Mechanistically, LPS stimulates toll-like receptor 4 (TLR4) to activate nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs) family, which are classified into at least three compone[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25637446
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"Indeed, we found that surfactin selectively suppressed LPS-induced ERK activation (data not shown), suggesting that it does not simply induce damage of the cell membrane, but regulates membrane attach[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17292358
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"Avicularin significantly attenuated LPS induced activation of ERK signaling pathway in a concentration dependent manner."
24009846
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"However, rIL-10 and RA rescued LPS mediated ERK activation in MEK1 deficient macrophages."
26208884
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"Wu and colleagues verified that a pretreatment with LPS induced ERK-1/2 and P38 activation in A549 cells, a phenomenon related to an increase in TLR2 gene expression [XREF_BIBR]."
28894350
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"Also, LPC blocked LPS induced ERK activation in peritoneal macrophages but not in TLR transfected cells."
26925065
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"In BV2 cells ( a murine microglial cell line ) , LPS increases the Ca2 + concentration and upregulates CaMKII phosphorylation , thus inducing ERK1 / 2 and NF-kappaB phosphorylation , which stimulate microglial activation and the expression of pro-inflammatory cytokines and enzymes ( Wu et al ., 2018 ) ."
33329005
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"In contrast, LPS in the presence of RA or rIL-10 led to ERK activation independent of MEK1."
26208884
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"In agreement with this observation, the inhibitors of ERK or JNK MAPK efficiently blocked IL-8 production in cells treated with the antibody and LPS."
25887375
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"The specificity of each antiserum for activated MAPKs in pigtailed macaques was confirmed by Western blot analysis of primary macaque macrophages that had been treated with lipopolysaccharide for 15 m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14742241
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"Using SB203580, Chen and Wang (1999) has reported that activation of p38 MAPK but not ERK by LPS resulted in the stimulation of NF-kappaB-specific DNA protein binding, whereas Baldassare et al (1999) [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12603851
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"As shown in XREF_FIG, LPS alone failed to induce ERK1/2 activation but LPS stimulation in the presence of RA led to ERK1/2 phosphorylation."
26208884
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"Consistent with inflammatory cytokine production TNF-α, IL-1β and IL-6, we suggest that FX1 may repress LPS-induced pro-inflammatory cytokines by at least partially inhibiting the NF-κB signaling path[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31401377
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"The MAP kinases ERK1/2, JNK and p38 are induced by LPS and can therefore regulate the activity of AP-1 and NF-κB [33] ."
19651243
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"TLR4- and TLR2-BBPs also strongly inhibited LPS induced activation of ERK."
17312106
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"Furthermore, avicularin significantly attenuated LPS induced activation of ERK signaling pathway."
24009846
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"Lipopolysaccharide (LPS) also activates MAPK downstream ERK in the non-canonical inflammasome pathway."
32858047
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"Consistent with in vivo study, NBP had significant inhibitory effect on LPS stimulated ERK activation while the phosphorylation of JNK and p38 MAPK were not affected (XREF_FIG)."
30873019
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"Lipopolysaccharide (LPS) also activates MAPK downstream ERK in the non-canonical inflammasome pathway."
32858047
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"In this research, E. coli LPS stimulated the vitalizations of the three MAPKs of ERK, JNK, and p38 in the RAW264.7 cells."
27488844
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"In addition, ERK (1/2) was activated by the coincubation of LPS with LrS."
25329163
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"Researchers have found that the level of LPS-induced inflammation in retinal pigment epithelium (RPE) can be alleviated via PLD inhibition, and confirmed that PLD promotes the inflammatory response by regulating ERK1/2 and COX-2 (Mateos et al., 2014)."
38572075
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"Here, we observed that LPS or PMA increased ERK1/2 and mTORC1 activity (assessed by S6K phosphorylation) and this effect was abolished by calphostin C (a PKC inhibitor) and U0126 (a MEK and ERK inhibitor)."
30073169
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"In CC2D1A/CC2D1B-depleted cells, however, the LPS-induced activation of ERK1/2 kinases was not observed."
27769858
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"Further, SFI attenuates the LPS-induced cardiac apoptosis by downregulating the MEK and ERK signaling pathways ( Chen et al., 2020 ), and protects mitochondrial function in prolonged cardiac arrest ( [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32592888
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"The effect of GRK2 on this pathway has been studied in a variety of contexts beginning with its role in macrophages where GRK2 was shown to negatively regulate LPS induced ERK signaling."
28950947
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"However, further studies are necessary to clearly demonstrate the exact mechanism by which avicularin inhibits LPS induced activation of ERK signaling pathway."
24009846
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"LPS induces activation of all three major classes of MAPKs : p38, JNK, and ERK."
18803301
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"Compound 2f suppressed LPS-induced activation of ERK ( Fig. 6 c), but not p38 and JNK (data not shown)."
26631441
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"LPS significantly induced the activation of ERK, p38, and JNK in control cells treated with DMSO."
26319953
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"However, nepetaefuran, leonotinin, and leonotin had no effect on the LPS-induced activation of ERK, p38, and JNK ( Fig. 7 )."
26319953
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"We and others have previously demonstrated that a serine-threonine kinase, Cot/Tpl2, is indispensable for the LPS-induced activation of ERKs in macrophages, dendritic cells, and osteoblasts [20–22] ."
21036155
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"Lipopolysaccharide (LPS) activates ERK1/2, p38 and JNK and SAPKs and all are required for the biosynthesis of tumor necrosis factor-alpha (TNF-alpha) (Geppert et al., 1994; Han et al., 1994; Lee et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10354710
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"Consistently, LPS-induced ERK and p38 activation in Orai1 KO cells were similar to those in WT astrocytes (Fig. 3D–F)."
35780680
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"Therefore, we examined the effect of LAPA on LPS-induced activation of ERK and p38."
17321474
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"This was shown to inhibit Toll like receptor-4-induced IkappaB kinase beta mediated phosphorylation of p105, thus negatively regulating lipopolysaccharide induced ERK activation in macrophages."
28950947
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"Indeed, this signaling pathway plays an important role in LPS-induced ERK1/2 signaling in alveolar macrophages [41] ."
18845389
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"Conversely, in macrophages, through its regulation of p105, GRK5 negatively regulates LPS stimulated ERK activation."
28950947
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"10 ng/mL LPS activated ERK signal in hDPCs, and overexpression of Cx43 significantly attenuated the activity of ERK signal induced by LPS(P＜0.01)."
38583020
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"It may be concluded that LPS-induced activation of the ERK1/2 and p38 MAPK cascades were responsible for the synthesis of HSPA12B in microglia.Inflammation, a common denominator among the diverse list[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20488464
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"As shown in Fig. 6 A , BV2 cells were pretreated with LAPA (2.0 μM) for 1 h and then stimulated with LPS for 1 h. LPS rapidly activated ERK and p38 MAPK within 1 h after stimulation."
17321474
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"Inhibition of Cx43 or blocking of HC promotes LPS-induced ERK signal activity and odontoblast differentiation of hDPCs."
38583020
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"Cs-TP treatment inhibited LPS-induced ERK and p38 activation in a dose-dependent manner ( Fig. 4 D)."
21440530
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"For example, CpG DNA upregulates the expression of the cellular inhibitor of apoptosis (c-IAP) 1 and 2, while it downregulates the levels of active caspase-3 in a PI3K dependent manner; HIV infected DCs become resistant to NK induced TRAIL mediated apoptosis due to the upregulation of the cellular-Flice-like inhibitory protein and c-IAP2; LPS activates ERK, which regulates DC survival."
24670806
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"Our promising in these experimental data could form the basis of future studies examining acute lung injury caused by inflammation.In summary, the current data, for the first time, indicated that MDSP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33182034
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"LPS, IL-1beta, and TNF-alpha, which mediate ocular inflammation, stimulate activation of p38, ERK, and Akt kinases in the corneal cell line."
16760261
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"However, this difference was not observed in the alpha2 silenced groups, as LPS did not activate ERK in these groups."
28687727
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"Activation of NF-κB and ERK1/2 is required for pro-inflammatory responses [58,60,72] , and LPS is known to activate NF-κB and ERK1/2 in vascular inflammatory responses [2,21,68] ."
24792192
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"Therefore, we tested the effects of orientin or isoorientin on the activation of NF-κB and ERK1/2 by LPS."
24792192
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"In an LPS-induced ARDS model, lipocalin-2 knockdown inhibited ferroptosis by inhibiting the MAPK/ERK pathway (Wang X. et al., 2022)."
36891270
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"Isabel Fernandez-Pisonero et al. revealed that S1P combined with lipopolysaccharide (LPS) activates human umbilical endothelial cells (HUVECs), famous endothelial cells, via NF-kappaB, ERK1/2, and p38 and activated HUVECs secrete IL-6 [XREF_BIBR]."
24686514
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"It was found that LPS induced ERK, JNK, and p38 MAPK activation in THP-1 cells as detected by Western blot analysis with corresponding phospho specific antibodies, while PMA induced ERK activation and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19027716
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"Consistent with other study, we demonstrated that LPS activates the p38, ERK and JNK MAPK pathways in RAW264.7, as detected by the phosphorylation of p38, ERK1/2 and JNK MAPKs, respectively."
25637446
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"We found that silencing of RasGRP3 in peritoneal macrophages enhanced the activation of ERK1/2 stimulated by low doses of LPS, Poly (I : C) or CpG ODN (XREF_FIG)."
25118589
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"CA140 alters LPS induced ERK signaling in BV2 microglial cells."
30309372
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"Further studies demonstrated that isoimperatorin inhibited LPS-induced ERK1/2 and nuclear factor (NF)-κB pathway activation in periodontal cells."
36742455
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"These results indicate that MSL suppresses LPS-induced PGE 2 and COX, at least in part, through down-regulating LPS-induced ERK, p38-MAPK and NF-κB signal pathway in RAW264.7 cells.In summary, the res[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25637446
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"These data suggest that ELA significantly suppressed the LPS-induced activation of ERK1/2, JNK, p38, and Akt in RAW 264.7 cells ( Fig. 4 A )."
24508058
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"Xanthotoxin suppressed the LPS-induced activation of ERK 1/2 and p38 MAPK in a concentration-dependent manner, with no inhibition of JNK phosphorylation ( Fig. 6 A )."
28550731
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"As LPS and C5a activate ERK1/2, PI3K, and downstream Akt pathways in neutrophils, phosphorylation of Bad inhibits mitochondrial cytochrome C release and reduces apoptosis (Paunel-Görgülü et al., 2012)."
39252831
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"The present study indicates that LAPA is a potent inhibitor of MAPKs such as ERK and p38 MAPK induced by LPS stimulation in BV2 microglia."
17321474
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"Thereafter, ERK1/2 MAPK signaling, which is also activated by LPS, controls the progressive accumulation of the active hyperphosphorylated form of CPEB4 (Guillén-Boixet et al., 2016)."
35442882
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"Salidroside markedly inhibited LPS-induced activation of ERK/MAPKs in a dose-dependent manner."
22019446
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"LPS have been reported to activate ERKs in some cell types, but no such effects were observed in our experiments with the rat liver epithelial WB-F344 cells, even when we used LPS isolated from Salmonella typhimurium, a serotype producing LPS known to induce significant biological responses."
19619572
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"Although LPS potently stimulates ERK activation in RAW 264.7 macrophages, it does not activate ERK-1/-2 in BV-2 microglia."
11786532
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"Treatment with ginsenoside Rg1 suppresses downstream inflammatory markers by inhibiting the phosphorylation levels of IkappaB, nuclear translocation of p65 subunit of NF-kappaB, and phosphorylation level of ERK1/2 kinase induced by LPS [XREF_BIBR]."
24073012
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"Interestingly, our results indicated that pre- or post-treatment with CA140 significantly suppressed LPS stimulated ERK signaling in BV2 microglial cells."
30309372
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"As shown in Fig. 6 B, the activation of ERα and ERβ did not repress LPS-induced ERKs activation.Estrogens are involved in the immune response ( Cutolo et al., 2006 ), and macrophages express estrogen [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19447495
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"Retraction: Tetrandrine Suppresses Lipopolysaccharide-Induced Microglial Activation by Inhibiting NF-kappaB and ERK Signaling Pathways in BV2 Cells."
31671159
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"Moreover, antagonism of the MEK and ERK pathway potentiates LPS stimulated nitric oxide production, suggesting that LPS stimulated ERK activation can exert inhibitory effects in macrophage like cells."
11786532
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"Treatment with (+)-pentazocine suppressed inflammatory responses of retinal microglia and inhibited LPS induced activation of ERK and JNK MAPK."
24812552
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"LPS activated Erk1/2 and induced iNOS and subsequent NO production."
10945876
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"In line with those observations, we revealed that the intra-tracheal administration of LPS induces the activation of ERK1/2 and P38 in mouse lung tissues."
34072430
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"Chronic inflammation occurs in breast tissue due to fat accumulation caused by obesity [10] In this study, lipopolysaccharide (LPS) was used to trigger inflammation; high concentrations of LPS activated TLR4, ERK and NF-kB pathways, leading to IL-6 production and Mcp1 release [11]."
40153121
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"At concentrations of 0.5, 0.75, and 1mg/mL, treatment with BPTS inhibited levels of expression of LPS induced NF-kappaB and MAPKs (ERK, JNK, and p38) as well as production of proinflammatory mediators, such as nitric oxide (NO), prostaglandin E 2 (PGE 2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) by LPS."
22899961
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"Further studies demonstrated that isoimperatorin inhibited LPS-induced ERK1/2 and NF-κB pathways in periodontal cells."
36742455
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"The small compound cordycepin from Cordyceps militaris inhibited LPS-induced dendritic cell activation by inhibiting the AKT, ERK, and NFκB signaling pathways and ROS production."
35063441
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"For iNOS, it is highly likely that the NF-κB pathway and ERK pathway, both induced by LPS, are involved in its mechanism."
40227209
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"LPS activates all three types of MAPKs in mouse macrophages and activated ERK, JNK, and p38 contribute to the expression of inflammatory mediators [XREF_BIBR]."
24348728
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"Thus, we further tested the LPS-induced ERKs activation upon ERB-041 treatment."
19447495
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"In vitro experiments have shown that TPL-2 expression in neutrophils is required for LPS activation of ERK1/2 and induction of tumour necrosis factor (TNF) secretion, similar to that in macrophages (Acuff et al, 2017)."
33881780
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"The mechanism of action for compound 503 might be associated with inhibition against LPS-induced NF-κB and ERK pathway activation."
36234878
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"These results indicated that LPS stimulation triggers signal transduction in the NF-κB [40] and ERK1/2 [41] pathways."
35286916
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"Pro inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA (2)-IIA expression in astrocytes and microglia."
30848963
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"Thus, LPS activates all three MAPK families ERK1/2, JNK/SAPK and p38."
15288774
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"Moreover, MOTS-c treatment significantly promoted p-AMPKalpha and SIRT1 expression and suppressed LPS induced ERK, JNK, p38, p65, and STAT3 activation in the mouse lung tissues."
31931370
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"In agreement with our results, the inhibition or silencing of either PLD1 or PLD2 has been shown to inhibit nicotine- and LPS-induced ERK1/2 and NFκB activation, COX-2 expression, and secretion of tumor necrosis factor α, IL-1 β, and IL-8 in human periodontal ligament cells [36]."
36233124
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"Gαi proteins regulate LPS-induced ERK1/2 activation and downstream pro-inflammatory mediator production ( Fan et al., 2004; Lentschat et al., 2005 )."
17418896
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"Our findings demonstrated, for the first time, that d -pinitol treatment inhibited phenotypic and functional maturation in the DC. d -pinitol treatment also suppressed the LPS-induced activation of ER[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17466913
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"These results indicated that HCA/BCA inhibited LPS-induced ERK, JNK, p38 MAPK and NF-κB pathways in microglial cells, and the HCA/BCA inhibition of iNOS, IL-1β, and TNF-α gene expression was likely du[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20933287
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"Interestingly, LiCl pretreatment enhanced LPS induced MEK1/2 phosphorylation unlike ERK (data not shown) suggesting that Li 's effect on LPS induced ERK likely occurs below MEK1/2 and potentially via a protein that could directly affect ERK."
24277481
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"LPS treatment in astrocytes activates ERK, a kinase activated in response to cellular stress 64 that can also activate NF-kappaB 65."
28687727
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"The Aqueous Extract from Horseradish Interferes with LPS Activated ERK Signalling."
28182113
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"4-HNE was shown to significantly inhibit p38 and ERK activity induced by LPS ( Figure 4, A and B , respectively)."
18772336
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"MEK2 is dispensable in LPS mediated ERK activation in BMDMs."
30710049
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"We observed that CD80 and ERK1/2 positive cells were increased by LPS treatment, that was effectively reversed by aSIRP pre-treatment ( Figure 6A )."
35634325
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"In macrophages, LPS activation of ERK, but not JNK or p38 MAPK, is mediated by the MAP 3-kinase TPL-2, which phosphorylates and activates the ERK specific MAPKKs MEK-1/2."
19667062
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"Expression of the C-terminal ankyrin repeat domain of p105 in Nfkb1 -/- macrophages, which reconstitutes LPS induced ERK activation, also suppresses IFN-beta secretion, consistent with the role of the C-terminal domain in stabilizing the steady-state expression of TPL-2."
21217011
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"We found that both LPS and alpha-synuclein induce activation of p38 and ERK1/2 in microglial cells and p38 activation is required for induction of pro inflammatory cytokines and NO production."
28256519
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"The results showed that LPS increased p-ERKs/ERKs ratios in both groups, with more pronounced increase in the Hspa12a o/e group than in NC group ( Fig. 4 A)."
34343936
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"Furthermore, we found that 4-HNE inhibits LPS-stimulated ERK activity in MonoMac 6 and primary monocytes."
18772336
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"In the lipopolysaccharide induced inflammatory response of rat embryonic ventricular myocardial cells (H 9 C 2 cells), our group also found [XREF_BIBR] that SPRC prevented nuclear factor-kappaB (NF-kappaB) activation and suppressed LPS induced extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation and intracellular reactive oxygen species (ROS) production."
