IndraLab

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USP4 inhibits TP53. 15 / 20
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"Furthermore, we demonstrated that USP4 inhibited p53 mediated transcriptional activity in wild-type but not HDAC2 knockdown U2OS cells in response to DNA damage or not (XREF_FIG)."
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sparser
"USP4 could inhibit p53 through deubiquitinating and stabilizing ARF-BP1 xref or HDAC2 xref and was upregulated in several cancer tissues."
31302495
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"Previous study has also demonstrated that USP4 inhibits p53 functions by deubiquitinating HDAC [80]."
28801249
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"Recently, it has been reported that USP4 could antagonize p53 signalling through its deubiquitinating activity.15, 18 Given that Bax and Bcl2 are 2 canonical downstream regulators of p53 in mediating cell apoptosis and were regulated by USP4 in response to cisplatin treatment, we speculated that pro survival effect of USP4 in response to cisplatin treatment may be associated with p53 signalling pathway."
29542252
sparser
"Because USP4 inhibits ubiquitination-mediated HDAC2 degradation, we hypothesized that USP4 inhibits p53 functions through HDAC2."
26411366
trips
"USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1."
21522127
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"USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1."
21522127
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"Therefore, USP4 suppresses p53 transcriptional activity and proapoptotic functions."
26411366
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"USP4 inhibits p53 and NF-kappaB through deubiquitinating and stabilizing HDAC2."
26411366
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"Increased ARF-BP1 and Mule degradation causes p53 stabilization, which is antagonized by the DUBs USP7 and USP4."
25806049
sparser
"USP4 inhibits p53- and p53-mediated apoptosis, regulates NF-κB signaling pathway and modulates TGFβ signaling, xref , xref , xref , xref promoting breast cancer xref and lung adenocarcinoma invasiveness. xref We demonstrate here that both USP17 and USP4 are expressed at higher levels in breast and lung cancer cell lines compared to normal cells."
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"Also, USP4 de-ubiquitinated and then inhibited the activation of p53 and NF-kappaB [XREF_BIBR]."
32308208
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"USP4 inhibits p53 transcriptional activation via stabilizing HDAC2 and ARF-BP1, which acts as a deacetylase and E3 ubiquitin ligase of p53, respectively."
33681193
eidos
"USP4 and USP5 inhibit p53 expression , but the molecular mechanism has yet to be elucidated [ 47-49 ] ."
31133011
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"Therefore, our studies reveal USP4 suppresses p53 and NF-kappaB activation by stabilizing HDAC2."
26411366