IndraLab

Statements

USP18 activates CD8. 3 / 3
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"Therefore we would suggest that Usp18 expression in dendritic cells could drive autoimmune diabetes by promoting activation of cross-reactive CD8 + T cells, but also by induction of high levels of IFN-I."
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"This finding suggests that, in the presence of virus specific antibodies, Usp18 is necessary for viral replication in marginal zone macrophages and also enhances the priming of virus specific CD8 + T cells."
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"These results suggest that USP18 deletion leads to CSF1R downregulation in TAMs and a decrease in pro-tumor/immunosuppressive macrophages, contributing to enhanced anti-tumor macrophage polarization, consequently promoting a Th1-dominant TME and enhancing CD8 T cell-mediated anti-tumor immunity, in agreement with previous reports."
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