IndraLab

Statements

UCHL1 inhibits cell cycle. 9 / 9
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"Restoring UCHL1 expression in silenced cell lines significantly inhibited their growth and colony formation ability by inhibiting cell proliferation, causing cell cycle arrest in G2/M phase and inducing apoptosis through the intrinsic caspase dependent pathway."
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"Targeting UCHL1 Induces Cell Cycle Arrest in High-Risk Multiple Myeloma with t (4; 14)."
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"Our data showed a low expression of Uch-L1 in UT-B null bladder epithelium and supports that inhibition of Uch-L1 induced cell cycle arrest and apoptosis XREF_BIBR, XREF_BIBR, XREF_BIBR."
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"Bheda et al. presented a series of genes regulated by UCH-L1 using microarray and quantitative real-time PCR analysis, and they found that the inhibition of UCH-L1 activated genes controlling apoptosi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"UCHL1 could promote proliferation of B-cell lymphoma and gastric cancer cells [ 40 , 42 ] ; while others demonstrated that UCHL1 induced cell cycle arrest and inhibited tumor cell proliferation in breast , ovarian and hepatocellular cancer [ 15 , 20 , 21 ] ."
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"Furthermore, cell cycle analysis revealed up-regulation of S phase both in A2780-shUCHL1 and IGROV1-shUCHL1, indicating that UCHL1 knockdown promoted cell proliferation by progressing cell cycle."
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"Other recent studies have found that UCHL1 could promote tumor cell proliferation and inhibit cell cycle arrest XREF_BIBR, which are involved in the development of chemoresistance in cervical cancer and pancreatic cancer XREF_BIBR, XREF_BIBR."
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"Suppression of UCHL1 protein level by LDN-5744 inhibitor could arrest the cell cycle in G1 phase in cell lines."
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"We showed that knockdown of UCHL1 in ovarian cancer cells promoted cell proliferation by inducing S phase cell cycle and reduced apoptosis."
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