IndraLab

Statements

F3 binds IL1B. 5 / 5
| 5
sparser
"In addition, the stimulatory effect of ceramide on basal and IL-1β-induced TF protein formation was confirmed by incubating cells with nSMase from B. cereus (Figure xref )."
27556861
sparser
"Whereas treatment of cells with nSMase spiroepoxide inhibitor was associated with a substantial suppression of IL-1β-induced TF formation, fumonisin B 1 and ISP-1 failed to elicit such effect (Figure xref )."
27556861
sparser
"According to Figure xref , inhibition of all kinases was associated with a partial but significant inhibition of IL-1β-induced TF formation with the most pronounced effect observed with the p38 MAPK inhibitor."
27556861
sparser
"First, treatment of cells with nSMase spiroepoxide inhibitor [ xref ], which selectively inhibits the nSMase-catalyzed hydrolysis of membrane sphingomyelin to ceramide, was associated with a substantial suppression of IL-1β-induced TF formation and cellular ceramide levels."
27556861
sparser
"Subsequent experiments revealed WIN 55,212-2 to impair the phosphorylation of p38 MAPK and JNK thereby proving an additional target of the cannabinoid in interfering with TF formation by IL-1β."
27556861