IndraLab

Statements

USP38 binds TBK1. 9 / 9
| 9
reach
"To examine the interaction between USP38 and TBK1 under physiological conditions, we infected 293T cells, THP-1 cells, or PBMCs with VSV-EGFP, and we found that the interaction between USP38 and TBK1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27692986
reach
"After viral infection, the interaction between USP38 and TBK1 was significantly increased in all three cell types ( Figures 3 D–3F)."
27692986
reach
"To substantiate these findings, we specifically knocked down NLRP4 and found that the interaction between USP38 and TBK1 was markedly attenuated ( Figure 6 F)."
27692986
reach
"Furthermore, we demonstrated that the dynamic interaction between USP38 and TBK1 was totally abrogated in NLRP4 small interfering RNA (siRNA)-treated THP-1 cells after viral infection ( Figure 6 G)."
27692986
reach
"These results suggest that USP38, TRIP, and DTX4 may bind to TBK1 in an NLRP4-dependent manner."
27692986
reach
"Mechanistically, USP38 interacts with TANK-binding kinase 1 (TBK1) and removes K48-linked polyubiquitination of TBK1, stabilizing p-TBK1 and promoting the activation of its downstream mediators."
38481817
reach
"As TBK1 is an upstream component of the Akt signaling pathway, and the TBK1-Akt signaling cascade is known to be significant in pathological cardiac remodeling4, we conducted a comprehensive analysis to explore the association between USP38 and TBK1."
38481817
reach
"Conversely, the K48-linked polyubiquitination level of TBK1 was obviously decreased after AdUSP38 transduced NRCMs (Figure 7B), These findings strongly indicate that USP38 interacts with and deubiquitinates TBK1 in hypertrophied cardiomyocytes."
38481817
reach
"co-immunoprecipitation suggests an interaction between USP38 and TBK1."
38937697