26078822
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"More recently, we have shown that LPS induced activation of the p42 and p44 isoforms of MAPK in canine TSMCs [32] ."
16278065
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"In our current study, GalN/LPS significantly increased activation of NF-κB as well as ERK, p38 MAPK, and JNK."
26254779
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"We have previously shown that TPL-2 promotes the production of soluble TNF in LPS stimulated macrophages independently of ERK1/2 activation [XREF_BIBR]."
27402796
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"However, herein we found that TI-I-175 did not significantly affect LPS induced activation of ERK1/2, p38MAPK and JNK (data not shown), indicating that MAPK signaling pathways are not implicated in the modulation of AP-1 by TI-I-175 in RAW 264.7 macrophages."
25767679
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"As shown in XREF_SUPPLEMENTARY, LPS activated ERK1/2 and JNK in a time dependent manner, as evidenced by the increases in phosphorylated ERK1/2 and JNK, but not p-38."
26288180
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"For instance, LPS can activate MEK and ERK through PKC zeta."
30710049
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"The activation of the MAPK/ERK signaling pathway induced by LPS triggers ferroptosis in human bronchial epithelial cells, while knockdown of lipocalin-2 suppresses LPS-induced ferroptosis by inhibitin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37993079
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"However, HRP pretreatment and dexamethasone treatment inhibited LPS/d-GalN-induced activation of ERK, JNK, and p38 MAPK.NF-κB is an important transcription factor and its activation plays a vital role[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26494508
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"Meanwhile, we firstly illustrated BBD can inhibit LPS induced HSCs activation and proliferation in vitro through TLR4 and NF-kappaB and TLR4 and ERK signaling pathway, respectively."
27776340
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"However, no obvious difference was detected in the LPS-stimulated ERK1/2 pathway (Figure S3B)."
36072548
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"Immunoblotting using cell extracts showed higher ERK phosphorylation in cells treated with PA and LPS than in those treated with LPS alone (XREF_FIG)."
32975056
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"Cholesterol extraction from the intact macrophage with methyl-beta-cyclodextrin was sufficient to activate ERK, recapitulating the LPS-IkappaB kinase-p105-MEK-ERK cascade, whereas both it and the alternate raft disrupting agent nystatin blocked subsequent LPS activation of the ERK cascade."
18815123
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"We have shown that desialylation increases LPS induced ERK activation and cytokine expression in human PBMC."
24068662
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"The cells treated with mmLDL and LPS showed higher ERK phosphorylation than those treated with LPS alone (XREF_FIG)."
32975056
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"Because LPS-induced inflammatory reactions mainly activate the IKK/NF-κB, ERK1/2, JNK and p38 pathways, we further examined these four pathways to pinpoint the anti-inflammatory effect of AIH."
25218163
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"Regarding the signalling pathways coupled to DRD5 in DCs, in a previous report we showed that DRD5 stimulation in DCs was coupled to the inhibition of ERK1/2 activation triggered by LPS."
29619030
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"As shown in Fig. 6 , 150 μM BHMB markedly decreased the phosphorylation of LPS-induced p38 MAPK and ERK but not that of JNK.One of the most extensively investigated transduction pathways involved in t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27569861
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"Activation of the ERK1/2 signaling pathway is involved in mediating the downregulation of intestinal tight junction proteins, and LPS stimulation of intestinal epithelial cells also activated ERK1/2, leading to a decrease in tight junction proteins."
38740741
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"Furthermore, KPR reversed LPS-induced elevation of p-IκBα/IκBα, p-p65/p65, p-JNK/JNK, p-ERK/ERK, and p-p38/p38 ratios."
38570708
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"Given previous reports of an essential role for proteasomal degradation of IkappaB kinase phosphorylated p105 in LPS activation of ERK mitogen activated protein kinase, we tested for a role of rafts in compartmentalization of these events."
18815123
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"To clarify the relation between augmented MIF by LOS and ERK1/2 signaling in GBS, monocytes from GBS patients treated with LPS were used as the control for the LOS treated monocytes."
23411097
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"Taken together, these data indicate that Ko143 induced conversion of LPS stimulated DCs into tolerogenic DCs requires ERK signaling pathways."
25111504
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"As shown in Figures XREF_FIG and XREF_FIG, torilin significantly suppressed LPS induced ERK1/2, p38, and JNK1/2 activation in a dose dependent manner while it had no effect on PI3k and Akt phosphorylation."
28316375
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"Following 90 min of LPS stimulation the stability of the TNF-alpha message drops and TNF-alpha message levels begin to decrease, representing the recovery phase.Our data establish that LPS activation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17606294
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"The results demonstrated that LOS has no effects on the phosphorylation levels of ERK1/2 while exogenous LPS significantly activated the ERK signaling in GBS monocytes."
23411097
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"These results indicated that PTERC-T suppresses the expression of iNOS and COX-2 through the attenuation of the DNA binding activity of the transcription factor NFκB.The three MAPKs, ERK, p38 and JNK,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25981112
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"By defining the intracellular signals that are transduced in heterophils following pathogen recognition, we can potentially develop agents that regulate the physiological innate host defenses in poult[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17045653
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"Although the consequences of TPL-2 deficiency on cytokine production after TLR stimulation were very similar in BMDMs and BMDCs (XREF_FIG), it has been suggested previously that LPS does not stimulate ERK activation in BMDCs."
19667062
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"In this study, we investigated the role of small G proteins in the activation of ERK1/2 by FLG and LPS in avian heterophils.Leghorn chickens (Hy-Line W-36) were obtained on the day-of-hatch from a com[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17045653
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"Thus, it is an intriguing possibility that the worsening effect of LPS on asthma is at least partially due to the Th2-type cytokine secretion by mast cells.A serine/threonine protein kinase, Cot/Tpl2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20732300
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"LPS activation is known to increase the activities of ERK, JNK, p38 and IKK in macrophages."
18180038
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"The results of immunoblot analyses showed that ERK1/2, NF-κB p65, JNK, and AKT were strongly activated by LPS stimulation."
34303280
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"Notably, the data presented here show for the first time that alpha2 NKA isoform silencing decreases LPS induced ERK activation and TNF-alpha release and modulates RelA nuclear translocation and, therefore, NF-kappaB activity."
28687727
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"To explore the roles of Ras protein and the Ras target protein, Raf-1, in mediating LPS activation of ERK1/2, we observed the effects of FTI-277, a specific Ras inhibitor ( Lerner et al., 1995 ) and t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17045653
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"However, there was no change in the activation of ERK1/2, JNK, and AKT induced by LPS ( Fig. 6 A, C, D, F)."
34303280
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"Our results showed that LPS induced the activation of ERK and p38 MAP kinase in a Rac dependent manner, suggesting a mediatory role of Rac1 in LPS signaling to MAPKs stimulation."
12132588
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"LPS activated C-Jun N-terminal kinase, p38MAPK, and extracellular signal regulated kinase in wt cells, but the levels were much higher in p60-/-, p80-/-, and p60-/- p80-/- cells."
12695514
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"LPS stimulation of monocytes induces ERK activation, which then phosphorylates various cytoplasmic and nuclear substrates that regulate cell growth, survival, and death."
35240935
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"The LPS stimulation of macrophages activates several intracellular signaling pathways that include the IκB kinase (IKK)–nuclear factor kappa B (NF-κB) pathway and three classical mitogen-activated protein kinase (MAPK) pathways: extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 [18,19,20]."
31671623
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"It has been shown that chronic alcohol induces LPS induced ERK1/2 activation and subsequent transcription of Egr-1, an immediate early gene transcription factor, which contributes to TNFalpha expression in murine hepatic macrophages."
19398236
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"Numerous studies have shown that LPS can stimulate the cells and activate p38 MAPK, ERK 1/2, and JNK, which act on the corresponding substrates."
25082394
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"P. gingivalis LPS activated mainly through NF-κB, while P. gingivalis LPS primarily induced the p38/MAPK and ERK1/2 signaling pathways."
32085888
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"K. parviflora has been shown to have anti-inflammatory properties that suppress the production of IL-6 in lipopolysaccharide-stimulated monocytes by inhibiting the activation of ERK1/2 and protein kinase B (Akt) [14,15]."
36904098
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"Our study indicates that the C-terminal ankyrin repeat domain of p105, which is known to interact with and stabilize TPL-2, inhibits IFN-beta expression by facilitating LPS induced ERK activation."
21217011
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"Moreover, VD3 and HX630 inhibited LPS induced activation of extracellular signal regulated kinase (ERK) and nuclear translocation of nuclear factor kappaB (NF-kappaB)."
27401255
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"Furthermore , we observed that LPS stimulation can markedly increase p38 , ERK1 / 2 , and JNK phosphorylation ; however , Farrerol markedly decreased the ERK1 / 2 and JNK1 / 2 phosphorylation but had no effect on the p38 phosphorylation in LPS-stimulated RAW264.7 cells ( Figure 7A-D ) ."
30011811
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"LPS stimulation for 60 min resulted in marked activation (Figure 3A) of the three MAPK subfamilies, ERK 1/2, p38, and c-Jun N-terminal kinase (JNK), that are required for the activation of inflammatory genes upon TLR stimulation through transcription factor complex AP-1 [19]."
38474770
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"To test the possibility that the LPS induced nuclear translocation of NF-kappaB was ERK and/or p38 MAPK cascade dependent [25,26], we treated the cells with ERK and p38 MAPK pathways inhibitors."
23773963
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"Later, the mechanism of P. intermedia LPS induced TNF- α production was studied in THP-1 monocytes and was found to be induced via a mitogen-activated protein kinase (MAPK) signalling pathway using MA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35843443
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"It also inhibited LPS induced activation of ERK 1/2, p38, JNK, and IkappaBalpha."
28443180
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"It has been repeatedly observed that ' activation ' of macrophages and other cells can lead to an accumulation of Anx-A1 at the plasma membrane where it can (for example) block EGF XREF_BIBR and LPS induced ERK activation XREF_BIBR and undoubtedly fulfil other intracellular roles."
19428336
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"MAPK- (p38, ERK 1/2 and JNK) and NF-kappaB-mediated signaling pathways are differentially activated by LPS in human chorioamniotic cells (Jung et al., 2005; Shoji et al., 2007)."
19969371
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"Therefore, we would detect the effect of JHQG on p-ERK, STAT3 signal pathway related proteins for further analysis.To explore the potential mechanism of action of JHQG, we conducted an investigation i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38373663
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"Although these pathways are significantly involved in the regulation of the iNOS expression and in the production of inflammatory mediators (e.g., NO, ROS, TNF-α, and others), the amount of informatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26188591
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"This result suggests that ESH inhibits the production of inflammatory genes at the transcriptional levels.ESH Inhibits LPS induced Activation of ERK MAPKs such as ERK1/2 and p38 are involved in the signaling pathways leading to the regulation of inflammatory mediators via the activation of transcription factors especially NF-kB."
25140761
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"The LPS-induced activation of ERK/MAP kinase, but not JNK or p38, was markedly suppressed by saurolactam ( Fig. 5 A )."
19962455
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"For example, both LPS and bacterial lipoproteins of E. coli activate all members of MAP-kinases (ERK, JNK, and p38) in murine macrophages ( Sumanth et al., 2019; Abhilasha et al., 2019 ) and stimulate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34488139
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"To do this, the activation of MAP kinase (ERK, JNK and p38) induced by LPS was evaluated."
17134693
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"Moreover, CD pretreatment abrogated adherence induced activation of Pyk2, a major focal adhesion kinase, and ERK 1/2, a component of the mitogen activated protein kinase (MAPK) signaling pathway, and it completely inhibited LPS induced ERK 1/2 activation."
11837785
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"In addition, LPS stimulation resulted in the activation of NF-κB and ERK/MAPK signalling, which was abolished by CM1."
38474770
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"We have previously shown that inducible inflammatory mediator production is inhibited by a post-transcriptional mechanism, since mycolactone does not modulate the LPS dependent activation of ERK, JNK, p38 MAPK or NFkappaB and induced levels of mRNA are maintained or even enhanced XREF_BIBR."
24699819
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"Fucoidan, a sulfated polysaccharide attenuated inflammatory response in LPS-stimulated BV2 microglia by suppressing NF-κB and extracellular signal-regulated kinases (ERK)/MAPK/Akt pathways [92]."
32630301
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"Moreover, the inhibition of STAT1/IRF1 signaling by Fluda decreased LPS-induced increases in iNOS, NF-κB, and ERK1/2 signaling as well as NO production in BALF."
40336064
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"LPS stimulation also activated ERK1 / 2 and increased its interaction with CDK5 ."
34164484
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"LPS/TLR4 activation of the ERK pathway was identified as a mechanism of IL-8 [80] and MCP-1 [81,82] activation."
36902278
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"It is likely that TMP exerted an antiinflammation in part through interfering with the NF-κB-mediated signaling.To clarify whether TMP affects LPS-induced MAPK activation, we examined the effects of v[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19540326
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"XREF_BIBR Existing reports suggest that RGD peptide ameliorated the LPS induced ERK signaling and also mitigated the inflammatory WISP1-integrin beta6 signaling pathway in lung inflammatory conditions."
33418136
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"Based on the inhibitor studies, LPS engagement of TLR induces the canonical Ras → Raf-1 → MEK → ERK1/2 pathway."
17045653
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"Thereby, MSKs integrate signals not only from p38 MAPK , but also from Erk1/2, which is activated by LPS via the serine/threonine kinase Tpl2 — a pathway essentially required for LPS-induced COX2 gene[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22330073
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"LPS stimulated ERK, JNK, and p38 MAP kinases in J774 macrophages but with different activation kinetics."
20396387
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"Signaling cascade analysis showed that LPS induced activation of Erk, JNK, p38 mitogen-activated protein kinase (MAPK), and NF-kappaB, and RA treatments attenuated the activation of the three MAPKs and NF-kappaB."
35455434
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"The present data on LPS in avian heterophils concur with published data where three bacterial products peptidoglycan, CpG, and LPS, all induce the activation of Ras and ERK in mammalian macrophages fo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17045653
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"By studying its mode of action, we found that SM-7409 inhibits LPS-induced ERK activity, which is crucially required for TNF-α expression in PBMCs."
16842752
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"Pretreatment of THSG significantly enhanced LPS reduced AMPK activation and increased ERK1/2 activation even in the presence of LPS."
27504055
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"LPS stimulation activated ERK, JNK and p38; however, timosaponin AIII and sarsasapogenin significantly suppressed their phosphorylation."
25698557
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"Activation of ERK1/2 by peptidoglycan and CpG was Ras-dependent; whereas, LPS-induced activation of ERK was not dependent on the activation of Ras ( Chen et al., 2004; Xu et al., 2003; David et al., 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17045653
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"In the present study, we found that the stimulation of PBMCs with 100 ng/ml of LPS elicited ERK activation in a time-dependent manner, and that it shows maximal activity at 10 min (data not shown)."
16842752
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"The results of our study indicate that LPS-induced activation of ERK1/2 in avian heterophils was Ras-dependent since treatment of the cells with pharmacological inhibitor of Ras (FTI-277) and Raf-1 (G[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17045653
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"This effect of SM-7409 on LPS-induced ERK activity was further investigated, and it was found that preincubating PBMCs with 5 μM of SM-7409 prior to adding LPS completely inhibited LPS-induced ERK act[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16842752
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"Interestingly, JNK inhibitor SP600125 increased LPS-induced CCL20 production in CT26 cells, which may be due to SP600125 pretreatment-enhanced LPS-induced ERK activation in CT26 cells (Fig. S2B) ."
18083111
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"Figure 4 shows that LPS strongly activated ERK, JNK, and p38 MAPK, whereas AKT was more weakly activated by LPS (Supplementary Figure S3)."
38302598
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"In macrophages, lipopolysaccharide activates ERK, JNK and SAPK, and p38, and all are required for the translation of tumor necrosis factor (J Swantek, M Cobb, T Geppert, unpublished data)."
9069255
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"Among MAPKs (JNK/SAPK, p38, ERK1/2, and p38), which are important for NF-κB activation, cardamomin induced the phosphorylation of p38 but did not inhibit the LPS-stimulated activation of JNK/SAPK and ERK1/2 (Lee et al., 2006)."
37533631
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"In agreement with these reports, in our studies we found that LPS treatment of human macrophages induced the early activation of NF-kappaB, p38, JNK and ERK."
23911403
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"In addition, studies on infected intestinal epithelial cells suggested a role for the S. flexneri LPS-mediated activation of Erk in bacterial invasion through the basolateral surface of these cells [73]."
37569283
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"LPC or TLR ligand-like Leishmania antigens, counteracts NO production by blocking LPS-induced ERK activation and the nuclear translocation of NF-қB [51] ."
25601495
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"mRNA expression profile of SFKs and involvement of SFKs in the regulation of LPS induced Erk1/2 signaling in PBMCs of active BD patients."
30659554
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"LPS also activates the ERK, JNK, and p38 MAPK signaling pathways to exert different biological effects ( Sweet and Hume, 1996; Guha and Mackman, 2001; Hommes, 2003 )."
24685589
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"In the present study, we have described the essential role of the Ras subfamily in mediating FLG and LPS-mediated activation of the ERK1/2 MAP kinase cascade in avian heterophils."
17045653
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"Taken together, these results indicate that RA treatments significantly inhibit LPS-induced Erk1/2, JNK, and p38 MAPK activation and NF-kB signaling."
35455434
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"G-CSF did not affect LPS induced activation of ERK, p38, JNK, and NF-kappa B, indicating that G-CSF affects the pathway downstream or independently of these signaling molecules."
14736711
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"Our results shown in the XREF_FIG indicate that benfotiamine significantly prevented the LPS induced activation ERK1/2 and the transcription factors NF-kB and Egr-1 which transcribe gene for COX-2 and mPGES-1 [XREF_BIBR]."
22067901
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"An intriguing finding is that zerumbone did not have an effect on lipopolysaccharide (LPS)-triggered activation of mitogen activated protein kinases (MAPKs; extracellular signal regulated kinase 1/2, c-Jun N-terminal kinase1/2, p38MAPK) or key transcription factors (activator protein-1 and nuclear factor kappaB; NF-kappaB), while it targeted a post-transcriptional mechanism."
