IndraLab

Statements

PHF20 methylates TP53. 3 / 3
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"Dual recognition of doubly dimethylated p53 by PHF20 Tudor2."
22864287
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"Furthermore, our findings are in line with previous studies that found that PHF20 could stabilize and activate p53 by promoting p53 methylation [XREF_BIBR], and that PHF20 inhibits p53 transcriptional activity via PKB mediated PHF20 phosphorylation [XREF_BIBR]."
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"Our results are also consistent with a recent report that PHF20 leads to p53 stabilization and activation XREF_BIBR because PHF20 binding to methylated p53 protected it from SCF Fbxo22 -KDM4A mediated degradation (XREF_FIG)."
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