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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified NOTCH1 decreases the amount of TSC2. 1 / 1

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"Three pieces of evidence indicate that transcriptional repression of TSC2 occurs downstream of N activation in the ISC lineage : (i) TSC2 expression is significantly reduced in EBs with high levels of N signaling activity, (ii) forced expression of N ICD suppresses TSC2 expression in ISCs, and (iii) loss of TSC2 is sufficient to rescue N loss of function phenotypes in the ISC lineage."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...