IndraLab

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OTUB1 activates CTNNB1. 4 / 4
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"Subsequent experiments further suggested that OTUB1 promoted CRC malignancy by enhancing protein stability of beta-catenin, via inhibition of its protein degradation by UPP pathway, which indicated its crucial role in enhancement of CRC tumor cellular proliferative and chemo-resistant capabilities."
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"At the same time, a high level of N-cadherin expression blocks beta-catenin entry into the nucleus [XREF_BIBR], so the changes in beta-catenin mediated by OTUB1 were observed in the cytoplasm in our model, which might be the reason why TCF1, LEF1 were not activated in our models (Additional file 11 : Figure S9)."
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"Based on the above results, the fact that OTUB1 promotes cisplatin resistance in BLCA through mediating β-catenin has been confirmed."
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"OTUB1-induced β-catenin stabilization by inhibition of UPP pathway-induced protein degradation further expanded the regulatory network of Wnt/β-catenin signaling pathway."
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