IndraLab

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COPS5 decreases the amount of CDKN1B. 13 / 22
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"We hypothesized that Jab1 inhibition increases p27 expression in some BTC cell lines, resulting in anti-proliferative activity."
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"Jab1 is known to downregulate the expression of the cell cycle inhibitor p27 Kip1 in some cancer models."
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"Stable knockdown of Jab1 by shRNA increases p27 expression and decreases proliferative and migratory activity."
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"Moreover, Jab1 knockdown also increased p27 expression in BTC cells, which is in line with the results of previous studies in other cancers [6-10]."
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"Based on these results, we suggest that XLGalpha olf and CSN5 down-regulate the expression of p27 Kip1 cooperatively and this function is controlled by phosphorylation.Furthermore, Galpha s, classifie[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, Jab1 depletion decreased Ki-67 expression and AKT phosphorylation and increased TUNEL and p27 expression in vivo.Our in vitro and in vivo experimental data suggest that Jab1 silencing alone or in combination with cisplatin has a promising anti-tumor activity in BTC."
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"In addition, Jab1 silencing by siRNA increased p27 expression levels."
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"In contrast, SNU245, SNU1079, and HuCCT-1 cell lines had relatively lower basal Jab1 expression levels.Previous studies demonstrated that Jab1 decreases p27 expression levels and is inversely correlated with p27 in several cancers [6-10]."
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"In line with the results of Jab1 silencing by siRNA, stable knockdown of Jab1 by shRNA increased p27 expression levels (Fig. 5A) and significantly decreased proliferative (Fig. 5B) and migratory activities (Fig. 5C) compared with the control in HuCCT-1 cells.In the HuCCT-1 mouse xenograft model, mice injected with HuCCT-1 cell stably knocked down for Jab1 by shRNA showed significantly decreased tumor volume in vivo (Fig. 5D)."
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"Jab1 and COPS5 negatively regulates p27 expression by exporting p27 from the nucleus to the cytoplasm, mediating p27 degradation via the proteasome pathway and promoting cell-cycle progression."
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"Recently, Jab1 and CSN5, the fifth component of the COP9 signalosome complex, was found to specifically translocate p27Kip1 from the nucleus to the cytoplasm, and reduce the protein level of p27Kip1 by accelerating its degradation."
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"For example, inhibition of Jab1/COPS5 promotes the increase of p27 level and thus suppresses the proliferation of cancer cells, such as serous ovarian cancer and nasopharyngeal carcinoma cells [30, 31]."
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"Thus, disruption of the Jab1 gene not only abolished JAB1 expression but also increased p27, p53 and c-Myc levels and cell death, suggesting that JAB1 is involved in maintaining the integrity and stability of critical regulators of cell proliferation and apoptosis."
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