IndraLab

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USP15 activates Interferon. 6 / 6
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"In addition, the ectopic expression of USP15 enhances the TRIM25- and RIG-I-mediated production of type I IFN and thus suppresses RNA virus replication, whereas the depletion of USP15 causes decreased IFN production and markedly enhanced viral replication (85)."
34707613
reach
"Knockdown of USP15 results in upregulation of type I IFN."
26061460
reach
"In addition, we demonstrated that in contrast to USP15 de-ubiquitinating (DUB) activity, USP15 mediated inhibition of IFN signaling was not abolished by mutations eliminating the catalytic activity, indicating that a fraction of USP15 mediated IFN antagonism was independent of the DUB activity."
26061460
eidos
"In addition , the ectopic expression of USP15 enhances the TRIM25 - and RIG-I-mediated production of type I IFN and thus suppresses RNA virus replication , whereas the depletion of USP15 causes decreased IFN production and markedly enhanced viral replication ( 85 ) ."
34707613
reach
"Furthermore, ectopic expression of USP15 enhanced the TRIM25- and RIG-I-dependent production of type I IFN and suppressed RNA virus replication."
24399297
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"Among these proteins, we found Ubiquitin carboxyl-terminal hydrolase 15 (Usp15) which positively regulates type I interferon responses and thereby antiviral immune response."
33402730