IndraLab

Statements

OTULIN binds monoubiquitin. 2 / 2
| 1 1
reach
"Interestingly, monoubiquitin binding to OTULIN did not induce rearrangement of the active site into a catalytically competent configuration 30, and monoubiquitin based suicide probes, where the C terminus of ubiquitin is replaced with a Cys reactive group 44, were unable to react with OTULIN, confirming that the catalytic triad in OTULIN was incompetent 29."
26503766
sparser
"Interestingly, monoubiquitin binding to OTULIN did not induce rearrangement of the active site into a catalytically competent configuration xref , and monoubiquitin‐based suicide probes, where the C terminus of ubiquitin is replaced with a Cys‐reactive group xref , were unable to react with OTULIN, confirming that the catalytic triad in OTULIN was incompetent xref ."
26503766