
IndraLab
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eidos
"USP8 regulates NF-kappaB activation through EGFR and PI3K stabilization to promote PCa cell proliferation and survival In multiple studies ( 29-32 ) , the EGFR is a substrate of USP8 deubiquitination , while USP8 has been shown to enhance gastric cancer cell proliferation and metastasis via the PI3K / AKT signaling pathway ( 30 ) ."