IndraLab

Statements

MTOR phosphorylated on S2448 is active. 4 / 4
3 1 |
biopax:pid
No evidence text available
10499523
biopax:pid
No evidence text available
1614535
biopax:pid
No evidence text available
15051500
signor
"Importantly, phosphorylation of mTOR by S6K1 occurs at threonine 2446/serine 2448. This region has been shown previously to be part of a regulatory repressor domain. These sites are also constitutively phosphorylated in the breast cancer cell line MCF7 carrying an amplification of the S6K1 geneit has been proposed that other inputs, in addition to phosphorylation of Thr-2446/Ser-2448 by S6K1, are part of the mechanism involved in inhibiting this repressor domain"
15905173