IndraLab

Statements

CACNA1A activates buk. 18 / 18
| 18
sparser
"Interestingly, although experimental data suggest that the TM segments of β1, β2, and β4 subunits similarly localize with the Slo1 VSD, the functional effects of these β subunits on the voltage-dependent activation of BK channels differ (see below)."
22529812
sparser
"Unlike the β1 subunit, the β2 subunit effects on voltage-dependent activation of BK channels are minimal (Orio and Latorre, xref )."
22529812
sparser
"Although distinct mechanisms underlie Ca 2+ - and voltage-dependent activation of BK channels, it is apparent that the G–V relation shifts to more negative voltages with increasing [Ca 2+ ] i ( xref ), while the G-[Ca 2+ ] i dose response curve is altered by increasing voltage to decrease EC 50 and increase the Hill coefficient [ xref ]."
19099186
sparser
"The shortening of APD in +hBKα-transfected cells was reversed by the BK channel inhibitor, IBTX, and by lowering intracellular free Ca 2+ , which is expected to shift the voltage-dependent activation of BK channels to more depolarized potentials [ xref ]."
26091273
sparser
"The Core-MT channel provides a tool to study the function of the gating ring in voltage-dependent activation of BK channels."
28196879
sparser
"All four known LRRC proteins (i.e., LRRC26, 38, 52, and 55) have been reported to enhance voltage-dependent activation of BK channels (Yan and Aldrich, xref , xref ), with LRRC26 producing an impressive shift of up to −150 mV."
25202279
sparser
"This study examines the functional interaction between Mg 2+ - and voltage-dependent activation of mSlo1 BK channels."
18166624
sparser
"The purpose of the present study is to evaluate the ability of a two-tiered allosteric gating mechanism to describe both the Ca 2+ and voltage-dependent activation of BK channels."
10871641
sparser
"As previously described, loss of the BKβ 1 subunit would be expected to decrease Ca 2+ - and voltage-dependent activation of VSM BK channels (Brenner et al., xref ), leading to exaggerated membrane depolarization and smooth muscle contraction."
25202279
sparser
"Single vascular smooth muscle cell patch clamp protocols suggested that adiponectin had a small effect on the voltage dependent activation of BK channels when the cytoplasm of the cell was intact."
28830977
sparser
"A. Voltage-dependent activation of BK channels."
19099186
sparser
"Finally, evidence for the β1 subunit modulating the coupling between the VSD and the activation gate comes from fitting the above data to the HCA model (Horrigan et al., xref ) that describes the allosteric mechanism of voltage-dependent activation of BK channels."
22529812
sparser
"Although at least 10 µM Ca 2+ was required to bring the midpoint of voltage-dependent activation (V 1/2 ) of both BK 0 and BK SRKR channels into the physiological voltage range, the G-V relationships remained right-shifted when compared with mouse mbr5 channels, a benchmark clone of BK."
24277601
sparser
"Consequently, substitutions in S0 disrupt the voltage-dependent activation of BK channels, underscoring the critical role of S0 in channel function xref ."
25275635
sparser
"In comparison, the voltage-dependent activation of BK channels has received less attention."
10436003
sparser
"Voltage-dependent activation of BK channels occurs on a millisecond time scale, similar to many purely voltage-gated K + (K v ) channels."
10436003
sparser
"The voltage-sensitive dye bis-(1, 3-dibutylbarbituric acid) trimethine oxonol [DiBAC4(3)] at submicromalor levels (Morimoto et al., xref ) produced a shift in the voltage-dependence of the BK channel only when β-1 and β-4 subunits were present, whereas saturating concentrations (30 μM), produced huge negative shifts by up to −300 mV in the voltage-dependent activation of BK channels, but this effect was neither dependent on calcium nor the presence of β-subunits (Scornik et al., xref )."
25346695
sparser
"The variables of voltage-dependent activation of BK channels calculated from the I-V relationships ( xref ) were fitted to a Boltzmann function ( xref ), and the V 1/2 of the channel activation was 6.6±1.4 mV in control, 10.2±1.7 mV in LDL, and 5.8±1.5 mV in LDL plus MβCD (n = 10 for each group, P  = NS vs. control), suggesting that LDL, like MβCD-cholesterol, reduces BK current without significantly affecting the voltage-dependent activation."
24260325