IndraLab

Statements

NPM1 is phosphorylated on threonine. 4 / 4
| 2 2
rlimsp
"Furthermore, knockdown of PP1β, but not of PP1α or PP1γ, blocked the UV-induced dephosphorylation of NPM on Thr199 and Thr234/237 (Figure 2B and Supplemental Figure S3B). Similar outcomes of PP1β knockdown also were observed in 293T cells (Supplemental Figure S3C). Consistently, when PP1β was overexpressed in cells, phosphorylation at these threonine residues underwent considerable reduction (Supplemental Figure S3D)."
20962268
rlimsp
"Since AR is expressed in nucleoplasm and not in nucleolus, which is preferential localization of NPM1, we examined if this interaction could occur in the nucleoplasm where NPM1 is phosphorylated especially at the Thr199 and 234/237 sites."
26993766
trips
"It has been shown that Thr(199) phosphorylation of NPM/B23 is critical for the physical separation of the paired centrioles, an initial event of the centrosome duplication process."
17015463
trips
"Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication."
11278991