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COPS5 activates cell population proliferation. 74 / 84
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"Also, Jab1 activate the c-jun gene resulted cell proliferation."
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"Our results demonstrated that suppression of CSN5 expression in these cells could inhibit cell proliferation and promote apoptosis."
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"The results showed that CSN5 knockdown led to considerably reduced cellular proliferation, and AGS has more obvious inhibition tendency comparing with MKN45 ( Fig. 3 A and B)."
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"Obviously, these data showed that suppression of CSN5 expression could inhibit cell proliferation in gastric cancer cells.Since CSN5 knockdown could inhibit cell proliferation, we next sought to deter[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"27 In the present study, we demonstrated that the expression of CSN5 was higher in gastric cancer tissues and gastric cancer cells, meanwhile, knockdown of CSN5 inhibited proliferation and induced apo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Loss of CSN5 ortholog in D. discoideum , csn5 , severely impairs cell proliferation , suggesting that the cycling of neddylation and de-neddylation is important during growth [ 32 ] ."
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"Also, Jab1 activate the c-jun gene resulted cell proliferation."
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"Taken together, our results suggest that HER-2 and neu transcriptionally activates Jab1 expression to promote proliferation of breast cancer cells."
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"Additionally, using CCK-8 assay, we also found that cell proliferation rate of MDA-MB-231 cells treated with Jab1 siRNA exhibited a significant decrease compared with the negative control siRNA or moc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Loss of CSN5 ortholog in D. discoideum , csn5 , severely impairs cell proliferation , suggesting that de-neddylation is important during growth [ 32 ] ."
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"Our data demonstrated that Jab1 protein was a vital upstream negative modulation factor of p14ARF, and Jab1 could promote cell proliferation and tumor growth via inhibiting the expression of p14ARF in vivo and in vitro."
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"This interaction suggests that pJAB1 can contribute to the cell proliferation."
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"In addition, a high level of Jab1 is observed in a variety of human cancers and is sometimes correlated with a poor prognosis, suggesting that Jab1 contributes to cancer cell proliferation and survival and could be a novel target of cancer therapy."
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"Jab1 is upstream of p14ARF and promote gastric cancer cell proliferation in vitro and in vivo."
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"The key findings of the current study are that BRSK1 down-expression was significantly associated with progression of human breast cancer and that ectopic expression of BRSK1 was inversely regulated b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Additionally, we found there was a positive correlation between CSN5 and angiopoietin like protein 2 (ANGPTL2) protein levels in thyroid carcinoma tissues and that CSN5 promoted thyroid carcinoma cell proliferation and metastasis through ANGPTL2."
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"These results demonstrated that Jab1 knockdown inhibited the cellular proliferation of MDA-MB-231 cells which may associate with the specific inhibitory effect on BRSK1 expression."
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"CCK-8 assays data showed that the knockdown of CSN5 significantly suppressed the proliferation rate of H460 and A549 cells ( Fig. 2 D)."
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"Mechanistically, CSN5 is upstream of p14ARF and promotes the proliferation of gastric cancer cells."
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"Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors."
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"These results suggest that CSN5 promotes NSCLC cell proliferation by facilitating cell cycle progression and inhibiting cell apoptosis.To further investigate whether CSN5 silencing could affect tumor [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CSN5 can also promote cell proliferation and inhibit apoptosis by accelerating the nuclear export of p53 and inducing its degradation in a MDM2-mediated manner [38]."
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"CCK8 and colony formation assays show that the reduced proliferation induced by CSN5 knockdown in H460 cells was partly abolished by the introduction of survivin overexpression vector ( Fig. 4 B and C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, it appears that in CRC cells CSN5 can both promote cell proliferation but also enhance apoptosis.Together, these results underscore the importance of CSN5 and presumably the CSN complex in CRC c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Knockdown of CSN5 inhibits the proliferation of human tumor cells XREF_BIBR XREF_BIBR, suggesting that overexpression of CSN5 not only serves as a marker of malignant transformation, but also actually contributes to tumor cell proliferation."
