IndraLab

Statements

MDM2 bound to CDKN2A activates TP53. 13 / 13
| 13
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"ARF bound Hdm2 blocks Hdm2 dependent nucleocytoplasmic shuttling of p53, to produce nuclear retention and activation of p53 [XREF_BIBR, XREF_BIBR]."
15318938
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"XREF_BIBR p19 Arf (p14 ARF) directly binds to Mdm2 (HDM2), sequesters Mdm2 to the nucleus and neutralizes its activity, and thereby activates p53."
26997872
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"Oncogene activation and inappropriate mitogenic signaling activate the expression of Arf, which binds to Hdm2 and relieves inhibition of p53, ultimately leading to p53 dependent and -independent cell cycle arrest or apoptosis XREF_BIBR; XREF_BIBR."
18809412
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"ARF binds and sequesters MDM2 in the nucleolus, thus preventing the degradation of p53."
27470213
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"p19 ARF binds to Mdm2, a negative regulator of p53, thus stabilizing it and allowing p53 to act as a tumor suppressor responsible for cell cycle arrest and apoptosis [XREF_BIBR, XREF_BIBR]."
26528722
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"By contrast, p19 ARF induces cell-cycle arrest independently of CDKs by binding to the E3 ubiquitin ligase MDM2 to inhibit p53 degradation; loss of p19 ARF abrogates p53 induced apoptosis and cell cycle arrest 55."
27444064
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"For example, binding of p14 ARF and pRb to the MDM2 acidic region have been shown to increase p53 stability, while interaction with the chromatin remodeling protein, p300, stimulates MDM2 dependent p53 degradation [XREF_BIBR]."
23464371
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"As mentioned above, ARF interaction with MDM2 causes MDM2 to target MDMX for degradation, and in the event of mitogenic stimulation MDMX is often downregulated to allow p53 activation."
23002429
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"p14ARF interacts with MDM2, which targets p53 for degradation, thereby inducing p53 dependent cell-cycle arrest in both G1 and G2 phases [XREF_BIBR, XREF_BIBR]."
20565749
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"p14ARF, along with other free, non assembled ribosomal proteins, bind MDM2 and inhibit p53 degradation."
24147052
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"p19 Arf (p14 ARF in humans) directly binds to Mdm2 (HDM2), sequesters Mdm2 to the nucleous and neutralize its activity, and thereby activates p53."
26802432
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"p19 Arf binds to Mdm2 and inhibits the degradation of p53, thus p16 Ink4a and the p19 Arf -p53 pathway synergistically downregulate the self-renewal capacity of HSCs [XREF_BIBR]."
22778557
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"p14ARF directly interacts with HDM2 and leads to upregulation of p53 transcriptional response."
23401782