29610550
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"Mechanistically, RA reduces the LPS-induced Erk, JNK, and NF-κB signaling cascade, which may contribute to the downregulation of the proinflammatory mediators."
35455434
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"TRAF6-siRNA prevented LPS-induced activation of NF-ƙB, ERK, JNK, p38, CCL2, and CXCL1 in cultured astrocytes."
35729835
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"The effects of basolateral LPS to activate ERK and inhibit HCO (3) (-) absorption were eliminated in MTALs from TLR4 (-/-) and myeloid differentiation factor 88 (MyD88) (-/-) mice but were preserved in MTALs from TIR (Toll and interleukin -1 receptor) domain containing adapter inducing interferon-beta (Trif) (-/-) mice."
21881005
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"PI3K p110beta siRNA inhibited JNK activation, but not p38 MAPK or ERK activation, stimulated by LPS, while PI3K p110alpha siRNA did not affect LPS induced JNK, p38 MAPK, or ERK activation in both cell types."
19380768
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"Moreover, LPS could induce the activation of p38 mitogen activated protein kinase (MAPK) and c-jun N-terminal kinase but not extracellular signal regulated kinase."
12473078
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"Furthermore, we found that 5-hydroxytryptophan played a role in LPS induced inducible nitric oxide synthase (iNOS), cyclo oxygenase-2 (COX-2) and extracellular-signal regulated protein kinase (ERK) activation."
19336883
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"In addition, inhibition of the ERK1/2 pathway suppressed the formation of calcium deposits in cells treated with LPS for 4 weeks (XREF_FIG)."
23640488
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"The C-terminal region of p105 is necessary for LPS induced ERK activation and it has been suggested that ERK activity inhibits both IFN-beta and IL-12 p40 following LPS stimulation."
22427889
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"Activation of NF-κB and ERK1/2 is required for pro-inflammatory responses [ 33 , 38 , 40 ], and LPS is known to activate NF-κB and ERK1/2 in vascular inflammatory responses [ 41–43 ]."
30753810
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"Therefore, we tested the effects of PEL on the activation of NF-κB and ERK1/2 by LPS."
30753810
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"ERK1/2 and pERK1/2 induced by LPS were significantly inhibited by glabridin."
28039487
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"Effects of rice hull extract on lipopolysaccharide induced extracellular signal regulated kinase and c-Jun N-terminal kinase activation."
27867272
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"Although PDTC is an inhibitor of NF-κB, but the inhibition of NF-κB also regulates ERK1/2 activation, for example, in human bronchial epithelial cells, PDTC not only down-regulated the activation of ERK1/2 by LPS, NF-κB p65 was also inhibited [65]."
38012694
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"LPS-induced significant ERK1/2 and JNK activation."
19665057
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"Therefore, we next examined whether nicotine inhibits LPS-induced NO synthesis by modulating LPS-induced p42/44 MAPK activation."
18723372
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"In our study, 1 µg/mL of LPS significantly activated the ERK 1/2 and NF-κB signaling pathways and upregulated proinflammatory cytokines in 3T3-L1 adipocytes."
37570719
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"Mechanistically, TFSB blocked LPS and CSE induced activation of ERK, Akt, and PKCalpha."
31209984
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"A role for SK1 in LPS signalling was also observed by Wu et al. (2004) who demonstrated that SK inhibitors or siRNA knockdown of SK1 expression reduces LPS-stimulation of ERK-1/2 and p38 MAPK, and enh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24070975
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"Moreover, these reverse effects of ITE were suppressed with the treatment of AhR antagonist CH223191 (Fig. 7G–H), supporting the AhR dependent role in ITE inhibiting the activation of NFκB. Taken together, these results indicated that AhR activation could down-regulate LPS-induced ERK and NFκB signaling in BV2 microglia and thus limit downstream inflammation.In summary, our results illustrated the unbalanced tryptophan metabolism in glaucoma patients and the role of AhR signaling in retinal neuroprotection."
36754954
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"Stimulation with the S1P 3 agonist (Compound 20), increased ERK-1/2 phosphorylation by two-fold in cells not treated with LPS and was further elevated in cells pre-challenged with LPS."
21887342
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"LPS activated Akt1-/- macrophages exhibited increased ERK1/2 activation (XREF_SUPPLEMENTARY) but no change in IkBalpha degradation (XREF_SUPPLEMENTARY), suggesting that Akt1 plays an inhibitory role in early TLR4 signals but its ablation is not sufficient to suppress pro inflammatory cytokine production at the early stages of endotoxemia."
19699171
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"It also inhibited TNFalpha- and IL6 induced activation of Erk1/2 in myotubes from overweight subjects, but did not change LPS induced activation of Erk1/2."
24521217
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"We also found that LPS-stimulated ERK, p38, and JNK activation within 30 min were not altered by TM or BFA ( Fig. 2 C)."
22841895
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"Interestingly, nicotine inhibited LPS-induced p42/44 MAPK activation."
18723372
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"LPS induces intracellular signaling pathways involving nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs), such as p38, extracellular signal-regulated kinase (ERK), and c-Jun[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22465818
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"We have demonstrated that expression of a C-terminal fragment of p105 that does not contain the Rel homology domain (p105DeltaN) rescues LPS induced ERK activation and inhibits LPS induced Ifnb expression XREF_BIBR."
22427889
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"Accumulating evidence suggests that LPS can activate nuclear factor-kappa B (NF-kappaB) and three mitogen activated protein kinase (MAPK) pathways, inculding the c-Jun NH2-terminal kinase (JNK), extracellular signal regulated kinase (ERK), and p38 pathways, which result in the overexpression of inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), NO and prostaglandin (PG) E 2."
26722219
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"It has previously been demonstrated that phosphorylation of S930 in p105 is essential for LPS induced ERK activation XREF_BIBR, XREF_BIBR."
22427889
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"Simultaneously obtained results showed that plant extracts (5–50 μg/mL) substantially diminished the release of NF-κB, the expression of ICAM-1, and the secretion of IL-8 by LPS-stimulated Hs68 fibroblasts (Table 7) and suppressed (25–50 μg/mL) the LPS-induced Erk kinase activation in dermal cells [89]."
38203735
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"ATL inhibits LPS induced ERK and p38 MAPK activation."
21831303
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"In addition, chronic alcohol intake activates LPS induced ERK1/2 activation, which contributes to TNF-alpha expression in murine hepatic macrophages."
25009584
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"Numerous studies have shown that LPS activates ERK1/2 in monocytes and macrophages, and the MEK1/2 inhibitor, PD98059, blocked LPS induced TNFalpha activation in human monocytes."
26065826
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"The results showed that the increased expression of phosphorylated JNK, ERK, and p38 induced by LPS stimulation was significantly inhibited in a concentration-dependent manner by ED treatment (Figure 3C–E)."
37631100
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"Consistent with a role for phosphorylation of serine 930 in LPS induced ERK activation and stabilization of c-Fos, expression of p105DeltaN but not p105DeltaNS930A rescued the defect in ERK activation and c-Fos induction observed in Nfkb1 -/- BMDM (XREF_FIG)."
22427889
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"Our results revealed that LPS induced a significant increase in e phosphorylation of MAPK signaling molecules including ERK1/2, P38 and JNK in the BMMCs of mice."
27156126
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"The LPS mediated activation of ERK and JNK in macrophages was then examined and it was shown that these signalling pathways were defective in KO mice."
12160628
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"Additionally, AF-MSCs-exosomes assisted with reducing the activation of mitogen-activated protein kinase components (JNK, ERK1/2, and P38) triggered by LPS [63]."
39095888
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"As shown in Fig. 7 B, ILG suppressed the LPS-induced activations of ERK1/2 and p38 MAP kinases, but did not affect the phosphorylation of JNK1/2."
18295200
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"Fig. 4 shows, in N9 microglia, that although both LPS and BzATP can individually increase ERK-1/2 activation, when microglia are presented with both stimuli simultaneously, the amount of ERK activatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16735081
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"The results from Fig. 6 , implied that compound 1 at the concentration of 30 μM could notably inhibit the activation of p38, ERK, and JNK induced by LPS."
37236383
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"In agreement with these reports, we found that LPS and TNFalpha activated Erk1/2, NFkB, IkBalpha pathways, whereas IL6 induced only activation of Erk1/2 signalling in our HSMM model."
24521217
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"As shown in Figures XREF_FIG, XREF_FIG, and XREF_FIG, LPS treatment caused a marked increase in the phosphorylation of ERK1/2, JNK1/2, and p38 MAPK proteins at 5, 15, and 5min, respectively, whereas LPS induced ERK1/2, JNK1/2, and p38 MAPK phosphorylation was significantly inhibited by TS and GA treatment."
24723997
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"We found that LPS-induced ERK activation was suppressed by transfection with dominant negative mutants of RasN17 in Raw 264.7 cells, as previously reported in other cell types [30] , suggesting that R[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16527246
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"In OGT-deficient bone marrow-derived macrophages (BMMs), LPS stimulation has been shown to induce excessive pro-inflammatory cytokine production by inducing NF-κB and extracellular signal-regulated kinase (ERK) signaling."
36473120
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"Using human keratinocytes, we investigated the effect of 3,4,5-triCQA on the LPS stimulated production of inflammatory mediators in relation to the nuclear factor (NF)-kB, Akt and ERK pathways."
22947851
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"28 Figure 2D–F showed that both ERK and JNK are activated by LPS stimulation."
34668232
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"Evaluating proteins involved in the MAPK pathway revealed that LPS stimulation of BMSCs activated the ERK pathway and inhibited the p38 pathway when compared to LPS only control in the absence of BMSC[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34418459
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"The results also indicated that LPS significantly activated ERK1/2 and STAT3 signaling pathways, and expression trend of them was consistent with direction of EGFR in HK2 cells."
29207668
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"Gefitinib suppressed LPS induced activation of ERK1/2 and STAT3 by blocking EGFR activation in HK-2 cells."
29207668
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"The evolutionary divergence between mammalian and fish species is considerable, and we do not know if LPS can induce the IKK-NF-kappaB pathway and MAPK pathways (the ERK, JNK, and p38 pathways) in fish as in mammals."
16740160
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"When clam hemocytes were stimulated by LPS for 24 h, we found that LPS-treated group showed significant up-regulation of p38, ERK and JNK phosphorylation compared with the control group ( Fig. 7 C and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28476674
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"Guo and colleagues [38] demonstrated that LPS significantly ameliorated osteoblast differentiation and induced apoptosis in MC3T3-E1 cells by activating the ERK1/2 and JNK pathway [38]."
38069267
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"In this study, although LPS activated all three MAPK families – p38 MAPK, ERK1/2, and JNK – only p38 MAPK was down-regulated by E 2 ."
24321566
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"Interestingly, LPC blocked LPS induced ERK activation in peritoneal macrophages but not in TLR transfected cells."
24312681
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"In addition to facilitating LPS induced ERK activation, the C-terminal region of p105 contains ankyrin repeats similar to those found in the classical IkappaBs XREF_BIBR, XREF_BIBR."
22427889
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"To further confirm the finding that LPS activated ERK1/2 and STAT3 signaling pathways through activation of EGFR, we used gefitinib, a specific EGFR inhibitor, to block EGFR activation."
29207668
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"A time course of the activation and phosphorylation of ERK, JNK and p38 in microglia treated with LPS in the presence and absence of the Tpl2KI is shown in XREF_FIG."
24188160
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"The results of the present study suggest that astrocytes contributed to the upregulation of iNOS in Fyn-deficient cortices and that the lack of Fyn expression promoted LPS-induced ERK activation in as[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29180007
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"G-CSF did not affect LPS-induced activation of ERK, p38, JNK, and NF-kappa B, indicating that G-CSF affects the pathway downstream or independently of these signaling molecules."
14736711
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"However, although ERK phosphorylation in cells treated 15d-PGJ 2 alone was not detected, a remarkable increase in ERK phosphorylation in VSMCs that were treated with 15d-PGJ 2 / LPS relative to VSMCs that were treated with LPS alone was also detected (XREF_FIG)."
20107546
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"The results showed that the phosphorylation of ERK1/2 was significantly upregulated in the LPS group compared with the control (P < 0.05), whereas alpha-mangostin reversed the LPS induced ERK1/2 activation (XREF_FIG)."
23833675
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"ERK and p38 kinase are activated by inflammatory mediators, including chemoattractants and GM-CSF [26-31], while LPS is reported to activate p38 kinase, but not ERK [32,33]."
11369515
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"Western blot analysis revealed that LPS stimulation induced the activation of ERK-1/2, p38 MAPK, and NF-kappaB, as well as Akt activation."
33777049
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"KP suppressed LPS-induced activation of ERK1/2 and JNK in a dose-dependent manner (Fig. 3), while the amount of kinases was unaffected by either LPS or KP treatment."
21286382
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"MAP3K8 is essential for the activation of the intracellular MAPK/ERK pathway induced by LPS in cells (36)."
35911118
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"Pretreatment (1h) with U0126 (10muM) strongly inhibited the activation of ERK and NF-kappaB induced by LPS (p < 0.01), which was similar to the effect of BTW."
33597862
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"Notably, Ntcp and Bsep RNA levels were maintained at 78Ϯ50% and 60Ϯ46% of control levels, respectively.following authors have indicated they have no relationships to disclose: Claus Hellerbrand, Marcus Mü hlbauer, Martin Fleck, Thomas Weiss, Matthias Froh, Sabine Hoves, Jü rgen Schö lmerich956 ENHANCED LPS-STIMULATED ERK1/2 ACTIVATION AND TNFÁ SECRETION BY RAT KUPFFER CELLS AFTER CHRONIC ETHANOL FEEDING IS MEDIATED VIA INCREASED PRODUCTION OF REACTIVE OXYGEN SPECIES (ROS) BY NADPH OXIDASE Varsha Thakur, Megan R. McMullen, Qifang Wang, Laura E. Nagy, Case Western Reserve University, Cleveland, OHBackground: Production of ROS by Kupffer cells (KC) contributes to the development of chronic ethanol (EtOH)-induced liver injury."
| PMC
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"Furthermore, ALOE reduced the protein expression of P65 in NF-kappaB signaling pathway and suppressed LPS-induced activation of ERK and JNK, instead of p38 MAPK pathway."
36742263
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"However, maximal phosphorylation of ERK was observed in cells treated with 50 mug/ml LPS."
12901876
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"KP greatly inhibited the LPS-induced ERK1/2 and JNK after LPS application."
21286382
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"The finding that inhibition of ERK attenuated the effect of LPS was surprising, as LPS failed to stimulate ERK activity in human neutrophils in several previous studies [32-34]."
11369515
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"The reason for the failure to demonstrate LPS stimulation of ERK activity in the previous studies is not clear, but may be related to differences in methodology or time of exposure to LPS."
11369515
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"The activation of ERK1/2 by lipopolysaccharide, brain-derived neurotrophic factor, sesamin and microgravity have been shown to increase the osteoclastogenesis-associated cytokines."
25304090
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"We also found that p38 and ERK1/2 pathways are activated by LPS as well as by photobiomodulation."
31390315
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"To study this, we examined whether Tt-ME modulates LPS stimulated ERK upstream kinases MEK1/2, MKK3/6, TAK1, and IRAK1."
31929819
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"As LPS stimulated TLR4 can activate MAPK/ERK pathway and FGF/ERK MAP kinase signaling can regulate the expression of BRF16, 23."
30320187
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"LPC blocks LPS induced ERK activation in peritoneal macrophages but not in TLR transfected cells."
24312681
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"Raf1 is reported to be involved in the LPS induced activation of ERK [21-23]."
12901876
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"LA also alleviates LPS induced acute lung and kidney injury through NF-kappaB and p38 and ERK mitogen activated protein kinase (MAPK) signaling and attenuates pertussis toxin induced autoimmune encephalomyelitis by reducing the production of tumor necrosis factor-alpha and interferon-gamma in vivo [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
28704925
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"Moreover, Smith et al. (2015) showed that in endotoxemic conditions, LPS systemic exposure promoted the activation of TLR-4 and MAPK/ERK pathway, inducing a significant decrease in PGC-1α synthesis."
33995028
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"Effect of PRE on LPS-induced activation of ERK1/2, JNK, and p38 MAPK in RAW 264.7 macrophages."
26797110
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"d-GalN/LPS treatment resulted in a marked inflammatory cytokine release and stimulated the activation of signal transducer and activator of transcription (STAT) 3, c-Jun N-terminal kinases (JNK) and extracellular signal-regulated kinase (ERK) signaling comparably in the hepatic compartment of Bcl-3 Hep and WT mice."
35641486
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"Ohyama et al. reported that sudachitin (5,7,4′-trihydroxy-6,8,3-trimethoxyflavone), found specifically in Citrus sudachi, blocked LPS-induced calvarial bone destruction by repressing the ERK and JNK pathways and decreasing intracellular reactive oxygen species (ROS) production in osteoclast precursors [12]."
36986133
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"Figure 4a–c shows that LPS significantly induced increased levels of p‐ERK and p‐p38 compared with the control groups; however, their expressions were significantly downregulated after 4 µg mL SFZ NPs treatment."
36808856
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"In present study, our data showed that intranigral injection of LPS produced a strong activation of ERK1/2, JNK and p38MAPK, which correlated with the increase of inflammatory mediators."
26455404
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"These protective effects were mediated through MPLA stimulation of a TRIF dependent PI3K-Akt pathway that prevents sepsis- and LPS induced ERK activation."
29741098
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"Vav null macrophages XREF_BIBR exhibit defects in LPS induced ERK and p38 MAPK signalling while JNK responses are normal XREF_BIBR."
20644716
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"Moreover, Zc3h12c exerted a notable inhibitory effect on JNK, ERK, p38, and NF-κB signaling induced by LPS."
38810592
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"However, the treatment of macrophages with presence LPC and LPS a classical TLR ligand leads to a counteraction of LPS induced ERK activation but not of JNK and p38."
24312681
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"Chronic alcohol enhances LPS induced ERK1/2 activation and transcription of Egr-1, contributing to murine hepatic macrophage activation [XREF_BIBR, XREF_BIBR]."
