IndraLab

Statements

ATXN3 deubiquitinates CHEK1. 4 / 4
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"Our result indicated that GST-ATX3 effectively decreased the polyubiquitination of Chk1 in a dose dependent manner."
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ubibrowser
"Taken together, these findings reveal ATX3 to be a novel deubiquitinase of Chk1, providing a new mechanism of Chk1 stabilization in genome integrity maintenance."
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reach
"We discover that, under unperturbed conditions and upon DNA damage, deubiquitination of Chk1 by ATX3 limits its polyubiquitination and subsequent degradation mediated by CUL1- and CUL4A- containing E3 ligase complexes, thus promoting Chk1 stabilization and further checkpoint signaling and DNA repair."
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reach
"Therefore, it is plausible that ATX3, as a DUB, functions to deubiquitinate Chk1 to counteract the action of E3 ligases."
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