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TNFAIP3 inhibits TNF. 29 / 32
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"Although our in silico analysis by PolyPhen-2, SIFT, and ModePred indicated that TNFAIP3 rs2230926T/G (located in exon 3 and in the A20 desubiquitinase [DUB] domain) is benign, tolerable, and does not[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Recently, it has been shown by gene knock-out studies that A20, a protein interacting with IKKγ, can also specifically inhibit TNF- but not IL-1-induced NF-κB activation [34] ."
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"TNFAIP3 , also known as A20 , inhibits the NFκB pathway ( Fig. 2 ), as well as tumor necrosis factor (TNF) mediated apoptosis."
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"TNFAIP3 inhibits TNF induced signaling pathways; therefore, we examined whether TNFAIP3 plays a central role in regulating IEC barrier permeability."
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"TNFAIP3 inhibits NF-κB activation as well as TNFα-mediated apoptosis by binding to TRAF family adaptor proteins (Heyninck et al., 1999)."
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"TNFAIP3 in MSCs inhibits TNF-α generation and promotes IL-10 proliferation; whereas knockdown of TNFAIP3 weakens the immunosuppressive capacity of MSCs both in vitro and in vivo as indicated that inhibition of T-cell proliferation is reversed."
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"The feedback regulator TNFAIP3 (A20) which negatively regulates TNF-alpha and IL-1beta signalling is up-regulated in two datasets and is down-regulated in one dataset."
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"TNFAIP3 also perturbs caspase activation of TNF receptor 1 (TNFR1) which is coupled to apoptotic caspases 8 and 10 [XREF_BIBR, XREF_BIBR]."
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"TNFAIP3 is known to reduce the inflammatory response by strongly inhibiting TNF-a/NF-kB signaling [29] ."
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"For example, the expression of tumor necrosis factor-alpha inducing protein (TNFAIP3) that inhibits NF-kappaB activation and negatively regulates TNF-alpha signaling exhibited individual variability among our human donors."
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"While A20 restricts TNF signaling in vitro , elimination of TNF does not prevent spontaneous disease in A20 - / - mice or A20Flox LysM-Cre mice 10 , 34 ."
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"However, histone H3K4 methyltransferase ASH1L inhibited NF-κB signaling downstream of the TLR by promoting the expression of TNFaip3 (a negative regulator of TLR signaling pathway), thereby inhibiting macrophage production of IL-6 and TNF-α (115)."
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"Thus, the heterologous expression of TNFAIP3 in IECs can prevent TNF induced decreases in barrier function in these cells."
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"The TNFAIP3 gene product inhibits the NF-kappa B pathway as well as TNFα-mediated apoptosis, and this may contribute to tumor progression in myeloma patients [54]."
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"C6 was distinguished by an abundance of TNFAIP3 , which inhibits IFN-γ and TNF-α in CD8 + T cells."
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"A20 also inhibited TNF and IL-1-induced NF-kappaB activation, suggesting that it may inhibit NF-kappaB activation signaled by diverse stimuli."
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"We found that TNFAIP3 inhibited the TNF signaling pathway, which could inhibit cell migration and proliferation and contribute to apoptosis."
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"Early evidence also revealed that A20 inhibited the TNF-alpha - and IL-1beta-activated NF-kappaB signaling pathway by mediating TNF-receptor associated factor ( TRAF ) pathways in endothelial cells [ 74,75,78 ] ."
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"For example, the tissue protective TNFAIP3 (A20) protein was previously shown to specifically reduce TNF toxicity and protect the liver and endothelial cells from apoptosis [50, 51] and was strongly induced by entolimod in both our liver and hepatocyte experiments (10.42-fold and 7.15-fold, respectively), but was not upregulated in livers after LPS treatment."
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"Tnfaip3 could inhibit TNF- and TLR4-induced NF-kB activation ( xref )."
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"[39] On the other hand, the TNFAIP3 rs2230926G allele (127Cys) leads to lower TNF-induced NF-κB inhibitory activity compared to the T allele (Phe127)."
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"C6 was distinguished by an abundance of TNFAIP3, which inhibits IFN-γ and TNF-α in CD8 T cells."
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"Furthermore, A20 inhibits TNF- and IL-1-induced NF-κB activation in 293 cells [ xref ], and deregulated Toll-like receptor signaling in response to commensal bacteria was shown to be responsible for the multiorgan inflammation and premature death of A20-knockout mice [ xref ]."
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"TNFAIP3 is primarily responsible for attenuation of NFkappaB signaling and thereby inhibits inflammation and tumorigenesis and TNF mediated mediated apoptosis [XREF_BIBR]."
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"A20 also inhibits TNF and IL-1 induced activation of NF-κB, suggesting that it may act as a general inhibitor of NF-κB activation xref – xref ."
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"Early evidence also revealed that A20 inhibited the TNF-α- and IL-1β-activated NF-κB signaling pathway by mediating TNF-receptor associated factor (TRAF) pathways in endothelial cells [ xref , xref , xref ]."
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"We thus propose a model in which A20 inhibits TNF- and LUBAC-induced NF-κB signalling by binding to linear polyubiquitin chains via its seventh zinc finger, which prevents the TNF-induced interaction between LUBAC and NEMO."
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"TNFAIP3 functions to inhibit NFκB activation and TNFα-mediated apoptosis [32,33]."
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"This inhibition led to downregulation of TNFalpha induced NFkappaB target gene expression of IL6, ICAM1, and TNFAIP3, which had reduced basal and/or TNFalpha induced expression upon COUP-TFII overexpression."
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