26201323
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"Pretreatment with MPLA prevented LPS induced ERK activation; this effect was dependent on PI3K."
28356284
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"This protective effect is mediated directly through MPLA stimulation of a TLR4-TRIF-PI3K-Akt pathway that prevents LPS induced ERK activation."
28356284
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"LPS-stimulated cells can activate ERK, JNK and p38 and subsequently act on their substrates to affect the activity of various transcription factors, thus regulating the expressions of diverse cytokines, including TNF, IL-6 and IL-8."
38516705
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"On the other hand, phosphorylation levels of JNK (Figure 5B) and ERK (Figure 5C) were increased; p-JNK/JNK (Supplementary Figure 3A) and p-ERK/ERK (Supplementary Figure 3B) ratios were also increased and decreased when treating ALOE, indicating that ALOE suppressed the LPS-stimulated activation of ERK (Figure 5C) and JNK (Figure 5B), instead of p38 (Figure 5D) MAPK pathway."
36742263
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"LPS activates all three MAP kinases, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 ( Kyriakis and Avruch, 2001 )."
17614138
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"To examine the negative functional role of TAM receptors on microglia in response to TLR activation, we activated TLR4 on primary cultured microglia with LPS and found that LPS stimulation caused rapid activation of both ERK1/2 and p38 in TKO cells compared to WT microglia (XREF_FIG)."
24244024
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"As shown in Fig. 4 , LPS challenge appears to increase the protein levels of native as well as phosphorylated forms of PTEN, PI3K, Akt, NF-κB, ERK and p38, when compared with control cells ( Fig. 4 a-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37499907
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"LPS activates the classical MAP kinase (Erk1/2), the so-called stress-activated (p38 and Jnk) protein kinase cascades, and other signalling pathways within 5–15 min of LPS detection, as documented in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17142025
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"XREF_FIG shows LPS induced activation of ERK, p38, and JNK (indicated by an increase in phosphorylation of the activated tyrosine and threonine sites) that was inhibited by ash exposure."
23478268
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"2 and 3 ), this result suggests that the PC extract is an efficient anti-inflammatory as well as neuroprotective agent by inhibiting gene induction, production and release of anti-inflammatory agents [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17499198
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"Activation of the A (3) AR or inhibition of intracellular Ca (2+) release also reduced LPS stimulated nuclear factor-kappaB (NF-kappaB) activation and extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation."
16188954
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"PKC- and ERK dependent activation of I kappa B kinase by lipopolysaccharide in macrophages : enhancement by P2Y receptor mediated CaMK activation."
11682454
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"LPS elicits activation of both ERK and p38 MAP kinase, and inhibition of ERK activation by specific MEK inhibitor, U0126, does not efficiently attenuate LPS-elicited NF-κB activation [21] ."
17499198
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"Therefore, ECVs (LmV, LcV, and LpV) prevent inflammatory responses in the LPS-stimulated microglial cells by blocking the extracellular signal-regulated kinase (Erk) and p38 signaling pathways."
35159463
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"In addition, we also examined whether LPS could activate ERK1/2 signal in DSCs."
25757669
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"LPS regulates tumor cells mainly through binding with toll like receptor 4 (TLR4), and then activates the PKC, MAPKs, JNK and ERK1/2 signaling pathways, thereby affecting the activity of the transcription factors AP-1 and NF-kappaB XREF_BIBR."
33456361
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"Secondly, inhibitory effect of U0126, an inhibitor of ERK, an important enzyme for AP-1 activation ( Xu et al., 2006 ), and up-regulation of phospho-ERK level also implied the potential involvement of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19429360
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"We also detected an increase in ERK phosphorylation in SHR VSMCs treated with 15d-PGJ 2 / LPS."
20107546
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"Additional evidence suggesting that P2 receptors are involved in LPS mediated macrophage activation comes from the work of Hu et al. [XREF_BIBR] wherein it was shown that pretreatment of RAW 264.7 macrophages with P2 receptor antagonists, oATP or pyridoxal-phosphate-6-azophenyl-2-4-disulfonic acid (PPADS), inhibited LPS stimulated NO production and/or iNOS expression and attenuated LPS activation of NF-kappaB and ERK-1/2."
18404417
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"Notably matching the profile of pathways modulated in Vav deficient macrophages, Themis2 appeared to enhance the LPS induced activation of both p38 and ERK compared to parental RAW cells whereas activation of JNK in the same cells was unaffected (XREF_FIG)."
20644716
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"Here we demonstrated that LPS induced the activations of p38, JNK and ERK in RAW264.7 macrophages."
23944357
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"For the first time, our results suggest that dehydrogeijerin significantly inhibits pro-inflammatory cytokine production due to activated macrophages, suggesting that dehydrogeijerin could be a prospe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23102664
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"LPS activated p38 and ERK in RAW264.7 cells and ALI model, which were significantly decreased after CX-CS herb pair treatment ( Fig. 6 B)."
38342157
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"It was unsurprising, therefore, that LPS priming of the inflammasome resulted in strong ERK1/2 activation, but we were surprised to observe such a dramatic inactivation upon nigericin treatment, especially when compared with other MAP kinases like JNK and p38."
39982821
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"Secondly, DOK3 negatively regulates TLR4 (Toll-like receptor 4) signaling by limiting LPS-induced ERK (extracellular regulated protein kinases) activation and cytokine responses in macrophages [39]."
36768499
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"NF-κB and ERK1/2 were activated by LPS [5] ."
32575007
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"In macrophages and other types of cells, LPS activates three subclasses of MAPKs: extracellular signal-regulated kinase (ERK), c-Jun-terminal kinase (JNK) and p38."
21160452
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"LPS treatment induced changes in MAPK/ERK, including increases in MAPK 1, MAPK 3, and dual-specificity mitogen-activated protein kinase kinase 2 (MAPK2K), of 2.1, 2.4, and 2.8-fold change increases, respectively (Table 2)."
33863932
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"Additionally, LPS stimulation activates MAPKs, such Erk and p38."
23667114
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"Importantly, pretreatment with TS or GA inhibited the LPS induced activation of ERK1/2, JNK1/2, and p38MAPK."
24723997
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"Taken together, these results suggested that PPAR-γ subsequently inhibited LPS-induced ERK1/2 and p38 MAPK activation in RAW264.7.Our work explored the potential therapeutic effect of a flavonoid comp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26526086
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"Since LPS-elicited induction of these cytokine genes are both ERK and p38MAP kinase dependent, we investigated whether the PC extract inhibits ERK and p38MAPK phosphorylation."
17499198
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"These results suggest that LL-37 attenuates the increased autophagy caused by inflammatory responses.To further understand the signaling pathways upstream of the LL-37 effect, we examined a potential [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24984264
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"LPS activates ERK, p38 and JNK pathways in BMDMs."
29354064
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"LL-37 pretreatment enhanced LPS-induced ERK and mTOR activation in HaCaT cells ( Fig. 6 A and B )."
24984264
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"To examine whether ERK regulates P65-miR23a/27a/24 in GC, we treated GC cells with the ERK inhibitor PD98059 [XREF_BIBR] or ERK activator LPS [XREF_BIBR] and determined the levels of p-ERK, p-P65, miR-23a, miR-27a, and miR-24."
29866191
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"Finally, we showed that the inhibition of LPS-stimulated ERK activation by simvastatin was reversed by GGPP."
18625914
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"The results reveal ERK1/2 as an important factor in mediating LPS-induced increment in the levels of fibrosis associated FGF-2, uPA, MMP-2 and MMP-9 proteins in cardiac fibroblasts.We further identifi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30980805
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"Additionally, the LPS induced activation of extracellular signal regulated kinase 1/2 (ERK1/2), P38 and c-Jun N-terminal kinase (JNK) was suppressed by DPL extract."
30747232
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"These results indicate that cFLIP is dispensable in LPS induced activation of Erk1/2 MAPKs, and plays a role in the downregulation of p38 and Jnk."
19109151
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"Recently it was reported that LPS induced cytokine expression was increased in ANXA1 -/- macrophages, and that it was accompanied by significantly increased LPS induced activation of ERK and JNK MAPK [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22056994
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"Lastly, we tested whether dasatinib alters LPS-stimulated AKT and ERK signaling in mouse primary microglial cells."
31655606
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"Furthermore, lipopolysaccharide treatment induced the p38, JNK, and ERK pathways in the placenta of mice [ 49 ]."
30301612
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"Although we have no results showing that NF-kB inhibition prevents IL-8 secretion, data from our laboratory show that LPS activates AKT, ERK1/2 and NF-kB (Boza et al., 2016); and it is well documented in the literature that NF-KB regulates the expression of IL-8; although in this case it was because of IL-1beta (Mizuno et al., 2022)."
37799272
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"As shown in Fig. 5 , the combination of phillyrin, emodin, baicalin, and liquiritin effectively inhibited LPS-induced up-regulation of MyD88, IκBα, NF-κB, ERK, p38 and JNK in zebrafish ( Fig. 5 A–F), [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33359185
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"However, this compound did not inhibit LPS induced activation of extracellular signal regulated kinase and stress activated protein kinase and c-Jun NH (2)-terminal kinase, but significantly impaired activation of p38 mitogen activated protein kinase."
16183703
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"The results indicated that arctigenin reduced LPS-induced ERK and Src activation ( Fig. 4 B)."
22770942
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"Exploring possible signaling events in hemocytes challenged with Gram-negative bacteria, we have shown that LPS can cause a strong and prompt activation of ERK."
14563359
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"LPS at 100 ng/ml induced peak activation of MAPKs (p38 and ERK1/2) within 30 min of stimulation (XREF_FIG)."
18053081
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"We found that ERK and mTOR activation were involved after LPS stimulation and that LL-37 pretreatment and overexpression enhanced LPS-induced ERK and mTOR activation in HaCaT cells."
24984264
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"It reduces the expression of genes that code the oxidative stress response in the inflammatory gut (Welch et al., 2014), inhibits the LPS-induced activation of ERK 1/2 and p38 MAPK (Yuan et al., 2016), and alleviates cisplatin-induced nephrotoxicity by inhibiting NADPH oxidase and p38 MAPK (Rashed et al., 2011)."
38655179
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"Furthermore, LPC was able to block LPS induced ERK activation (XREF_FIG)."
24312681
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"However, LPS induced extracellular signal regulated kinase (ERK) activation was prolonged in pMphi comparing with sMphi."
16636012
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"The LPS-activated ERK contributes in LPS endocytosis independent of actin reorganization, whereas, Rho GTPases and PI-3K modulate the morphological changes in response to LPS.Monoclonal antibodies aga[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14563359
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"Agents that induce LT synthesis, i.e. ionophore and fMLP as well as TNFα, GM-CSF, LPS and phorbol esters that prime leukocytes for enhanced LT synthesis, activate ERKs, p38 MAPK and downstream MKs in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15907806
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"LPS upregulated p38 and transiently ERK1/2, while GA led to more sustained activation of ERK1/2, only."
20511709
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"Wild type Shigella flexneri but not LPS-defective mutant was able to stimulate ERK of the intestinal epithelium indicating that LPS may plays an important role in mediating epithelia signaling [22] ."
15748812
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"LPS dependent stimulation of PI3K activity, ERK1/2 activation, and p38 kinase activity was greater in PerMphi from db/db mice as compared with db/+ mice."
17202326
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"Consequently, these findings corroborate and extend our previous data ( Foukas et al., 1998 ), that LPS activates ERK via a sequential activation of Ras, Raf and MEK1/2, a signaling pathway described [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14563359
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"Based on toxin A results, which inactivates Rho family proteins, it appears that although Rho family proteins are activated in response to LPS (see below), they are not involved in ERK activation, as [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14563359
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"Numerous studies have shown that LPS can stimulate the cells and activate p38 MAPK, ERK 1/2, and JNK, which act on the corresponding substrates and influence the activity of various transcription factors [9]."
25082394
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"Moreover, it attenuated LPS-stimulated Erk–FoxO1 activation."
36012249
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"Specifically, inhibition of AKT enhances LPS-induced activation of ERK1/2, p38, JNK and NFκB in human monocytes, thus suggesting that AKT signalling may mediate inhibitory mechanisms of inflammation (33)."
36817783
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"Also, Hsu and Wen reported that LPS-induced intracellular ROS generation activated the ERK1/2 and p38 MAPK pathways, and regulated the release of IL-1β from mouse Mϕ ( Hsu and Wen, 2002 )."
18538348
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"LPS significantly enhanced the activation of JNK and ERK1/2 in PBMCs."
28942176
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"Several studies have shown that LPS-challenged monocytes/macrophages stimulate ERKs in a Raf-dependent manner via Ras ( Guha and Mackman, 2001 )."
14563359
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"In addition, LPS induced activation of extracellular signal regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK) was suppressed by quercetin and galangin."
29207037
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"Interestingly, we found that IRF-8-/- macrophages were impaired in the activation of LPS induced ERK and JNK and the production of proinflammatory cytokines induced by LPS or IFN-gamma plus LPS."
16484229
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"However, SA treatment significantly attenuated the LPS-stimulated activation of JNK, p38 and ERK."
36443908
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"While MT itself did not elicit any effect on the phosphorylation status of these signaling molecules, it ablated LPS induced activation of ERK, JNK and p38."
19914257
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"phorylation levels of IRAK4, TAK1, IKKa, ERK, P38, and JNK in PBMCs treated with PSP or LPS for 48 h were significantly upregulated (while p values of TAK1 and ERK in LPS group40.05), as shown by semi-quantification using densitometry and as fold-changes relative to b-actin."
23802631
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"P38, JNK, ERK and NF-kappaB subunit p65 inhibitors could significantly inhibit the secretion of IL-1beta, TNF-alpha and HMGB1 induced by LPS."
32862374
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"Therefore, we investigated the influence of malvidin on LPS induced activation of ERK, JNK and p38-MAPK."
23755222
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"Indeed, we found that ERK, p38 and JNK pathways were activated by LPS/D-GalN, which is consistent with the previous studies [32] ."
32272395
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"For Western blotting analysis of ERK, LPS was used as a positive control to stimulate ERK signaling pathway."
25708177
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"OT inhibited the LPS-induced activation of ERK1/2 and p38 MAPK in microglia (Yuan et al., 2016)."
38655179
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"Nox4 knockdown inhibited LPS induced ERK1/2, AP1, and NF-kB activation."
29085012
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"The results of our findings point to H. pylori LPS induced ERK dependent cPLA (2) activation as a critical factor influencing the level of PAF generation, and hence the extent of pathological consequences of H. pylori infection on the synthesis of gastric mucin."
17440231
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"However, this compound did not inhibit LPS induced activation of extracellular signal regulated kinase and stress activated protein kinase and c-Jun NH (2)-terminal kinase, but significantly impaired activation of p38 mitogen activated protein kinase."
21184860
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"In view of these findings, we examined whether RvD1 could inhibit LPS induced ERK1/2 activation and change endothelial permeability by protecting TJ integrity in endothelial cells and whether the changes in TJ protein expression could be reduced by inhibiting ERK1/2 activation."
24381712
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"Taken together, dasatinib affects TLR4 signaling to modulate LPS-induced proinflammatory cytokine levels.AKT and ERK signaling are associated with LPS-induced immune responses via TLR4 signaling [37]."
31655606
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"Consistently, our study showed that pre-treatment of RAW 264.7 cells with PNAP-6 and PNAP-8 decreased the LPS induced activation of ERK, p38 MAPK, and JNK."
28060845
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"However, N15 treatment reversed MCAO-induced and LPS-stimulated NF-κB p65, STAT3, and ERK1/2 activations."
28736035
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"These results suggest that daidzein ameliorated LPS-induced hepatocyte injury by inhibiting ERK1/2 and NF-κB signaling pathways.The increase in reactive oxygen species leads to the damage of cellular [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32712091
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"These evidences revealed that overexpression of TLR4 could activate LPS-induced ERK1/2 signaling dependently on IRAK4."
30522781
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"We have previously shown that LPS induces rapid activation of NF-kappaB p65 and ERK1/2 in macrophages, while STAT1 and STAT3 are activated with delayed kinetics, due to IFN-beta production and signaling."
22925925
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"LPS-stimulated RAW264.7 cells can activate ERK, JNK and P38 in MAPK signaling, thereby affecting the activity of a variety of transcription factors, which can further regulate the expression of various cytokines."
36834992
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"Early LPS induced ERK activation in retinal pigment epithelium cells is dependent on PIP 2 -PLC *."
27006973
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"LPS activation of ERK-1/2 additionally requires transphosphorylation of TPL-2 on serine 400 in its C terminus, which controls TPL-2 signaling to ERK-1/2 independently of p105."
22988300
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"Furthermore, BRE pre-treatment of the cells for 1 h significantly decreased ERK and JNK activation that was induced by LPS (XREF_FIG)."
33505935
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"LPS is thought to activate ERK1/2 via the Ras/Raf-1/MAPK kinase-1 (MKK1 (mitogen-activated protein kinase kinase 1) or MEK1 (MAP kinase/ERK kinase 1)) cascade."
24975832
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"The present results obtained with BV-2 cultures showed that KHG26693 suppresses LPS-induced activation of ERK, but not p38 MAPK ( Fig. 4 )."
24975832
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"Fig. 4 E shown that LPS-induced p42/44 MAPK activation only was decreased by DN-PLD2 transfection."
19963059
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"In this study, WAS inhibited LPS-induced activation of NF-κB and ERK."
33242622
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"Experimental evidence demonstrates that LPS stimulation of murine peritoneal macrophages activated ERK1/2 signaling, causing the subsequent induction of TNF-alpha secretion."
32655419
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"Recent studies done by Skinner et al. demonstrated that LPS induced ERK activation is responsible for regulation of TNF-alpha nuclear export through modulating exon junction complex proteins, TAP and NxT1, in macrophages [XREF_BIBR]."
19447225
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"In molluscan hemocytes, also, LPS induces a transient activation of ERK that is critical to efficient phagocytosis ( Plows et al., 2004 )."
21167168
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"It has been demonstrated that LPS treatment in macrophages leads to ERK 1/2, p38, and Akt activation ( Xagorari et al., 2002 )."