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"Interestingly, Jab1 appears to induce proliferation, as demonstrated in transfection studies using Jab1 overexpressing HCC cell lines and in siRNA experiments blocking Jab1 expression [2]."
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"In addition, Hsieh et al. demonstrated that the pre-S2 LHBS mutant induces the Ub-dependent proteasomal degradation of cyclin-dependent kinase inhibitor p27 (Kip1) through interacting with the Jun activation domain-binding protein 1 (JAB1) to promote the proliferation of HCC cells [75]."
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"Our previous studies showed that Jab1 and COPS5 was highly expressed in breast cancer and played an essential role in the breast cancer pathogenesis, and that Jab1 knockdown significantly inhibited breast cancer cell proliferation and metastasis."
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"Jab1 may lead to cell proliferation and regulate the cell cycle; it also interacts with p53 inducing phosphorylation mediated by CSN and subsequent degradation."
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"Jab1 promotes cell proliferation and inactivates P27 by inducing translocation of P27 from the nucleus to the cytoplasm , which accelerates P27 degradation through the Ub-dependent proteasome pathway and promotes cell cycle progression [ 34 ] ."
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"It suggests that strong expression of Jab1 not only represents a prognostic marker for malignant transformation but also contributes to cancer cell proliferation and survival."
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"This data complements previous studies demonstrating that CSN5 loss inhibits proliferation and induces apoptosis [XREF_BIBR - XREF_BIBR]."
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"Our results show that Stat3 and LAP2 (C/EBP-beta 2) are the two major transcription factors that contribute to Jab1 overexpression that leads to increased proliferation of breast cancer cells."
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"Fig. 2 A shows that depletion of CSN5 markedly suppressed cell proliferation in the presence and absence of active Ras."
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"A previous study demonstrated that the specific knockdown of COPS5 inhibits the proliferation of colorectal cancer cells, and that COPS5-transgenic mice developed a phenotype similar to that of myeloproliferative disorders."
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"These results suggest that overexpression of CSN5 may contribute to both cell survival and proliferation and thus represent a prognostic marker for malignant conversion in liver cancer."
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"A previous investigation reported that overexpression of CSN5, a homologue of CSN6, leads to HSC proliferation and development of a myeloproliferative disorder in mice by increasing p53 degradation [47]."
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"Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells."
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"Further research, including clinical based and high-throughput analyses using disease samples and various tumor cell lines, has provided compelling support that CSN5 promotes proliferation."
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"In line with this finding, knockdown of CSN5 and CSN4 in cultured cells can significantly reduce the rate of cellular proliferation; this proliferation defect can be fully rescued by forced expression[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Second, in a manner independent of the CSN holocomplex, CSN5 (or a CSN5 containing small complex) promotes cell proliferation by inducing p27 degradation [22,23] and HIF1-alpha stabilization [41]."
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"According to the results of CCK8 assays, ectopic expression of CSN5 could promotes cell proliferation in 143B cells ( Fig. 2 C)."
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"Jab1 promotes glioma cell proliferation by regulating Siah1 and beta-catenin pathway."
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"We found that the knockdown of CSN5 significantly suppressed cell proliferation and cell cycle progression ( Fig. 2 G and I)."
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"Therefore, these findings suggest that CSN5 promotes OS cell proliferation by facilitating cell cycle progression.To further investigate whether CSN5 could affect tumor growth in vivo , we performed t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Depletion of one can reduce global levels of the others, while overexpression of CSN5 can enhance cell proliferation ( Wei and Deng, 2003 )."
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"Taken together, our results suggest that Trx may regulate cell cycle and growth through a novel modulation of Jab1 mediated proliferation signals, further indicating that Trx may have the ability to control tumor progression."
