IndraLab

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TGFB1 increases the amount of CDKN1A. 42 / 50
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"Peripheral blood mononuclear cells of patients with COPD have decreased telomere length, a hallmark of senescing cells in vitro, when compared with normal individuals (225). This observation has been extended to lung cells, as alveolar epithelial and endothelial cells of emphysema patients exhibited enhanced expression of markers of cell senescence including p16Ink4a and p21CIP1/WAF1/Sdi1 and telomere shortening when compared with smokers without emphysema and normal individuals (320).TGF-beta1 played a role in the upregulation of p21CIP1/WAF1/Sdi1 in the alveolar type II-like epithelial cell line A549 (205). "
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"Transforming growth factor beta 1 can induce CIP1 and WAF1 expression independent of the p53 pathway in ovarian cancer cells."
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"The current study demonstrates that TGF- beta 1 is also able to upregulate p21 transcription and protein levels in MCF-7 cells."
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"In the present report, firstly we confirmed that TGF-beta1 treatment could upregulate p21 gene expression in RMC; then we found significant changes of histone lysine methylations, including H3K9me2/3 and H3K4me1/2/3 levels at p21 gene promoter, which were closely associated with p21 gene expression; further results showed that SET7/9, the specific H3K4me1 HMT, was involved in TGF-beta1 induced p21 gene upregulation in RMC."
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"TGFbeta1 selectively increased the expression of p21 in the VZ."
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"The basal and TGFβ1-induced expression of p21 WAF1 was higher in Ad-EPSM–infected cells than Ad-GFP- and Ad-Smad3–infected controls ( xref and xref )."
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"Several studies have shown that TGFbeta1 induces p21 waf1 and cip1 expression [XREF_BIBR, XREF_BIBR]."
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"Therefore, we decided to address the role of miR-106b-25 in the presence of TGFb: this cytokine, by inducing the expression of p21 and other antiproliferative molecules, ensures timely coordinated cell-cycle arrest and apoptosis of mature cells in the gastrointestinal tract, thus controlling the physiological turnover of epithelial cells (van den Brink and Offerhaus, 2007)."
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"In contrast, p21 expression by PDGF-BB or TGF-beta1 was not detected in Hic-5-/- MCs (XREF_FIG)."
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"To further understand the key roles of H3K4me in regulating TGF-beta1-induced p21 expression, we investigated the levels of H3K4me1/2/3 in RMC exposed to TGF-beta1 for 24h; subsequently our current results showed that TGF-beta1 upregulated p21 gene expression in RMC, which is positively correlative with the increased H3K4me1/2/3 levels at the p21 promoter."
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"P21 expression was increased by both TGFB1 and activin A in the Sui66 cell line."
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"Overexpression of p21 alone induced SMA transcription by down-regulating YB1 and independent of TGFbeta1."
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"Although the known TbetaRIII ligands, BMP-2, BMP-4, and TGFbeta-1, also increased p21 and p27 expression (XREF_FIG), the magnitude of increase was similar in the presence and absence of TbetaRIII, suggesting that, consistent with the proliferation data, the effects of TbetaRIII are largely independent of its ligand presentation role."
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"Surprised that TGF-beta1 induced Trp53 and Cdkn1a expression, but shTrp53 and shCdkn1a had no significant effect on TPC quiescence, we wondered whether these genes were already mutated in our tumors."
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"TGF-beta 1 was previously shown to increase p21 protein levels, which in turn mediated G (1) arrest through inactivation of the CDK2-cyclin E complex in HD3 cells (Yan, Z., Kim, G.-Y., Deng, X., and Friedman, E. (2002) J. Biol."
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"In addition, TGF-beta1 increased expression levels of p-Smad2/3 and p21 (XREF_FIG)."
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"These results suggested that TGF-beta1 can increase the expression of p21 gene in RMC as expected."
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"Our results indicated that TGF-beta1 upregulated the expression of p21 gene in RMCs, which was positively correlated with the increased chromatin marks associated with active genes (H3K4me1/H3K4me2/H3K4me3) and negatively correlated with the decreased levels of repressive marks (H3K9me2 and H3K9me3) at p21 gene promoter."
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"In that vein, we previously demonstrated that both Activin A and TGFbeta1 signal via SMAD dependent pathways to up-regulate expression of the cell cycle inhibitor p21 at early time points and further identified p21 as a predictor of net upstream Activin A and TGFbeta1 pathway signaling both in vitro and in patient samples 15."