16762341
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"BRE was seen to inhibite the LPS induced ERK and JNK activation in RAW 264.7 cells."
33505935
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"The data suggest that AT-RvD1 can suppress LPS-induced kidney inflammation by modulating STAT3/ERK signaling."
24709673
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"In addition, dasatinib affects LPS-induced downstream AKT and/or ERK signaling to alter neuroinflammation in BV2 microglial cells, primary microglial cells, and primary astrocytes (Fig. 17)."
31655606
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"In addition, MT alleviated LPS induced activation of ERK, JNK and p38 signaling cascades."
19914257
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"LPS stimulated HSCs activate ERK1/2 and NFkB in hepatocytes."
26031389
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"LPS and UEA1 induced intestinal ERK and JNK signaling intermediates at levels comparable to induction by re-colonization of XBD (Figure 3D); specific inhibitors of these signaling pathways significantly attenuated fuc-TLR4 mediated colonic fucosylation."
37007789
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"LPS treatment significantly increased phosphorylation levels ERK 1/2, p38 and JNK 1/2 in RAW264.7 macrophages (P < 0.05; XREF_FIG)."
28677786
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"Modulatory effects of clarithromycin on LPS-stimulated IL-8 production and ERK1/2 activation have been reported in human bronchial epithelial cells in vitro ."
23462295
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"Western blot results in Fig. 3 A showed that LPS induced significant JNK, ERK and P38 MAPK cascades as well as Akt and its downstream mTOR activation RAW 264.7 mouse macrophages."
23806687
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"It is well known that LPS activates several intracellular signaling pathways including the three mitogen activated protein kinase (MAPK) pathways : extracellular signal regulated kinase (ERK), stress activated protein kinase and c-Jun N-terminal kinase (SAPK and JNK) and p38 MAP kinase."
19235539
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"Additionally, Ji et al. [51] suggested that LPS downregulates miR-132, which in turn attenuates LPS-stimulated inflammatory cell damage by regulating TRAF6 and inhibiting the activation of the NF-κB and MEK/ERK signaling pathways."
35443851
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"PEP-1-Prx2 significantly decreased the phosphorylation of LPS induced ERK1/2, p38 and JNK."
25241246
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"LPS and HSC stimulated ERK1/2 activation, which was still persistent at 12 h (XREF_SUPPLEMENTARY), unlike the decline in JNK activation (XREF_SUPPLEMENTARY)."
26031389
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"In addition, BDB also inhibited the LPS induced activation of ERK1/2."
20691245
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"The macrophage inflammatory response induced by the bacterial endotoxin lipopolysaccharide (LPS) activates several intracellular signaling pathways including the Iκ-B kinase (IKK)–NF-κB pathway and th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18544347
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"Moreover, as shown in Fig. 4 A, 15-MPA appeared to enhance slightly the LPS-mediated activation of ERK and SAPK/JNK."
18328446
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"Collectively, these results demonstrated that rigosertib prevented the LPS‐induced activation of the MEK/ERK pathway."
34061465
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"LPS activates all the three MAP kinase cascades in monocytes, namely p38, ERK and JNK pathways."
20430119
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"Generation of TNF-alpha, IL-1beta, ROS, and NO and ERK activation in cultured astrocytes treated with lipopolysaccharide (1mug/ml) were also prevented by 4-O-methylhonokiol in a dose dependent manner."
20974250
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"LPS can also stimulate phospho-ERK1/2 (p-ERK1/2) and phospho-cytosolic phospholipase A 2 (p-cPLA 2) pathways in primary and BV-2 microglial cells [XREF_BIBR]."
30795510
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"Namely, it dramatically attenuated the activation of the LPS induced extracellular signal regulated kinase (ERK) 1/2 and p38 mitogen activated protein (MAP) kinase in a tissue specific manner."
14999056
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"The new data presented here show that short exposure of RPE cells to lipopolysaccharide (LPS) induces an early and transient activation of the extracellular signal regulated kinase (ERK1/2)."
27006973
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"Another sigma-1 receptor agonist, (+)-pentazocine, reduced the release of tumor necrosis factor α (TNF-α), interleukin 10 (IL-10), monocyte chemoattractant protein-1 (MCP-1), and nitric oxide (NO) and inhibited LPS-induced activation of ERK and c-Jun N-terminal kinase (JNK) pathways (Zhao et al., 2014)."
| PMC
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"Blocking of ERK1/2 and NF- κB pathways prevent E.coli induced IL-8 production [89, 90] and TLRs present on the surfaces of intestinal epithelial cells appear to mediate LPS stimulation of ERK1/2 [91]."
36604713
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"6 remarkedly inhibited LPS-induced activation of ERK1/2 and JNK."
35597110
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"One possible mechanism is that LPS stimulates the TLR4 and ERK1/2 signaling which in turn activates hormone sensitive lipase and adipocyte triglyceride lipase."
21314942
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"Moreover, IL-21 inhibited LPS-mediated secretion of inflammatory cytokines, probably by downregulating the ERK1/2, in RA-SF MΦs. Conclusion ：For the first time, we indicated that IL-21 inhibits LPS-mediated cytokine production in RA-SF MΦs, and impairs pro-inflammatory activity of M1-like macrophages, hereby exerting anti-inflammatory effects on RA."
34842006
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"Western blot results showed that pharmacological inhibition of MyD88 reversed LPS-induced the activation of Notch ( Fig. 5 E), NF-κB ( Fig. 5 F), and ERK ( Fig. 5 G)."
30145468
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"Therefore, the antagonism of LPS-induced activation of ERK1/2 and JNK by 6 may lead to the decreased generation of pro-inflammatory molecules and thus obstruct M1-dominant phenotype polarization.NF-κB[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35597110
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"Immunobloting data revealed the abilities of TAKI to inhibit TAK1, IKK, ERK, p38 and JNK activation induced by LPS."
26381601
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"As shown in Fig. 8 a , LPS profoundly activated the ERK1/2, JNK, and p38."
35597110
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"As a control, we verified that U0126 treatment inhibited LPS induced ERK1/2 activation (XREF_FIG)."
18443198
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"inAtseralereuskuinlt, (ICL) P-S6, inILh-1ibbetai, taenddpproroinsftlaagmlamnadtionrEy2c (PytGoEk2i) nseesc, rieNtOioSn, and COX-2, which is attributed to the suppression of LPS induced ERK, JNK, and nuclear factor-kappaB (NF-kappaB) activation."
23131135
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"On the contrary, neither the phospholipase D 1 (PLD1) nor the PLD2 inhibition is able to modulate the early ERK1/2 activation induced by LPS in RPE cells."
27006973
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"It has been demonstrated that the inactivation of p38 and JNK was delayed in LPS-stimulated MKP-1-deficient macrophages without affecting ERK inactivation, supporting the notion that MKP-1 does not pl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21802073
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"We report that, in human PBMC, CD14 dependent LPS stimulation of p42/44 is regulated by PI3 kinase activity."
17126402
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"LPS upregulated the phosphorylated forms (i.e., activated forms) of p38, ERK1/2, and c-Fos (XREF_FIG), but these effects were attenuated by the CS or CSE pretreatments."
28617322
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"Knockdown of MLK4 enhanced LPS induced activation of JNK and ERK (XREF_FIG), while overexpression only reduced LPS induced ERK activation (XREF_FIG), suggesting that the effect of MLK4 on JNK and ERK activation is not all the same."
21602844
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"In addition, dioscoreanone in the range of 1.2-5microM significantly enhanced LPS induced ERK1/2 activation and dioscoreanone alone induced the activation of ERK1/2 proteins in a concentration- and time dependent response."
22678775
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"* The data provide additional information regarding the LPS induced ERK1/2 signaling in RPE cells."
27006973
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"Galangin was demonstrated to have anti-inflammatory effect in a different investigation using LPS-stimulated RAW264.7 macrophages, where the compound significantly decreased the production of NO, inducible NO synthase, IL-6, the NF-κB and suppressed the LPS-induced activation of ERK-1/2 and c-Jun N-terminal kinase [107].4.2.3 Antimicrobial activities."
38496846
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"As shown in Fig. 5 , LPS activated ERK, p38 MAPK, and JNK ( Fig. 5 A and B)."
25035231
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"* Results shown here demonstrate that the early and the late LPS induced ERK1/2 activation are differentially modulated by PIP2-PLC and PLD pathways."
27006973
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"Therefore, we concluded that TNG may reduce the levels of LPS-stimulated pro-inflammatory cytokines in LPS-induced ALI by inhibiting IκB, ERK and p38 MAPK signalling pathway activation.In conclusion, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25930113
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"These data demonstrate that the LPS induced early ERK1/2 depends exclusively on PIP 2 -PLC (XREF_FIG), while PLD2 activation is necessary to maintain ERK1/2 phosphorylation after 24h treatment XREF_BIBR."
27006973
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"LPS induced the activations of ERKs, p38 MAPK, and JNK, but S1P suppressed p38 MAPK and JNK, but further activated ERKs."
25035231
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"Specifically, DHC decreases lipopolysaccharide (LPS)-induced expression of various proinflammatory mediators by repressing p65 and extracellular signal-regulated kinase 1/2 (ERK1/2) activation in macrophages."
34552216
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"Most recently, TAOK1 was identified as a positive regulator of TLR4-mediated inflammatory responses, as the overexpression of TAOK1 led to an increase in LPS-induced ERK1/2 activation and cytokine production [62]."
37523115
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"In contrast, LPS treatment induced biphasic activation of ERK and p38 with a transient peak early on followed by sustained activation ( Fig. 5 A)."
17112694
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"Furthermore, alcohol and LPS have been found to induce macrophage M2b polarization by activating the MAPK/P38, MAPK/ERK, and NF-κB signaling pathways."
40034694
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"LPS stimulated extracellular signal regulated kinase (ERK) 1/2 and p38 phosphorylation, two signaling pathways regulated by ROS, were increased twofold in Kupffer cells from ethanol fed rats compared with pair fed controls."
16554353
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"LPS treatment in human retinal pigment epithelial cells activated ERK signaling, which is required for cytokine gene transcription [XREF_BIBR]."
29301251
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"Both PPARgamma ligands only have the effect of inhibiting LPS mediated ERK activity, but not p38 or JNK (XREF_FIG C)."
33339154
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"Pretreatment of cells with IFN-gamma did not affect LPS induced ERK, p38, JNK, Akt, and IkappaBalpha phosphorylation, suggesting that IFN-gamma-mediated enhancement of LPS induced TNF-alpha production[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24140406
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"Further, miR-335 inhibited LPS mediated ERK1/2 activation."
34211970
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"PKCzeta, an atypical protein kinase C isozyme, has been shown to play a central role in LPS induced activation of the ERK1/2 signalling pathways in macrophages."
18503635
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"The modulatory action of TLR7 on M-MØ responses was evident at the intracellular signaling level because CL264-treated M-MØ exhibited a weaker LPS-induced activation of ERK, JNK, and NFκB, and a complete loss of LPS- and CL264-induced STAT3 activation (Fig. 3e; online suppl."
37040733
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"Indeed, U0126 significantly inhibited LPS-induced ERK activation and cytokine expression by Mlkl −/− BMDCs ( Fig. 6 F and G)."
31158430
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"LPS induced ERK, p38, JNK, Akt, and IkappaBalpha phosphorylation in neutrophils was not affected by pretreatment of cells with IFN-gamma, suggesting that IFN-gamma affects the pathway downstream or in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24140406
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"Using immunoblot analysis with anti-phospho-specific antibody, we found that AEDF suppressed LPS-induced activation of ERK1/2, JNK and Akt in a dose-dependent manner ( Fig. 6 ), while activity of p38 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19607899
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"MCE critically suppressed LPS induced activation of ERK and p38 and had a milder inhibitory effect on that of JNK."
24489593
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"Both P. gingivalis LPS and E. coli LPS activated ERK1/2 in a similar manner (XREF_FIG.2)."
23554896
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"Forced expression of either adaptor, but not a mutant having a Tyr and Phe substitution, in macrophages inhibited LPS induced Erk activation and TNF-alpha production."
15699069
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"Moreover, PGN and LPS induce differential activation of MAP kinases, with LPS strongly inducing all three families of kinases (ERK, JNK, and p38), whereas PGN only induces ERK and JNK without affecting p38."
23264652
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"In our present study, similar results were obtained, with OOA significantly inhibiting the LPS activation of ERK and JNK pathway, which suggests that OOA is at least partly responsible for the anti-inflammatory effects previously observed."
30190667
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"Both LPS and EGF were stimulated ERK activation."
22675459
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"TLR4 stimulation by LPS increases ERK1/2 activity in macrophages by engaging the tumor progression locus‐2 (TPL‐2)/MEK1/2/ERK1/2 cascade."
34061465
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"Forced expression of Dok-1 or Dok-2 inhibits LPS induced Erk activation and TNF-alpha production."
15699069
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"Solanine A also managed to inhibit LPS/INFγ stimulated ERK1/2 signaling in RAW264.7 macrophages, indicating a possible contribution to its anti-inflammatory potency, which was observed by lower levels of STAT-1 and 3 phosphorylation in western blotting."
37446619
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"XREF_BIBR, XREF_BIBR To study the molecular mechanism underlying the downregulation of these signaling pathways, we investigated the inhibitory effects of these AMAC compounds (3f, 3m, 4b, and 4d) on ERK1/2 and NF-kappaB stimulated by LPS."
25834403
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"Moreover both forms of LPS activated NF-kappaB, p38 MAPK and ERK pathways, but not the SAPK and JNK pathway."
23554896
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"In contrast, E 2 did not affect the LPS induced activation of ERK1/2 and JNK (data not shown)."
24376635
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"In contrast, iNOS and COX-2 levels were found to be clearly decreased in the treatment of HA in a concentration-dependent manner (1.25–5 μM) compared to the LPS group ( p < 0.01), as expected.As illus[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34506938
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"We therefore focussed our research on identifying activators of the MEK and ERK cassette that were stimulated by LPS, inhibited by the anti CD14 blocking antibody 28C5 and essential for cytokine produ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17126402
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"Collectively, these data support the novel concept that TLR4 activation in ASM elicits changes in ASM function that are regulated by opposing effects of MAPK signaling, wherein LPS induced ERK1/2 activation mediates NF-kappaB-dependent proasthmatic like changes in ASM function, whereas coactivation of p38 MAPK serves to homeostatically downregulate the proasthmatic effects of ERK1/2 activation."
16581829
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"Although little is known about the regulation of Erk downstream of LPS, it was reported that a MAP kinase kinase kinase, Tpl2 and Cot, is required for the LPS mediated activation of Erk in macrophages."
15699069
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"In conclusion, our findings demonstrated for the first time, that signaling initiated by WISP1-integrin ligation modulated LPS induced ERK activation and primed macrophages to an enhanced response to LPS exposure."
27349568
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"The p38, ERK1/2 and JNK pathways were activated by LPS; however, the p38 and ERK1/2 pathways were blocked in AQP-1-overexpressing cells."
29731819
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"Solanine A shows strong anti-inflammatory activity in LPS or IFN-γ activated macrophages and animal inflammatory models by inhibiting NF-κB, ERK1/2, AKT and STAT1 signaling pathways [84]."
34284780
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"Emodin also inhibits proinflammatory cytokine expression in LPS-induced macrophages by suppressing ERK1/2 and p38 signaling."
35873545
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"Valnemulin markedly inhibited LPS-induced activation of ERK1/2, p38 and JNK MAPKs in a dose-dependent manner."
19293003
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"Lipopolysaccharide (LPS) is a well-known activator of ERK1/2 through Toll-like receptor stimulation [52] ."
16427623
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"In addition to its role in receptor internalization, beta-arrestin 2 is required for LPS induced extracellular signal regulated kinase (ERK) 1/2 activation in macrophages."
29507126
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"While Western blotting showed that 100 microM PD 98059 completely inhibited LPS mediated ERK activation, oxidative response to fMLP by a chemiluminescence assay revealed that the same concentration inhibited the LPS primed oxidative burst by only 40%."
11292734
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"The increased LPS-induced activation of ERK1/2 in Bcl3 cells was sensitive to treatment with MEK1 inhibitor, demonstrating that it results from enhanced MEK1 activity (Fig. 2E)."
31772019
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"We therefore designed FA-functionalized exosomes co-loaded with resveratrol (an anti-inflammatory polyphenol) and celastrol (an immunosuppressive pentacyclic triterpenoid; FA-Exo/R+C), which exhibited powerful anti-inflammatory and immunosuppressive activities against LPS-stimulated macrophages in vitro by regulating NF-κB and ERK1/2 signaling pathways."
37530416
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"Although 13-HOA abrogates the LPS-induced activation of ERK1/2, JNK1/2, and p38 MAPK, the relevance of MAPK inhibitory activities toward NFκB and AP-1 suppression, as well as its inhibition of the exp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16143312
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"Previously it has been shown that LPS activates ERK in macrophage cell lines and human monocytes [16] and that CD3/CD28 stimulation activates MAPKs in T-cells [17] ."
19428337
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"To assess the mechanism by which Tau-Cl treatment suppresses LPS-induced ERK1/2 activation, we evaluated the influence of Tau-Cl on the small molecular weight G protein Ras, which is a known to be an [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16169526
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"Furthermore, the pathways used by Salmonella and LPS to stimulate ERK are identical, suggesting that kinase activation might be solely mediated by LPS."
10024537
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"As shown in Fig. 3 , treatment of Tau-Cl reduced the LPS-induced Ras-GTP level, suggesting that Tau-Cl regulates LPS-induced ERK activation by interfering with Ras activation.Among several transcripti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16169526
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"First, LPS activates not only ERK, but also JNK and p38 in Kupffer cells 30."
29317674
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"Furthermore, fisetin also finds application in treating depression and LPS induced depression by increasing the expression of Tropomyosin-related kinase B (TrkB)/brain-derived- neurotropic factor, PI3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34516952
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"We show that treatment of differentiated THP-1 cells with purified Stx1 resulted in prolonged activation of c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase (MAPK) cascades, and lipopolysaccharides (LPS) rapidly triggered transient activation of JNK and p38 and prolonged activation of extracellular signal regulated kinase cascades."