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"In various human cancer cell lines, the knockdown of CSN5 and JAB1 inhibited the proliferation of tumor cells, suggesting that over-expression of CSN5 and JAB1 not only serves as a marker of malignant transformation, but also actually contributes to tumorigenesis 13."
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"Moreover, we revealed that the PI3K/Akt signaling pathway is responsible for CSN5-mediated tumor cell proliferation and cell cycle progression in OS."
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"Consistent with this, loss of csn5 impairs cell proliferation in D. discoideum (Figure 6; Rosel and Kimmel, 2006)."
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"Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer."
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"Cops5 KO leads to decreased expression of the pluripotency marker Nanog, proliferation defect, G2/M cell-cycle arrest, and apoptosis of ESCs."
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"CSN5 promotes tumor cell proliferation by depleting NEDD8 to accumulate beta-catenin."
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"C-Jun activation domain-binding protein-1 ( Jab1 ) , which was initially identified as a c-Jun coactivator , is known to modulate cell proliferation , cell cycle , and apoptosis ."
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"Our results showed that Jab1 silencing significantly retarded the growth of SNU478 and HuCCT-1 cells (Fig. 1D), indicating that Jab1 silencing inhibited the proliferation of BTC cells."
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"Masaaki group revealed that overexpression of CSN5 promoted hematopoietic progenitor cell proliferation and initiated myeloproliferative disorders in transgenic mice."
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"Previous studies have shown that CSN3 and CSN5 could accelerate the cancer cell proliferation and growth XREF_BIBR, XREF_BIBR."
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"In line with our previous data, CSN5 knockdown reduced SW480 cell proliferation, whereas it was slightly elevated in DKK1 -depleted cells."
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"As hypothesized, CSN5 and DKK1 double knockdown abrogated the CSN5 knockdown effect, suggesting that DKK1 is involved in CSN5 mediated proliferation effects.To further confirm that secreted supernatan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Second, knockdown of CSN5/Jab1 inhibits the proliferation of human tumor cells [11,12] , suggesting that overexpression of CSN5/Jab1 not only serves as a marker of malignant transformation, but also a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, Jab1 depletion inhibited proliferation of pancreatic [19], colorectal [20], gastric [21], and nasopharyngeal cancer cell lines [22] in vitro."
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"CSN5/Jab1 knockdown in cancer cells inhibited proliferation in culture [11,12] ."
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"Conditional knockout of CSN5/Jab1 in T cells prevented cell proliferation [16] ."
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"Overexpression of JAB1 promoted the proliferation, migration, and invasion of ESCC cells, and was significantly associated with poor prognosis of ESCC patients."
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"The binding of MIF with JAB1 / CSN5 also modulates AP-1 activity and cell proliferation by inactivation of p53 [ 8] ."
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"The CSN complex may also be a good target for anti-cancer treatment.We have previously found that in cells originating from Chronic Myeloid Leukemia (CML), the smaller form of CSN5 was accumulated dep[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Jab1 and CSN5 knockdown also impaired proliferation and enhanced apoptosis in these cells regardless of the genotype of the tumor suppressor p53 [XREF_BIBR]."
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"Jab1 and COPS5 knockdown significantly inhibits proliferation and induces apoptosis in hepatocellular carcinoma cells."
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"Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors."
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"Inhibition of Jab1 not only blocks cancer cell proliferation, but also reduces the DNA HR repair function after cancer therapy."
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"It has been suggested that Jab1 can lead to cell proliferation through the translocation of p27 from the nucleus to cytoplasm and accelerating p27 degradation through the ubiquitin/proteosome pathway [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Jab1 promotes cell proliferation by interacting directly with p27 and induces nuclear export and subsequent p27 degradation [ 46 ]."
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"In the current study, we have shown that overexpression of Jab1 stimulated the proliferation of GBC cells; whereas downregulation of Jab1 by using Jab1-siRNA approach resulted in the cell growth inhibition and apoptotic induction."
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"We found that COPS5 knockdown repressed proliferation, migration, and invasion and facilitated apoptosis of OS cells."
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