IndraLab

Statements

ATXN3 deubiquitinates CHEK1. 4 / 4
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"Our result indicated that GST-ATX3 effectively decreased the polyubiquitination of Chk1 in a dose dependent manner."
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"We discover that, under unperturbed conditions and upon DNA damage, deubiquitination of Chk1 by ATX3 limits its polyubiquitination and subsequent degradation mediated by CUL1- and CUL4A- containing E3 ligase complexes, thus promoting Chk1 stabilization and further checkpoint signaling and DNA repair."
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"Therefore, it is plausible that ATX3, as a DUB, functions to deubiquitinate Chk1 to counteract the action of E3 ligases."
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"Taken together, these findings reveal <span class="match term0">ATX3</span> to be a novel deubiquitinase of <span class="match term1">Chk1</span>, providing a new mechanism of <span class="match term1">Chk1</span> stabilization in genome integrity maintenance."
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