IndraLab

Statements

TP53 binds CDK2AP2 and MDM2. 22 / 22
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"SUMO-1 conjugation is effected via the coordinated collaboration of Mdm2 and the tumour-suppressor ARF, which are both required in a p53, Mdm2, and ARF complex to stimulate p53 SUMOylation via SUMOylation and nucleolar targeting of Mdm2."
19522844
sparser
"Three lines of evidence support the genuineness and physiological relevance of ARF-MDM2-p53 nuclear bodies: the dependency of nuclear body formation on the integrity of ARF-MDM2-p53 triprotein interac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10360174
sparser
"Thus, both the MDM2-binding activity, encoded by the exon 1β, and the nucleolus-localizing activity residing in the exon 2 domain are important for ARF, p53, and MDM2 to form nuclear bodies."
10360174
sparser
"ARF binds to the MDM2-P53 complex and prolongs the half-life of P53."
12063677
sparser
"In the nucleus, ARF interacts physically and functionally with Mdm2 to inhibit cell cycle progression through activation of p53."
19033735
sparser
"Complicated feedback and control mechanisms regulate ARF, Mdm2, and p53 interactions."
15467748
sparser
"Formation of a ternary ARF–MDM2–p53 complex suggests that if ARF regulates MDM2 function, it may not involve simple competitive disruption of MDM2's association with p53."
9529249
sparser
"The nuclear bodies formed by p53, MDM2, and ARF, although variable in size, are clearly visible by light microscopy, which suggests that they likely contain a large number of additional proteins and a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10360174
sparser
"Because ARF binding does not compromise the ability of Mdm2 to interact with p53, both binary ARF–Mdm2 and ternary ARF–Mdm2–p53 complexes can be formed, and their roles in vivo remain a subject of s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10679383
sparser
"ARF binds MDM2, preventing it from interacting with p53 [ xref ]."
21052502
sparser
"It should be emphasized, however, that overexpression of Mdm2 in some tumors lacking ARF points to more complex biochemical interactions between ARF, Mdm2, and p53 than had been previously expected."
10679383
sparser
"Another model proposes that ARF forms a ternary complex with MDM2 and p53 in the nucleoplasm, thereby blocking p53 nuclear export and stabilizing and activating p53 ."
14636574
sparser
"ARF-promoted MDM2 degradation is associated with MDM2 modification and concurrent p53 stabilization and accumulation."
9529249
sparser
"However, this does not appear to be the case [87,94] , consistent with another similar scenario, such as the protection of p53 by ARF [99] , where Mdm2, p53, and ARF form a complex in which p53 is a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15865930
sparser
"This model, however, cannot justify the readily observed formation of ARF-MDM2-p53 ternary complex , and how p53 can be stabilized and activated even though still-abundant MDM2 is in the nucleoplasm w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14636574
sparser
"ARF binds MDM2 (murine double minute 2) and releases p53 from inhibition by MDM2, resulting in stabilization, accumulation and activation of p53."
16173922
sparser
"The observation that ARF binds to a C-terminal domain of MDM2 prompted us to test whether ARF can form a ternary complex with MDM2 and p53."
9529249
sparser
"In cells triply transfected with plasmids expressing all three proteins, an ARF–MDM2–p53 ternary complex was formed as determined by the presence of ARF in anti-p53 immunoprecipitates (lane 18) and re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9529249
sparser
"It now appears that p19 ARF binds MDM2 to prevent the degradation of p53 and thus permits p53-induced apoptosis or growth arrest (see Figure 1b ) [31 •• ,32 •• ,33 • ,34 • ] ."
10072356
sparser
"Intriguingly, ARF, MDM2, and p53 can form a stable ternary complex, likely bridged by MDM2 via its two separate domains, which can independently interact with p53 and ARF ( Figure 3 )."
9529249
sparser
"ARF binds and inhibits MDM2 to activate p53, which has both cell cycle arrest and apoptotic functions."
20505340
sparser
"Here, we show that endogenous ARF sequentially interacts with p53 and MDM2 following irradiation of primary human and mouse embryonic fibroblasts."
15195142