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TNFAIP3 decreases the amount of IL17A. 2 / 2

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"Together, these data suggest that TNFα signaling via TNFR2 promotes the expression of the anti-inflammatory mediator TNFAIP3/A20, which seems to prevent IL-17A expression in regulatory T cells, as ablation of TNFα signaling suppresses TNFAIP3/A20 and results in increased IL-17A expression in human Treg."

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"Functional blockage of TNFAIP3 in normal CD4 + T cells using small interfering RNA increased the expression of IFN-gamma and IL-17, but not IL-2, IL-4 and IL-5."

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IndraLab

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TNFAIP3 decreases the amount of IL17A. 2 / 2

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