IndraLab

Statements

COPS5 decreases the amount of CDKN1B. 10 / 15
3 1 | 6
bel
"Jab1 was also identified as a direct negative regulator of the CDK inhibitor, p27Kip1, resulting in cell cycle progression (Tomoda et al., 1999)."
15480426
reach
"Based on these results, we suggest that XLGalpha olf and CSN5 down-regulate the expression of p27 Kip1 cooperatively and this function is controlled by phosphorylation.Furthermore, Galpha s, classifie[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22120635
reach
"Recently, Jab1 and CSN5, the fifth component of the COP9 signalosome complex, was found to specifically translocate p27Kip1 from the nucleus to the cytoplasm, and reduce the protein level of p27Kip1 by accelerating its degradation."
14719054
trrust
No evidence text available
16951171
reach
"Jab1 is known to downregulate the expression of the cell cycle inhibitor p27 Kip1 in some cancer models."
30203426
reach
"Jab1 and COPS5 negatively regulates p27 expression by exporting p27 from the nucleus to the cytoplasm, mediating p27 degradation via the proteasome pathway and promoting cell-cycle progression."
29535627
reach
"Thus, disruption of the Jab1 gene not only abolished JAB1 expression but also increased p27, p53 and c-Myc levels and cell death, suggesting that JAB1 is involved in maintaining the integrity and stability of critical regulators of cell proliferation and apoptosis."
20802511
bel
"Jun activation domain-binding protein 1 (Jab1) was originally identified as a coactivator of activator protein 1 (AP1) transcription and was also shown to promote degradation of the cyclin-dependent kinase inhibitor, p27Kip1."
15480426
bel
"Jab1 promotes degradation of the cyclin-dependent kinase inhibitor p27(Kip1)"
15353483
reach
"In addition, Jab1 silencing by siRNA increased p27 expression levels."
30282449