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Arachidonic acid activates KCNMA1. 29 / 29
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"In conclusion, these results strongly suggest that BK channel activation by AA requires the expression of beta1, beta2, or beta3 subunits."
25346693
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"The cis FFA, palmitoleic, oleic, linoleic, linolenic, eicosapentaenoic, and the triple bond analog of AA, eicosatetraynoic acid, all increased BK channel activity, whereas stearic (saturated) or the trans isomers elaidic, linolelaidic, and linolenelaidic had no effect."
11003601
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"Finally, BK channel activation by arachidonic acid and analogues has recently been linked to the ability of these FAs to remove beta 2 - or beta 3 -mediated BK inactivation."
18562499
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"Both arachidonic acid and nitric oxide potentiate BK channel activity by slowing inactivation kinetics and enhancing channel opening, respectively [XREF_BIBR, XREF_BIBR]."
21923633
eidos
"Direct exposure to 10muM AA robustly increases BK channel activity in inside-out excised patches from human umbilical arterial SMCs , suggesting activation of BK channels directly by AA ( Martin et al ., 2021 ) ."
34744789
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"In contrast, treating the RA-FLS with 30muM AA, known to enhance KCa1.1 currents only in the presence of beta2 or beta3 subunits [XREF_BIBR], induced an increase in current amplitude in the majority of the cells."
27165430
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"We present evidence that AA activates BK channel in a direct way, inducing VSD stabilization on its active configuration observed as a significant left shift in the Q-V curve obtained from gating currents recordings."
33417967
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"Because arachidonic acid does not relieve BK channel block by TEA (Figs. 2 and 3 and 10), these results indicate that TBA is not directly inhibiting BK channel activity, but is acting upstream of arac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8938725
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"Nevertheless, BK channel stimulation by arachidonic acid was only partially reduced from a 442% increase on control cells down to 344% by acutely blocking calcium entry through voltage dependent chann[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8938725
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"Application of arachidonic acid increased BK channel activity, and this occurred to a greater extent in rats on a high-K diet compared with a normal-K diet."
19073823
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"Thus, lipoxygenase metabolites of arachidonic acid stimulate BK channel activity in GH cells through a calcium independent mechanism involving a protein phosphatase."
8938725
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"Discussion The present study provided direct evidence that four regioisomeric EETs, metabolites of arachidonic acid via the cytochrome P450 pathway, potentiated the BK channel activity with a concomit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8422904
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"For instance, DHA, or AA augmentation of the Slo1 channel is potentiated or enabled, respectively, when the channel is co-expressed with specific β subunits (Sun et al., 2007; Hoshi et al., 2013a)."
32595524
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"BK channel stimulation by arachidonic acid under these conditions did not result from an increase in intracellular calcium nor from stimulation of protein kinase C (Keyser and Alger, 1990)."
8938725
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"Also, AA and LOM potentiation of BK channel activity in outside-out patches exposed to strong Ca2+ buffering ruled out cytoplasmic messengers or changes in intracellular Ca2+ levels as causative factors."
9211722
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"KCa1.1 was first activated by 30microM AA then inhibited fully by paxillin (the subunit composition independent inhibitor of the KCa1.1 channels)."
32346069
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"In conclusion, these results strongly suggest that BK channel activation by AA requires the expression of β1, β2, or β3 subunits."
25346693
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"KCa1.1 was first activated by 30 µM AA then inhibited fully by paxillin (the subunit composition-independent inhibitor of the KCa1.1 channels)."
32346069
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"AA enhances KCa1.1 currents only when the channel contains beta2 or beta3 subunits [XREF_BIBR, XREF_BIBR]."
27165430
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"Arachidonic acid (AA) dissolved in DMSO activated the BK channel in a dose dependent manner (from 0.5 to 10 microM), and DMSO (0.1%) alone had no effect on the activity of the BK channel."
8009892
sparser
"We present evidence that AA activates BK channel in a direct way, inducing VSD stabilization on its active configuration observed as a significant left shift in the Q-V curve obtained from gating currents recordings."
33417967
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"Although higher concentrations of ETI had no effect on BK channel gating in cell-free patches in the absence of exogenous ATP to support protein phosphorylation (not shown), BK channel stimulation by [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8938725
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"The co-existence of AA-induced activation of both KCa1.1 and the hHv1 current was also tested using K + -containing solutions (Supplementary Fig.  xref )."
32346069
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"The concentration of Ca2+ and Mg2+ in the bathing solution had no appreciable effects on the AA induced increase of BK channel activity."
8009892
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"AA also activates potassium current trough KCa1.1, however, there was no potassium ion neither in the intracellular or the extracellular solution thereby excluding the contamination of the whole-cell current by KCa1.1."
32346069
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"Exogenous arachidonic acid (1-20 muM) stimulated BK channel activity through protein dephosphorylation as effectively as somatostatin and was also blocked by inhibitors of lipoxygenases but not by inhibitors of phospholipase A2."
8938725
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"BK channel stimulation by arachidonic acid was confirmed in recordings from cell attached patches, in which the BK channels were identified by their characteristic large-conductance (120 pS) and volta[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8938725
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"Arachidonic acid (AA) dissolved in DMSO activated the BK channel in a dose dependent manner (from 0.5 to 10 microM), and DMSO (0.1%) alone had no effect on the activity of the BK channel."
8009892
sparser
"AA also activates potassium current trough KCa1.1, however, there was no potassium ion neither in the intracellular or the extracellular solution thereby excluding the contamination of the whole-cell current by KCa1.1."
32346069