IndraLab

Statements

TSC2 bound to TSC1 inhibits MTOR. 18 / 18
| 18
reach
"The TSC1 and TSC2 complex is the only known GTPase for Rheb, serving to reduce Rheb-GTP levels, and thereby inhibit the activation of mTOR."
21618507
reach
"Once activated, AKT mediated phosphorylation of TSC2 (tuberous sclerosis complex 2) inhibits the TSC1 and TSC2 complex function, and thus activates mTOR signaling."
26905199
reach
"The TSC1 and TSC2 complex normally inhibits mTOR activity, with loss of function mutations resulting in overactive mTOR and consequential increased protein synthesis and decreased protein degradation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
28828560
reach
"40 TSC1 and TSC2 complex inhibits mTOR activity by activating the GTPase activity of Ras homologue enriched in brain, and both Akt and AMPK converged at TSC1 and TSC2 to regulate mTOR activity."
21618507
reach
"Under the condition that AMPK is activated, AMPK phosphorylates tuberous sclerosis complex 2 (TSC2) and increases the activity of the TSC1 and TSC2 complex to inhibit mTOR."
28067305
reach
"The TSC1 and TSC2 complex inactivates Rheb to inhibit mTOR signaling, which would lead to autophagy."
23903681
reach
"The TSC1 and TSC2 heterodimer inhibits mTOR function through Rheb inactivation."
18443221
reach
"Overall, these results demonstrate that activation of p38 inhibits the TSC1 and TSC2 complex allowing mTOR activation potentially via MK2 dependent phosphorylation of TSC2 at Ser 1210."
23315073
reach
"CTuberin binds to hamartin and Rheb and inhibits mTOR activation."
| PMC
reach
"Interestingly, our RNA sequencing analysis of Etv TKO mutant lenses showed significant down-regulation of Tsc2, which forms a heterodimer with Tsc1 to inhibit mTOR activity (Figure 3C)."
32043969
reach
"Tuberin and hamartin form heterodimeric complexes that negatively regulate the mTOR serine threonine kinase."
20666708
reach
"Activation of AMPK induces activation of the TSC2 and TSC1 complex to inhibit mTOR [29]."
22846543
reach
"Hamartin and tuberin, the TSC1 and TSC2 gene products, form a complex that inhibits mammalian target of rapamycin (mTOR) in a conserved cellular signaling pathway (PI3kinase- Akt-mTOR pathway) that regulates nutrient uptake, growth and protein translation [9], [10], [11]."
21915260
reach
"TSC1 is a subunit of the TSC1 and TSC2 complex that suppresses the mTOR pathway by inhibiting the small GTPase RAS homolog enriched in brain (Rheb), which is upstream of mTORC1."
29984036
reach
"However, when growth factors are depleted, the active TSC1 and TSC2 complex suppresses mTOR activity, followed by induction of autophagy."
28534010
reach
"The TSC1 and TSC2 complex negatively regulates mTOR through the GTPase activating protein activity."
28656223
reach
"The tuberous sclerosis 1 and 2 complex (Tsc1 and Tsc2 complex) negatively regulates mTOR activity [XREF_BIBR - XREF_BIBR]."
26683340
reach
"For example, the TSC1 and TSC2 complex inhibits mTOR functions by inactivating Rheb; Rheb binds and activates mTOR only when the former is in its GTP bound form."
21967333