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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

OTUB1 activates CTNNB1. 2 / 2

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"Subsequent experiments further suggested that OTUB1 promoted CRC malignancy by enhancing protein stability of β-catenin, via inhibition of its protein degradation by UPP pathway, which indicated its crucial role in enhancement of CRC tumor cellular proliferative and chemo-resistant capabilities."

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"At the same time, a high level of N-cadherin expression blocks beta-catenin entry into the nucleus [XREF_BIBR], so the changes in beta-catenin mediated by OTUB1 were observed in the cytoplasm in our model, which might be the reason why TCF1, LEF1 were not activated in our models (Additional file 11 : Figure S9)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...