IndraLab

Statements

USP17L2 binds WP1130. 3 / 3
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"As shown in XREF_FIG (right panel), WP1130 binding to Dub3 significantly shifted the melting temperature (Tm) of Dub3 while the furan compound (negative control) had no effect under the same conditions."
28198361
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"IL-6 also stabilizes Snail1 by inducing Dub3 expression, the specific inhibitor WP1130 binds to Dub3 and inhibits the Dub3 mediating Snail1 stabilization in vitro and in vivo."
28198361
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"These data clearly indicate that WP1130 physically interacts with Dub3 and can potentially alter its enzymatic activity."
28198361