IndraLab

Statements

USP14 deubiquitinates NLRC5. 7 / 7
1 | 6
reach
"The ubiquitination of NLRC5 could be reversely regulated by USP14."
26620909
reach
"Mechanistically, USF1 functioned as a transcriptional activator of USP14 that caused de-ubiquitination of NLRC5, resulting in Smad2/3 pathway activation and EndMT induction in ox-LDL-exposed HUVECs."
38424494
reach
"In this study, we verified that USP14 enhanced NLRC5 protein level via de-ubiquitination of NLRC5."
38424494
ubibrowser
"The researchers propose that, after the ubiquitination of <span class="match term1">NLRC5</span> at lysine 1178 is catalyzed by TRAF2/6, <span class="match term0">USP14</span> specifically removes the polyubiquitin chains from <span class="match term1">NLRC5</span> to enhance <span class="match term1">NLRC5</span>-mediated inhibition of IKK-NF-kappaB signaling, thus forming a coherent feedforward loop to regulate IKK-NF-kappaB activation"
26620908
reach
"Next, we determined whether USP14 inhibited NLRC5 ubiquitination through its DUB activity."
26620909
reach
"These results suggest that USP14 inhibits NLRC5 ubiquitination through its DUB activity."
26620909
reach
"In an effort to elucidate the mechanisms underlying this regulation, the Cui group showed that TLR4 stimulation activates the TRAF2/6 complex, which ubiquitinates NLRC5 on Lys1178 residue, presumably leading to its degradation and release of IKKalpha and IKKbeta to complex with IKKgamma [XREF_BIBR, XREF_BIBR] (XREF_FIG) This study also showed that the ubiquitin specific protease 14 (USP14) deubiquitinates NLRC5 to sustain the NLRC5 mediated inhibition of NF-kappaB activation."
33671123