16301326
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"In that pharmacological inhibitors of PI3K inhibited LPS induced activation of p21Ras, but not activation of ERK, we concluded that LPS induced activation of ERK occurs through a pathway that is not dependent on the activation of p21Ras."
16339563
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"Our previous report also showed that LPS plus IFNgamma induces ERK activation in microglial cells [ 26,27 ] ."
30585203
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"These results prove that CP treatments exhibit anti-inflammatory effects on suppressed inflammatory chemokines and cytokines by inhibiting pro-inflammatory mediators, including PI3K-p55, Akt, Erk1/2, p38, and NF-κB, in the LPS-stimulated LA4 cells (Figure 4, Figure 5 and Figure 6)."
35743888
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"LPS induced ERK1/2 activity in a dose-dependent manner ( Fig. 3 A and B )."
21762685
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"Our preliminary experiments indicated that both cell lines required a much higher LPS concentration to evaluate the phosphorylation of ERK1/2 with Western blotting than to evaluate IL-8 mRNA expressio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21762685
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"Many MPs are capable of inducing inflammatory pathways in DCs mediated by signaling via the extracellular signal regulated kinase 1/2 (ERK1/2) which can be activated by growth factors, cytokines, stress factors, viral infections, carcinogens, and bacterial components such as, lipopolysaccharide."
28894739
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"6-S also inhibited LPS mediated ERK1/2 activation as well as NOS2 and MyD88 induced expression as determined by Western blot."
24039109
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"These findings were consistent with LPS activation of ERK in vivo (XREF_FIG)."
19895919
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"Signaling analyses showed that LPS induced activation of ERK but not AMPK, which was constitutively activated in rENSpc neurons."
25497784
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"Diosmetin inhibited the LPS-induced activation of the ERK, p38, and JNK pathways, as well as iNOS expression and NO production [37]."
35807509
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"As shown in Fig. 2 B–E, LPS stimulation induced a notable enhanced phosphorylation of p38, ERK, JNK, IκBα, and p65 ( p < 0.05, p < 0.01 versus naïve neutrophils), whereas pretreatment with PVB substan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38006749
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"On the other hand, lipopolysaccharide stimulation of ERK1/2 was shown to increase TNFalpha production."
26069204
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"Specifically, LPS activation of the p38, JNK1/2 and ERK1/2 MAPK signaling pathways that regulate proinflammatory gene expression in macrophages were significantly reduced in PTEN -/- macrophages, which have enhanced Akt activation."
19447494
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"Similarly, LPS activation of ERK1/2 and induction of TNFalpha expression were reduced in SH2 domain containing inositol 5 -phosphatase (SHIP) -1 -/- macrophages, which have enhanced Akt activity."
19447494
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"We show the anti CD14 blocking antibody 28C5 suppresses LPS induced ERK1/2 activation and TNF-alpha production in PBMC."
17126402
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"Since PKC phosphorylates Raf, which acts directly upstream of MEK [20] and since LPS induced ERK-1/2 activation may be mediated by PKC [21], we reasoned that PKC may be involved in LPS mediated phosph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14505805
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"Thus, we investigated whether PO could inhibit the phosphorylation of MAPKs including p38 MAPK, JNK, and ERK1/2 induced by LPS."
25256685
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"Nguyen et al. reported that miRNA-193a targets TGF-β-2 directly and further attenuates the production of inflammatory factors IL-6, TNF-α, and IL-1β induced by LPS through ERK activation (43)."
34988180
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"However, BMD compound did not inhibit LPS-induced activation of ERK-1/2, JNK and p38 kinase ( Fig. 8 ), where MAP kinase pathways are also involved in transcriptional activation of LPS-inducible iNOS [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16183054
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"In addition, LPS treatment also induces a more sustained activation of ERK and p38 than PMA."
25768345
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"Although we showed LPS activated ERK signaling with a simultaneous increase of RANKL and M-CSF in calvarial tissues, we were not able to identify the specific cell types that play a major role in inflammatory osteolysis."
19895919
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"LPS treatment induced activation of Erk1/2 within 30 min, which was dose-dependently inhibited by PD98059, a specific inhibitor of the Erk kinase (MEK)."
12465042
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"And LPS is known to activate NF-κB and ERK 1/2 in vascular inflammatory responses [48–50] ."
24262867
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"Therefore, we tested the effects of PT on the activation of NF-κB and ERK 1/2 by LPS."
24262867
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"LPS stimulation of extracellular signal regulated kinase 1/2 (ERK1/2) and p38 MAPK was inhibited by torilin."
19298258
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"High dose of LPS induced significant downregulation of ERK 1/2 proteins in the young WT animals, whereas pretreatment with the low dose of LPS prevented this change."
32693349
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"Furthermore, it has been reported that a 100 nM incubation with the PI3 kinase inhibitor wortmannin inhibits LPS induced activation of ERK1/2 in LPS stimulated BAC1.2 F5 cells (Procyk et al., 1999)."
17126402
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"These findings suggest that P. gulae LPS activates p38 and ERK1/2 via TLR2 and TLR4, leading to inflammatory responses in human gingival epithelial cells."
32827217
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"PYR and ACh ameliorated diabetic myocardial injury by inhibiting the LPS-induced ERK/Egr-1 pathway and metabolic inflammation."
37039813
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"TIIA alone had no effect on ROS production and Nox2 expression.Accumulating research data have demonstrated that LPS activates the ERK1/2 and p38 MAPK, both of which are essential for TNF-α expression[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26202805
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"Here, the depletion of PKC by PMA precluded the activation of ERK-1/2 and suppressed the induction of iNOS mediated by LPS, indicating that conventional and novel PKC isoforms are involved in LPS medi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14505805
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"Heparin inhibited HMGB1-dependent enhanced activation of p38 and ERK1/2 induced by LPS."
25562836
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"Yu et al. [1] found that RANKL gene expression was up-regulated by lipopolysaccharide-induced ERK1/2 signaling pathway activation and induced inflammatory reaction."
32769069
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"Moreover, LPS pretreatment enhanced the activation of NF-kappaB, ERK and JNK by MDP in hepatocytes."
22218461
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"LPS also activated P38 and ERK activation ( Fig. 4 B, C)."
17673145
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"Interestingly, in the study, we observed that LPS can induce ERK1/2 and p38 MAPK activation, both of which were suppressed by pretreatment with TIIA."
26202805
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"As shown in Fig. 2, LPS stimulation resulted in activation of ERK, p38 kinase and NF-kappaB signal pathways."
11947920
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"PD98059 and SB203580 could inhibit LPS induced activation of ERK and p38kinase, respectively, at the dose of 30 muM."
11947920
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"In addition, pretreatment with NJ-6 significantly inhibited the LPS induced activation of ERK 1/2, JNK, and p38 (XREF_FIG)."
24795771
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"NF-kappaB, ERK and p38 kinase signal pathways activated by LPS are involved in the upregulation of TLR9 gene expression by LPS."
11947920
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"Our results demonstrated that p38, ERK, and JNK signaling pathways were activated by LPS in RAW264.7 cells, and stauntoside B mainly inhibited ERK phosphorylation expression ( Fig. 8 A⿿C)."
27343699
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"As shown in Figure 5A–D, LPS strongly activated ERK, JNK, and p38 MAPK (their phosphorylated forms, pERK, pJNK, pP38 MAPK are shown) whereas ERK and JNK were slightly activated."
35234314
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"As shown in Fig. 5 A, TRIM7 overexpression significantly promoted the LPS-induced activation of ERK1/2, p38 and JNK1/2."
30928727
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"In this study, LPS was shown to activate ERK, P38, Akt and NF-κB in DC maturation."
17673145
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"These results demonstrate that the AMPK and ERK pathways participate independently in LPS induction of TNF-alpha production by the ENS. Electrical field stimulation inhibits AMPK and lipopolysaccharide induced ERK activation."
25497784
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"A possibility, however, is that PI3 kinase activation of PKC overcomes the PKB block of Raf activity as PI3 kinase activation of PKC has been reported necessary for LPS induced ERK1/2 activation (Proc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17126402
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"Here, TLR4 internalization was necessary for LPS induced ERK1/2 activation and TNFalpha production."
33643293
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"Indeed, LPS induces p38, JNK, and ERK activation in BV2 cells [165,166]."
| PMC
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"The first aim was to determine whether LPS induces ERK1/2 activation and changes in epithelial permeability in epithelial cells alone or only in the presence of immune cells."
15025824
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"Fig. 5 Effect of CpG ODN preexposure on LPS mediated activation of ERK, JNK, and p38 MAP kinases in RAW 264.7 cells."
12219019
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"As shown in Fig. 5C, although cholesterol accumulation in PMφs impaired LPS-induced NF-κB and ERK activation, they remained unaffected in PMφs with accumulated oxLDL, as was shown in our past study (5)."
38193847
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"Inhibition of IL-6 production was the least affected by Sim alone treatment through LPS-induced ERK, JNK and AKT activity."
31513872
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"Previous studies have established that LPS treatment of cells such as macrophages and synovial fibroblasts induce TLR4 mediated MyD88- and TRIF dependent ERK activation leading cytosolic PLA 2 activation and AA-COX-2-PGE 2 synthesis."
22448089
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"Investigation of underlying mechanisms of stauntoside B showed that it exhibited anti-inflammatory activity by inhibiting LPS-induced NF-κB signaling pathway and ERK activation in RAW264.7 cells, and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27343699
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"Overall, these results suggested that the knockdown of circDHTKD1 alleviated the LPS-induced production of inflammatory cytokines and activation of the ERK pathway in BEAS-2B cells through the miR-338-3p/ETS1 axis."
37273760
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"The results revealed that kaempferol inhibited LPS‐induced activation of p38 MAPK, JNK, and ERK in BV2 cells, which have been reported to be involved in inflammatory mediator production in response to a wide variety of stimuli, including LPS."
35234314
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"Moreover, the up-regulation of P-gp expression, the activation of AKT and NF-kappaB and MAPK and ERK pathway induced by LPS was attenuated by GSP administration."
23967153
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"Here, we also found that LPS treatment increased the activation of ERK, JNK, and p38 MAPK in RAW264.7 cells."
33812268
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"Western blot analysis showed that LPS treatment elicited the activation of ERK 1/2 and p38 MAP kinases."
12203390
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"Furthermore, it has been reported that LPS-stimulated ERK activation is MyD88 dependent or independent [35,37]."
36613563
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"To clarify the phosphorylation sites on C/EBPbeta by LPS activated ERK, these two amino acids were separately mutated to alanine by point mutation to create the C/EBPbeta-S 64A and C/EBPbeta-T 188A mutants."
26114754
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"However, LPS did not stimulate ERK1/2 activation in BV-2 cells, indicating that ERK1/2 activation is not involved in LPS action in this cell type, which is consistent with previous finding [XREF_BIBR]."
18036262
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"In RAW264.7 cells, PDL treatment prevented LPS-induced activation of the ERK/Akt signaling pathway and significantly decreased the levels of inflammatory cytokines, such as IL-1beta, IL-6, and TNF-alpha."
36797333
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"Astragaloside IV decreased LPS stimulated activation of ERK in renal tissue during endotoxinemia."
28328867
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"The data showed that LPS treatment increased activations of JNK, ERK, and p38; however, Herbacetin inhibited the activation of JNK in a dose-dependent manner."
26297979
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"Addition of low doses of LPS (10, 100 ng/ml) up to 1 mug/ml of LPS had no effect on iHsp70 expression, but strongly activated ERK."
23043959
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"Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal regulated kinase in macrophages."
17709378
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"These data suggested that PA suppressed LPS-induced activation of ERK1/2 pathway, and augmented LPS-induced activation of p38 and JNK pathways.The production of TNF-α and IL-1β has been shown to be di[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34923420
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"DNase accessibility analysis was therefore employed to determine whether LPS activation of ERK resulted in modulation of chromatin remodeling at the promoter region of the G-CSF gene."
26114754
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"In macrophages, Tpl2 and Cot is essential for the activation of ERK by LPS via TLR4 and the export of TNF-alpha mRNA from the nucleus [XREF_BIBR]."
15575964
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"Lipopolysaccharide (LPS), a component of bacterial wall and commonly used inducer of the monocyte/macrophage cell lineage, acting via Toll-like receptor 4 (TLR4), also stimulates mitogen-activated pro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16198162
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"Lipopolysaccharide (LPS), a component of bacterial wall and commonly used inducer of the monocyte/macrophage cell lineage, acting via Toll-like receptor 4 (TLR4), also stimulates mitogen-activated pro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16198162
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"PDL may also be able to reverse LPS-induced cellular inflammation by inhibiting the ERK/Akt pathway.As important immune cells, macrophages serve as the first line of defense against invaders (e.g."
36797333
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"We found that LPS induced ERK and P38 activation."
26872986
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"Emodin suppressed Erk1/2 and p38 signaling induced by LPS in macrophages."
24740873
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"In in vitro studies, we found that pretreatment with ambroxol at 0.2, 2 and 20 μM dose-dependently inhibited LPS-induced increases in MUC5AC, TNF-α and IL-1β mRNA in the lung epithelial cells by inhib[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26872986
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"Pon1 deficiency in rat primary microglia activated Trem2 pathway but decreased LPS-induced ERK activation."
35589918
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"Addition of low doses of LPS had no effects on iHsp70 expression, but strongly activated ERK."
23043959
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"Previous studies demonstrated that the racemic form of PCB inhibited LPS-induced PGE production and significantly inhibited TNF-α, IL-1β, and IL-6 production by disrupting MAPK activation involving p38, JNK, and ERK kinases [30]."
39512302
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"For instance, it has been reported that also NRG-M downregulates TNF-α, IL-6, and IL-1β in lipopolysaccharide-stimulated macrophages in vitro by suppressing the activation of the ERK1/2, JNK, and NF-κ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29174382
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"Our study demonstrated that Sa.LTA decreased LPS induced ERK activation in splenocytes and B cells."
29367683
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"LPS plays little or no role in the induction of iNOS in human cells including astrocytes and hepatocytes (Liu et al., 1996; Geller et al., 1995), therefore, we can not address the role of LPS induced [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12020969
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"One study recently found that treatment of bone-marrow-derived macrophages with Li induces degradation of p105 that subsequently leads to inhibition of LPS induced ERK pathway and therefore LPS induced TNFalpha transcription [XREF_BIBR]."
23904208
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"The previous study showed that sauchinone did not inhibit the activation of p38 and JNK in Raw264.7 cells treated with LPS, whereas it reduced LPS-stimulated ERK1/2 activation [17] ."
22824073
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"Our studies indicated that ERK1/2, p38, JNK, NF-kappaB, AP-1 can be activated by LPS treatment."
27713159
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"Youssef et al. showed that LPS can quickly activate p38, ERK, and JNK signaling in microglia [XREF_BIBR]."
33727946
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"The phosphorylation of intracellular signaling molecules of NF-kB pathway, including phosphoinositide 3-kinase (PI3K)/p85, AKT, inhibitor of NF-kappaB (IkappaBalpha) kinase alpha/beta (IKKalpha and beta) and IkappaBalpha, and TRAF family member associated NF-kappaB activator (TNAK)-binding kinase 1 (TBK1), a key intracellular signaling molecule of IRF-3 pathway, as well as MARK pathways were activated by extracellular LPS, as expected, in WT Raw264.7 macrophages, while their activations, with the exception of ERK, were reduced in p204 deficient Raw264.7 macrophages treated with LPS."
29472103
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"Effect of ATL-III on LPS induced activation of ERK1/2, JNK1/2 and p38Since NF-kB activation was inhibited by ATL-III, we further examined the role of ERK1/2, JNK1/2 and p38."
26667579
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"The LPS increased the p/t volume of ERK up to 2.26 +/- 0.091."
28665991
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"P38 is one of three MAPK signaling pathway subfamilies, and phase I LPS has been shown to activate the other two pathways, c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) (70)."
37533862
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"Besides, enhanced ERK phosphorylation was also observed in splenocytes treated with LPS and Sa.LTA after the pretreatment with the JAK inhibitor."
29367683
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"Yoshimura et al. (2002) found that the expression of human TLR-4 in cells respond to LPS preparation from A. actionomycetemcomitans , here we reported the ERK 1/2 activation induced by LPS is due to t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16318859
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"Furthermore, if we blocked LPS induced ERK signaling by U0126, the expression of connexin 43 and UDP release was also inhibited dramatically."
26783339
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"EGCG has also been reported to inhibit the phenotypic and functional maturation of murine DCs by suppressing the LPS induced activation of ERK, JNK and p38 MAPK [XREF_BIBR]."
26185959
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"This protein may thus specifically inhibit LPS-induced inflammatory cytokine production by affecting JNK, ERK1/2, and p38 activities.In summary, the present study suggested that 2″-hydroxy-3″-en-anhyd[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20462523
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"MAPK signaling, including JNK, ERK1/2 and p38 MAPK, which can be activated by LPS and TNF-alpha, is reported to play an important role in LPS induced inflammation [XREF_BIBR]."
27191745
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"Although we showed that IH-1 did not affect the LPS-induced activation of ERK ( Fig. 8 ), our results also revealed that IH-1 augmented the LPS-induced phosphorylation of not only MKK3/6 and p38, but [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34474272
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"We found that Nlrp12 is predominantly expressed by neutrophils, and Nlrp12 deficiency did not affect NF-κB and ERK signalling pathways induced by LPS stimulation, or infection with Salmonella typhimur[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26514298
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"miR-101 regulates the LPS induced activation of ERK1/2, p38 and JNK and induces production of TGF-beta."
26158762
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"These results suggest that miR-101 may regulate the LPS induced activation of ERK1/2, p38 or JNK through targeting DUSP1."
26158762
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"[7980] The findings of the present investigations demonstrated that LPS treatment stimulated ERK and JNK and that RIC drastically inhibited ERK and JNK activation and decreased the levels of TNF-α, IL-1 β, IL-6, and HMGB1."
37576576
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"The previous paper has reported that LPS plus zVAD induced more ERK activation in BMDMs ."
