IndraLab

Statements

PPP3 binds CACNA1H. 9 / 10
| 6 3
sparser
"Previous research demonstrated that Ca 2+ and calmodulin regulate the interaction between Cav3.2 and calcineurin."
39469589
sparser
"The binding of Cav3.2 to calcineurin results in a reduction of the enzyme’s phosphatase activity and subsequently decrease the current density of Cav3.2, which has been identified as a key regulator of sperm acrosome reaction ( xref ; xref ; xref )."
39469589
sparser
"It was found that Calmodulin and 0.1 mM Ca 2+ enhanced the physical interaction between Cav3.2 and calcineurin, but 2 mM EGTA entirely eliminated it, suggesting that the interaction between Cav3.2 and calcineurin is Ca 2+ /calmodulin dependent."
36766802
reach
"The interaction between CaN and Cav3.2 was discovered via anti-tag immunoprecipitation."
36766802
reach
"It was found that Calmodulin and 0.1 mM Ca enhanced the physical interaction between Cav3.2 and calcineurin, but 2 mM EGTA entirely eliminated it, suggesting that the interaction between Cav3.2 and calcineurin is Ca /calmodulin dependent."
36766802
reach
"Calcineurin binds to Cav3.2 [17] and also dephosphorylates Cav3.2."
38001892
reach
"In earlier investigations, we observed a peak binding of calcineurin with Cav3.2 at a calcium concentration of 30 μM, along with 20% binding at a calcium concentration of 1 μM [17]."
38001892
reach
"This interaction between Cav3.2 and calcineurin is dependent on calmodulin and calcium concentration."
38001892
reach
"While it is established that calcineurin interacts with and modulates Cav3.2, the specific dephosphorylation of Cav3.2 by calcineurin has remained unclear."
38001892