IndraLab

Statements

BI-2536 inhibits IFNB1. 5 / 5
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"Since BI-2536 and JQ1 blocked IFNbeta production by preventing the interaction of transcription factors with the Ifnb promoter, it was of interest to examine the effects of these compounds on the transcription of other poly (I : C) - and LPS regulated genes."
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"It was therefore surprising when BI-2536 and some other PLK inhibitors were reported to suppress the production of Ifnb mRNA and the transcription of some ISGs in primary BMDCs (bone-marrow-derived dendritic cells) stimulated with the dsRNA-mimetic poly (I : C) or LPS, or infected with VSV (vesicular stomatitis virus)."
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"Similar to the TLR3-TBK1-IRF3 pathway, we found that BI-2536, JQ1 and I-BET151 blocked the TLR7- or TLR9 stimulated secretion of IFNbeta in Gen2.2 cells (XREF_FIG A and XREF_FIG B), without affecting the TLR stimulated translocation of the endogenous IRF5 to the nucleus (XREF_FIG C)."
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"We confirmed earlier observations that BI-2536 prevents the LPS stimulated secretion of IFNbeta when included in the cell culture medium at a concentration of 1.0 muM or higher."
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"BI-2536 blocks Ifnb mRNA production without affecting the phosphorylation, dimerization or nuclear translocation of IRF3."
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