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Mutated EGFR activates AKT. 24 / 24
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"Sordella and colleagues showed that these EGFR mutants selectively activate the Akt survival pathway."
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"15 Mutant EGFR, such as exon 19 deletions and L858R, activate Akt and STAT signaling pathways, which protect cells against apoptosis and promote cell survival."
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"Gefitinib induced substantial clinical responses and reduced tumour burden in ~ 10% of patients with chemotherapy-refractory non small cell lung cancers; however, the majority of these patients had EGFR mutations that constitutively activated the antiapoptotic protein AKT (Baselga, 2002; Fukuoka et al, 2003; Kris et al, 2003; Giaccone et al, 2004)."
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"It was also noted that EGFR mutant lung cancer cell lines selectively activate AKT and STAT3 signaling pathways, promoting cell survival."
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"EGFR mutations activate mitogen activated protein kinase (MAPK) / extracellular signal regulated kinase 1/2 (ERK1/2) and phosphatidylinositol 3 ' -kinase-AKT (PI3K and AKT) pro survival pathways."
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"Our findings that both EML4-ALK and mutant EGFR upregulate PD-L1 by activating PI3K-AKT and MEK-ERK signaling pathways in NSCLC reveal a direct link between oncogenic drivers and PD-L1 expression."
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"EGFRvIII is a constitutively active EGFR mutant that persistently activates the PI3K-Akt signaling compared with the WT EGFR."
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"These results suggest that these constitutively active EGFR mutants down regulate pERK1/2 but do not activate Akt."
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"Mutant EGFR is reported to selectively activate Akt and signal transducer and activator of transcription protein (STAT) signaling pathways that promote cell survival but less effect on the mitogen act[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It is also known that EGFR mutations activated the antiapoptotic protein Akt (Sordella et al, 2004), and that patients whose tumours have activated Akt are more sensitive to TKIs than patient whose tumours are phospho-AKT negative (Cappuzzo et al, 2004)."
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"EGFR mutations activate MAPK, PI3K-AKT, and STAT3 directly or through IL-6-JAK2 (5,10,21)."
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"As an initial test system for this hypothesis, we used the NSCLC line H3255, which expresses HER3, HER2, and a mutant EGFR that cooperates with HER3 to activate PI3K and Akt and is not known to express HER4 (supplemental Fig."
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"Based on these results, we propose that mutant EGFR activates the PI3K and AKT pathway through both ERBB3 dependent and ERBB3 independent mechanisms."
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"XREF_BIBR - XREF_BIBR Mutant EGFR leads to constitutive activation of downstream ERK, PI3K and Akt, and STAT signalling resulting in ' oncogene addiction ' and tumour cell growth and survival."
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"Because mutant EGFR potently stimulates the AKT pathway [XREF_BIBR], we anticipated that a similar mechanism of BIM induction would be activated after gefitinib treatment of NSCLC cells expressing hyperactive mutant EGFR."
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"EGFR mutations activate ERK, AKT and STAT3 directly or through IL-6-JAK2 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"As the above results demonstrate an important role for SRC, we considered if dual SRC inhibition in conjunction with inhibition of mutant EGFR driven AKT signaling could be effective in cells with EGFR gatekeeper mutations."
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"Of these genes, we found a coincidence of an AKT2 mutation in a lung adenocarcinoma, suggesting that alterations in the AKT signaling by both AKT2 and EGFR mutation can occur and could possibly contri[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"XREF_BIBR Consistent with these findings, pre-clinical studies have shown that those EGFR mutations that sensitize to gefitinib selectively activated the Akt pathway."
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"Mutant EGFR expressing cells, such as HCC827, selectively activate Akt and signal transducer and activator of transcription (STAT) pathway which promote cell survival, whereas wild-type EGFR expressin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"XREF_BIBR - XREF_BIBR Mutant EGFR heterodimerizes with ErbB-3 to activate the PI3K and Akt signaling pathway."
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"Mutant EGFR upregulated PD-L1 by activating PI3K-AKT and MEK-ERK signaling pathways in NSCLC."
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"XREF_BIBR The results showed that mutant EGFR selectively activated Akt and signal transducer and activator of transcription (STAT) signaling is related to cell survival; however, mutant EGFR could not act on extracellular signal regulated kinase signaling, the function of which is to induce proliferation."
25302015
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"Mutations of the epidermal growth factor receptor (EGFR) selectively activate Akt and signal transducer and activator of transcription (STAT) pathways that are important in lung cancer cell survival."
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