30442927
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"PD184352 has been previously shown to block LPS induced ERK1/2 activation XREF_BIBR and is also able to block ERK1/2 phosphorylation in response to heat killed C. albicans (XREF_FIG)."
21060679
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"The results of a study by Kil-Nam et al. [143] indicate that essential oil obtained from Citrus medica L. inhibits LPS-stimulated inflammation by blocking the NF-κB, JNK, and ERK pathways in macrophages, which is evidence of its effectiveness as an anti-inflammatory agent."
35745226
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"Our results showed that LPS activation of JNK, ERK, and p38 was down-regulated by parkin overexpression."
31479867
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"These results as well as ours placed LPS and IFNgamma activation of ERK1/2 and cPLA 2 upstream of the NF-kappaB transcriptional pathway."
26520095
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"Importantly, we found that both SNL surgery and LPS exposure remarkably promoted the activation of TAK1, TBK1, p38, ERK1/2 and JNK1/2 in spinal cord tissues and microglial BV2 cells."
36279673
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"Subfractions of the chloroform extract markedly suppressed LPS mediated activation of the extracellular signal regulated kinase and nuclear factor kappa-B."
23631491
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"LPS activates the NFκB pathway and all three MAPK pathways (ERK, JNK/SAPK, and p38α), leading to a wide range of cellular responses, including cell differentiation, survival or apoptosis, and inflammatory responses ."
34083739
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"Cells that were co-stimulated with palmitate and mmLDL had significantly higher levels of phosphorylated ERK and p38 compared to the macrophages treated with LPS alone."
29518116
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"Functional differences between TGF-M-DCs and TGF-GM-DCs included enhanced responses to LPS induced ERK, JNK, and P38 activation in TGF-M-DCs and their immune suppressive skewed cytokine release profiles."
17585053
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"LPS stimulation increased ERK1/2 activation compared to unstimulated cells."
30515163
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"Our previous study showed that AR inhibition reduces lipopolysaccharide-induced ERK activation in macrophages [22]."
36499422
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"In order to investigate whether the inhibition of TNF-α, IL-6 and NO production by THC is mediated through the MAPK pathway, we examined the effects of THC on the LPS-induced phospho-ERK1/2 and phosph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23810685
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"In addition, it also inhibited the LPS induced activation of ERK1/2."
32802090
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"The maximal activity of LPS induced ERK, JNK, and p38 was 12- (30 min), 5- (30 min), and 16-fold (15 min), respectively."
11940570
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"In glial cultures, LPS induced activation of ERK1/2, p38 and JNK."
23034047
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"Regarding the TLR4 mediated NF-kappaB and ERK signaling, overexpression of ROCK1 increased the activity (phosphorylation form) of ERK1/2, JNK, and p38 which was firstly induced by LPS (XREF_FIG, XREF_SUPPLEMENTARY)."
29804125
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"In contrast, in neuronal cultures, LPS activated JNK but not ERK1/2 or p38, and the specific JNK inhibitor SP600125 significantly blocked LPS induced KC expression and release."
23034047
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"PD98059, which prevented TNF- and LPS induced ERK activation (not shown), proved to be a potent inhibitor of ODC induction, but did not influence NOS induction."
11852055
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"GRK2 can negatively regulate LPS-induced ERK pathway in macrophages and decrease cytokine production."
35430346
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"To determine if LPS induced ERK or JNK and p38 kinases are affected by paclitaxel treatment, we quantitated the activities of these kinases in spleen cells."
10988356
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"Interestingly, despite inhibition of Raf-1 kinase activation, paclitaxel treatment exhibited no effect on LPS induced ERK activation."
10988356
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"These data suggests that LC extract regulates the LPS-induced IκB-α degradation and JNK phosphorylation, but does not affect LPS-induced ERK and p38 phosphorylation.NF-κB and AP-1 binding sites have b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24145006
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"As previously reported [23,24], we observed that LPS could activate the stress activated MAPKs, JNK and p38 as well as Raf-1 and ERK pathway in both 70Z/3 and spleen cells."
10988356
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"Three MAPK pathways, JNK, ERK and p38 have been reported to be activated by LPS in macrophages and the latter two also in HUVECs [35] ."
15225624
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"Additional in vitro experiment shows that DHA treatment plays a protective role in LPS induced vascular smooth muscle cell (VSMC) proliferation and inflammatory response by regulating ERK, p38 and NF-kappaB and p65 signaling pathways [XREF_BIBR]."
27482523
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"There are three MAPKs called ERK, p38 and JNK, which are activated by LPS treatment."
29957490
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"We show here that DOK3 is a negative regulator of TLR signaling by limiting LPS induced ERK activation and cytokine responses in macrophages."
22761938
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"Because IL-6 activates ERK1/2, which has been reported to be a kinase for STAT3 phosphorylation on Ser 727, and we have previously reported that GW501516 prevents LPS induced ERK1/2 activation in adipocytes, we evaluated the effect of the PPAR-delta agonist on the activation of this kinase."
21617181
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"Both GRK2 and 5 can negatively regulate LPS induced ERK pathway in macrophages XREF_BIBR, XREF_BIBR."
26226012
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"In addition, Cortex Phellodendri inhibited inducible nitric oxide synthase (iNOS), activated nuclear factor-kappaB (NF-kappaB) by degradation and phosphorylation of IkappaBalpha, and attenuated phosphorylation of mitogen activated protein kinases such as ERK1/2, p38, and JNK in mice treated with lipopolysaccharide [XREF_BIBR]."
25834623
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"administration of LPS to rats, endotoxin induces NF-κB p65, p38 MAPK, and ERK activation."
21195213
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"Neither LPS nor anisomycin induced an increase in ERK, perhaps because of high basal levels of ERK activity resulting from culture in GM-CSF (Valledor et al., 2000)."
12617997
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"The involvement of D3R in the regulation of the ERK1/2 signaling pathway caused by LPS induced depressive like behavior was evaluated by performing western blotting analysis."
29390063
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"These data clearly highlighted the potent anti-inflammatory effect of Compound A.TLR4 regulates multiple inflammatory signaling cascades including NF-κB, ERK, JNK and p38 pathways all of which can be [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26869203
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"Because ligation of TLR4 triggers the activation of MAP kinase and NF-kappaB, leading to production of proinflammatory cytokines through the MyD88 dependent pathway, we investigated the activation of MAP kinase such as JNK, p38, and ERK1/2 in macrophages treated with LPS or 2,000 kDa gamma-PGA."
19294383
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"Liu et al. reported that geniposide inhibits IL-6 and IL-8 production in LPS-induced human umbilical vein endothelial cells by blocking P38 and ERK 1/2 signaling [27]."
38339007
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"Pg LPS also induced ERK, p38, and JNK activation, and Pg LPS induced PAI-1 expression was inhibited by ERK/p38/JNK inhibitor pretreatment."
24500480
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"AP-1 promoter activity and p38 MAPK activation but not PKC, ERK and JNK activation induced by LPS were attenuated by oregonin."
16025135
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"First, phosphorylation of MAPK, a signaling protein representative of ERK, JNK, and p38, activated by LPS, was confirmed by western blotting."
33572173
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"LPS activates TLR4/CD14 and a series of downstream targets, such as senescence-associated receptor PK, JNK, ERK1/2, and p38, through the myeloid differentiation factor 88–dependent/independent MAPK signalling pathway."
37143126
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"These results suggest that SFEIO exerts its anti-inflammatory effects in LPS activated RAW 264.7 cells by down-regulating the activation of ERK, JNK, and NF-kappaB."
27822172
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"To examine the direct effect of LPS on the activation of ERK1/2, p38 and JNK, H9c2 cells were treated with various concentrations of LPS (0.1-10mug/ml) for 15min to assess activation."
28878808
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"On osteoclasts, icariin suppresses LPS mediated activation of the p38 and JNK; while on the osteoblasts, icariin reduced the LPS induced activation of ERK1/2 and I-kappa-B-alpha (IkappaBalpha), but increased the activation of p38."
20554188
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"LPS-mediated extracellular signal-regulated kinase (ERK) activation abrogates the binding of hepatocyte nuclear factor 4 (HNF4) to the Ppara promoter and attenuates PPARα expression, while PPARα promotes PEDF expression by binding to the Pedf promoter."
39027319
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"Although LPS activated three MAP kinases in murine macrophages, only JNK was targeted by CLEN : while LPS activated p38, ERK, and JNK, CLEN only attenuated the LPS induced rise of JNK activation."
28929026
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"Finally, whether S100A1 could affect the inflammation, oxidative stress and apoptosis of PC12 induced by LPS through ERK signaling pathway was explored."
36524376
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"The results showed that LPS-induced ERK, p38, JNK and IκBα protein phosphorylation were decreased by L1, L4, W2 and W4, respectively ( Fig. 7 A–F)."
29494841
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"LPS activates all three types of MAPKs (ERK, JNK, and p38) in mouse macrophages [49] ."
26327113
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"LPS treatment has been reported to induce ERK, JNK, and p38 activation in macrophages [XREF_BIBR]."
19294383
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"Consistent with the in vivo study results, LPS significantly increased the p-ERK/ERK, p-JNK/JNK, and p-P38/P38 ratios in LPS-stimulated RAW 264.7 cells, and MAN reduced the p-ERK/ERK, p-JNK/JINK, and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38621336
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"TGF-beta activity fromAM of model group was suppressed by PD98059 (30 uM), which showed that LPS selectively up-regulated TGF-betavia ERK MAPK in AM of CB rats."
21428715
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"LPS and MTP-PE induce a rapid activation of the extracellular regulated kinase (ERK) isoenzymes-1 and -2."
10815618
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"By preventing LPS-induced ERK, JNK, and p38 MAPK activation in cells, trans-cinnamaldehyde prevents the production of pro-inflammatory mediators ( Kim et al., 2018 )."
37369335
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"In addition, several studies had reported that PKC play critical roles in reactive oxygen species production induced by PMA and activation of NF-κB, ERK1/2 and IRF3 signaling pathways stimulated by LP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28865677
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"DUSP10 negatively regulates lipopolysaccharide-induced macrophage ERK signaling (Zhang et al., 2004) but has not been implicated in CD40 or B cell regulation.To investigate putative DUSP10 roles in CD40 MAPK regulation, we measured ERK, p38, and JNK activation loop phosphorylation levels in control versus DUSP10 KO cells."
31365872
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"One of the Lactobacillus gasseri strains, SF1109, strongly inhibited : (1) Pseudomonas aeruginosa growth; (2) Escherichia coli biofilm production; (3) LPS induction of P-ERK1/2 in HCT116 cells, and was selected for further characterisation of the secreted active molecule."
27824276
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"In this study, we find that SESLA decreases LPS-induced ERK activation, which contributes to the expression of TNF-α, IL-1β and IL-10 ( Dumitru et al., 2000 ; Mielke et al., 2009 )."
31981749
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"Densitometric analysis for N = 3–4 independent protein extracts, normalized to β-actin, confirms that LPS increased p-p38 MAPK/p38 MAPK and p-ERK/ERK ratio ( p < 0.05, Kruskal–Wallis ANOVA, followed b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21195213
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"The cyclopentenone ring 2-cyclopenten-1-one also inhibited LPS induced ERK 1/2 activation; however, neither 15-PGJ2 nor the cyclopentenone inhibited PMA induced ERK 1/2 activation."
11310850
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"The densitometric quantification results verified that LPS potently induced rapid activation of Akt ( Fig. 4 B), ERK1/2 ( Fig. 4 C), JNK1/2 ( Fig. 4 D), and p38 MAPK ( Fig. 4 E), supporting its pleiot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28689803
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"LPS stimulation induced a strong phoshorylation of JNK, ERK and p38after 30min, which was prevented in the presence of GIP (XREF_FIG F-H), suggesting that GIP directly inhibits inflammatory activation of macrophages invitro."
29884547
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"LPS stimulation of microglia activates all three MAPK pathways : p38, ERK1/2 and JNK [XREF_BIBR, XREF_BIBR]."
21194439
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"RDSW regressed the LPS induced ERK 1/2 and JNK 1/2 phosphorylations in RAW 264.7 macrophage cells."
29088069
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"As shown in Fig. 6 , EAAD suppressed LPS-induced activation of ERK1/2 and p38 MAPK in a concentration-dependent manner."
17229575
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"A great deal of work on primary human macrophage cultures as well as on immortalized cell lines shows that LPS systematically activates the Erk1/2 MAP Kinase pathway [XREF_BIBR - XREF_BIBR]."
20148136
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"We did not find that LPS can activate ERK in 30 min through upregulation of Wnt-1, which is a secreted lipid modified signaling glycoprotein [25]."
29032172
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"In particular, with respect to MAPKs, LPS stimulation causes activation of ERK in RAW 264.7 cells but not in P388D1 cells (Barbour et al., 1998)."
12028827
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"(4) rHBsAg interferes with the LPS induced activation of ERK-1/2 and JNK1-1/2 MAP kinases, which might explain the reduction of TNFalpha mRNA [2]."
12270119
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"Ghrelin significantly inhibited LPS/leptin-activated extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinases (MAPKs)."
36177976
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"In CHO cells expressing human GPR34, LPS activated ERK via a PTX-sensitive G-protein."
23089136
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"LPS activates all three types of MAPKs (ERK, JNK, and p38) in mouse macrophages ( Hommes et al., 2003 )."
19429315
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"Wang et al. [ 52 ] concluded that resveratrol ( Scheme 1 ) could inhibit the inflammatory response stimulated by LPS by blocking phospholipase D and its downstream signal molecules sphingosine kinase [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38452729
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"2.3 High-Dose LPS Induces Microglial ERK and MAPK Signaling Molecules."
24513404
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"LPS strongly induced ERK activation in iDCs after 10 min of stimulation, as previously reported."
17462920
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"Ghrelin significantly inhibited LPS-activated ERK1/2 and p38 MAPK."
36177976
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"Previously, both C5a and LPS were shown to activate NF-kappaB, p38 MAPK, Erk1/2, JNK and PI3K signaling pathways in human monocytes XREF_BIBR XREF_BIBR."
27624143
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"DOK3 Inhibits LPS induced ERK Activation."
22761938
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"In this study, we demonstrated that administration of LPS and D-GalN initiated the activation of ERK, JNK, and p38 MAPK."
28430612
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"Taken together, these findings demonstrate that RO impedes osteoclast fusion by suppressing RANKL-mediated activation of the ERK/c-fos/NFATc1 axis.3.5 RO blocks inflammation of chondrocytes and enhances chondrocyte autophagy by inhibiting LPS-induced activation of the ERK pathway."
40231159
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"Our data also showed that C5a and LPS at 100ng/mL activated NF-kappaB, p38 MAPK, Erk1/2 and Akt signaling pathway in a time course study (XREF_SUPPLEMENTARY)."
27624143
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"As shown in XREF_FIG, NE could enhance LPS induced ERK and JNK phosphorylation as well as inhibit LPS induced P38 phosphorylation."
27237101
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"LPS induced ERK signaling events critical to priming."
24623131
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"In DOK3 knock-down cells, LPS stimulation induced earlier ERK activation compared to control cells (XREF_FIG)."
22761938
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"To ensure that the increases in LPS induced ERK activation were not due to off-target effects of the lentivirus, BMM were derived from DOK3 deficient mice XREF_BIBR and stimulated with LPS."
22761938
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"In contrast, OEA treatment markedly reduced the activation of ERK1/2 induced by LPS, while the total protein levels of ERK1/2 remained unchanged, which indicates that OEA blocked the activation but not the biosynthesis of ERK1/2."
27721381
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"DOK3 deficient BMM demonstrated increased LPS induced ERK activation compared to wild type macrophages (XREF_FIG)."
22761938
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"These results suggest that DOK3 protein levels inhibit LPS induced ERK activation."
22761938
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"In control cells treated with DMSO, LPS stimulation induced ERK activation in parallel to DOK3 degradation, with a peak at 20 minutes consistent with degradation of 50% of DOK3."
22761938
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"Several studies showed that treatment with MOTS-c significantly suppressed the LPS-induced activation of ERK, JNK, and p38 ( Kim et al., 2017 ; Lu et al., 2019 ; Xinqiang et al., 2020 )."
36528071
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"Thus, PLCγ1 signalling represents a novel pathway by which LPS induces ERK1/2 MAPK activation, leading to COX-2 expression in cardiomyocytes.COX-2 plays an important role in myocardial depression duri[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17655858
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"Pre-incubation of cap with various concentrations (1-25microM) for 30min did not alter LPS activated ERK and JNK as shown in Fig."
28273917
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"Additionally, others have also reported that butyrate may inhibit NF-κB and ERK signaling pathways to play anti-inflammatory effects in IFN-γ-stimulated RAW 264.7 cells or LPS-induced RAW 264.7 cells by inhibiting NF-κB and ERK signaling pathways [67,68]."
34384038
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"We demonstrated that RO effectively inhibits LPS-induced inflammatory degeneration of chondrocytes and promotes chondrocyte autophagy by blocking the ERK pathway in osteoarthritis treatment.The study also has some limitations."
40231159
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"The BV-2 monoculture and BV-2-N2a cocultures treated with LPS revealed that LPS-stimulated ERK1/2 activity by increasing their phosphorylated forms ( Fig. 6 A and B), whereas PN extract, gallic acid, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35671865
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"We propose that PN inhibits LPS-induced microglial activation by suppressing the ERK1/2 signaling pathway, which might be one of the underlying pathways of the extract's anti-inflammatory effect."
35671865
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"Notably, we found that p38 and ERK activation caused by LPS in RAW 264.7 cells were not significantly altered by the presence of SykI ( Fig. 3 D)."
20138367
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"Although both LPS and VLP treatment activated ERK1/2, they did so with different kinetics."
17434557
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"Furthermore, to confirm the role of MAPK pathway in MDR1 suppression by GSP, the MAPK and ERK pathway were activated by LPS in A2780/T cells."
23967153
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"The Ras/Raf-1/MAP pathway is thought to play an active role in the modulation of cell survival, proliferation, and differentiation.In this study, our results clearly show that TLR4 mediates the LPS-induced activation of ERK1/2 proteins via Ras/Raf-1/MAP kinase."
