IndraLab

Statements

VCP binds YOD1. 29 / 29
7 | 10 12
reach
"We show that a catalytically inactive deubiquitinating enzyme and p97 cofactor YOD1 enhances the accumulation of K11- and K48 linked polyubiquitin in the cytoplasm, at the ER membrane, and bound to p97."
24417208
reach
"In aggregate, YOD1 interacts directly with p97 and is a novel constituent of the ER dislocation machinery, thereby placing it in a perfect position to process ubiquitinated dislocation substrates in association with p97."
19818707
biogrid
No evidence text available
19818707
sparser
"YOD1, the mammalian homolog of Otu1, also interacts with p97 through its UBX domain [ xref ]."
28159894
sparser
"In addition, p97 binds to a deubiquitinating enzyme YOD1, presumably so that polyubiquitin chains will not interfere with insertion into the proteasome ( xref )."
25071743
reach
"In addition, whereas both H. sapiens YOD1 and OTUD2 and S. cerevisiae Otu1 interact with p97 and Cdc48 through an N-terminal UBL or UBX domain, the A. thaliana OTU2 has a relatively shorter N-terminus and does not interact with CDC48."
24659992
sparser
"The UBX-like domain of OTUD2 binds AAA+ ATPase p97, an important Ub-dependent regulator of protein homeostasis (Ernst et al., 2009)."
27066941
reach
"In addition, p97 binds to a deubiquitinating enzyme YOD1, presumably so that polyubiquitin chains will not interfere with insertion into the proteasome."
25071743
sparser
"In addition, we confirmed binding of recombinant YOD1 to p97 by GST-PD ( xref )."
28244869
biogrid
No evidence text available
19818707
reach
"The DUB YOD1, which binds to p97 via its UBX (ubiquitin regulatory X) domain, is also associated with ERAD [XREF_BIBR]."
28819009
sparser
"Yod1 , which is specifically associated with macro-autophagy, and codes for the cofactor YOD1, which binds with p97 to promote lysosomal clearance ( xref ), was significantly increased in the FMD 3xTg male cohort compared with male 3xTg controls, although this effect was not observed in female 3xTg mice ( xref ; xref , page 47)."
36170815
sparser
"In addition, p97 binds to a deubiquitinating enzyme YOD1, presumably so that polyubiquitin chains will not interfere with insertion into the proteasome (Ernst et al., 2009)."
25071743
reach
"Yod1, which is specifically associated with macro-autophagy, and codes for the cofactor YOD1, which binds with p97 to promote lysosomal clearance (Papadopoulos et al., 2017), was significantly increased in the FMD 3xTg male cohort compared with male 3xTg controls, although this effect was not observed in female 3xTg mice (Table S1; Data S1, page 47)."
36170815
reach
"yOtu1 and D.melanogaster (dm) Otu1 are orthologs of human OTUD2 (38% and 53% identical in OTU domain, respectively), and OTUD2 and yOtu1 both bind cdc48 and p97 and are involved in endoplasmic-reticulum-associated protein degradation."
23827681
reach
"We show that a catalytically inactive deubiquitinating enzyme and p97 cofactor YOD1 enhances the accumulation of Lys11- and Lys48 linked polyubiquitin in the cytoplasm, at the ER membrane and bound to p97."
24417208
reach
"To confirm that p97 and YOD1 form a complex in a cellular context, we transfected FLAG tagged YOD1 variants, followed by preparation of detergent extracts."
19818707
sparser
"In aggregate, YOD1 interacts directly with p97 and is a novel constituent of the ER dislocation machinery, thereby placing it in a perfect position to process ubiquitinated dislocation substrates in association with p97."
19818707
sparser
"The UBX-like domain of OTUD2 binds AAA+ ATPase p97, an important Ub-dependent regulator of protein homeostasis ( xref )."
27066941
biogrid
No evidence text available
19818707
sparser
"Importantly, a deletion variant of YOD1 (ΔUBX-GFP YOD1) that does not bind p97 still co-precipitated UBXD8 ( xref )."
19818707
sparser
"We showed that p97 associates with YOD1 by virtue of its UBX domain and that YOD1 participates in a p97 complex that also contains NPL4 and UFD1 ( xref and xref ), involved in the dislocation of misfolded proteins from the ER (Ye et al., xref , xref )."
19818707
biogrid
No evidence text available
28244869
biogrid
No evidence text available
24417208
sparser
"YOD1 interacts with p97 via its UBX domain."
21468305
sparser
"To confirm that p97 and YOD1 form a complex in a cellular context, we transfected FLAG-tagged YOD1 variants, followed by preparation of detergent extracts."
19818707
biogrid
No evidence text available
28244869
reach
"In addition, p97 binds to a deubiquitinating enzyme YOD1, presumably so that polyubiquitin chains will not interfere with insertion into the proteasome (Ernst et al., 2009)."
25071743
biogrid
No evidence text available
24417208