IndraLab

Statements

USP2 inhibits USP2. 4 / 4
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"Specifically, USP2 overexpression could markedly reduce elevated Nox2, Nox4, and p22phox at the mRNA level in pressure-overloaded hearts, indicating an unprecedented regulatory role of USP2 in mediating oxidative stress and Nox protein expression during cardiac pressure overload."
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"The above data suggested that USP2 overexpression attenuated calcium overload and mitochondrial dysfunction in cardiomyocytes of mice with cardiac hypertrophy.We further validated the role of USP2 in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In summary, our data show that the ubiquitin core and the ubiquitin C terminus alone bind USP2 very weakly with affinities at best in the high micromolar range, while full-length ubiquitin inhibits USP2 with a K of 2.8 μM. Discussion."
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"Collectively, these results confirmed the ACE2 dependency in the inhibition of USP2 by ML364 or MS102, thereby resulting in their inhibitory effects on viral infections."
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