IndraLab

Statements

PCDH15 binds HCN1. 11 / 11
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"Competition may therefore exist in vivo between the two binding sites for HCN1, with binding of HCN1 to protocadherin 15 CD3 favored between 26.5 and 68 microm Ca (2+)."
19008224
sparser
"We did not investigate the reported interaction between HCN1 and protocadherin-15."
20062532
sparser
"As such, given the expression of HCN mRNA in auditory and vestibular epithelia and the putative interaction between HCN1 and protocadherin-15 xref we wondered whether disruption of HCN function would cause dysfunction in hair cell transduction."
20062532
sparser
"HCN1 interacts with Pcdh15 in cochlear hair cell stereocilia, but in photoreceptors they are found in different subcellular compartments xref , xref ."
24409334
sparser
"Ramakrishnan et al. xref found several lines of evidence that supported their hypothesis including expression of HCN1 mRNA in hair cells of trout vestibular organs and mammalian cochlea, immunolocalization of HCN1 protein in sensory hair bundles and a calcium-dependent interaction between HCN1 and the putative tip link molecule protocadherin-15."
20062532
reach
"XREF_BIBR found several lines of evidence that supported their hypothesis including expression of HCN1 mRNA in hair cells of trout vestibular organs and mammalian cochlea, immunolocalization of HCN1 protein in sensory hair bundles and a calcium dependent interaction between HCN1 and the putative tip link molecule protocadherin-15."
20062532
sparser
"Since protocadherin-15 has been localized at the lower end of tip-links xref and a recent calcium imaging study placed transduction channels at the lower end of tip-links xref , the interaction between protocadherin-15 and HCN1 would place the HCN1 subunit in the correct location to mediate hair cell transduction."
20062532
reach
"In the presence of calcium chelators, binding between HCN1 and protocadherin 15 CD3 was characterized by a K (D) = 2.39 x 10 (-7) m. Ca (2+) at 26.5-68.0 microm promoted binding, with K (D) = 5.26 x 10 (-8) m (at 61 microm Ca (2+))."
19008224
reach
"We did not investigate the reported interaction between HCN1 and protocadherin-15."
20062532
reach
"HCN1 interacts with Pcdh15 in cochlear hair cell stereocilia, but in photoreceptors they are found in different subcellular compartments XREF_BIBR, XREF_BIBR."
24409334
reach
"Since protocadherin-15 has been localized at the lower end of tip-links XREF_BIBR and a recent calcium imaging study placed transduction channels at the lower end of tip-links XREF_BIBR, the interaction between protocadherin-15 and HCN1 would place the HCN1 subunit in the correct location to mediate hair cell transduction."
20062532