IndraLab

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11 | 3

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"OTUD2 orthologues bind to the AAA+ ATPase/unfoldase p97/VCP and furnish it with ubiquitin linkage processing or editing capability (Rumpf & Jentsch, 2006; Messick et al, 2008; Ernst et al, 2009)."

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"Yod1, which is specifically associated with macro-autophagy, and codes for the cofactor YOD1, which binds with p97 to promote lysosomal clearance (Papadopoulos et al., 2017), was significantly increased in the FMD 3xTg male cohort compared with male 3xTg controls, although this effect was not observed in female 3xTg mice (Table S1; Data S1, page 47)."

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"YOD1 is associated with p97 to facilitate protein dislocation, in which the dominant negative effect is dependent on the UBX and Zinc finger domains, appended to the N- and C-terminus of the catalytic otubain core domain, respectively [24]."

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