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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

HCN1 inhibits MCF2L2. 2 / 2

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"In conclusion, selective blockade of HCN1/HCN2 channels, over HCN4 isoform, was able to modulate electrophysiological properties of DRG neurons similarly to that reported for classical I h blockers, ivabradine, resulting in a pain-relieving activity."

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"To our knowledge, this is the first demonstration that preferential blockade of HCN2 and HCN1 channels, over HCN4 isoform, was able to modulate the electrophysiological properties of DRG neurons similarly to that reported for classical I blockers, ZD7288 and ivabradine (Chaplan et al., 2003; Descoeur et al., 2011)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...