IndraLab

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UAF1 activates USP1. 4 / 4
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"Using ubiquitin-7-amido-4-methylcoumarin ( Ub-AMC ) as a substrate , we have previously shown that UAF1 activates USP1 mainly by increasing its catalytic turnover ( k cat ) , instead of its affinity toward the substrate ( K M ) ( Cohn et al ., 2007 ) ."
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"Our study also revealed the molecular basis for the activation of USP1 by UAF1 ."
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"Although ATAD5 depletion does not alter protein levels of USP1 [ 34 ] , since UAF1 increases USP1 activity [ 37 ] , it is still possible that ATAD5 regulates deubiquitination activity of USP1 through UAF1 ."
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"Our results support a regulatory mechanism in which UAF1 activates USP1 by modulating its active site conformation ."
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