30200495
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"These findings indicate that Cot and Tpl2 is essential for LPS induced ERK activation and RANKL induction in osteoblasts."
12821717
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"Moreover, over-expression of DOK3 (FLAG tagged DOK3) in RAW264.7 macrophage cells attenuated LPS induced ERK activation (XREF_FIG)."
22761938
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"ERK activation has been previously shown to be critical for ICAM-1 expression, and in accordance with that report, we found that LPS induced ERK activation is critical for ICAM-1 expression in MDA-MB-231 cells and for their adhesion to monocytes (XREF_FIG), Several reports have suggested that NF-kappaB lies downstream of ERK, thus regulating ICAM-1 expression."
26299331
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"In a subsequent study, we demonstrated that p38 kinase, rather than ERK1/2, was activated in Dami cells by LPS in dose- and time dependent manner, suggesting that the phosphorylation of ERK and p38 is regulated by different mechanisms and that p38 kinase plays the key role in the response of Dami cells to LPS stimulation (XREF_FIG)."
26330186
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"Together, these observations suggest that LPS and overnutrition activates the ERK pathway thereby promoting the development of inflammation and fibrosis."
34557866
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"In this study, we examined the inhibitory effect of diosmetin on MAP kinase pathway and NO production activated by LPS in raw 264.7 cells, and as a result, diosmetin inhibits the LPS induced activation of ERK, p38 and JNK pathway and it also inhibits iNOS expression and NO production."
| PMC
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"Results showed that CASP11 significantly downregulated 120 genes and decreased 14 inflammatory pathways, including IL6 signaling pathway, ferroptosis signaling pathway, HMGB1 signaling pathway, NRF2-mediated oxidative stress response, PI3K/Akt signaling pathway, LPS-stimulated MAPK signaling pathway, senescence pathway, NK cell signaling pathway, ERK/MAPK signaling pathway, mTOR signaling pathway, PI3K signaling in B lymphocytes, CXCR4 signaling pathway, production of nitric oxide and ROS in macrophages, and leukocyte extravasation signaling pathway (Figure 3, A and B)."
39024553
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"In the current study, the activation of the p38 and ERK1/2 MAPK signaling pathways by LPS or leptin was significantly inhibited by ghrelin."
36177976
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"LPS can up-regulate the expression of several TLRs and nuclear factor kappa B (NF-kB), extracellular-signal-regulated kinase (ERK) and p38 kinase signal pathways."
32179425
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"Incubated with either different concentrations of GSP for 6 h or 40 muM GSP 0 to 6 h, A2780/T cells were treated with 1 mug/ml LPS for 30 min, the LPS treated A2780/T cells were significantly induced the MAPK and ERK pathway (XREF_FIG)."
23967153
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"LPS has been shown to stimulate both ERK1/2 and ERK 5 in macrophages [XREF_BIBR]."
19823867
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"Moreover, diosgenin pretreatment significantly suppressed LPS-induced extracellular signal-regulated kinase (ERK) activation."
34638697
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"Consistent with the enhancement of cytokine responses observed, LPS stimulated ERK activation was strongly enhanced in both PDMCs and BMMCs from ST2 deficient mice."
29540770
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"In addition, the PKA inhibitor down-regulated the LPS-induced activation of ERK and p38 MAPK ( Fig. 6 A), but did not have any effect on the LPS-induced activation of PKC ( Fig. 6 B)."
16098594
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"In our study, we observed that both Pam3 and LPS activate ERK1/2, p38, and JNK to a similar extent, despite the differential effect of the applied ligands on pro- and anti-inflammatory cytokine levels."
29096690
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"LPS treatment of chicken heterophils (which are functionally equivalent to mammalian neutrophils) activates both Erk and p38 MAPK signaling pathways downstream of TLRs to induce the secretion of pro inflammatory cytokines."
21527280
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"We have previously shown that Cbl leads to ubiquitination of DOK3 and associated protein, SOS1, to limit LPS induced ERK signaling in macrophages."
28650106
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"LPS induced ERK1/2 activation through phosphorylation, which was inhibited by all the compounds tested, the most active being epigallocatechin (EG), followed by epigallocatechin gallate (EGCG) and C1."
21405989
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"Our data confirmed these findings, as LPS increased the receptor subunit expressions and the activated form of ERK1/2 and STAT3."
40251174
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"For example, one report suggested that LPS or GM-CSF induces ERK in macrophages, albeit with different kinetics [the latter induces ERK activation much more quickly -- 5 min vs. 15 min, respectively; ref.]"
27824592
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"The current results showed that miR-124-3p promoted migration and viability of LPS-induced BV2 microglia, and inhibited apoptosis and phosphorylation of pro-inflammatory signaling pathways (p38 MAPK, Erk1/2, and PI3K/Akt) activated by LPS."
34277703
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"LPS activates ERK in MPhi; however, it apparently does not do so in DCs."
27824592
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"Moreover, LPS was also found to stimulate ERK, p38 MAPK, JNK, and Akt activities in U87 cells."
18616930
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"Cholinergic drugs reduce metabolic inflammation and diabetic myocardial injury by regulating the gut bacterial component lipopolysaccharide-induced ERK/Egr-1 pathway."
37039813
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"Furthermore, pyrocatechol failed to suppress the LPS-induced activation of ERK, JNK, and p38, similar to the coffee and decaffeinated coffee decoctions (Figure 8)."
38203488
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"Likewise, LPS increased the activation of p42/44 and p38 in wounded HCEC."
25183764
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"P. gingivalis LPS with penta-acylated lipid A mainly activates the NF-κB signaling pathway, while P. gingivalis LPS with tetra-acylated lipid A mainly induces p38/MAPK and ERK1/2 signaling pathways (74)."
36999040
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"In the present study, AUDA attenuated phosphorylation of P38 but not JNK or ERK induced by LPS or IFN-gamma, indicating that the P38-MAPK pathway could represent a molecular target for sEH inhibition and thus mediate its anti-inflammatory properties in activated microglia."
29262558
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"As shown, the phosphorylation levels of the MAPK increased dramatically after 30 min of stimulation with LPS and pinocembrin markedly inhibited LPS-induced activation of ERK1/2, JNK and p38MAPK in a d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22713932
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"Moreover, LPS promoted the activation of the nuclear factor kappa-B and extracellular signal-regulated kinase/c-Jun NH-terminal kinase signaling pathways, which were inhibited by AuNPs."
34523392
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"High dose LPS stimulation activated ERK, SAPK, and p38 kinases in both C3H and HeN and C3H and HeJ Mphi."
9921718
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"In contrast, mercury alone had no effect on activation of extracellular signal regulated kinase (ERK) but inhibited LPS induced ERK activation."
15803865
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"Also, sargaquinoic acid influenced the phosphorylation of JNK1/2 MAPK, except ERK1/2 and p38 MAPKs, stimulated by LPS."
22758221
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"In glial cultures, LPS induced strong activation of ERK1/2, JNK and p38 in a time dependent manner, with maximum activation of p38 and JNK detected at 60 min, and ERK1/2 detected at 30 min (XREF_FIG a)."
23034047
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"LPS also induced an increase in phosphorylated p38, JNK, and ERK."
30807931
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"Thus, we examined the effects of CAPE on the LPS-induced activation of ERK-1/2, p38 and JNK/SAPK MAP kinase."
18571461
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"However, LPS-stimulated activation of extracellular signal-regulated kinase, c-Jun N-terminal kinase (JNK) and p38 was similar in the stable Hsp70-expressing and control RAW264.7 cells ( Fig. 4 D)."
16697380
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"These findings suggest that in the absence of DOK3, BMM are more sensitive to LPS induced ERK activation with subsequent upregulation of a gene expression profile that promotes endotoxin tolerance."
22761938
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"RAW 264.7 cells were treated with LPS for 12 h and then incubated with or without curcumin for another 1 h. Data showed that curcumin reduced LPS induced ERK1/2 activation."
21094287
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"As shown in Fig. 2 , HP pretreatment attenuated the LPS-induced activation of ERK or JNK, which are involved in cell death signaling of the MAPK pathways in BV2 cells."
23500882
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"The LPS-induced increase in pERK levels was abolished by alkaline phosphatase treatment, indicating activation of ERK following LPS stimulation ( Supplementary Fig. 3B )."
20093193
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"HLJD Modulated AMPK and ERK1/2 Signaling Pathway Caused by LPS."
29576800
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"In neuronal cultures, LPS failed to induce activation of p38 or ERK1/2, but induced significant activation of JNK, 30 min after LPS treatment (level of activation detected was similar to that detected in glial cultures)."
23034047
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"Consequently, LPS induces enhanced ERK activation in the absence of DOK3."
22761938
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"Moreover, LPS administration significantly activated the MAPKs (p38, ERK and JNK)."
32251714
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"The ERK, JNK, and p38 MAPKs are all activated by LPS and are important upstream modulators for the production of proinflammatory mediators such as NO, PGE-2 and TNF-α [16,17] ."
20347053
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"Similarly, vitisin A, a resveratrol tetramer from Vitis vinifera roots, inhibits LPS-induced ERK1/2 in RAW 264.7 cells [30]."
37375908
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"LPS induced a TLR4 dependent stimulation of NF-kappaB and the MAPKs p38, ERK1/2, and JNK."
21937604
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"Pretreating murine macrophages (RAW 264.7) with luteolin inhibited LPS stimulated TNFalpha and IL-6 release, which was associated with blockage of LPS induced activation of nuclear factor kappa B (NF-kappaB) and mitogen activated protein kinase (MAPK) family members ERK, p38, and JNK [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
18991571
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"Our study showed that LPS increased the activation of p38, JNK, and Erk in BV2 cells."
25088370
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"Moreover, we found that p38MAPK, JNK, and ERK were activated by APAP or LPS alone or in association."
19589095
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"However this division is somewhat of an oversimplification since some mitogens can stimulate JNK and SAPK and p38, and the proinflammatory cytokines and LPS can activate the erks."
9918123
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"The present study demonstrated that lutein and zeaxanthin inhibited the secretion of IL-8 induced by LPS through the activation of JNK1/2 and NF-kappaB signal pathway, but not p38 and ERK pathway; this is consistent with the animal study, which showed that lutein inhibited the activation of NF-kappaB in the iris-ciliary body in LPS induced uveitis and in cultured macrophages [XREF_BIBR, XREF_BIBR]."
26609426
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"In addition, LPS prolonged osteoclast survival by activating the Akt, NF-kappaB, and ERK pathways."
19258321
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"LPS stimulation of macrophages activates several intracellular signaling pathways that include the IKK–NF-κB pathway and three mitogen-activated protein kinase (MAPK) pathways: ERKs 1 and 2, JNK and p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18544347
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"To confirm the related mechanisms, we evaluated signal transduction pathways induced by LPS on microglia, including MAPKs (including p38, JNK and ERK)."
29970291
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"In particular, they found that LPS rapidly induces p38, ERK, and NF-kappaB within 15-30min in monocytes, followed by slower S6 induction at 2h."
26003204
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"LPS is known to stimulate ERK1/2 and p38 in primary mouse microglia and JNK in BV-2 immortalized microglia."
38751621
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"Simvastatin also inhibited LPS stimulated ERK but not p38 MAPK and JNK."
18625914
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"In the late phase of LPS exposure, 2-AG could reverse the decrease of GS expression and activation of ERK1/2 induced by LPS."
30075820
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"To determine the inhibitory effects of AG or U0126 on LPS activated ERK or IKKepsilon enzyme activities, immunoprecipitated phospho-ERK or IKKepsilon prepared from RAW264.7 cells (5 x 10 6 cells/mL) treated with LPS (1mug/mL) for 30 (ERK) or 10 (IKKepsilon) min were incubated with AG or U0126 in the presence or absence of substrate protein [myelin basic protein (MBP)] or immunoprecipitated IRF-3 from unstimulated RAW264.7 cells, according to the manufacturer 's instructions."
23840248
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"Pertinently, megalin is down-regulated via the LPS induced ERK1/2 signaling pathway [XREF_BIBR], through which, as noted earlier, both Cbl and * NO achieve their coincidentally regulatory, beneficial effects."
23781123
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"Finally, we showed that the inhibition of LPS stimulated ERK activation by simvastatin was reversed by GGPP."
18625914
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"In addition, ERK activation by LPS was not altered in the presence of Salp15, demonstrating that Salp15 does not sequester MEK away from ERK and thereby inhibiting LPS induced cytokine production."
18282094
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"In the HBE-1 normal bronchial cell, only fully sulfated heparin 's effects on ERK signaling were of significance and again, desulfated heparin had little effect upon LPS induced ERK signaling."
26495958
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"Nevertheless, the effects of fully sulfated heparin on LPS stimulated ERK1/2 signaling were marked and significant (P < 0.001, n = 7) while desulfated heparin had no significant effects (XREF_FIG)."
26495958
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"It has been demonstrated that andrographolide inhibit the LPS-induced ERK1/2 activation in murine peritoneal macrophages ( Qin et al., 2006 )."
19038244
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"As depicted in Fig. 4, the LPS challenge on RAW264.7 macrophages caused significant activation of ERK, JNK, and p38 MAPK (p < 0.05)."
31838828
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"In this study, we found that the three MAPK signaling pathways (JNK, ERK, and p38 MAPK) in RAW264.7 cells and BMDM were all activated by LPS, which was consistent with previous reports ( Rao, 2001 )."
34339793
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"These results suggest that regulation of ERK and JNK MAPK signaling cascade is another possible mechanism underlying the inhibitory effect of TH-4-PX in LPS-activated RAW264.7 cells.Because TAK1 is th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21232528
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"It remains interesting to investigate the therapeutic efficacy of miR-130b agonist in other acute and chronic vascular inflammatory diseases.Therefore, taken together, our data demonstrated that miR-1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28759810
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"All results imply that GLP-2 inhibits LPS induced microglia activation by collectively regulating ERK1/2, JNK1/2 and p65."
26861286
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"Effects of capillarisin (CPS) on lipopolysaccharide (LPS)-induced activation of (A) ERK, (B) JNK, and (C) p38."
23131135
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"Stimulation with a combination of sCD26 and DPPIV (+) and LPS upregulates ERK in the cytosol and c-Fos, NF-kappaB p65, NF-kappaB p50, and CUX1 in the nucleus (XREF_FIG, XREF_FIG)."
23805228
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"Treatment with 10 μM U0126 abolished LPS-induced ERK1/2 activation ( Fig. 2 A and B )."
38191050
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"LPS added directly to endothelial cultures induced significant activation of JNK and ERK1/2."
23034047
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"Previously reported results showed that ketamine and propofol can suppress LPS induced upregulation of IL-1beta and extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation in glia cells and brains [XREF_BIBR, XREF_BIBR]."
33381594
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"NO had no effect on LPS stimulated ERK1/2 and p38 MAPK activation, suggesting that the inhibitory action of NO occurs downstream of MAPK cascades."
16683234
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"The results showed that LPS (1 mug/mL) induced marked activation of ERK1/2, p38 and JNK1/2 in a time dependent manner (XREF_FIG A)."
26861286
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"Pretreatment with GLP-2 in BV-2 cells markedly blocked LPS induced activation of ERK1/2 (XREF_FIG A, B) and JNK1/2 (XREF_FIG A, D)."
26861286
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"The LPS tolerance in DOK3 deficient cells was accompanied by significant upregulation of SHIP1, IRAK-M, and SOCS1 suggesting that the enhanced ERK and NF-kappaB activation, induced by the initial LPS stimulation, primes the cells for rapid induction of tolerance upon re-challenge."
22761938
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"Consistently, knockdown of endogenous H-Ras in BMDMs specifically inhibited curdlan- or yeast induced phosphorylation of ERK (XREF_FIG) but had no effect on alpha-mannans- or LPS induced ERK activation (XREF_FIG)."
25267792
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"Altogether, 3′-SL effectively prevented the LPS-induced ERK1/2-mediated STAT1 signaling pathway, and at a concentration of 400 μM, 3′-SL exhibited significance comparable to that of the ERK1/2 inhibit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38191050
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"To determine the inhibitory effects of Dc-EE on LPS-activated ERK activity, immunoprecipitated ERK prepared from LPS treated RAW264.7 cells (5×10 6 cells/ml) in the presence or absence of Dc-EE were i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23178662
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"Because the protein amount of the kinase did not change during the course of stimulation, the findings suggest that LPS induces activation of ERK."
12384141
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"More specifically, activation of ERK by LPS is required for the correct induction of NO and various cytokines including IL-1β, IL-6, and TNF-α [26,27] ."
25451593
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"The results showed that pretreatment with 2-AG inhibited the nuclear translocation of ERK1/2 and cytoplasmic GS downregulation induced by late LPS exposure."
30075820
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"Equivalent levels of ERK1/2 activation by LPS in CD14 deficient RPMphi may be due to soluble CD14 provided by fetal calf serum in the medium and the high dose of LPS used XREF_BIBR."
19521507
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"LPS induced endotoxin-tolerance with a significant inhibition of LPS stimulated TNF secretion and less p44 and p42 ERK kinase activation."
12688542
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"Pretreatment of RAW 264.7 with luteolin inhibited the LPS induced ERK1/2 and p38, but not JNK1/2, phosphorylation, and blocked the LPS induced TNF-alpha release."
12145106
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"The present study indicated that p38 and ERK1/2 were activated and translocated into nucleus in astrocytes by LPS exposure with different patterns, i.e., p38 was firstly activated at 30min and reached peak at 2h while ERK1/2 activated at 1h and reached peak at 3h, while inhibition of p38 and ERK1/2 attenuated the changes of GS expression induced by LPS."
30075820
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"It should be noted that although ERK1/2 and p38 were activated by early LPS exposure and late LPS exposure, respectively, the activation was relatively weaker when compared to late and early LPS exposure, respectively."
30075820
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"Our biochemical analysis here showed that LPS mediated activation of ERK, JNK, and p38 MAPKs was enhanced in LAB -/- DCs, indicating that LAB negatively regulates MAPK activation in TLR4 mediated signaling."
22308309
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"In this context, members of mitogen-activated protein kinases (MAPK) family, p38 MAPK and extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) but not c-Jun N-terminal kinase (JNK), partici[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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