IndraLab

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UCHL5 activates NLRP3. 7 / 7
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"Consistent with the higher expressions of NLRP3 and UCHL5 upon LPS stimulation, NLRP3 ubiquitination was markedly reduced, suggesting UCHL5 inhibits NLRP3 degradation by de-ubiquitination (Figure 4I)."
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"The following evidences showed that UCHL5 knockdown accelerated NLRP3 degradation ( Fig. 5 C)."
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"A recent study has demonstrated that Uchl5 can deubiquitinate and activate NLRP3 in HCV-infected cells, leading to IL-1β maturation and secretion ( xref )."
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"To follow up our above findings demonstrating that inhibiting UCHL5 concurrently increased NLRP3 degradation by ubiquitination (Figures 4F-K), we then asked whether UCHL5 regulates osteoblast differentiation by preventing degradation of NLRP3."
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"Together, these data verify that UCHL5 directly interacts with NLRP3 and induces the activation of NLRP3 inflammasomes."
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"In addition, the reduced UCHL5 expression markedly decreased the activity of the NLRP3 inflammasome."
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"Furthermore, we indicated that UCHL5 directly interacts with NLRP3 and induces the activation of NLRP3 inflammasomes in M-MSCs, which inhibits OB differentiation by promoting NLRP3 de-ubiquitination (Figure 7)."
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