IndraLab

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USP14 deubiquitinates NLRC5. 5 / 5
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"The ubiquitination of NLRC5 could be reversely regulated by USP14."
26620909
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"Next, we determined whether USP14 inhibited NLRC5 ubiquitination through its DUB activity."
26620909
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"In an effort to elucidate the mechanisms underlying this regulation, the Cui group showed that TLR4 stimulation activates the TRAF2/6 complex, which ubiquitinates NLRC5 on Lys1178 residue, presumably leading to its degradation and release of IKKalpha and IKKbeta to complex with IKKgamma [XREF_BIBR, XREF_BIBR] (XREF_FIG) This study also showed that the ubiquitin specific protease 14 (USP14) deubiquitinates NLRC5 to sustain the NLRC5 mediated inhibition of NF-kappaB activation."
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ubibrowser
"The researchers propose that, after the ubiquitination of NLRC5 at lysine 1178 is catalyzed by TRAF2/6, USP14 specifically removes the polyubiquitin chains from NLRC5 to enhance NLRC5-mediated inhibition of IKK–NF-κB signaling, thus forming a coherent feedforward loop to regulate IKK–NF-κB activation"
26620908
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"These results suggest that USP14 inhibits NLRC5 ubiquitination through its DUB activity."
26620909