IndraLab

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USP18 activates CD8. 3 / 3
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"This finding suggests that, in the presence of virus specific antibodies, Usp18 is necessary for viral replication in marginal zone macrophages and also enhances the priming of virus specific CD8 + T cells."
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"(b) In case of enforced viral replication in dendritic cells of a virus resembling an autoantigen, autoreactive CD8 + T cells will be primed, which leads to autoimmune diseases such as type I diabetes, whereas USP18 deficiency reduces the priming of autoreactive CD8 + T cells and onset of autoimmune diabetes owing to inhibition of enforced viral replication Functions of USP18 N Honke et al recognized as essential player for the development of MS."
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"Therefore we would suggest that Usp18 expression in dendritic cells could drive autoimmune diabetes by promoting activation of cross-reactive CD8 + T cells, but also by induction of high levels of IFN-I."
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