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"P21 is important for inhibiting hepatocyte proliferation in vivo, especially at the G1/S transition of the cell cycle, and the expression of p21 is upregulated by TGF-beta1."
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"Unexpectedly, p21 expression was induced by TGF-beta1 treatment in HSC-2 cells, although TGF-beta-mediated elevation of p21 level did not affect HSC-2 cell growth (Figs. 2 and 4 A)."
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"P21 mRNA expression was greatly induced by TGF-beta1 in a p53 independent mechanism, while p27 mRNA expression was not affected by TGF-beta1."
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"FOXO factors form a complex with SMAD transcription factors (which also act as tumor suppressors), resulting in transforming growth factor-b-dependent activation of p21Cip1 and subsequent G1 arrest (Seoane et al., 2004)."
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"TGFβ1 induced p21 expression and subsequently suppressed cdk2 kinase activity, followed by a reduction in phosphorylation of the product of the retinoblastoma tumor suppressor gene in TMK‐1 cells, which are responsive to TGFβ1."
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"TGF-beta1 caused a delayed but sustained increase in the protein levels of the cyclin dependent kinase inhibitors p15 (Ink4B), p21 (Cip1), and p27 (Kip1) and a sustained increase in type I and II TGF-beta receptors (TbetaRI and TbetaRII) mRNA and protein levels."
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"OVCA420, a cell line that is dramatically growth inhibited by TGF beta 1, significantly induced CIP1 expression in response to TGF beta 1."
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"Exposure of the LNCaP TGF-beta receptor II (TbetaRII) cells to the combined treatment of TGF-beta and DHT resulted in a 1.5-fold induction of p21 protein levels following 24h treatment."
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"As expected, TGF-beta1 significantly induced the expression of p15, PAI-1, and p21 both at mRNA and protein levels, whereas TGF-beta1 inhibited the expression of c-Myc."
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"Our results demonstrate that hesperetin significantly inhibits TGF-beta1 stimulated expression of p21 (XREF_FIG)."
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"Furthermore, TGF-beta1 induced cell-cycle arrest in NK cells by up-regulating the expression of p15 and p21 in NK cells from immunotolerant (IT) patients."
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"The Rac1b siRNA mediated relief from inhibition of ERK signaling might account for Rac1b siRNA induced increase in TGF-beta1 induction of p21 WAF1 expression since p21 WAF1 is upregulated by TGF-beta and Smad and MEK-ERK signaling in an oxidative stress and ROS dependent manner [XREF_BIBR, XREF_BIBR]."
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"We found that the expression of cyclin A and p21 (WAF1) molecules was primarily modulated by TGFbeta1 treatment while the expression of other regulatory components, like cyclins D, cyclin E, cdk2, cdk4, and cdk6 or p15 (INK4B), p16 (INK4A), and p27 (KIP1) was not significantly affected."
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"Many studies reported that TGF-beta1 could increase the expression of p16 INK4A and p21, which functioned as negative regulators of cell cycle progression and might be associated with TGF-beta1-mediated G0/G1 cell cycle arrest."
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"In association with the G1 arrest, we also found TGF-beta1 increased the percentage of SA-beta-gal-staining cells and concomitantly increased the expression of p16 and p21, as analyzed by real-time PCR or western blot."
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"TGF-beta1 rapidly increased the expression of p15 and p21 in both Tca8113 and Tb cells."
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"As a cell cycle inhibitor, TGF-beta1 not only suppresses the transcription of the Bcl-2, c-Myc, and hTERT genes, but also activates expression of the cell cycle inhibitor p21 CIP and WAF1."
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"Based on studies reporting that activin A and TGF-beta1 are potent regulators of cell proliferation and induce p15 INK4b and p21 and CIP1 expression in various cell types, we analyzed aging liver for activin A and TGF-beta1 gene expression."
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"H (2) O (2) and TGF-beta1 and -beta2 markedly enhanced the expression of p21 but downregulated pRb."
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"TGFbeta1 is known to induce p21 expression."
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"Upon control Ad-GFP infection, TGF-beta1 induced endogenous p21 protein levels, and GSI partially blocked this response (XREF_FIG) as described for uninfected cells (XREF_FIG)."
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"Smad proteins may play a role in regulation of CDK inhibitor p21 gene expression by TGF-beta1, because TGF-beta1-induced p21 gene expression is further enhanced by overexpression of Smad3 and Smad4."
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"TGF-beta1, a major cytokine involved in the development of kidney diseases, can upregulate p21 expression."
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