IndraLab

Statements

USP22 deubiquitinates H2Bub1. 7 / 7
| 7
reach
"Interestingly, neither free recombinant USP22 nor Ubp8p can efficiently deubiquitylate H2Bub1 or H2Aub1 (in the case of USP22) in vitro , indicating that an interaction(s) between the ZnF-UBP and othe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18603431
reach
"In addition, USP22 can also enhance DNA damage repair by deubiquitinating histones H2A and H2Bub1."
35935969
reach
"Thus, ATXN7L3 is required for the full activity of the three related DUB modules to regulate global H2Bub1 levels, whereas USP22-containing DUB module is less involved in genome-wide deubiquitylation of H2Bub1."
33731875
reach
"Along these lines it is interesting to note that neither free USP22 nor a stable recombinant subcomplex, composed of TAF5L, ATXN7L3, ENY2, and USP22, can deubiquitinate H2Aub1 or H2Bub1 in vitro, sugg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18206972
reach
"Finally, USP22 and the 2A-DUB (KIAA1915), both target H2Aub1 (although USP22 can also deubiquitylate H2Bub1), and both were described as co-activators of androgen receptor (AR)-mediated transcription."
21245042
reach
"Unlike the ATXN7L3 DUB complex, a USP22, ATXN7L3B, and ENY2 complex can not deubiquitinate H2Bub1 efficiently in vitro Moreover, ATXN7L3B knockdown inhibits migration of breast cancer cells in vitro and limits expression of ER target genes."
27601583
reach
"USP22, USP27X, or USP51 require ATXN7L3 and ENY2 for their full activity and are unable to deubiquitinate H2Bub1 alone."
35806465