IndraLab

Statements

CYLD binds PRNP. 14 / 14
3 | 7 4
reach
"Experiments are also in progress to determine whether the binding between PrP and CYLD is direct."
28900035
sparser
"We posit that when PrP binds CYLD, it sequesters CYLD, preventing it from binding RIP1 and TRAF2."
28900035
reach
"When PrP binds CYLD, it may sequester CYLD, consequentially reducing the levels of CYLD available to bind RIP1 or TRAF2."
28900035
reach
"Thus, in the presence of PrP, TNFalpha treatment increased the interaction between PrP and CYLD but alleviated binding between CYLD and RIP1 or TRAF2."
28900035
sparser
"Because CYLD is involved in NF-κB cascade and PrP expression is critical for activation of NF-κB pathway, we thus focused on studying the interaction between PrP and CYLD."
28900035
biogrid
No evidence text available
28900035
reach
"PrP interacts with CYLD to regulate NF-kappaB signaling."
28900035
biogrid
No evidence text available
28900035
reach
"Binding between PrP and CYLD reduces RIP1 and TRAF2 ubiquitination."
28900035
reach
"Because CYLD is involved in NF-kappaB cascade and PrP expression is critical for activation of NF-kappaB pathway, we thus focused on studying the interaction between PrP and CYLD."
28900035
biogrid
No evidence text available
28900035
reach
"We posit that when PrP binds CYLD, it sequesters CYLD, preventing it from binding RIP1 and TRAF2."
28900035
sparser
"Thus, in the presence of PrP, TNFα treatment increased the interaction between PrP and CYLD but alleviated binding between CYLD and RIP1 or TRAF2."
28900035
sparser
"We found that in PrP +/+ M2 cells PrP is physically associated with CYLD."
28900035